Genevac has published an informative customer article that reviews the development of a new sample preparation method using its EZ-2 centrifugal evaporator to help simplify and accelerate the detection and quantitation of algal toxins in surface water.
Due to a warming global environment there has been a rise in occurrences of cyanobacteria blooms in lakes which can generate cyanotoxins. With surface water a major source of drinking water, the presence of cyano bacterial blooms pose a potential threat to human health. Using Ultra-high Performance Liquid Chromatography (UPLC) researchers have been able to...
The fluorescent probe NR12S detects changes in plasma membrane cholesterol levels
The cell membrane is a bilayer of phospholipids with embedded proteins. It contains cholesterol that determines the membrane’s fluidity, permeability and activity of membrane proteins. Changes in membrane cholesterol are implicated in diseases such as Alzheimer’s and cancer, demanding its investigation....
Chromatrap® has published a new application note that demonstrates how its unique solid state patented technology provides unrivalled sensitivity allowing users to perform ChIP assays using as few as 1000 cells per immunoprecipitation.
Usually large cell numbers are required for performing ChIP, which poses something of a challenge when dealing with limited starting material. The available techniques for tackling small amounts of sample, rare cell types or difficult cell types which provide low yield of chromatin are usually long and complex, and involve DNA amplification or the spiking of samples...
The Biorepository at the Guy’s and St Thomas’ Bioresource stores a variety of samples, including whole blood, plasma and sera.
With some 30,000 samples from 5,200 volunteers and patients now collected, a Matrix Gemini Laboratory Information Management System (LIMS) from Autoscribe Informatics has been implemented to manage all aspects of sample handling and allow the most efficient use of freezer storage space. System actions include sample tracking, location recording and chain of custody reporting with full audit trails of all activities...
A white paper that provides evidence of the positive effects of post-curing on the reduction of cyclosiloxane contamination in silicone tubing manufacture has been publishedby Watson-Marlow Fluid Technology Group (WMFTG).
As a provider of single-use components including world-leading niche peristaltic pump and associated fluid path technologies, WMFTG demonstrates that the post-curing process significantly reduces the presence of cyclosiloxane contaminates in silicone tubing. Thereby, drug manufacturers opting to use post-cured tubing and tube assemblies, will benefit from improvements to the safety of the final drug product...
SP Scientific has published a white paper that discusses how the pharmaceutical industry and safety regulators are putting more emphasis on the importance of using external washers to remove particles from the outside of vials.
Many organizations today are electing to install external vial washers in association with filling applications involving powders, high potency liquids and freeze-dried materials to minimize the risk of operator or end-user exposure to harmful products. The white paper provides an informative introduction to...
Genevac, market leader in solvent removal, has announced the latest version of its proprietary autostop when dry control software which allows it’s EZ-2, Rocket and HT-Series evaporators to automatically detect when the samples are dry and then shut it down - safeguarding valuable samples from potential thermal degradation.
Combined with Genevac's continuous running condensers, autostop when dry control software allows easy unattended operation offering the possibility of significant increases in productivity through use of overnight evaporation runs. Until the introduction of autostop when dry control software - evaporators users had to constantly monitor or estimate the drying time for a given sample....
Merck, a leading science and technology company, has launched the CellASIC® ONIX2 Microfluidic System for advanced live cell imaging.
The system converts laboratory microscopes into powerful tools for live cell imaging to more effectively perform in-depth analysis of cellular mechanisms and behavior in a live environment....
Optibrium™ and Collaborative Drug Discovery (CDD), developers of software products and services for drug discovery and development, today announced a collaboration to integrate the StarDrop™ and CDD Vault® platforms.
This creates a seamless connection in real time between project data, securely held and managed in CDD Vault, and StarDrop’s unique compound design and optimisation capabilities. Instant access to the latest assay and compound data, with which a project team can share, interpret and model their chemistry, will lead to better decisions and shorter project timelines. CDD Vault is a hosted biological and chemical database that securely manages project data...
Chromatrap® has published a comprehensive Applications Compendium that includes hints and tips to improve your Chromatin Immunoprecipitation (ChIP) experiments, increase the effectiveness of your ChIP-seq library preparation and brings together its latest application notes in one informative document.
