AMSBIO announces RapidSeq – new convenient and cost-effective library sample preparation kits for Next Generation Sequencing (NGS) research and diagnostic work.
The RapidSeq Small RNA Sample Prep Kit is optimised for preparation of NGS libraries for subsequent cluster generation, using purified mRNA or total RNA which contains small RNA fragments as input. The protocol includes steps for adapters ligation, reverse transcription, PCR amplification, and size selection by gel purification to generate a library product compatible with a range of commercial NGS platforms. The RapidSeq Directional...
Users of the BÜHLMANN range of Faecal Calprotectin Assays can now improve efficiency and laboratory workflow with the unique, new, CALEX® Cap sample collection and extraction device.
Available from Alpha Laboratories Ltd, CALEX Cap eliminates the need for laborious, messy and variable weighing of faecal samples. There is no need for pipetting or decanting as the design also permits loading of the primary tube directly onto ELISA robots. With the BÜHLMANN CALEX Cap device, users can collect a sample of stool material without the need to manipulate it by hand. The grooved dosing tip of the device together with the presentation funnel ensures a precise amount of...
Medical Research Council (MRC) scientists have created the world’s first enzymes made from artificial genetic material. Their synthetic enzymes, which are made from molecules that do not occur anywhere in nature, are capable of triggering chemical reactions in the lab.
The research, published today in Nature, gives new insights into the origins of life and could provide a starting point for an entirely new generation of drugs and diagnostics. The findings build on previous work by the team at the MRC Laboratory of Molecular Biology, which saw them create synthetic molecules called ‘XNAs’ that can store and pass on genetic information, in a similar way to DNA....
Thermo Fisher Scientific has developed a pH-gradient-based method that provides excellent resolution for monoclonal antibody (MAb) charge variants.
Application Note 1092: Separation of Intact Monoclonal Antibody Sialylation Isoforms by pH Gradient Ion-Exchange Chromatography demonstrates that this approach is more convenient and straightforward than the isoelectric focusing method routinely used for protein sialylation profiling. This new method uses a cation-exchange protein column on a biocompatible analytical liquid chromatography system; a separate project is...
Merck Millipore, the Life Science division of Merck, has introduced the SNAP i.d.® 2.0 Protein Detection System for Immunohistochemistry (IHC), which streamlines immunohistochemistry workflows and significantly decreases slide handling time.
The system enables parallel processing of up to 24 tissue slides at a time, making it easier to apply consistent conditions and reduce potential process variability inherent in manual IHC methods. The system's intuitive format reduces slide handling and speeds wash steps during blocking, washing, antibody incubation and labeling. A controlled vacuum force removes solutions evenly from all slides at once, in seconds. This approach systemizes the...
R-Biopharm AG has launched a new Immunoaffinity Automation Platform incorporating Spark Holland‘s online sample prep platform to enable smooth automation of mycotoxin analysis.
Spark Holland, R-Biopharm AG and R Biopharm Rhone Ltd (the UK subsidiary of R-Biopharm AG) have collaborated for over 5 years on the development of an immunoaffinity cartridge to be used in the new platform. The R-Biopharm online automation platform, the RIDA® CREST system, will be an OEM version of Spark Holland’s renowned Symbiosis™ technology platform
TAP Biosystems announces that a top ten pharma company is using the fill-it™ automated cryovial processing system in its biomanufacturing to reduce costs by up to fifty percent, while ensuring consistent end to end quality of cell banks and reference standards distributed globally for biologics production.
The fill-it system is being used at this major pharmaceutical company at the beginning of biomanufacturing to routinely decap 1500, 2mL cryovials, automatically dispense 2mL from 3L of cell banks into these cryovials and then recap each vial. With fill-it this task takes two scientists three hours to produce a single batch of 1500 processed cryovials. The system has significantly reduced the company’s production and QC costs as previously...
Thermo Fisher Scientific has developed an efficient high-performance liquid chromatography (HPLC) method using a mixed-mode column, the Thermo Scientific™Acclaim™ Mixed-Mode WAX-1 column, with ultraviolet detection for a rapid and sensitive determination of acesulfame in vinegar.
Application Note 1104: Rapid and Sensitive Determination of Acesulfame in Vinegar demonstrates that this approach offers the advantages of simple sample preparation, good method reproducibility, and a wide linear calibration range. This new method also achieves a detection limit much lower than that specified by the Standardization Administration of China. Acesulfame is extensively used as a sugar substitute in foods and...
NanoHybrids Corporation, a provider of nanotechnology-based contrast agents announced the launch of its new website and premium product line of gold nanoparticles specially designed to improve imaging results.
