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Effective Determination of Dibasic Acids

Thermo Fisher Scientific is proud to announce an effective new method for the determination of succinic, glutaric, and adipic acids in solutions of mixed dibasic acids generated during cyclohexane oxidation.

Effective Determination of Dibasic AcidsApplication Note 285: Determination of Succinic, Glutaric, and Adipic Acids as Quality Control of Cyclohexone Production demonstrates use of our liquid chromatography system (Thermo Scientific Dionex UltiMateTM 3000 RSLC system) with organic acid analytical column (Thermo Scientific AcclaimTM OA column) and mass spectrometry (MS) detection to achieve a fast baseline separation of these three dibasic acids with good resolution values (Rs ≥ 2.6), good method reproducibility, excellent linearity within 0.1 to 5 mg/L, and accurate results for industrial samples.

Cyclohexone is the key intermediate for the production of adipic acid, an important compound for the synthesis of nylon 66. Cyclohexane oxidation is the normal method for the production of cyclohexone; and succinic, glutaric, and adipic acids, as well as their dehydration products, are the main by-products. The three aliphatic dicarboxylic acids are also important chemical raw materials, and their determination is important for the quality control of cyclohexone production and recycling of the by-products.

This application note and many others can be found at under the Documents tab.

About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. is the world leader in serving science. Our mission is to enable our customers to make the world healthier, cleaner and safer. With revenues of $12 billion, we have approximately 39,000 employees and serve customers within pharmaceutical and biotech companies, hospitals and clinical diagnostic labs, universities, research institutions and government agencies, as well as in environmental and process control industries. We create value for our key stakeholders through three premier brands, Thermo Scientific, Fisher Scientific and UnityTM Lab Services, which offer a unique combination of innovative technologies, convenient purchasing options and a single solution for laboratory operations management. Our products and services help our customers solve complex analytical challenges, improve patient diagnostics and increase laboratory productivity.

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