Greenovation Biotech GmbH announced today that scientists at Baylor Institute, USA and Greenovation, Germany published results from a preclinical study in Fabry mice in the Journal of Inherited Metabolic Diseases.
Results of the study imply that replacement enzymes exhibiting mannose-terminated glycosylation patterns are efficiently delivered to their subcellular targets, the lysosomes. Lysosomal storage diseases (LSDs) like Fabry disease are caused by inborn absence of certain degradation enzymes, leading to continuous accumulation of problematic compounds in the cells. In Fabry patients, sphingolipid accumulation leads to various symptoms like...
Nanolab Orders Advanced Local Electrode Atom Probe (LEAP®) Microscope from CAMECA Unit of AMETEK Materials Analysis Division
Nanolab Technologies Inc., a Silicon Valley-based analytical services lab, has purchased a new Local Electrode Atom Probe from CAMECA Instruments Inc. The high-performance atom probe from CAMECA, a unit of the AMETEK Materials Analysis Division, is used to provide advanced materials analysis, including precise atom-by-atom identification, 3-D spatial positioning, and accurate atomic-scale reconstruction of a material’s...
INTEGRA reports on how researchers at the renowned Forsyth Institute (Cambridge, MA) are using a VIAFLO Assist to enhance the efficiency while maintaining the accuracy of pipetting protocols related to the discovery, measurement, and validation of new biomarkers of disease that can be found in saliva.
Founded over 100 years ago, the Forsyth Institute has established itself as the leading independent research institute in America specializing in oral health and its impact on overall wellness. In addition to its affiliation with the Harvard School of Dental Medicine, Forsyth has collaborations with a vast array of academic institutions, hospitals, independent research institutes, and biotech and pharmaceutical companies. These interactions...
Magritek, a leading provider of compact NMR and MRI instruments, report on the use of their Spinsolve Benchtop NMR spectrometer the Chemistry Department of the University of Queensland where it is in use in the undergraduate laboratory curricula.
Dr Philip Sharpe is a teaching-focused academic in the School of Chemistry & Molecular Biosciences at the University of Queensland, Australia. His active research interests are in the field of chemistry education research, particularly student learning within the laboratory environment. His goal is to remove the barriers that hinder student success in the laboratory and to provide situations that allow students to maximize their learning. As the academic in charge of the first year chemistry laboratory, Dr Sharpe...
Antibiotic Research UK will announce at its Annual General meeting today its first research programme to tackle antibiotic resistant bacteria (superbugs).
Superbugs are becoming an increasing problem in hospitals as bacteria become more and more resistant to our existing antibiotics. The Chief Medical Officer, Dame Sally Davies recently said that if we don’t tackle the problem now our grandchildren will not thank us. All the medical procedures we currently take for granted such as cancer treatment, open heart surgery, hip and knee replacement and organ transplantation will become much more...
The European Commission annually awards outstanding projects in various research areas with research grants. One special program supports young scientists in international exchange networks.
baseclick GmbH is part of a Marie Curie actions research program within the 7th framework program EScoDNA (an Initial Training Network, ITN). The EScoDNA program is a joint initiative by leading scientists in this field from recognized universities and companies. The research within this project focuses on the application of DNA nanotechnology in the key sectors life science and biomedicine. In January 2015, baseclick has been awarded another...
In the run up to our 2nd Annual Drug Discovery USA Congress 2015, we spoke with Matthew Wagoner a discovery safety specialist from AstraZeneca, a confirmed speaker at the congress where he will talk about Bromodomain And ExtraTerminal (BET) Domain Inhibitors Induce A Loss Of Intestinal Stem Cells And Villous Atrophy.
Big Pharma is keen to increase drug discovery productivity; which strategies do you think will help to increase R&D output? “I think the strategies for increasing drug discovery productivity will be multifaceted. We do quite a bit of the traditional internal repurposing and rescue, which is a great way of accelerating a nascent project idea with more advanced chemistry. The most promising of these approaches, in my opinion, is opening up your pharmacology...
CLSI recently released new and revised standards on method evaluation.
A Framework for Using CLSI Documents to Evaluate Clinical Laboratory Measurement Procedures (EP19-Ed2) uses the “measurement procedure lifecycle” framework to aid users of CLSI evaluation protocols documents during establishment and implementation of measurement procedures developed by both commercial manufacturers and clinical laboratories, ie, for laboratory-developed tests. Harmonization of Symbology and Equations (EP36-Ed1) provides a standardized...
JPK Instruments, a world-leading manufacturer of nanoanalytic instrumentation for research in life sciences and soft matter, reports on the application of scanning electrochemical microscopy to study nanometric biostructures by the Demaille and Anne Group in the Laboratoire d'Electrochimie Moléculaire at the Université Paris Diderot, France.
