Merrimack will utilize RNAscope to identify patients with heregulin positive, locally advanced or metastatic non-small cell lung cancer, making this Merrimack's first MM-121 trial to include only patients with a high heregulin biomarker profile. In previous MM-121 Phase 2 clinical trials, heregulin-positive patients, determined by RNAscope, have demonstrated significant therapeutic benefits when treated with a combination of MM-121 and...
Study suggests that millions of modern Asian men are descended from 11 ancient leaders, including Genghis Khan
The article, entitled “The role of NGS in stratified cancer medicine”, presents a valuable resource to better understand the present and the future of NGS in stratified cancer medicine, detailing the most relevant aspects of this revolutionary technology. A key focus of current cancer research is developing the use of stratified medicine. The approach is highly advantageous in guiding effective therapy as it profiles the genetic makeup of individual tumour samples...
This report addresses topics relating to clinical applications, amplified and nonamplified nucleic acid methods, selection and qualification of nucleic acid sequences, establishment and evaluation of test performance characteristics, inhibitors, and interfering substances, controlling false-positive reactions, reporting and interpretation of results, quality assurance, regulatory issues, and recommendations for manufacturers and clinical laboratories...
For two days pioneers in the field – spanning from researchers, governments, patient organisations, and funders – will discuss the challenges involved in navigating the complex pathways for drug and diagnostics development. Registration is free, but places are limited. EATRIS is the permanent, academic translational research infrastructure supporting researchers and funders in mitigating risk and adding value to high potential products...
When used along with standard culture, this conventional PCR kit will help to provide up-to-date information for infection control by identifying which gram-negative ampC resistant bacterial strains are present in the hospital. Resistance to the beta-lactam class of anti-microbials is a significant cause of multidrug-resistant urinary tract and bloodstream infections. The Philisa ampC ID kit, available exclusively in the UK from Alpha Laboratories, is a PCR based...
To support this highly specialised work, Nottingham-based Scientific Laboratory Supplies Ltd (SLS) has recently launched a new range of pathology and mortuary products for use by forensic and histopathologists as well as by mortuary professionals. SLS is the UK’s largest independent British-owned supplier of scientific equipment, chemicals and consumables, and in building the catalogue staff looked into how and why post-mortem examinations...
Building on the company’s decades of experience, Eppendorf cell biology solutions deliver researchers and technicians with upmost levels of confidence, accuracy and reliability. When reproducible results are essential for laboratory work, it is possible for results to be affected by many factors. With the Eppendorf Xplorer® electronic pipettes, all relevant factors, from volume and speed to mixing cycles, are precisely and reproducibly set...
If successful, the realisation of this technology for specialised biological applications, generally known as ‘biofabrication’, has the potential to replace the long established (and often controversial) process of using animals for testing new drugs. However, there are many challenges to overcome to enable the successful production of a valve-based cell printer for the formation of human embryonic stem cell spheroid aggregates. For example, printing techniques need to be...
Dr. Michael Kempe and Dr. Michael Totzeck have been designated as Fellows, the highest level of the ZEISS technical ladder. They both work at Corporate Research & Technology. Kempe is Head of the Technology area. Totzeck is Head of Industrial and Consumer Innovations. President and CEO of ZEISS Dr. Michael Kaschke congratulated them both on their designation and thanked them for their excellent work to date...
This will help to put an end to the outbreaks occurring in countries in the WHO European Region and to prevent similar outbreaks in the future. Seven countries in the Region have reported 22,149 cases of measles in 2014 and thus far in 2015. This threatens the Region’s goal of eliminating the disease by the end of 2015. Even though measles cases fell by 50% from 2013 to 2014, large outbreaks continue...
Now, chemists and engineers at KU Leuven, in Belgium, have devised a strikingly simple and effective solution: they inject genetic material into a droplet of water and use a pipet tip to drag it over a glass plate covered with a sticky polymer. The droplet rolls like a ball over the plate, sticking the DNA to the plate surface. The unraveled DNA can then be studied under a microscope. The researchers described the technique in...
Offering high transfection efficiency and expression levels across a broad range of cell types, including stem cells and primary cells, mRNA-In™ is a robust and easy-to-use mRNA delivery solution proven in applications including protein expression and iPSC-reprogramming. Recognized as among the most difficult cell types to transfect, either freshly isolated or cryopreserved neurons or neural stem cells can be transfected with...
These technology developments are now available on all of Stuart’s digital and analogue Tube Rollers, bringing greater application versatility as well as peace of mind to lab scientists in education, life science and healthcare. Stuart’s detachable roller tubes are designed so that users can customise the roller bed in order to fit larger vessels as and when required. The motor driven rollers can be easily removed or inserted to accommodate different sized sample tubes and media bottles...
“Delegates were particularly enthusiastic about OMNISEC’s sensitivity,” said Paul Clarke, Industrial Portfolio Manager at Malvern Instruments. “Announcing ‘the most sensitive light scattering detector on the market’ is one thing but seeing what that actually means in practice is another. Demonstrations of the system measuring the molecular weight (MW) of a 100,000 Da Polystyrene standard with just a 100 ng of sample made a big impression and...
Both are deployment options of GENALICE MAP, the company’s breakthrough Next-Generation Sequencing (NGS) data processing software. GENALICE MAP processes genomics data up to 100-fold faster than conventional tools and produces improved quality outcome data, while radically reducing the storage requirements. It is the only product in the market today that makes secondary analysis of large-scale genomics data... 
Prior to this era, heating in chemical laboratories was potentially very dangerous, since open flame gas burners and electric glow coils were commonly used to heat oil, sand, molten metal, and water baths. Despite widespread safety concerns, heating baths are still in common usage today. They remain inherently dangerous as the hot fluid they contain is liable to be spilled or spattered should water be accidentally introduced, and a hot bath is very difficult to deal with in an emergency situation....
Stuart has been designing and manufacturing reliable benchtop laboratory equipment for over 40 years. Stuart’s current range of products features agitation products to suit almost any mixing or shaking application, including:
EKF Diagnostics subsidiary, Selah Genomics, has announced a major, four-way collaboration with Greenville Health System (GHS, South Carolina), DecisionQ Corporation (Virginia), and BD (Becton Dickinson and Company, New Jersey). Expected to last 18 months, the collaboration aims to unite classic clinical annotations with proprietary next generation sequencing (NGS) technology and artificial intelligence-based decision...