Supporting the ongoing clinical and commercial development of early Diabetic Kidney Disease biomarkers
EKF Diagnostics, the global diagnostics company, has entered a multi-year, collaborative relationship with Joslin Diabetes Center (“Joslin”) in support of the ongoing clinical and commercial translation of TNFR1 & 2 biomarkers. These novel biomarkers can help identify patients with Type 1 and Type 2 diabetes that are at an increased risk of developing end stage renal disease (ESRD), up to ten years in advance. The new agreement between...
Protagen AG has announced that it has entered into a long-term collaboration agreement with QIAGEN targeting the development of novel protein-based companion diagnostics for autoimmune disorders.
Under the terms of the agreement, QIAGEN will gain access to the proprietary SeroTag® technology platform of Protagen, which enables the discovery and validation of novel protein-based marker panels. Such markers hold great promise for the development into companion diagnostics to guide treatment decisions in various autoimmune disorders. Financial details of the collaboration were not disclosed...
In collaboration with scientists from the European Union Reference Laboratory for Dioxins and PCBs in Feed and Food, Thermo Fisher Scientific has developed a simple, reliable and robust method for detecting and confirming low levels of dioxins in food and feed samples using a triple quadrupole gas chromatograph-mass spectrometer (GC-MS/MS) system equipped with an autosampler.
Application Note 10406: Validation of GC-MS/MS for Detection and Confirmation of Low-Level Dioxins illustrates the excellent selectivity and sensitivity of this GC-MS/MS System for low levels of dioxins, even in complex matrices. Dioxins are a group of chemically-related compounds, including polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and some dioxin-like polychlorinated biphenyls (PCBs). These compounds are...
A team of international researchers, including Professor Joel D. Irish from Liverpool John Moores University (LJMU), have discovered the remains of two infants, buried some 11,500 years ago at a site in Alaska.
They represent the youngest human remains ever found in the North American Arctic, according to a new paper published in the Proceedings of the National Academy of Sciences. The site and its artifacts provide new insights into funeral practices and other rarely preserved aspects of life among people who inhabited the area during that early time, according to Ben Potter, the paper’s lead author from the University of Alaska Fairbanks. Potter led the archaeological team that made the discovery in fall of 2013 at an excavation of the Upward Sun River site, near the...
Two new case studies highlighting the versatility of the Matrix Laboratory Information Management System (LIMS) at Castrol’s Lubricant Technology Centre and Cavendish Nuclear’s environmental laboratory are now available for download.
'Matrix Provides Paperless LIMS At Castrol’ describes how product and development scientists at the Lubricant Technology Centre at Castrol, Pangbourne, Berkshire, UK, can request analytical tests and receive results by accessing Matrix from their own computers. Castrol, part of BP, has been a Matrix LIMS customer for more than 20 years. The analytical laboratory at Pangbourne provides a comprehensive test facility for the...
Pharmacists are among the best positioned to promote the appropriate use of antibiotics, according to a new survey in the WHO European Region.
They therefore have a crucial role in combating antimicrobial resistance, along with policy-makers and health practitioners: every player is key. On European Antibiotic Awareness Day, 18 November 2014, WHO advocates increasing the prudent use of antibiotics through pharmaceutical services in Europe. “We need to shift from the concept of the pharmacy as a ‘shop’ and build a culture of pharmaceutical services. This is already happening in...
ESA’s comet-chasing mission Rosetta was launched on the 2nd of March 2004 and through a complex series of flybys (three times past Earth and once past Mars) arrived ten years after at its destination: comet 67P/Churyumov–Gerasimenko.
In June 2011, Rosetta was put into deep-space hibernation for the coldest, most distant leg of the journey (800 million kilometres from the sun) and was woken up on 20th of January 2014. Finally, Rosetta was set on comet’s orbit on August 2014 to achieve a successful landing of Philae lander on 12th of November 2014. Comets are the primitive building blocks of the Solar System and the likely source of many elements such as water and...
Cresset, innovative provider of computational chemistry software and services, is pleased to announce that Monash University Faculty of Pharmacy and Pharmaceutical Sciences, Australia’s leading pharmacy and pharmaceutical science educators and researchers, has licensed Cresset’s Forge and Spark software.
