At the 57th Experimental Nuclear Magnetic Resonance Conference, Bruker announced new GHz-class NMR magnet and probe technologies to enable expanding frontiers in structural biology, membrane protein and intrinsically disordered protein (IDP) research.
Bruker has successfully installed the world’s first, next-generation 1GHz NMR system equipped with an actively-shielded Aeon™ 1 GHz magnet at the University of Bayreuth, Germany. Active shielding reduces the space requirements for the two-story magnet by more than an order of magnitude, and makes siting of next-generation Aeon 1 GHz magnets...
Watson-Marlow Fluid Technology Group (WMFTG) has demonstrated its support of the opening of a new, world-class Biotech Training Facility (BTF) in Leiden, Holland with the donation of its equipment.
Watson-Marlow hopes that the contribution of its equipment – which includes two of its new 530 series pumps and two 620 series pumps, plus a consignment of Pumpsil and PureWeld tubing - will support the aims and objectives of this impressive training facility. As a world-leader in complete fluid path solutions for the biopharmaceutical sector, WMFTG has also provided world-class technology from elsewhere in...
Reliance Precision Limited is delighted to announce that its Cool Muscle motors have now been used in 500 Biosafe Sepax systems. The Sepax systems are used for automated adult stem cell banking and cell processing applications.
The Biosafe Sepax system is an automated, mobile, closed unit for the efficient and consistent processing of umbilical cord blood, bone marrow, peripheral blood or other cell based products. Biosafe began trialling Reliance’s Cool Muscle motors in 2010 in its Sepax systems, using the motor to help accurately separate the different cell components via single-use cell separation kits. The Cool Muscle motor senses when the...
Cancers can resist treatment by ‘stealing’ blood vessels from nearby tissues, a new study shows.
The important new study is the first to show that tumours can become resistant to drugs over time by learning to steal normal blood vessels from surrounding tissue – a process that researchers call vessel co-option. The process of new blood vessel growth – angiogenesis – is important for cancers to grow, and several anti-angiogenic drugs have been developed to combat it. However, cancers often become resistant to...
BioSilta Ltd has acquired a license to worldwide exclusive rights to CyDisCo™ (Cytoplasmic Disulphide bond formation in E. coli) protein production technology from the University of Oulu.
This license agreement will enable BioSilta will combine its EnPresso culture systems technology with CyDisCo protein production technology to make EnPresso-CyDisCo expression systems available to scientists and bio-processing engineers. As part of the agreement, BioSilta will also have future access to those that invented and enhanced the CyDisCo protein production technology for future R&D consultation...
Brookfield AMETEK, the world standard for viscosity measurement and control, offers its Practical Course on Viscosity Measurements.
This popular course is designed to help Brookfield AMETEK Viscometer users comprehend the functionality of their instrument, solve the mysteries of fluid behavior and Rheology, and create successful and repeatable viscosity test methods for use in both R&D and QA/QC environments. Consistent measurement is vital in the success of any product and understanding viscosity is a key part to maintaining quality control...
Providing 9-11-year-old children with a unique opportunity to experience an exciting high-tech manufacturing environment
Sartorius Stedim Biotech (SSB) is delighted to announce that its Royston site has joined the Children Challenging Industry (CCI programme) and is offering primary and middle schools an on-site workshop and learning resources for 9-11-year-old children. Sartorius Stedim Biotech in Royston is only the second company in the south of England to join the CCI programme, which has been successfully running in the north of...
In research involving pipetting, it has, on occasion, often been the case that experimental results were not easily reproducible, even though all variables within the experimental procedure have undergone a thorough review.
So in these instances, can it be said that all sources of error have truly been accounted for? In many cases the assumption is made that the pipetting system, consisting of pipette and pipette tip, is not a source of error as long as the tip fits the pipette. However, even if this is the case, it does not guarantee that the pipetting result will be accurate. Therefore, with good reason, the international standard...
Respiratory Failure – Researchers in Vienna Investigate Damage Mechanism
Mechanical ventilation can contribute to lung damage by inducing rapid changes in oxygen levels. Researchers at the Medical University of Vienna are now conducting studies for the first time into the significance of these changes as aggravating factors in lung failure. Many severely ill patients suffer acute respiratory failure in intensive care units (ICUs). These patients have great difficulty in breathing, their blood oxygen...
Optical Surfaces Ltd. has received a sizeable order from the Culham Centre for Fusion Energy (CCFE) to manufacture the relay imaging reflective optics that will form part of two critical viewing diagnostic assemblies for the Joint European Torus (JET) when operating with a deuterium-tritium fuel mixture.
The project is funded under the framework of EUROfusion**. Comprising a series of large diameter (up to 500mm) ultra-smooth flat and spherical mirrors, some of which will have a very long radius of curvature, the relay imaging reflective optics will allow CCFE to monitor a number of physical and operational parameters within the JET fusion vessel with remote cameras from behind the 3m thick concrete shield wall. Knowledge of these parameters...
