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Gyros Protein Technologies Signs Distribution Agreement with Euro Diagnostica

publication date: Nov 7, 2017
author/source: Gyros AB

Gyros Protein Technologies becomes distributor of iLite cell-based reporter gene assays for drug development

gyrosGyros Protein Technologies AB, a pioneer in automated nanoliter-scale immunoassays and leading provider of peptide synthesizers and reagents, has announced it has signed a distribution agreement with Euro Diagnostica, the full service assay solution company. The agreement will give Gyros Protein Technologies’ customers in Europe and North America direct access to the iLite® assay ready cell lines from Euro Diagnostica, which help overcome limitations of conventional cell-based assays and improve productivity.

The iLite technology is based upon a unique reporter gene assay format, modified and adapted for applications through the whole drug development cycle as well as for monitoring of biological drugs. The applications addressed by iLite reporter gene assays are highly complementary to those addressed by Gyros Protein Technologies’ Gyrolab™ immunoassays systems, such as pharmacokinetics studies, detection of ADA (anti-drug antibodies) and bioprocess applications. The iLite dual reporter gene format allows for normalization of the response, eliminating unwanted matrix effects and compensating for differences in cell numbers, to achieve accurate and biologically relevant results. The cells are delivered frozen and assay ready, requiring no culture or maintenance, to enable cost reductions and time savings.

iLite assays have been designed to support screening of drug candidates, detection of neutralizing antibodies (NAb) as part of immunogenicity assessment, and potency measurements in manufacturing release tests. NAb are a subset of anti-drug antibodies (ADA) that bind to the therapeutic molecule resulting in its inhibition or complete neutralization, and affect the clinical efficacy of the drug. Detection and elimination of NAb is key to reducing the potential patient side effects of these unwanted drug components. The FDA recommends the use of cell-based neutralization assays over ligand-binding formats, when appropriate, as these more frequently provide physiologically relevant results.

Dan Calvo, CEO and President at Gyros Protein Technologies, said: “The iLite technology is an ideal addition to our offering, and is a natural complement to Gyrolab systems. This agreement with Euro Diagnostica further strengthens the position of Gyros Protein Technologies as a key analytical tools provider focused on developing and supplying drug immunogenicity and biologics solutions that increase productivity for customers in the biopharma and biotech industry.”

Dennis Hutchison, CCO of Euro Diagnostica, commented: “We are pleased to have Gyros Protein Technologies as our partner. This distribution agreement is an important step in enabling more researchers to access iLite cell lines, saving costs and improving productivity in cell-based assays.”

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