Watson-Marlow Fluid Technology Group has supplied peristaltic pumps to Novasep for its Sius™ TFF Skid, a tangential flow filtration system used in the biopharmaceutical industry to separate and concentrate biomolecules according to their size.
The new skid is the first on the market to offer a 100 per cent single-use TFF solution. Watson Marlow 520UN/R2 and 620UN/RE pumps were selected to facilitate the system’s fluid transfer operations. In tangential flow filtration (TFF), the fluid to be processed circulates across a porous membrane and, under pressure, passes through its pores. Molecules of a greater size than the pores remain in the retentate, whereas small...
Cresset Discovery Services, provider of contract research services for early phase discovery, and Medicines for Malaria Venture (MMV), have entered into a collaborative agreement to use computer-aided drug discovery to identify back-up compounds for a recently discovered molecule in MMV’s portfolio.
“Cresset Discovery Services offer expertise in computational chemistry,” says Dr James Duffy, Associate Director, Drug Discovery, MMV. “We look forward to working with them to identify a back-up compound for one of our promising projects.” “Our experts in computational biology and computational chemistry are ideally placed to solve high impact problems in drug discovery such as the identification of back-up compounds...
Metrohm USA is pleased to announce the winner of the 2016 Young Chemist Award, Amay Bandodkar.
Amay is completing his Ph.D. at the University of California San Diego where he works under the supervision of Professor Joseph Wang, SAIC Endowed Professor and Chair of the NanoEngineering Department. Amay’s research focuses on developing next generation of wearable sensors that, unlike today’s wearable devices, possess the power to continuously monitor physiologically relevant chemicals directly on the human body in a completely non-invasive fashion...
“In a study of 11 healthy human volunteers, adherence to the specially designed low PAMP diet for just one week caused a significant 18% reduction in LDL (bad) cholesterol and an 11% reduction in white blood cell count.
Volunteers also lost weight (on average 0.6 kg) and their waist circumference was reduced (average 1.5 cm), during the low PAMP diet. These are key risk factors for coronary artery disease and Type II diabetes.” Dr Clett Erridge, University of Leicester...
Magritek, a leading provider of compact NMR and MRI instruments, report on the use of their Spinsolve Benchtop NMR spectrometer is used in the practical teaching of organic chemistry students at Tarrant County College in Fort Worth, Texas.
Tarrant County College (TCC) was established in 1965 in Fort Worth, Texas to provide quality, affordable education. The College is accredited by the Southern Association of Colleges to award Associate's degrees. In 2014, TCC's Board of Trustees together with the Texas Higher Education Coordinating Board approved for the College to award Associate of Science degree in Chemistry. Graduates with an AS-Chemistry degree are qualified to...
US-based Molecular Pathology Laboratory Network (MPLN) has teamed up with the Northern Health Science Alliance (NHSA) to speed up delivery of cutting-edge diagnostic tests to patients.
The partnership, created to help MPLN access the North of England’s expertise in diagnostic testing, will put in place support to develop early stage diagnostic tests into clinically viable assays. The potential of this is that tests developed in the North will help patients across the globe to access effective treatments quicker. The collaboration is supported by hospitals and universities across the North including National Institute for...
Primerdesign launches one of the world’s first Zika virus tests
Novacyt (ALTERNEXT: ALNOV), an international specialist in cancer and infectious disease diagnostics, updates the market on its intended acquisition of Primerdesign Ltd (“Primerdesign”), a profitable and rapidly growing UK molecular diagnostics company. On 18 January 2016, Novacyt announced its intention to acquire the entire share capital of Primerdesign for £9.85m (approximately €13.0m), plus an additional....
Essential steps you need to know about scanning electrophoresis gels
Do you want a fast and easy way to scan your electrophoresis gels? Look no further than the Bio-5000 Plus two platform scanner. Designed for researchers who want to quickly scan their electrophoresis gels, the Bio-5000 Plus offers an alternative to those camera based systems which can often produce unsatisfactory results. This image capture system is equipped with an optical CCD sensor whose...
Eppendorf and the journal Science are now accepting applications for the 2016 Eppendorf & Science Prize for Neurobiology.
This annual international research prize of US$25,000 is awarded to young scientists for their outstanding contributions to neurobiology research based on methods of molecular and cell biology. Researchers who are not older than 35 years are invited to apply by June 15, 2016. The winner and finalists are selected by a committee of independent scientists, chaired by Science’s Senior Editor, Dr. Peter Stern. The 2015 prize was...