These applications provide extensive capabilities in SAR analysis, ligand-based molecular design and bioisosteric replacement. “Cresset’s software is used in the R&D departments of the world’s leading pharmaceutical companies. It is great to know that our students will be using the very same cutting edge tools for their molecular design and optimization work,” says Dr David Manallack, Senior Lecturer at Monash University. “Cresset’s software will...
The failure of experimental liver cancer therapies directed specifically against the EGFR protein is presumably the result of insufficiently specific patient selection.
This is the conclusion that can be drawn from data that were obtained within the framework of a project carried out by an Austrian Science Fund FWF doctoral programme, and that have now been published in NATURE Cell Biology. The data prove that the tumour-promoting effect of EGFR originates, not directly from its expression in the tumour cells, but rather from its presence in the surrounding cells (macrophages) of the immune system. This predicts that experimental anti-EGFR therapeutic agents will prove effective only in patients who exhibit EGFR in the...
Porvair Sciences has published a new guide to help laboratories choose the best way to verify the quality and quantity of their Chromatin Immunoprecipitation (ChIP) DNA.
Researchers at the National Institute for Environmental Protection and Research (Istituto Superiore per la Protezione e la Ricerca Ambientale, ISPRA) in Italy have been testing the TouchTools™ PCR Wizard with the Freedom EVO® PCR workstation to simplify complex genetics workflows.
Dr Nadia Mucci, a technologist in ISPRA’s Laboratory of Genetics, explained: “We purchased two Freedom EVO platforms in 2010 to automate our pre- and post-PCR sample processing, and chose Tecan instruments because we appreciated the technology, the support from Tecan’s application specialists, and the user-friendly software which offered us the opportunity to develop automated protocols for many more applications.”....Read MoreEnvironmental and Food Applications using Cogent TYPE-C Silica ColumnsDec 8, 2014
A new flyer is available demonstrating the benefits of Cogent TYPE-C silica columns for environmental and food applications.
Cogent TYPE-C silica HPLC phases offer unique opportunities for the separation of a wide range of sometimes difficult to separate compounds. They have the ability to retain polar solutes at high concentrations of organic solvent by aqueous normal-phase (ANP) and non-polar compounds under reversed-phase (RP) conditions.
Read MoreLinkam Launch Educational Videos Describing Thermal Microscopy and Associated ApplicationsDec 8, 2014
Market leaders in temperature controlled microscopy, Linkam Scientific Instruments have launched their first educational videos to help introduce users to some of the new thermal microscopy techniques and associated testing methods.
Organic chemists at the University of Oxford are benefitting from the recent acquisition of an RC900 Rotary Evaporator from KNF Lab.
As one of the UK's premier academic centres for research into organic chemistry, the Chemistry Research Laboratory is engaged in a range of organic synthesis projects. Rotary evaporators are essential for this work, and the RC900 Rotary Evaporator, launched at Analytica in April this year, is a key addition to the laboratory
Read MoreProximagen Licenses CressetDec 5, 2014
Cresset, innovative provider of computational chemistry software and services, is pleased to announce that Proximagen, a company focused on the development and commercialisation of novel therapeutics for diseases of the central nervous system (CNS), has licensed Cresset’s Forge and Spark software.
These applications provide extensive capabilities in SAR analysis, ligand-based molecular design and bioisosteric replacement. "Proximagen has successfully used Cresset’s computational chemistry tools in the past to generate pharmacophores from known ligands and to identify novel chemical series by scaffold hopping,” says Dr Ed Savory, Deputy Head of Chemistry at Proximagen. “We will be using Spark to identify new drug scaffolds and to...
“Should we try and make our own gold nanoparticles or buy them from a supplier?”
If you work with gold nanoparticles, you have probably considered this question.
NanoHybrids Inc has released a new white paper titled “Gold Nanoparticles: To Make or To Buy? A quick look at the economics behind the decision.” The paper is available for free download at the company’s website. The paper takes an in-depth look at various costs involved in making gold nanoparticles by dividing the process into two main phases - the research phase that involves fine-tuning protocols and characterization and the actual production phase....
Spark Holland B.V. is pleased to announce that the company has been presented with the prestigious Frost & Sullivan 2014 award for Best Practices in Product Line Strategy Leadership in the LC-MS industry.