Chromatrap® solid-state ChIP technology has been adopted and shown by leading research groups worldwide to be more efficient than conventional bead-based methodologies. This is because the solid phase porous polymer, functionalized with either protein A or G, provides a greater surface area for chromatin antibody binding with very low non-specific binding....
Chromatrap® has published a comprehensive Applications Compendium that includes hints and tips to improve your Chromatin Immunoprecipitation (ChIP) experiments, increase the effectiveness of your ChIP-seq library preparation and brings together its latest application notes in one informative document.
Chromatrap® solid-state ChIP technology has been adopted and shown by leading research groups worldwide to be more efficient than conventional bead-based methodologies. This is because the solid phase porous polymer, functionalized with either protein A or G, provides a greater surface area for chromatin antibody binding with very low non-specific binding.....
Metrohm is pleased to present an application for the straightforward determination of the herbicide glyphosate and its primary metabolite AMPA in drinking water by ion chromatography with pulsed amperometric detection.
With a detection limit of approximately 1 µg/L, the method is sensitive enough to comply with limit values in the US, Canada, Australia, and others. A free whitepaper provides more details on the method and its application. Glyphosate and its metabolite AMPA (aminomethylphosphonic acid) are usually determined by HPLC with post-column derivatization and subsequent fluorescence detection...
Chromatrap, a business unit of Porvair Sciences, has published a new technical article that discusses and describes methodologies to increase Chromatin Immunoprecipitation (ChIP) efficiency by making sure chromatin in your samples is sheared to the correct size range.
The authors describe how for every chromatin preparation it is essential to check the chromatin is sheared to fragments between 100-500 bp. They emphasise using a microfluidics platform is the most accurate measure of quantifying DNA. Problems associated with over or under sheared Chromatin fragments are discussed....
Chromatrap, a business unit of Porvair Sciences, has published a new technical article that discusses and describes methodologies to increase Chromatin Immunoprecipitation (ChIP) efficiency by making sure chromatin in your samples is sheared to the correct size range.
The authors describe how for every chromatin preparation it is essential to check the chromatin is sheared to fragments between 100-500 bp. They emphasise using a microfluidics platform is the most accurate measure of quantifying DNA. Problems associated with over or under sheared Chromatin fragments are discussed and a protocol for optimised enzymatic shearing described.....
FLIR Systems has published a new paper that looks to strip away the technical jargon terms and explain infrared camera accuracy and measurement uncertainty in plain language.
Often explanations of infrared camera measurement accuracy involve complex terms and jargon that can be confusing and misleading. To trust measurements from infrared cameras when you don’t have a clear understanding of how their sensitivity and accuracy is derived means you are unlikely to get the best results. The authors of the paper explain infrared camera accuracy specifications and introduce the...
A case study describing the experiences of Niguarda Hospital, Milan, in assessing the new DxN VERIS Molecular Diagnostics System is now available from Beckman Coulter. The case study describes the workflow improvements and reduced turnaround times that the hospital’s Molecular Biology Laboratory was able to achieve for viral load measurements using the DxN VERIS system. One of Italy’s leading General Hospitals...
Sartorius Stedim Biotech (SSB) today announced a new paper entitled, ‘Shortening Timelines for Upstream Bioprocessing of Protein-based Therapeutics’ has been published in the journal, BioPharma Asia.
The paper details how scientists at leading Asian pharmaceutical company, WuXi AppTec are using the ambr® 15 automated micro bioreactor system to mimic bench-top and production scale bioreactors, producing comparable results with cell growth, cell metabolism and protein production, including similar protein titre to BIOSTAT® STR single-use bioreactors.In the article, one case study describes how...
INTEGRA, in conjunction with DPX Labs LLC, has produced an application note that describes a novel high throughput semi-automated sample method for processing urine samples ready for drugs of abuse analysis by LC-MS/MS.
Using an INTEGRA VIAFLO 96 electronic pipette with DPX mixed mode tips, a single 96-well plate loaded with samples can be extracted and ready for LC-MS/MS analysis in less than ten minutes eliminating the need for a time-consuming evaporation step. Sample preparation is required to remove matrix interferences from urine samples prior to LC-MS/MS analysis. This procedure is typically very time-consuming and is...