In the production of margarine millions of tons of unsaturated fatty acids are converted from vegetable oils using hydrogen.
While searching for improved catalysts for these so-called hydrogenation reactions, a German-American research team made a discovery that puts a 50-year old rule in question: In catalytic particles comprising only a few atoms, shape and size influence reactivity much more strongly then previously thought. Millions of tons of margarine are produced every year by converting unsaturated fatty acids from vegetable oils using...
Cresset Discovery Services, provider of contract research services for early phase discovery, has developed an innovative clustering method that made it possible to assess the 3D similarity across BioBlocks’ virtual database of over 1.5 million fragments.
Cresset’s work enabled BioBlocks, a collaborative medicinal chemistry company, to design new fragment libraries with maximal coverage of 3D chemical space. “Our goal was to help BioBlocks to build the maximum 3D diversity into small libraries of fragments from a starting pool of over a million compounds,” explains Dr Mark Mackey, CSO of Cresset. “Existing techniques would have required an unfeasible amount of computing...
Meridian Bioscience collaborates with the Centers for Disease Control and Prevention and Cheikh Anta Diop University of Dakar to launch diagnostic test up to 80,000 times more sensitive than current options
Meridian Bioscience, Inc., Cincinnati, Ohio (NASDAQ: VIVO) today announced that it has received the CE Mark for illumigene® Malaria, a novel, highly accurate test developed by Meridian with the technical assistance of the Centers for Disease Control and Prevention (CDC) and Cheikh Anta Diop University of Dakar, Senegal. The test is up to 80,000 times more sensitive at detecting the malaria parasite than...
In the February 2016 issue of Haematologica, critical research of blood and blood-forming organs in Europe is given a boost.
The European Hematology Association Roadmap for European Hematology Research: A Consensus Document summarizes the current status of basic, translational and clinical hematology research and identifies areas of unmet scientific and medical need in Europe. It provides guidance for European and national policy makers, funding agencies, charities, research institutes and researchers when they make decisions on initiating or...
Data measured using the NanoSight NS300 from Malvern Instruments is providing new insights into the role of exosomes in diseases such as cancer, arthritis, Alzheimer’s disease and cystic fibrosis, in pioneering research at the University of Alabama - Birmingham (UAB).
“Early research on exosomes, or extracellular vesicles, focused on their role in excreting unwanted waste from cells,” said Shawn Williams, facility manager and imaging specialist. “However, we’re now starting to understand their wider functionality in intercellular communication and the transmission of disease. The NanoSight system is playing a central role in helping us advance in this new and exciting area of research, by...
Antibiotic Research UK, the world’s first charity tackling antibiotic resistance, welcomes the declaration by 80 firms and pharmaceutical giants on the need to tackle antibiotic resistance.
The declaration is being launched at the World Economic Forum in Davos and calls on governments and industry around the world to work together to tackle the rise in so-called superbugs. Clearly this is a major step forward says Professor Colin Garner, the Charity’s Chief Executive. However it will be many years before any real progress can be made since it takes 15-20 years to develop a new drug and costs £100’s of...
Protagen AG, a company concerned with the development of advanced diagnostic tools to address some of the most severe autoimmune diseases, has today announced that it will join the RA-MAP Consortium.
The overarching goal of the Consortium is to identify the key predictors of clinical response and remission in RA patients, and to identify those individuals at high risk of developing Rheumatoid Arthritis (RA). RA is one of the most common auto-immune diseases in the world. RA patients may experience difficulties with everyday tasks and restricted work options. Thus, RA has massive health economic implications. Early intervention...
Midlands Asthma and Allergy Research Association funds projects to combat effects of asthma
A number of studies to better understand asthma – including how to diagnose and monitor the condition in children – will be conducted by researchers at the University of Leicester. The Midlands Asthma and Allergy Research Association (MAARA) Executive Committee has approved grants totalling £230,000 over the next five years for a number of projects in the East Midlands area. The projects led by researchers at...
Myeloma UK and the Structural Genomics Consortium (SGC) have entered into an open-access research partnership to discover and characterise novel drug targets for myeloma using structural biology and chemical proteomics.
In this first partnership of its kind in Europe, Myeloma UK and the SGC have explicitly agreed not to file for patents on any of the collaborative research and to make all reagents and knowledge available without restriction to the wider research community, including pharmaceutical, biotech, and academic research groups. As part of the collaboration, Myeloma UK will support scientists at the SGC to generate biology data and...