Frost & Sullivan is renowned as the the world leader in growth consulting and the integrated areas of technology research, market research, mega trends, economic research, best practices, training, customer research, competitive intelligence and corporate strategy....
Thermo Fisher Scientific has developed an efficient and simple high-performance liquid chromatography method for the determination of dicyandiamide in milk powder using an ion-exclusion chromatography column that is capable of rapidly analyzing polar compounds such as aliphatic organic acids and alcohols in complex and high-ionic-strength samples.
The modular Asia flow chemistry system from Syrris proved key to the success of a recently described process for accelerated total synthesis of spirodienal A and spirangien A methyl ester.
Developed by the Ley Group at the Department of Chemistry, University of Cambridge, UK – and recently published in Angewandte Chemie International Edition1 – the groundbreaking workdescribes the use of powerful flow chemistry techniques for complex multi-stage synthesis of spirocyclic polyketides. The flexible Asia system was crucial to the success of the study, offering a variety of flow techniques – including gas-liquid and...
Molecular Profiles Ltd., a subsidiary of Columbia Laboratories, Inc. and Maryland-based Xceleron have announced a collaboration to assist drug developers with improved efficiency during clinical development.
This partnership extends Molecular Profiles’ new ROADMAP to Clinical Trials enabling technologies platform, which it launched earlier this month. The company also has complementary collaborations in place with Onyx Scientific and XenoGesis that broaden its expertise to give clients an end-to-end solution using a connected network of industry experts allowing it to compete with larger CROs...
Medical Research Council (MRC) scientists have created the world’s first enzymes made from artificial genetic material. Their synthetic enzymes, which are made from molecules that do not occur anywhere in nature, are capable of triggering chemical reactions in the lab.
The research, published today in Nature, gives new insights into the origins of life and could provide a starting point for an entirely new generation of drugs and diagnostics. The findings build on previous work by the team at the MRC Laboratory of Molecular Biology, which saw them create synthetic molecules called ‘XNAs’ that can store and pass on genetic information, in a similar way to DNA....
Anthias are proud to be amongst the first companies to be given formal approval by the Royal Society of Chemistry for their courses under their new training course accreditation scheme.
Diane Turner Founder and Senior Consultant of Anthias said: “It is important to all at Anthias to know that the courses we write and deliver are of a high standard. We work hard to make sure this is the case but it was crucial to have independent affirmation to reassure potential course attendees; securing this from the Royal Society of Chemistry is something we are very proud of”...
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EKF Diagnostics, the global diagnostics company, has entered a multi-year, collaborative relationship with Joslin Diabetes Center (“Joslin”) in support of the ongoing clinical and commercial translation of TNFR1 & 2 biomarkers. These novel biomarkers can help identify patients with Type 1 and Type 2 diabetes that are at an increased risk of developing end stage renal disease (ESRD), up to ten years in advance. The new agreement between...
Under the terms of the agreement, QIAGEN will gain access to the proprietary SeroTag® technology platform of Protagen, which enables the discovery and validation of novel protein-based marker panels. Such markers hold great promise for the development into companion diagnostics to guide treatment decisions in various autoimmune disorders. Financial details of the collaboration were not disclosed...
Application Note 10406: Validation of GC-MS/MS for Detection and Confirmation of Low-Level Dioxins illustrates the excellent selectivity and sensitivity of this GC-MS/MS System for low levels of dioxins, even in complex matrices. Dioxins are a group of chemically-related compounds, including polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and some dioxin-like polychlorinated biphenyls (PCBs). These compounds are...
They represent the youngest human remains ever found in the North American Arctic, according to a new paper published in the Proceedings of the National Academy of Sciences. The site and its artifacts provide new insights into funeral practices and other rarely preserved aspects of life among people who inhabited the area during that early time, according to Ben Potter, the paper’s lead author from the University of Alaska Fairbanks. Potter led the archaeological team that made the discovery in fall of 2013 at an excavation of the Upward Sun River site, near the...
'Matrix Provides Paperless LIMS At Castrol’ describes how product and development scientists at the Lubricant Technology Centre at Castrol, Pangbourne, Berkshire, UK, can request analytical tests and receive results by accessing Matrix from their own computers. Castrol, part of BP, has been a Matrix LIMS customer for more than 20 years. The analytical laboratory at Pangbourne provides a comprehensive test facility for the...