Drs Christophe Demaille and Agnès Anne from CNRS work in the Laboratoire d'Electrochimie Moléculaire at the Université Paris Diderot as Group Leaders of a research team aiming to probe electron transport and communication in nanometric biostructures. Their studies are performed at the single nano-object scale using combined atomic force (AFM)-Electrochemical (SECM) microscopy. In this combined microscopy technique, the tip acts...
The largest study ever conducted on drug resistance in patients infected with Hepatitis B Virus (HBV) in Europe shows that half of patients in whom HBV is not fully suppressed by treatment harbor the drug-resistant virus.
This is because doctors in Europe are still prescribing old antiviral drugs, which may also cause resistance to modern compounds. The researchers reported these results in the latest issue of The Journal of Infectious Diseases, published this week. According to the WHO, approximately 13 million people in Europe are chronically infected with the Hepatitis B virus (HBV). These patients often develop a severe form of liver inflammation...
University of Leicester researchers involved in study demonstrating how combining novel treatments currently in development may lead to better asthma control.
Researchers from the University of Leicester and University Hospitals of Leicester NHS Trust, working with the National Institute of Allergy and Infectious Diseases (NIAID) and Genentech, have discovered new insights into how asthma may be caused, by identifying three distinct groups of asthma patients characterised by the activity of different genes in an individual’s airways. Asthma affects about five million people in the UK. Not all patients respond...
Brookfield Engineering, the world standard for viscosity measurement and control, offers its Practical Course on Viscosity Measurements.
This popular course is designed to help Brookfield viscometer users comprehend the functionality of their instrument, solve the mysteries of fluid behavior and Rheology, and create successful and repeatable viscosity test methods for use in both R&D and QA/QC environments. Consistent measurement is vital in the success of any product and understanding viscosity is a key part to maintaining quality control. The course is offered at Brookfield’s headquarters in Middleboro, MA and...
DefiniGEN Ltd, a leading provider of stem cell life science products and services, today announced that it has strengthened its IP portfolio with a licence for cutting edge lung stem cell technology from the University of Cambridge.
The technology will be used by DefiniGEN to develop new, optimised cell products and services for drug discovery and the study of lung diseases, including cystic fibrosis. The technology, licensed to DefiniGEN by Cambridge Enterprise, the commercialisation arm of the University of Cambridge uses induced pluripotent stem cells, or iPS cells, to recreate embryonic lung development in the lab by activating a process known as gastrulation, in which the cells form...
A new technical poster produced by Genevac, in conjunction with the Novartis Institute for BioMedical Research (Horsham, UK), examines the application of eXalt™ evaporative crystallisation technology to drug discovery projects.
eXalt™ is a proprietary Genevac technology designed to control evaporation using restricting baffles. Using this technology multiple solvents can be screened in parallel to identify optimum crystallisation conditions for amorphous materials. In the pharmaceutical industry, physical form can pose a significant challenge for small molecule drug discovery projects transitioning between the optimisation and characterisation phases. A crystalline form is desirable...
High Performance, Compact Flow Cytometry Instrument Delivers Full Analysis Capabilities
Beckman Coulter Life Sciences is running a major competition for flow cytometry scientists, with the prize the recently launched CytoFLEX Flow Cytometer, valued at approximately 200,000 US dollars. Applicants are being asked to challenge the CytoFLEX Flow Cytometer to solve a key experimental puzzle for their research and to describe how it would deliver the solution, in 300 words or less. For more information visit: CytoFLEX Competition...
DefiniGEN Ltd, a leading provider of stem cell life science products and services, today announced that it has strengthened its IP portfolio with a licence for cutting edge lung stem cell technology from the University of Cambridge.
The technology will be used by DefiniGEN to develop new, optimised cell products and services for drug discovery and the study of lung diseases, including cystic fibrosis. The technology, licensed to DefiniGEN by Cambridge Enterprise, the commercialisation arm of the University of Cambridge uses induced pluripotent stem cells, or iPS cells, to recreate embryonic lung development in the lab by activating a process known as gastrulation, in which the cells...
Partnership seeks to advance scientific discovery by offering important bioreagents
Kerafast Inc., developers of an online platform to facilitate accessibility to unique bioresearch materials from academic and government laboratories across the globe, today announced an agreement to make important research materials from the National Cancer Institute available through Kerafast’s platform. With this agreement, Kerafast has now partnered with 122institutes....
Ocean Optics’ spectrometer assures special effects color purity and safety for Le Maitre
Spectrometers from Ocean Optics are being used by Le Maitre Ltd (Surrey, England) to ensure the quality and safety of its close proximity pyrotechnics. Ocean Optics spectrometers measure plasma emission and emissive color of effects used in theater productions, concerts, and sporting events. The measurements help Le Maitre ensure these explosive displays are consistently amazing, and most important, safe. Le Maitre Pyrotechnics Developer Hamish...