A new customer technical note compares the performance of the INTEGRA VOYAGER adjustable tip spacing multichannel pipette with a manual single channel pipette for performing real-time PCR experiments.
In undertaking these experiments, independent researchers found that the unique electronically adjustable tip facility on the VOYAGER not only generated time savings of up to 80% from minimising the number of required manual handling steps but also improved pipetting reproducibility and reduced pipetting errors.
Synbiosis,a long-established, expert manufacturer of automated microbiological systems, is delighted to announce a new paper entitled, ‘Evaluation of heterotrophic plate and chromogenic agar colony counting in water quality laboratories’ has been published in the peer-reviewed journal, Methods X.
The paper details how scientists at the Australian Water Quality Centre (AWQC) have for the first time independently validated that results from the ProtoCOL 3 automated colony counter are as accurate as manual colony counting. The article describes how microbiologists at AWCQ, a leading NATA (National Association of Testing Authorities) accredited water testing laboratory in Adelaide, Australia cultured microorganisms isolated from...
Presenting a faster and more efficient alternative to electron microscopy, digital light microscopy has been advancing investigations into the mechanical properties of bone, as explored in a new application note from Olympus.
Unravelling the mechanical properties of bone with micro-indentation testing has significance in both health and disease. At the University Medical Center Hamburg-Eppendorf, Dr. Björn Busse and his research group have advanced their micro-indentation testing technique using an Olympus industrial inspection digital light microscope, as an alternative to electron microscopy. The cutting edge research is described in a new application...
Titan Enterprises reports on how agrochemical specialists -Stored Crop Conservation Limited has standardised on their900 series and OG series flow meters to accurately record use of low volumes of regulated chemicals.
Hygiene and the elimination of pests and fungus is a major problem in the growth and storage of bulk crops in modern agriculture. From the preparation of the buildings used for the food production through to the silos containing the mass storage of products cleanliness is essential to ensure the quality of the produce. Even when produce is being put into storage the application of various chemicals extends the life of the products...
Due to a warming global environment there has been a rise in occurrences of cyanobacteria blooms in lakes which can generate cyanotoxins. With surface water a major source of drinking water, the presence of cyano bacterial blooms pose a potential threat to human health. Using Ultra-high Performance Liquid Chromatography (UPLC) researchers have been able to...
The cell membrane is a bilayer of phospholipids with embedded proteins. It contains cholesterol that determines the membrane’s fluidity, permeability and activity of membrane proteins. Changes in membrane cholesterol are implicated in diseases such as Alzheimer’s and cancer, demanding its investigation....
Usually large cell numbers are required for performing ChIP, which poses something of a challenge when dealing with limited starting material. The available techniques for tackling small amounts of sample, rare cell types or difficult cell types which provide low yield of chromatin are usually long and complex, and involve DNA amplification or the spiking of samples...
With some 30,000 samples from 5,200 volunteers and patients now collected, a Matrix Gemini Laboratory Information Management System (LIMS) from Autoscribe Informatics has been implemented to manage all aspects of sample handling and allow the most efficient use of freezer storage space. System actions include sample tracking, location recording and chain of custody reporting with full audit trails of all activities...
As a provider of single-use components including world-leading niche peristaltic pump and associated fluid path technologies, WMFTG demonstrates that the post-curing process significantly reduces the presence of cyclosiloxane contaminates in silicone tubing. Thereby, drug manufacturers opting to use post-cured tubing and tube assemblies, will benefit from improvements to the safety of the final drug product...
Many organizations today are electing to install external vial washers in association with filling applications involving powders, high potency liquids and freeze-dried materials to minimize the risk of operator or end-user exposure to harmful products. The white paper provides an informative introduction to...
Combined with Genevac's continuous running condensers, autostop when dry control software allows easy unattended operation offering the possibility of significant increases in productivity through use of overnight evaporation runs. Until the introduction of autostop when dry control software - evaporators users had to constantly monitor or estimate the drying time for a given sample....
The system converts laboratory microscopes into powerful tools for live cell imaging to more effectively perform in-depth analysis of cellular mechanisms and behavior in a live environment....