Particle Metrix, developers of versatile particle characterization solutions for the life sciences, report on the work in the Liu Laboratory at Augusta University which is studying exosomes where size and concentration are critical parameters.
Dr Yutao Liu is an Associate Professor in the Department of Cellular Biology & Anatomy at Augusta University. The research goal of his group is to identify potential biomarkers for several human diseases. As a human genetics research lab, they are interested in studying how exosomes and its contents contribute to the development of glaucoma, such as primary open-angle glaucoma and exfoliation glaucoma...
University of Leicester researchers identify new process for preventing narrowing of airways that could lead to new treatments for disease
Scientists have discovered a new way in which the lungs operate during asthma that could lead to new treatments for the disease. In a study published today in the Proceedings of the National Academy of Sciences USA, the researchers at the Leicester Respiratory Biomedical Research Unit at the University of Leicester and the Medical Research Council (MRC) Toxicology Unit have identified a new biochemical process...
FLIR Systems reports on an academic journal paper, written by researchers Dr. Alexandros Charogiannis, Dr. Ivan Zadrazil and Dr. Christos Markides at the Department of Chemical Engineering, Imperial College London, that describes a novel, combined IR thermographic and velocimetry technique for the investigation of multiphase flows.
Liquid-film flows are open-flow systems that can exhibit a rich spectrum of complex wave regimes, flow transitions and dynamics. Ongoing research into these flow systems is motivated by a strong desire to harness the already excellent high heat and mass transfer capabilities of these flows in the broad range of engineering and industrial applications in which they are employed. Examples of such applications include cooling schemes used in electronic and...
A case study describing the experiences of Niguarda Hospital, Milan, in assessing the new DxN VERIS Molecular Diagnostics System is now available from Beckman Coulter. The case study describes the workflow improvements and reduced turnaround times that the hospital’s Molecular Biology Laboratory was able to achieve for viral load measurements using the DxN VERIS system. One of Italy’s leading General Hospitals...
Ms Elpis Barons of Barons Medical Consulting announced as Trajan Accelerator General Manager
Trajan Scientific and Medical has announced the commencement of the Trajan Accelerator program, a new collaborative model targeting early stage enterprises sharing Trajan’s vision to positively impact human wellbeing through the application of science into society. Conceived in late 2015, Trajan Accelerator aims to help start-up businesses cross the “Valley of Death” to build long-term sustainable businesses with...
ZEISS announces that it assisted University of Alberta enhance its open access micro and nano scale fabrication facility (nanoFAB) by providing ZEISS helium and electron systems.
The University's recent purchase of a ZEISS ORION NanoFab Helium Ion Microscope and a ZEISS SIGMA Field Emission Scanning Electron Microscope (FE-SEM) ensures that the nanoFAB can offer users the broadest range of characterization opportunities possible. The Helium Ion Microscope purchased is configured with a Capella Gallium Focused Ion Beam and the Fibics NanoPatterning and Visualization Engine (NPVE)...
JPK Instruments, a world-leading manufacturer of nanoanalytic instrumentation for research in life sciences and soft matter, reports on the use of their NanoWizard® ULTRA Speed AFM system at the University of Liverpool in the group of Dr Luning Liu of the Institute of Integrative Biology to study biological membrane structures and protein dynamics.
Dr Luning Liu leads a research group at the Institute of Integrative Biology at the University of Liverpool. Using interdisciplinary approaches, the Liu Lab aims to explore the molecular mechanism underlying the self-assembly, dynamics and regulation of biological membranes and macromolecular protein complexes. The long-term goal of the group is to understand the physiological adaptation of cellular metabolisms in...
LaVision BioTec, developers of advanced microscopy solutions for the life sciences, report on the work in the Tews Laboratory which is studying the molecular mechanisms of tumor invasion using an UltraMicroscope for enhanced imaging of cells.
Ultramicroscopy forms a toolkit with magnetic resonance imaging (MR-UM) to provide insight into the dynamics of glioma angiogenesis. Dr Julia Bode is a post-doctoral researcher studying the molecular mechanisms of tumor invasion in the Tews Laboratory. This is a part of the famous Schaller Research Group at the University of Heidelberg and the DKFZ, the German Cancer Research Center. The focus of her...
Porvair Sciences reports that a major Pharmaceutical company based in France has integrated its Ultravap Mistral blowdown evaporation system with a Hamilton Star robotic liquid handling system to enhance new drug candidate processing in its medicinal chemistry department.
Using the Ultravap Mistral the pharmaceutical scientists have been able to remove the traditional ‘bottleneck’ of solvent evaporation from microplates by automated this time consuming step. Set-up for unattended operation the Ultravap Mistral performs an evaporation every 20 minutes, and after each cycle, the level of liquid is checked by the robot and the needle depth is automatically modified to be about...