With courses delivered by world-renowned experts including John Dolan, Mel Euerby, Mark Powell, Diane Turner, Alan McKeown, Geoff Pickerell, Brian Montgomery, Helen Poole, Gemma Lo and Annette Larder, the new 2016 Hichrom training calendar is now available! Whether you are a relative newcomer to chromatography or a seasoned veteran, you can benefit from one of our courses.
Our courses will show you how to decrease costs, increase throughput, prevent costly method problems occurring, transfer methods between laboratories or from HPLC to UHPLC and develop faster, more reproducible HPLC/UHPLC or GC assays in a time effective manner. In fact, all of these courses are guaranteed to increase productivity and efficiency in your laboratory, reducing your analysis costs. If this doesn’t happen Hichrom will happily refund your money! New scheduled courses for 2016 include Data Integrity and CIM Monolith Chromatography for Biomolecules....
Quotient Clinical, the Translational Pharmaceutics® company, has announced that it has completed its 100th RapidFACT (Rapid Formulation development And Clinical Testing) program – a significant milestone in the growth of this service, which addresses drug R&D productivity issues.
RapidFACT has been proven to accelerate drug formulation development for all routes of delivery, and over 50 leading pharmaceutical and biotech companies globally have now adopted this approach.RapidFACT can reduce development timelines by at least 50 % while delivering significant cost savings. This is achieved through Quotient Clinical’s innovative Translational Pharmaceutics platform, which integrates formulation development, GMP manufacturing and clinical testing in one location, allowing the product to be adapted in real-time, based on emerging clinical data....
A new customer technical note compares the performance of the INTEGRA VOYAGER adjustable tip spacing multichannel pipette with a manual single channel pipette for performing real-time PCR experiments.
In undertaking these experiments, independent researchers found that the unique electronically adjustable tip facility on the VOYAGER not only generated time savings of up to 80% from minimising the number of required manual handling steps but also improved pipetting reproducibility and reduced pipetting errors.
Ingenza is using its proprietary inABLE® technology to help develop a robust, versatile platform for the production of cyclic peptides for therapeutic use.
This work is part of a collaboration with researchers at the University of Aberdeen and the University of St Andrews, as Professor Marcel Jaspars of the Marine Biodiscovery Centre at the University of Aberdeen explained: “Small molecule drugs, such as paracetamol, are cheap, easy to administer and readily available. At the other end of the scale are large biologics such as antibodies, which have to be administered by injection and may require patients to attend hospital for treatment....
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The new skid is the first on the market to offer a 100 per cent single-use TFF solution. Watson Marlow 520UN/R2 and 620UN/RE pumps were selected to facilitate the system’s fluid transfer operations. In tangential flow filtration (TFF), the fluid to be processed circulates across a porous membrane and, under pressure, passes through its pores. Molecules of a greater size than the pores remain in the retentate, whereas small...
“Cresset Discovery Services offer expertise in computational chemistry,” says Dr James Duffy, Associate Director, Drug Discovery, MMV. “We look forward to working with them to identify a back-up compound for one of our promising projects.” “Our experts in computational biology and computational chemistry are ideally placed to solve high impact problems in drug discovery such as the identification of back-up compounds...
Amay is completing his Ph.D. at the University of California San Diego where he works under the supervision of Professor Joseph Wang, SAIC Endowed Professor and Chair of the NanoEngineering Department. Amay’s research focuses on developing next generation of wearable sensors that, unlike today’s wearable devices, possess the power to continuously monitor physiologically relevant chemicals directly on the human body in a completely non-invasive fashion...
Volunteers also lost weight (on average 0.6 kg) and their waist circumference was reduced (average 1.5 cm), during the low PAMP diet. These are key risk factors for coronary artery disease and Type II diabetes.” Dr Clett Erridge, University of Leicester...
Tarrant County College (TCC) was established in 1965 in Fort Worth, Texas to provide quality, affordable education. The College is accredited by the Southern Association of Colleges to award Associate's degrees. In 2014, TCC's Board of Trustees together with the Texas Higher Education Coordinating Board approved for the College to award Associate of Science degree in Chemistry. Graduates with an AS-Chemistry degree are qualified to...
The partnership, created to help MPLN access the North of England’s expertise in diagnostic testing, will put in place support to develop early stage diagnostic tests into clinically viable assays. The potential of this is that tests developed in the North will help patients across the globe to access effective treatments quicker. The collaboration is supported by hospitals and universities across the North including National Institute for...