They therefore have a crucial role in combating antimicrobial resistance, along with policy-makers and health practitioners: every player is key. On European Antibiotic Awareness Day, 18 November 2014, WHO advocates increasing the prudent use of antibiotics through pharmaceutical services in Europe. “We need to shift from the concept of the pharmacy as a ‘shop’ and build a culture of pharmaceutical services. This is already happening in...
In June 2011, Rosetta was put into deep-space hibernation for the coldest, most distant leg of the journey (800 million kilometres from the sun) and was woken up on 20th of January 2014. Finally, Rosetta was set on comet’s orbit on August 2014 to achieve a successful landing of Philae lander on 12th of November 2014. Comets are the primitive building blocks of the Solar System and the likely source of many elements such as water and...
These applications provide extensive capabilities in SAR analysis, ligand-based molecular design and bioisosteric replacement. “Cresset’s software is used in the R&D departments of the world’s leading pharmaceutical companies. It is great to know that our students will be using the very same cutting edge tools for their molecular design and optimization work,” says Dr David Manallack, Senior Lecturer at Monash University. “Cresset’s software will...
This is the conclusion that can be drawn from data that were obtained within the framework of a project carried out by an Austrian Science Fund FWF doctoral programme, and that have now been published in NATURE Cell Biology. The data prove that the tumour-promoting effect of EGFR originates, not directly from its expression in the tumour cells, but rather from its presence in the surrounding cells (macrophages) of the immune system. This predicts that experimental anti-EGFR therapeutic agents will prove effective only in patients who exhibit EGFR in the...
The guide reports on experiments undertaken to compare the performance of the Thermo Scientific NanoDrop 2000™, the Life Technologies Qubit 2.0® fluorimeter and the Agilent Bioanalyzer 2100© for qualitative and quantitative analysis of double stranded immunoprecipitated DNA. The advantages and limitations of detection sensitivity, reproducibility and automated analysis of each instrument are discussed. The compatibility of...
Cogent TYPE-C silica HPLC phases offer unique opportunities for the separation of a wide range of sometimes difficult to separate compounds. They have the ability to retain polar solutes at high concentrations of organic solvent by aqueous normal-phase (ANP) and non-polar compounds under reversed-phase (RP) conditions.
These applications provide extensive capabilities in SAR analysis, ligand-based molecular design and bioisosteric replacement. "Proximagen has successfully used Cresset’s computational chemistry tools in the past to generate pharmacophores from known ligands and to identify novel chemical series by scaffold hopping,” says Dr Ed Savory, Deputy Head of Chemistry at Proximagen. “We will be using Spark to identify new drug scaffolds and to...
If you work with gold nanoparticles, you have probably considered this question.
Frost & Sullivan is renowned as the the world leader in growth consulting and the integrated areas of technology research, market research, mega trends, economic research, best practices, training, customer research, competitive intelligence and corporate strategy....
Developed by the Ley Group at the Department of Chemistry, University of Cambridge, UK – and recently published in Angewandte Chemie International Edition1 – the groundbreaking workdescribes the use of powerful flow chemistry techniques for complex multi-stage synthesis of spirocyclic polyketides. The flexible Asia system was crucial to the success of the study, offering a variety of flow techniques – including gas-liquid and...
This partnership extends Molecular Profiles’ new ROADMAP to Clinical Trials enabling technologies platform, which it launched earlier this month. The company also has complementary collaborations in place with Onyx Scientific and XenoGesis that broaden its expertise to give clients an end-to-end solution using a connected network of industry experts allowing it to compete with larger CROs...
The research, published today in Nature, gives new insights into the origins of life and could provide a starting point for an entirely new generation of drugs and diagnostics. The findings build on previous work by the team at the MRC Laboratory of Molecular Biology, which saw them create synthetic molecules called ‘XNAs’ that can store and pass on genetic information, in a similar way to DNA....
Diane Turner Founder and Senior Consultant of Anthias said: “It is important to all at Anthias to know that the courses we write and deliver are of a high standard. We work hard to make sure this is the case but it was crucial to have independent affirmation to reassure potential course attendees; securing this from the Royal Society of Chemistry is something we are very proud of”...