The company’s initial technology platform was developed in collaboration with researchers from the Biomedical Engineering Department at The University of Texas at Austin and M.D. Anderson Cancer Center. “Frustrated by inconsistent imaging results due to highly variable shape, size and other properties of commercially available gold nanoparticle contrast agents, our team has developed highly monodisperse gold nanorods and nanospheres that will help scientists obtain consistent and better quality data....
The Clinical and Laboratory Standards Institute (CLSI) has released a new document, Liquid Chromatography-Mass Spectrometry Methods; Approved Guideline (C62-A).
This document provides guidance to the clinical laboratorian for the reduction of interlaboratory variance and the evaluation of interferences, assay performance, and other pertinent characteristics of clinical assays. C62-A emphasizes particular areas related to assay development and presents a standardized approach for method verification that is specific to mass spectrometry (MS) technology. This document provides guidance for the development and verification of liquid...
MicroMatrices, a service provider specialised in high resolution cell type-specific analysis to characterise toxicological responses in different cell types in tissue, today announced a preferred partnership agreement with Advanced Cell Diagnostics, Inc. (ACD), a leader in the field of molecular pathology and developer of cell and tissue-based analysis tools.
MicroMatrices solves molecular toxicological problems using unique visualisation and localisation technologies, adding resolving power to standard methodologies. Consisting of a highly skilled core of scientists networked to facilities of excellence across the United Kingdom, MicroMatrices is scalable, efficient and flexible. MicroMatrices offers innovative, collaborative, state of the art solutions for unique efficacy and safety requirements...
XEI Scientific Inc. announces the release of the Evactron® EP at the annual meeting of the American Vacuum Society in Baltimore, MD.
This provides a new approach to plasma cleaning designed for those in the physics and materials science communities building and using custom-designed vacuum systems. The Evactron EP Remote Plasma Source from XEI Scientific uses flowing afterglow cleaning with air to clean carbon compounds from vacuum chambers operating with turbomolecular pumps. The unique new system has instant ignition from any vacuum level...
Imaging companies in Europe get closer to scientists by founding an open Board linked to the upcoming European research infrastructure Euro-BioImaging
Leading imaging companies Leica, Nikon, Zeiss, FEI, Olympus, SVI and Photometrics announced last week that for the first time they jointly founded an open Industry Board linked to the upcoming European research infrastructure for imaging “Euro-BioImaging”. The mission of the Board is to facilitate interaction between imaging industry and its academic users, enabling timely understanding of the users’ needs. This has potential to...
ZEISS present new microscope hard- and software for imaging of cleared tissue at Neuroscience meeting
Clearing methods make tissue transparent, thus allowing scientists to image deep into large biological samples such as tissue sections, brains, embryos, organs, spheroids or biopsies. The enhanced optical penetration depth even allows detection of fluorescent signals from whole organs. This means clearing is a promising technique when, for example, investigating neuronal networks in mouse brains....
Read MoreLaVision BioTec Launch New Products at Neuroscience 2014Nov 26, 2014
LaVison BioTec introduce new products for their UltraMicroscope and TriM Scope microscopy products at the 2014 annual meeting of the Society for Neuroscience.
LaVision BioTec announce the release of several ground-breaking new products at the 2014 meeting of the Society for Neuroscience to be held in Washington DC, November 15-19. Delegates are invited to visit LaVision on Booth #817 to meet the product group and learn about the latest innovations from the company. TriM Scope II is an intravital 2-photon microscope. Three new developments are announced at the meeting. First is a...
Thermo Fisher Scientific has developed a method to analyze food and environmental matrices for the presence of alkylphenol compounds using a GC-MS/MS system with automated selected reaction monitoring (AutoSRM).
Application Note 10407: Analysis of Alkylphenols Using GC-MS/MS and Automated SRM Development demonstrates the combined analytical power of the Thermo Scientific TRACE 1310 GC, the Thermo Scientific TSQ Duo triple quadrupole mass spectrometer and the Thermo Scientific Dionex Chromeleon Chromatography Data System (CDS) software to detect and quantify alkylphenol compounds in water and solid samples....
INTEGRA offer an efficient way to increase sample throughput without the expense of a robotic system.
The VIAFLO 96 benchtop electronic pipette offers an affordable solution to increase productivity when working with microplates. It closes the gap between traditional manual pipettes and robotic systems, allowing for accurate and reproducible 96-channel pipetting. The VIAFLO 384 is a more advanced system, which can work with both 96- and 384-channel pipetting heads to maximize productivity. It features the same footprint and intuitive user concept as VIAFLO 96....
When space is scarce but routine applications require high performance, then the answer is JULABO Cryo-Compact Circulators.