New applications notes from Advanced Chromatography Technologies (ACT) include Amino Acid Enantiomers in Seawater, Amino Acid Profile of the Edible Stink Bug, Brazilian Red Propolis Biomarkers, Caffeoylquinic and Dicaffeoylquinic Acids, Ginsenosides from Chinese Medicine, Paralytic Shellfish Toxins, a 300 Pesticide Screen, Phenolic Compounds from Red Grape Seed, Tocopherols and Sugars.
All application notes are available individually or in the newly extended ACE Food and Beverage LC Applications Guide, which now includes over 100 food & beverage LC and LC-MS related application notes. Please contact us for your free copy. Advanced Chromatography Technologies also offer a comprehensive range of HPLC and UHPLC Method Development Kits. These Kits are convenient and extremely cost effective providing up to 3 columns for the cost of a single column....
The ARNA Laboratory in Bordeaux, France, is using DNA and RNA aptamers to develop novel tools for biological applications.
To increase throughput, the laboratory has automated its procedures on two Freedom EVO® platforms, as Inserm Research Director Dr Jean-Jacques Toulmé explained: “Our association with Tecan began when we decided to automate our selection protocols to allow us to screen large libraries of oligonucleotides. We generally perform two selections in parallel, consisting of between 8 and 15 runs.
Read MoreQuotient Clinical extends spray drying capabilities for poorly soluble moleculesApr 25, 2016
Quotient Clinical, the Translational Pharmaceutics® company, has expanded its clinical spray drying capability through the acquisition of a Niro Mobile Minor™ Spray Dryer.
Quotient has a proven track record of developing spray-dried dispersions to overcome drug compound solubility issues, and the addition of a larger scale spray dryer will allow the production of a range of batch sizes, from milligrams up to two kilograms. Sited at Quotient’s new GMP facility at MediCity in Nottingham, UK – scheduled to open later in 2016 – this expansion is a direct response to customer requests for ongoing product development support, including toxicology and later stage clinical studies...
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Bruker has successfully installed the world’s first, next-generation 1GHz NMR system equipped with an actively-shielded Aeon™ 1 GHz magnet at the University of Bayreuth, Germany. Active shielding reduces the space requirements for the two-story magnet by more than an order of magnitude, and makes siting of next-generation Aeon 1 GHz magnets...
Watson-Marlow hopes that the contribution of its equipment – which includes two of its new 530 series pumps and two 620 series pumps, plus a consignment of Pumpsil and PureWeld tubing - will support the aims and objectives of this impressive training facility. As a world-leader in complete fluid path solutions for the biopharmaceutical sector, WMFTG has also provided world-class technology from elsewhere in...
The Biosafe Sepax system is an automated, mobile, closed unit for the efficient and consistent processing of umbilical cord blood, bone marrow, peripheral blood or other cell based products. Biosafe began trialling Reliance’s Cool Muscle motors in 2010 in its Sepax systems, using the motor to help accurately separate the different cell components via single-use cell separation kits. The Cool Muscle motor senses when the...
The important new study is the first to show that tumours can become resistant to drugs over time by learning to steal normal blood vessels from surrounding tissue – a process that researchers call vessel co-option. The process of new blood vessel growth – angiogenesis – is important for cancers to grow, and several anti-angiogenic drugs have been developed to combat it. However, cancers often become resistant to...
This license agreement will enable BioSilta will combine its EnPresso culture systems technology with CyDisCo protein production technology to make EnPresso-CyDisCo expression systems available to scientists and bio-processing engineers. As part of the agreement, BioSilta will also have future access to those that invented and enhanced the CyDisCo protein production technology for future R&D consultation...
This popular course is designed to help Brookfield AMETEK Viscometer users comprehend the functionality of their instrument, solve the mysteries of fluid behavior and Rheology, and create successful and repeatable viscosity test methods for use in both R&D and QA/QC environments. Consistent measurement is vital in the success of any product and understanding viscosity is a key part to maintaining quality control...
Sartorius Stedim Biotech (SSB) is delighted to announce that its Royston site has joined the Children Challenging Industry (CCI programme) and is offering primary and middle schools an on-site workshop and learning resources for 9-11-year-old children. Sartorius Stedim Biotech in Royston is only the second company in the south of England to join the CCI programme, which has been successfully running in the north of...
So in these instances, can it be said that all sources of error have truly been accounted for? In many cases the assumption is made that the pipetting system, consisting of pipette and pipette tip, is not a source of error as long as the tip fits the pipette. However, even if this is the case, it does not guarantee that the pipetting result will be accurate. Therefore, with good reason, the international standard...