Specialised Imaging reports on how the Leibniz Institute for Plasma Science and Technology eV is using an optimised version of its SIM Framing Camera to make ultra fast UV measurements of the mechanism of plasma being used to modify the electrical properties of polymer films.
The Leibniz Institute for Plasma Science and Technology eV (INP Greifswald) is the largest non-university research institute conducting basic research into and investigating the applications of low temperature plasmas. In addition to the application-oriented basic research, the INP promotes the development of plasma-supported processes and products. The Institute conducts research and development from idea to prototype. Using an optimised...
Sphere Medical publishes white paper discussing areas where Proxima mitigates sources of pre-analytical errors
Sphere Medical, innovator in critical care monitoring and diagnostics equipment, has published a white paper focusing on the mitigation of common pre-analytical errors associated with arterial blood gas analysis [1]. The informative paper is available for download from Sphere’s online clinical resource centre and explores how and why pre-analytical errors occur, as well as the impact of an error on analyte levels in the blood sample. It also considers the...
Microbiologists warn crop protection products are causing increased resistance in the most fatal fungal infections in humans
The European Society of Clinical Microbiology and Infectious Disease (ESCMID) – an organization that explores the risks and best practices in infectious disease – is imploring global healthcare professionals and bodies to take a more active role in the growing problem of fungal resistance. ESCMID Fungal Infection Study Group (EFISG) argues that fungal resistance now represents a huge healthcare threat – with many cases remaining massively...
Today marks the fifth official World Hepatitis Day where members of the public and the hepatitis community provide a voice for the 4000 lives lost every day
World Health Organization (WHO) and World Hepatitis Alliance join forces to bring together WHO Member State health ministers, policy makers, patient representatives and civil society for the first-ever World Hepatitis Summit. Inaugural Summit hosted in Glasgow, 2-4 September builds on WHO resolution in tackling the severity of the global hepatitis problem. Global hepatitis elimination strategy is key priority during Summit...
Results of the study imply that replacement enzymes exhibiting mannose-terminated glycosylation patterns are efficiently delivered to their subcellular targets, the lysosomes. Lysosomal storage diseases (LSDs) like Fabry disease are caused by inborn absence of certain degradation enzymes, leading to continuous accumulation of problematic compounds in the cells. In Fabry patients, sphingolipid accumulation leads to various symptoms like...
Nanolab Technologies Inc., a Silicon Valley-based analytical services lab, has purchased a new Local Electrode Atom Probe from CAMECA Instruments Inc. The high-performance atom probe from CAMECA, a unit of the AMETEK Materials Analysis Division, is used to provide advanced materials analysis, including precise atom-by-atom identification, 3-D spatial positioning, and accurate atomic-scale reconstruction of a material’s...
Founded over 100 years ago, the Forsyth Institute has established itself as the leading independent research institute in America specializing in oral health and its impact on overall wellness. In addition to its affiliation with the Harvard School of Dental Medicine, Forsyth has collaborations with a vast array of academic institutions, hospitals, independent research institutes, and biotech and pharmaceutical companies. These interactions...
Dr Philip Sharpe is a teaching-focused academic in the School of Chemistry & Molecular Biosciences at the University of Queensland, Australia. His active research interests are in the field of chemistry education research, particularly student learning within the laboratory environment. His goal is to remove the barriers that hinder student success in the laboratory and to provide situations that allow students to maximize their learning. As the academic in charge of the first year chemistry laboratory, Dr Sharpe...
Superbugs are becoming an increasing problem in hospitals as bacteria become more and more resistant to our existing antibiotics. The Chief Medical Officer, Dame Sally Davies recently said that if we don’t tackle the problem now our grandchildren will not thank us. All the medical procedures we currently take for granted such as cancer treatment, open heart surgery, hip and knee replacement and organ transplantation will become much more...
baseclick GmbH is part of a Marie Curie actions research program within the 7th framework program EScoDNA (an Initial Training Network, ITN). The EScoDNA program is a joint initiative by leading scientists in this field from recognized universities and companies. The research within this project focuses on the application of DNA nanotechnology in the key sectors life science and biomedicine. In January 2015, baseclick has been awarded another...
Big Pharma is keen to increase drug discovery productivity; which strategies do you think will help to increase R&D output? “I think the strategies for increasing drug discovery productivity will be multifaceted. We do quite a bit of the traditional internal repurposing and rescue, which is a great way of accelerating a nascent project idea with more advanced chemistry. The most promising of these approaches, in my opinion, is opening up your pharmacology...
