Follow us...

 

Search News Archives

News Channels

 

New Laboratory Products

Lab News

Research & Case Studies

Microscopy | Image Analysis

Separation Science

Brochures & Literature

Videos

Events | Webinars

 

 

Conferences | Events

Understanding How Natural Killer Cells are Educated

publication date: Aug 28, 2019
 | 
author/source: AMS Biotechnology (Europe) Ltd
understanding-how-natural-killer-cells-are-educated
Image A caption: Representative immuno-EM section showing staining with gold-particle coated anti-Chondroitin Sulfate-4 (CS-4) stub antibody of NK cells expressing non-self (left) or self (right) KIR. (Sectioning and staining performed for Malmberg Lab, Oslo University Hospital by Andreas Brech at the Norwegian Radium Hospital Institute for Cancer Research).

AMSBIO reports on a paper from the Malmberg Lab at Oslo University Hospital and the Norwegian Radium Hospital Institute for Cancer Research (Norway) that suggests a mechanism by which Natural Killer (NK) cell education operates through modulation of the lysosomal compartment under the influence of inhibitory receptor–ligand interactions.

The research reveals that educated NK cells expressing self-MHC specific inhibitory killer cell immunoglobulin-like receptors (KIR) accumulate granzyme B and Chondroitin Sulfate-4 in dense-core secretory lysosomes that converge close to the centrosome. Secretory lysosomes are critical to the cytotoxic function of NK cells, so these changes illuminate the mechanisms by which they learn to respond to cells that might be a danger to the organism.

Natural Killer cells are lymphocytes that can kill tumor cells or virus-infected cells without requiring antibodies. NK cells express both activating and inhibitory receptors on their surface, and the function of NK cells is regulated by the delicate signaling balance between these two types of receptors.

William Hadlington-Booth - a business unit manager at AMSBIO said "The Malmberg Lab researchers used our reagents and enzymes to detect one distinctive sulfation pattern of Chondroitin Sulfate, which helped them understand the process by which NK cells are “educated”. He added "This ground breaking research by the Malmberg Lab. demonstrates how our antibodies and enzymes work across species and tissues to detect subtle – but important - variations in glycosaminoglycans in the cellular and extracellular matrix".

AMSBIO is a leading global supplier of a highly purified Chondroitinase ABC enzyme (supplied as a protease-free, carrier-free format, with low endotoxin levels), as well as three associated monoclonal antibodies that recognise unsulfated, 4-sulfated and 6-sulfated Chondroitin and Dermatan Sulfate, following Chondroitinase ABC digestion of proteoglycans or perineuronal nets.

 

Download | View Full Paper

more news from AMSBIO


 


If you have not logged into the website then please enter your details below.



 

 

Popular this Month...

Our Top 10 most popular articles this month

 

Today's Picks...

 

 


 

Looking for a Supplier?

Search by company or by product

 


Company Name:

Product:


 

 

Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd

 


Promotions

 

Media Partners