This creates a seamless connection in real time between project data, securely held and managed in CDD Vault, and StarDrop’s unique compound design and optimisation capabilities. Instant access to the latest assay and compound data, with which a project team can share, interpret and model their chemistry, will lead to better decisions and shorter project timelines. CDD Vault is a hosted biological and chemical database that securely manages project data...
Chromatrap® solid-state ChIP technology has been adopted and shown by leading research groups worldwide to be more efficient than conventional bead-based methodologies. This is because the solid phase porous polymer, functionalized with either protein A or G, provides a greater surface area for chromatin antibody binding with very low non-specific binding....
Chromatrap® solid-state ChIP technology has been adopted and shown by leading research groups worldwide to be more efficient than conventional bead-based methodologies. This is because the solid phase porous polymer, functionalized with either protein A or G, provides a greater surface area for chromatin antibody binding with very low non-specific binding.....
With a detection limit of approximately 1 µg/L, the method is sensitive enough to comply with limit values in the US, Canada, Australia, and others. A free whitepaper provides more details on the method and its application. Glyphosate and its metabolite AMPA (aminomethylphosphonic acid) are usually determined by HPLC with post-column derivatization and subsequent fluorescence detection...
The authors describe how for every chromatin preparation it is essential to check the chromatin is sheared to fragments between 100-500 bp. They emphasise using a microfluidics platform is the most accurate measure of quantifying DNA. Problems associated with over or under sheared Chromatin fragments are discussed....
The authors describe how for every chromatin preparation it is essential to check the chromatin is sheared to fragments between 100-500 bp. They emphasise using a microfluidics platform is the most accurate measure of quantifying DNA. Problems associated with over or under sheared Chromatin fragments are discussed and a protocol for optimised enzymatic shearing described.....
Often explanations of infrared camera measurement accuracy involve complex terms and jargon that can be confusing and misleading. To trust measurements from infrared cameras when you don’t have a clear understanding of how their sensitivity and accuracy is derived means you are unlikely to get the best results. The authors of the paper explain infrared camera accuracy specifications and introduce the...
A case study describing the experiences of Niguarda Hospital, Milan, in assessing the new DxN VERIS Molecular Diagnostics System is now available from Beckman Coulter. The case study describes the workflow improvements and reduced turnaround times that the hospital’s Molecular Biology Laboratory was able to achieve for viral load measurements using the DxN VERIS system. One of Italy’s leading General Hospitals...
The paper details how scientists at leading Asian pharmaceutical company, WuXi AppTec are using the ambr® 15 automated micro bioreactor system to mimic bench-top and production scale bioreactors, producing comparable results with cell growth, cell metabolism and protein production, including similar protein titre to BIOSTAT® STR single-use bioreactors.In the article, one case study describes how...
Using an INTEGRA VIAFLO 96 electronic pipette with DPX mixed mode tips, a single 96-well plate loaded with samples can be extracted and ready for LC-MS/MS analysis in less than ten minutes eliminating the need for a time-consuming evaporation step. Sample preparation is required to remove matrix interferences from urine samples prior to LC-MS/MS analysis. This procedure is typically very time-consuming and is...
In undertaking these experiments, independent researchers found that the unique electronically adjustable tip facility on the VOYAGER not only generated time savings of up to 80% from minimising the number of required manual handling steps but also improved pipetting reproducibility and reduced pipetting errors.
The paper details how scientists at the Australian Water Quality Centre (AWQC) have for the first time independently validated that results from the ProtoCOL 3 automated colony counter are as accurate as manual colony counting. The article describes how microbiologists at AWCQ, a leading NATA (National Association of Testing Authorities) accredited water testing laboratory in Adelaide, Australia cultured microorganisms isolated from...
Unravelling the mechanical properties of bone with micro-indentation testing has significance in both health and disease. At the University Medical Center Hamburg-Eppendorf, Dr. Björn Busse and his research group have advanced their micro-indentation testing technique using an 
Hygiene and the elimination of pests and fungus is a major problem in the growth and storage of bulk crops in modern agriculture. From the preparation of the buildings used for the food production through to the silos containing the mass storage of products cleanliness is essential to ensure the quality of the produce. Even when produce is being put into storage the application of various chemicals extends the life of the products...