A Framework for Using CLSI Documents to Evaluate Clinical Laboratory Measurement Procedures (EP19-Ed2) uses the “measurement procedure lifecycle” framework to aid users of CLSI evaluation protocols documents during establishment and implementation of measurement procedures developed by both commercial manufacturers and clinical laboratories, ie, for laboratory-developed tests. Harmonization of Symbology and Equations (EP36-Ed1) provides a standardized...
Drs Christophe Demaille and Agnès Anne from CNRS work in the Laboratoire d'Electrochimie Moléculaire at the Université Paris Diderot as Group Leaders of a research team aiming to probe electron transport and communication in nanometric biostructures. Their studies are performed at the single nano-object scale using combined atomic force (AFM)-Electrochemical (SECM) microscopy. In this combined microscopy technique, the tip acts...
This is because doctors in Europe are still prescribing old antiviral drugs, which may also cause resistance to modern compounds. The researchers reported these results in the latest issue of The Journal of Infectious Diseases, published this week. According to the WHO, approximately 13 million people in Europe are chronically infected with the Hepatitis B virus (HBV). These patients often develop a severe form of liver inflammation...
Researchers from the University of Leicester and University Hospitals of Leicester NHS Trust, working with the National Institute of Allergy and Infectious Diseases (NIAID) and Genentech, have discovered new insights into how asthma may be caused, by identifying three distinct groups of asthma patients characterised by the activity of different genes in an individual’s airways. Asthma affects about five million people in the UK. Not all patients respond...
This popular course is designed to help Brookfield viscometer users comprehend the functionality of their instrument, solve the mysteries of fluid behavior and Rheology, and create successful and repeatable viscosity test methods for use in both R&D and QA/QC environments. Consistent measurement is vital in the success of any product and understanding viscosity is a key part to maintaining quality control. The course is offered at Brookfield’s headquarters in Middleboro, MA and...
The technology will be used by DefiniGEN to develop new, optimised cell products and services for drug discovery and the study of lung diseases, including cystic fibrosis. The technology, licensed to DefiniGEN by Cambridge Enterprise, the commercialisation arm of the University of Cambridge uses induced pluripotent stem cells, or iPS cells, to recreate embryonic lung development in the lab by activating a process known as gastrulation, in which the cells form...
eXalt™ is a proprietary Genevac technology designed to control evaporation using restricting baffles. Using this technology multiple solvents can be screened in parallel to identify optimum crystallisation conditions for amorphous materials. In the pharmaceutical industry, physical form can pose a significant challenge for small molecule drug discovery projects transitioning between the optimisation and characterisation phases. A crystalline form is desirable...
Beckman Coulter Life Sciences is running a major competition for flow cytometry scientists, with the prize the recently launched CytoFLEX Flow Cytometer, valued at approximately 200,000 US dollars. Applicants are being asked to challenge the CytoFLEX Flow Cytometer to solve a key experimental puzzle for their research and to describe how it would deliver the solution, in 300 words or less. For more information visit: CytoFLEX Competition...
Kerafast Inc., developers of an 
Spectrometers from Ocean Optics are being used by Le Maitre Ltd (Surrey, England) to ensure the quality and safety of its close proximity pyrotechnics. Ocean Optics spectrometers measure plasma emission and emissive color of effects used in theater productions, concerts, and sporting events. The measurements help Le Maitre ensure these explosive displays are consistently amazing, and most important, safe. Le Maitre Pyrotechnics Developer Hamish...
The Leibniz Institute for Plasma Science and Technology eV (INP Greifswald) is the largest non-university research institute conducting basic research into and investigating the applications of low temperature plasmas. In addition to the application-oriented basic research, the INP promotes the development of plasma-supported processes and products. The Institute conducts research and development from idea to prototype. Using an optimised...
Sphere Medical, innovator in critical care monitoring and diagnostics equipment, has published a white paper focusing on the mitigation of common pre-analytical errors associated with arterial blood gas analysis [1]. The informative paper is available for download from Sphere’s online clinical resource centre and explores how and why pre-analytical errors occur, as well as the impact of an error on analyte levels in the blood sample. It also considers the...
The European Society of Clinical Microbiology and Infectious Disease (ESCMID) – an organization that explores the risks and best practices in infectious disease – is imploring global healthcare professionals and bodies to take a more active role in the growing problem of fungal resistance. ESCMID Fungal Infection Study Group (EFISG) argues that fungal resistance now represents a huge healthcare threat – with many cases remaining massively...
World Health Organization (WHO) and World Hepatitis Alliance join forces to bring together WHO Member State health ministers, policy makers, patient representatives and civil society for the first-ever World Hepatitis Summit. Inaugural Summit hosted in Glasgow, 2-4 September builds on WHO resolution in tackling the severity of the global hepatitis problem. Global hepatitis elimination strategy is key priority during Summit...