JULABO presents the compact cooling circulators of the CF series with working temperatures ranging from -40 °C to +200 °C. These units can be installed in the tightest of spaces or inside of technical applications. All models are equipped with pump connections for external temperature control applications, for example distillation applications or mini-plants. An integrated bath permits the temperature control of smaller objects e.g. sensors.
J. G. Finneran Associates is pleased to announce the addition of QuEChers to their product offerings.
QuEChERS (pronounced “catchers”), is an acronym for Quick, Easy, Cheap, Effective, Rugged and Safe. QuEChERS offer a convenient and effective sample preparation technique for determining pesticide residues in fruit, vegetables and other foods. Finneran QuEChERS make it simple to prepare your food samples for analysis with...
With their range of Immersion Coolers, Huber Kältemaschinenbau offers a flexible solution for a variety of cooling applications.
These units are easy to use and ideally suited to quick liquid cooling. A typical application is to cool heating thermostats or as a substitute for dry ice. Immersion coolers offer an environmentally friendly cooling alternative by reducing consumption of tap water. The TC Immersion Coolers are available without a controller for continuous cooling or respectively with controller and Pt100 sensor connection. Models with the addition “E” are equipped with a...
Hichrom's 2015 training programme is now available, featuring courses covering every area of HPLC, UHPLC, GC and sample preparation and delivered by world-renowned experts including John Dolan, Mel Euerby, Mark Powell, Diane Turner, Alan McKeown, Geoff Pickerell, Brian Montgomery, Helen Poole, Gemma Lo and Annette Larder.
Whether you are a relative newcomer to chromatography or a seasoned veteran, you can benefit from one of our courses. In addition to the well-established and well received theoretical courses (which are available as full day training courses or short 1-2 hour seminars), a wide range of practical ‘Hands-On’ courses covering all aspects of LC, LC/MS, GC, GC/MS and sample preparation is now also available. Read MoreA New Magnetic Technology for Bioseparations and Studies of Biomolecular InteractionsNov 24, 2014
AMSBIO announces MagSi-Direct - a revolutionary technology that brings the power, simplicity, and convenience of magnetic separation to researchers involved in cell biology, protein chemistry, flow cytometry, diagnostics development and many other fields.
MagSi-Direct provides a convenient and efficient way to attach virtually any biomolecule to nanoscopic paramagnetic beads. It is particularly suited for exploiting interactions between a biomolecule and its binding partners. With MagSi-Direct, you can start with a molecule of interest, attach magnetic beads to it, and then use a magnet to isolate that molecule from any desired reaction mixture, together with any other molecules, complexes, or even intact cells to which the starting molecule has bound....
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The RapidSeq Small RNA Sample Prep Kit is optimised for preparation of NGS libraries for subsequent cluster generation, using purified mRNA or total RNA which contains small RNA fragments as input. The protocol includes steps for adapters ligation, reverse transcription, PCR amplification, and size selection by gel purification to generate a library product compatible with a range of commercial NGS platforms. The RapidSeq Directional...
Available from Alpha Laboratories Ltd, CALEX Cap eliminates the need for laborious, messy and variable weighing of faecal samples. There is no need for pipetting or decanting as the design also permits loading of the primary tube directly onto ELISA robots. With the BÜHLMANN CALEX Cap device, users can collect a sample of stool material without the need to manipulate it by hand. The grooved dosing tip of the device together with the presentation funnel ensures a precise amount of...
The research, published today in Nature, gives new insights into the origins of life and could provide a starting point for an entirely new generation of drugs and diagnostics. The findings build on previous work by the team at the MRC Laboratory of Molecular Biology, which saw them create synthetic molecules called ‘XNAs’ that can store and pass on genetic information, in a similar way to DNA....
Application Note 1092: Separation of Intact Monoclonal Antibody Sialylation Isoforms by pH Gradient Ion-Exchange Chromatography demonstrates that this approach is more convenient and straightforward than the isoelectric focusing method routinely used for protein sialylation profiling. This new method uses a cation-exchange protein column on a biocompatible analytical liquid chromatography system; a separate project is...
The system enables parallel processing of up to 24 tissue slides at a time, making it easier to apply consistent conditions and reduce potential process variability inherent in manual IHC methods. The system's intuitive format reduces slide handling and speeds wash steps during blocking, washing, antibody incubation and labeling. A controlled vacuum force removes solutions evenly from all slides at once, in seconds. This approach systemizes the...
