Thermo Fisher Scientific Inc. (NYSE: TMO), the world leader in serving science, strengthened its leadership in mass spectrometry by launching new technologies to advance cutting-edge research and improve results in applied markets during the 65^th Annual American Society for Mass Spectrometry (ASMS) Conference.

“Thermo Fisher has been the undisputed leader in mass spectrometry for more than 50 years, and this year is no exception,” said Dan Shine, senior vice president and president, analytical instruments. “During ASMS, customers will learn how our new innovations in mass spectrometry are advancing biological research, translational medicine, and food and environmental analysis.”

Accelerating Proteomics Research

The new Thermo Scientific Q Exactive HF-X Quadrupole Orbitrap mass spectrometeris designed for exceptional sensitivity and reproducibility in the analysis of complex biological samples. Exceptional specificity supports increasing customer focus on protein identification, biomarker verification and quantitative proteomics workflows as well as biotherapeutic characterization.

“In order to make more meaningful progress in proteomics, we need tools that identify and quantify proteins, peptides, lipids, glycans and small molecules accurately and in less time,” said Dr. Jesper V. Olsen, professor and vice director of the Novo Nordisk Foundation and Center for Protein Research at the University of Copenhagen. “Using the Q Exactive HF-X Hybrid spectrometer, we have managed to identify 1,100 unique peptides per minute, which is a new world record.”

The Q Exactive HF-X Quadrupole Orbitrap mass spectrometer is available with new consumables and software that enable researchers to customize workflows and identify thousands of proteins of interest in a single run.

Breaking New Ground in Tribrid Mass Spectrometry

New options for theaward-winning Thermo Scientific Orbitrap Fusion Lumos mass spectrometer can expand instrument power, performance and versatility. Used primarily in the structural characterization of large and small molecules, the system includes a new, integrated Ultraviolet Photodissociation (UVPD) feature that is standard on new systems and available as an upgrade to existing Fusion Lumos instruments.

This unique fragmentation mode is designed to improve productivity and provide researchers with accurate structural information.

Other options include Advanced Peak Determination (APD) and 1M resolution. Adding APD improves the performance of most proteomic workflows by providing high throughput while the 1M resolution Orbitrap option provides the ultra-high resolution necessary for obtaining unique structural and quantitative information.

Expanding Opportunities in Applied Markets

For applied markets, such as environmental and food safety, pharmaceutical and biopharmaceutical, and forensic toxicology, Thermo Fisher introduced two new triple-stage quadrupole (TSQ) mass spectrometers.

The new Thermo Scientific TSQ Altis Triple Stage Quadrupole (TSQ) mass spectrometer offers good sensitivity, selectivity and speed while providing the analytical flexibility, reproducibility and precision required for complex matrices.

“With the new TSQ Altis mass spectrometer, my lab can develop quantitative methods for biotherapeutic proteins and target receptors with extreme sensitivity, selectivity, accuracy and precision,” said Dr. Jun Qu, associate professor, department of pharmaceutical sciences, University at Buffalo in New York. “This is very exciting for our research since this capacity is very unique.”

The new Thermo Scientific TSQ Quantis Triple Stage Quadrupole (TSQ) mass spectrometeris a quantitative workhorse that is designed to support reliable workflows with the sensitivity and precision users require for quality results on every run. The TSQ Quantis Triple Stage Quadrupole (TSQ) mass spectrometer is designed to be simple to use and easy to maintain.

Custom Kits and New Software

Building on its leadership position in life science mass spectrometry, Thermo Fisher also announced an agreement with BIOCRATES Life Sciences AG, a leader in metabolic phenotyping, to offer the Biocrates AbsoluteIDQ p400 Kit. The kit enables researchers to reduce the complexity of metabolomics by enabling the rapid and reliable characterization of small molecules.

The new, ready-to-use Thermo Scientific InsuQuant Mass Spectrometric Kit is designed to simplify sample preparation during insulin bioanalysis. Users can achieve precise and sensitive separation on the Thermo Scientific Vanquish Flex Quaternary UHPLC system, and perform quantification of complex insulin analogues using the Q Exactive Hybrid Quadrupole-Orbitrap mass spectrometer.

In addition to previewing new versions of its industry-leading Thermo Scientific software, including ProteinCenter 4.0, TraceFinder 5.0 and Biopharma Finder 3.0, Thermo Fisher also introduced updated versions of its Proteome Discoverer 2.1 and Compound Discoverer 2.1 software.

To further address increasing customer needs for sharing data among the scientific community, Thermo Fisher offers a number of cloud-based applications. These include remote instrument monitoring, sample profiling and comparison of protein and gene lists.

For more information about Thermo Fisher and the American Society for Mass Spectrometry (ASMS) Conference, visit thermofisher.com/asms

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