Special Offers & Promotions



Latest News



View Channel

New Products



View Channel

Video Presentations



View Channel

Separation Science



View Channel

Microscopy & Image Analysis



View Channel

Laboratory Automation & IT Solutions



View Channel


Syrris Asia Helps to Accelerate Spirocyclic Polyketide Synthesis

publication date: Dec 3, 2014
author/source: Syrris

Leys chemistry

The modular Asia flow chemistry system from Syrris proved key to the success of a recently described process for accelerated total synthesis of spirodienal A and spirangien A methyl ester.

Developed by the Ley Group at the Department of Chemistry, University of Cambridge, UK – and recently published in Angewandte Chemie International Edition1 – the groundbreaking work describes the use of powerful flow chemistry techniques for complex multi-stage synthesis of spirocyclic polyketides.

The flexible Asia system was crucial to the success of the study, offering a variety of flow techniques – including gas-liquid and solid phase chemistries, liquid-liquid extraction and continuous work-up – to enable faster reaction optimization and telescoping of reaction steps. Researchers benefitted from the Asia Pump’s capacity to smoothly handle low boiling point solvents, as well as rapid mixing and continuous work-up in glass microreactors with the advanced Asia FLLEX (Flow Liquid Liquid Extraction). This set-up allowed synthesis of essential, complex coupling fragments using newly developed flow chemistry methods for automated reagent addition, silylation, crotylation, ozonolysis, olefination and oxidation, allowing these vital building blocks to be produced faster and more safely, with higher yields compared to batch reactions.

1 Newton, S., Carter, C. F., Pearson, C. M., de?C.?Alves, L., Lange, H., Thansandote, P. and Ley, S. V. (2014), Accelerating Spirocyclic Polyketide Synthesis using Flow Chemistry. Angew. Chem. Int. Ed., 53: 4915–4920. doi: 10.1002/anie.201402056

more about syrris

more news from syrris





Subscribe to any of our newsletters for the latest on new laboratory products, industry news, case studies and much more!

Newsletters from Lab Bulletin


Request your free copies HERE




Popular this Month

Top 10 most popular articles this month



Today's Picks



Looking for a Supplier?

Search by company or by product


Company Name:






Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd.


Media Partners


Exhibitions & Events