Mechanical ventilation can contribute to lung damage by inducing rapid changes in oxygen levels. Researchers at the Medical University of Vienna are now conducting studies for the first time into the significance of these changes as aggravating factors in lung failure. Many severely ill patients suffer acute respiratory failure in intensive care units (ICUs). These patients have great difficulty in breathing, their blood oxygen...
The project is funded under the framework of EUROfusion**. Comprising a series of large diameter (up to 500mm) ultra-smooth flat and spherical mirrors, some of which will have a very long radius of curvature, the relay imaging reflective optics will allow CCFE to monitor a number of physical and operational parameters within the JET fusion vessel with remote cameras from behind the 3m thick concrete shield wall. Knowledge of these parameters...
Dr Yutao Liu is an Associate Professor in the Department of Cellular Biology & Anatomy at Augusta University. The research goal of his group is to identify potential biomarkers for several human diseases. As a human genetics research lab, they are interested in studying how exosomes and its contents contribute to the development of glaucoma, such as primary open-angle glaucoma and exfoliation glaucoma...
Scientists have discovered a new way in which the lungs operate during asthma that could lead to new treatments for the disease. In a study published today in the Proceedings of the National Academy of Sciences USA, the researchers at the Leicester Respiratory Biomedical Research Unit at the University of Leicester and the Medical Research Council (MRC) Toxicology Unit have identified a new biochemical process...
Liquid-film flows are open-flow systems that can exhibit a rich spectrum of complex wave regimes, flow transitions and dynamics. Ongoing research into these flow systems is motivated by a strong desire to harness the already excellent high heat and mass transfer capabilities of these flows in the broad range of engineering and industrial applications in which they are employed. Examples of such applications include cooling schemes used in electronic and...
A case study describing the experiences of Niguarda Hospital, Milan, in assessing the new DxN VERIS Molecular Diagnostics System is now available from Beckman Coulter. The case study describes the workflow improvements and reduced turnaround times that the hospital’s Molecular Biology Laboratory was able to achieve for viral load measurements using the DxN VERIS system. One of Italy’s leading General Hospitals...
Trajan Scientific and Medical has announced the commencement of the Trajan Accelerator program, a new collaborative model targeting early stage enterprises sharing Trajan’s vision to positively impact human wellbeing through the application of science into society. Conceived in late 2015, Trajan Accelerator aims to help start-up businesses cross the “Valley of Death” to build long-term sustainable businesses with...
The University's recent purchase of a ZEISS ORION NanoFab Helium Ion Microscope and a ZEISS SIGMA Field Emission Scanning Electron Microscope (FE-SEM) ensures that the nanoFAB can offer users the broadest range of characterization opportunities possible. The Helium Ion Microscope purchased is configured with a Capella Gallium Focused Ion Beam and the Fibics NanoPatterning and Visualization Engine (NPVE)...
Dr Luning Liu leads a research group at the Institute of Integrative Biology at the University of Liverpool. Using interdisciplinary approaches, the Liu Lab aims to explore the molecular mechanism underlying the self-assembly, dynamics and regulation of biological membranes and macromolecular protein complexes. The long-term goal of the group is to understand the physiological adaptation of cellular metabolisms in...
Ultramicroscopy forms a toolkit with magnetic resonance imaging (MR-UM) to provide insight into the dynamics of glioma angiogenesis. Dr Julia Bode is a post-doctoral researcher studying the molecular mechanisms of tumor invasion in the Tews Laboratory. This is a part of the famous Schaller Research Group at the University of Heidelberg and the DKFZ, the German Cancer Research Center. The focus of her...
Using the Ultravap Mistral the pharmaceutical scientists have been able to remove the traditional ‘bottleneck’ of solvent evaporation from microplates by automated this time consuming step. Set-up for unattended operation the Ultravap Mistral performs an evaporation every 20 minutes, and after each cycle, the level of liquid is checked by the robot and the needle depth is automatically modified to be about...
All application notes are available individually or in the newly extended ACE Food and Beverage LC Applications Guide, which now includes over 100 food & beverage LC and LC-MS related application notes. Please contact us for your free copy. Advanced Chromatography Technologies also offer a comprehensive range of HPLC and UHPLC Method Development Kits. These Kits are convenient and extremely cost effective providing up to 3 columns for the cost of a single column....
To increase throughput, the laboratory has automated its procedures on two Freedom EVO® platforms, as Inserm Research Director Dr Jean-Jacques Toulmé explained: “Our association with Tecan began when we decided to automate our selection protocols to allow us to screen large libraries of oligonucleotides. We generally perform two selections in parallel, consisting of between 8 and 15 runs.
Quotient has a proven track record of developing spray-dried dispersions to overcome drug compound solubility issues, and the addition of a larger scale spray dryer will allow the production of a range of batch sizes, from milligrams up to two kilograms.