Novacyt (ALTERNEXT: ALNOV), an international specialist in cancer and infectious disease diagnostics, updates the market on its intended acquisition of Primerdesign Ltd (“Primerdesign”), a profitable and rapidly growing UK molecular diagnostics company. On 18 January 2016, Novacyt announced its intention to acquire the entire share capital of Primerdesign for £9.85m (approximately €13.0m), plus an additional....
Do you want a fast and easy way to scan your electrophoresis gels? Look no further than the Bio-5000 Plus two platform scanner. Designed for researchers who want to quickly scan their electrophoresis gels, the Bio-5000 Plus offers an alternative to those camera based systems which can often produce unsatisfactory results. This image capture system is equipped with an optical CCD sensor whose...
This annual international research prize of US$25,000 is awarded to young scientists for their outstanding contributions to neurobiology research based on methods of molecular and cell biology. Researchers who are not older than 35 years are invited to apply by June 15, 2016. The winner and finalists are selected by a committee of independent scientists, chaired by Science’s Senior Editor, Dr. Peter Stern. The 2015 prize was...
While searching for improved catalysts for these so-called hydrogenation reactions, a German-American research team made a discovery that puts a 50-year old rule in question: In catalytic particles comprising only a few atoms, shape and size influence reactivity much more strongly then previously thought. Millions of tons of margarine are produced every year by converting unsaturated fatty acids from vegetable oils using...
Cresset’s work enabled BioBlocks, a collaborative medicinal chemistry company, to design new fragment libraries with maximal coverage of 3D chemical space. “Our goal was to help BioBlocks to build the maximum 3D diversity into small libraries of fragments from a starting pool of over a million compounds,” explains Dr Mark Mackey, CSO of Cresset. “Existing techniques would have required an unfeasible amount of computing...
Meridian Bioscience, Inc., Cincinnati, Ohio (NASDAQ: VIVO) today announced that it has received the CE Mark for illumigene® Malaria, a novel, highly accurate test developed by Meridian with the technical assistance of the Centers for Disease Control and Prevention (CDC) and Cheikh Anta Diop University of Dakar, Senegal. The test is up to 80,000 times more sensitive at detecting the malaria parasite than...
The European Hematology Association Roadmap for European Hematology Research: A Consensus Document summarizes the current status of basic, translational and clinical hematology research and identifies areas of unmet scientific and medical need in Europe. It provides guidance for European and national policy makers, funding agencies, charities, research institutes and researchers when they make decisions on initiating or...
“Early research on exosomes, or extracellular vesicles, focused on their role in excreting unwanted waste from cells,” said Shawn Williams, facility manager and imaging specialist. “However, we’re now starting to understand their wider functionality in intercellular communication and the transmission of disease. The NanoSight system is playing a central role in helping us advance in this new and exciting area of research, by...
The declaration is being launched at the World Economic Forum in Davos and calls on governments and industry around the world to work together to tackle the rise in so-called superbugs. Clearly this is a major step forward says Professor Colin Garner, the Charity’s Chief Executive. However it will be many years before any real progress can be made since it takes 15-20 years to develop a new drug and costs £100’s of...
The overarching goal of the Consortium is to identify the key predictors of clinical response and remission in RA patients, and to identify those individuals at high risk of developing Rheumatoid Arthritis (RA). RA is one of the most common auto-immune diseases in the world. RA patients may experience difficulties with everyday tasks and restricted work options. Thus, RA has massive health economic implications. Early intervention...
In this first partnership of its kind in Europe, Myeloma UK and the SGC have explicitly agreed not to file for patents on any of the collaborative research and to make all reagents and knowledge available without restriction to the wider research community, including pharmaceutical, biotech, and academic research groups. 
RapidFACT has been proven to accelerate drug formulation development for all routes of delivery, and over 50 leading pharmaceutical and biotech companies globally have now adopted this approach.RapidFACT can reduce development timelines by at least 50 % while delivering significant cost savings. This is achieved through Quotient Clinical’s innovative Translational Pharmaceutics platform, which integrates formulation development, GMP manufacturing and clinical testing in one location, allowing the product to be adapted in real-time, based on emerging clinical data....
In undertaking these experiments, independent researchers found that the unique electronically adjustable tip facility on the VOYAGER not only generated time savings of up to 80% from minimising the number of required manual handling steps but also improved pipetting reproducibility and reduced pipetting errors.