Spark Holland, R-Biopharm AG and R Biopharm Rhone Ltd (the UK subsidiary of R-Biopharm AG) have collaborated for over 5 years on the development of an immunoaffinity cartridge to be used in the new platform. The R-Biopharm online automation platform, the RIDA® CREST system, will be an OEM version of Spark Holland’s renowned Symbiosis™ technology platform
The fill-it system is being used at this major pharmaceutical company at the beginning of biomanufacturing to routinely decap 1500, 2mL cryovials, automatically dispense 2mL from 3L of cell banks into these cryovials and then recap each vial. With fill-it this task takes two scientists three hours to produce a single batch of 1500 processed cryovials. The system has significantly reduced the company’s production and QC costs as previously...
The company’s initial technology platform was developed in collaboration with researchers from the Biomedical Engineering Department at The University of Texas at Austin and M.D. Anderson Cancer Center. “Frustrated by inconsistent imaging results due to highly variable shape, size and other properties of commercially available gold nanoparticle contrast agents, our team has developed highly monodisperse gold nanorods and nanospheres that will help scientists obtain consistent and better quality data....
This document provides guidance to the clinical laboratorian for the reduction of interlaboratory variance and the evaluation of interferences, assay performance, and other pertinent characteristics of clinical assays. C62-A emphasizes particular areas related to assay development and presents a standardized approach for method verification that is specific to mass spectrometry (MS) technology. This document provides guidance for the development and verification of liquid...
MicroMatrices solves molecular toxicological problems using unique visualisation and localisation technologies, adding resolving power to standard methodologies. Consisting of a highly skilled core of scientists networked to facilities of excellence across the United Kingdom, MicroMatrices is scalable, efficient and flexible. MicroMatrices offers innovative, collaborative, state of the art solutions for unique efficacy and safety requirements...
This provides a new approach to plasma cleaning designed for those in the physics and materials science communities building and using custom-designed vacuum systems. The Evactron EP Remote Plasma Source from XEI Scientific uses flowing afterglow cleaning with air to clean carbon compounds from vacuum chambers operating with turbomolecular pumps. The unique new system has instant ignition from any vacuum level...
Leading imaging companies Leica, Nikon, Zeiss, FEI, Olympus, SVI and Photometrics announced last week that for the first time they jointly founded an open Industry Board linked to the upcoming European research infrastructure for imaging “Euro-BioImaging”. The mission of the Board is to facilitate interaction between imaging industry and its academic users, enabling timely understanding of the users’ needs. This has potential to...
Clearing methods make tissue transparent, thus allowing scientists to image deep into large biological samples such as tissue sections, brains, embryos, organs, spheroids or biopsies. The enhanced optical penetration depth even allows detection of fluorescent signals from whole organs. This means clearing is a promising technique when, for example, investigating neuronal networks in mouse brains....
LaVision BioTec announce the release of several ground-breaking new products at the 2014 meeting of the Society for Neuroscience to be held in Washington DC, November 15-19. Delegates are invited to visit LaVision on Booth #817 to meet the product group and learn about the latest innovations from the company. TriM Scope II is an intravital 2-photon microscope. Three new developments are announced at the meeting. First is a...
JULABO presents the compact cooling circulators of the CF series with working temperatures ranging from -40 °C to +200 °C. These units can be installed in the tightest of spaces or inside of technical applications. All models are equipped with pump connections for external temperature control applications, for example distillation applications or mini-plants. An integrated bath permits the temperature control of smaller objects e.g. sensors.
QuEChERS (pronounced “catchers”), is an acronym for Quick, Easy, Cheap, Effective, Rugged and Safe. QuEChERS offer a convenient and effective sample preparation technique for determining pesticide residues in fruit, vegetables and other foods. Finneran QuEChERS make it simple to prepare your food samples for analysis with...
These units are easy to use and ideally suited to quick liquid cooling. A typical application is to cool heating thermostats or as a substitute for dry ice. Immersion coolers offer an environmentally friendly cooling alternative by reducing consumption of tap water. The TC Immersion Coolers are available without a controller for continuous cooling or respectively with controller and Pt100 sensor connection. Models with the addition “E” are equipped with a...
Whether you are a relative newcomer to chromatography or a seasoned veteran, you can benefit from one of our courses. In addition to the well-established and well received theoretical courses (which are available as full day training courses or short 1-2 hour seminars), a wide range of practical ‘Hands-On’ courses covering all aspects of LC, LC/MS, GC, GC/MS and sample preparation is now also available.
MagSi-Direct provides a convenient and efficient way to attach virtually any biomolecule to nanoscopic paramagnetic beads. It is particularly suited for exploiting interactions between a biomolecule and its binding partners. With MagSi-Direct, you can start with a molecule of interest, attach magnetic beads to it, and then use a magnet to isolate that molecule from any desired reaction mixture, together with any other molecules, complexes, or even intact cells to which the starting molecule has bound....