Molnupiravir (Lagevrio®) is an antiviral medication to treat mild to medium COVID-19 infection. Molnupiravir is actually a prodrug of the active substrate N4-hydroxycytidine (NHC), a synthetic ribonucleoside analogue. The treatment leads to the introduction of copying errors during viral RNA replication and by this inhibits the viral reproduction. This new Application Note demonstrates how molnupiravir and its active agent β-d-N4-hydroxycytidine can be separated by using a YMC-Triart C18 UHPLC column...
At the start of July 2022, The NHS became the first health system to embed net zero into legislation. However, its goal of achieving net zero by 2040 is challenging when every stage of the pharmaceutical supply chain has a carbon footprint, from packaging pills to active pharmaceutical ingredient (API) development. Here Aleiya Lonsdale, Head of Event, at the UK’s largest laboratory trade show Lab Innovations, explains how pharmaceutical companies in the UK can do their part to help reach this goal....
PhoreMost to deploy its SITESEEKER platform to identify novel targets for Roche’s discovery programmes. PhoreMost Ltd., the UK-based biopharmaceutical company dedicated to 'Drugging the Undruggable®' disease targets, has announced it has entered into a multi-project target discovery collaboration with Roche, one of the world's leading biotechnology companies. Under the terms of the agreement, PhoreMost will receive an upfront payment and is eligible for preclinical success-based milestones...
Beckman Coulter Life Sciences, a global leader in laboratory automation and innovation, announces it has acquired ValitaCell Ltd. (“ValitaCell”), a biotechnology company that creates pioneering analytical products and technologies for the biopharmaceutical industry. Headquartered in Dublin, Ireland, ValitaCell creates analytical technologies and products for the biopharmaceutical industry with the goal of reducing new therapeutics' cost and time to market...
Waters Corporation announced it is providing both technology and expertise to help advance plant-based protein science in collaboration with researchers of the Plant Protein Innovation Center (PPIC) at the University of Minnesota. Waters scientists will work with PPIC researchers to develop a workflow for measuring the amino acid content of plant-based proteins using a Waters ACQUITY™ Premier UPLC System....
Cherwell Laboratories, specialist supplier of environmental monitoring (EM) and process validation solutions for the pharmaceutical and related industries, has launched a new online video training library sharing educational content for individuals in the pharmaceutical and healthcare industries. Cherwell’s Delivering Knowledge platform offers best practice information delivered by experts in monitoring of controlled environments, aseptic processes and sterility...
Researchers at the University of Huddersfield have combined differential scanning calorimetry (DSC) with thermomicroscopy to reveal detailed energy changes in specific materials. In this first ever study that uses DSC-thermomicroscopy to harness the benefits of analysing rubidium nitrate and polyethylene oxidation using both methods simultaneously, researchers at the University of Huddersfield’s Thermal Methods Research Unit (TMRU) used the Optical DSC450 System from Linkam Scientific Instruments...
To ensure all medicines are produced to the highest quality, pharmaceutical manufacturers around the world are subjected to strict regulations. The problem is, monitoring the conditions in a manufacturing facility 24/7 requires high-end, often costly networking technology. Here Ian Loudon, international sales and marketing manager at remote monitoring instrumentation manufacturer Omniflex, discusses how temperature monitoring systems can be cost effective, reliable and compliant with regulatory standards...
Learn about CRISPR technology’s impact on cell and gene therapies and drug discovery and discover tips and tricks for optimized CRISPR editing and screening. On September 20, 2022, Lonza will host a free virtual workshop on using genome editing technologies for cell and gene therapies and drug discovery. The 3-hour workshop brings together renowned genome editing experts from across industry and academia and comprises four interactive speaker sessions....
Benchling, the R&D Cloud powering the biotechnology industry, today launched the industry’s first full set of capabilities for designing, modelling, and studying both natural and chemically modified RNA in a single solution. As the biopharmaceutical industry increases its focus on developing RNA therapeutics, Benchling’s new RNA solution is the first purpose-built offering on the market to help R&D organizations accelerate the delivery of drug candidates...
Medical research charity LifeArc and Great Ormond Street Hospital Children’s Charity (GOSH Charity) have jointly awarded more than£1.3 million of funding to help four GOSH researchers drive their discoveries towards new tests and treatments to tackle rare diseases affecting children. Four researchers based at the UCL Great Ormond Street Institute of Child Health and Great Ormond Street Hospital for Children NHS Foundation Trust have received project grants that aim to translate research discoveries...
Beckman Coulter Life Sciences, a global leader in laboratory automation and biotechnology innovation, announces a partnership with Flownamics to create an automated, on-line solution for bioprocess culture monitoring and control. This delivers a critical and practical update to the significant unmet need for automated, real-time cell analysis in the current bioprocessing environment....
Cansford Laboratories has made a significant investment in equipment at its in-house drug and alcohol testing laboratory in Cardiff, as part of its continuing development programme. The investment has been made in a new Robotic Automatic Liquid Pipetting Handler (RALPH) machine which will help the lab work more efficiently by allowing operators to perform separate processes, simultaneously....
Miniaturisation has existed for a while, but usually at a high cost to medical device manufacturers. When Manchester-based UK Robotics, a specialist in building integrated lab automation solutions for the life sciences, needed to create a new cost-effective two valve nanolitre microplate reagent dispenser, it turned to precision DC motor manufacturer maxon UK and Ireland for help...
EVONETIX LTD, the synthetic biology company bringing semiconductor technology to DNA synthesis, has announced the opening of its early access program for semiconductor synthesised DNA. Evonetix’s DNA synthesis capability brings together patented semiconductor chip design and proprietary, thermally controlled synthesis chemistry, which will be integral to the Company’s future gene synthesis platforms...
Drug molecules and biofuels can be made to order by living cell factories, where biological enzymes do the job. Now researchers at Chalmers University of Technology have developed a computer model that can predict how fast enzymes work, making it possible to find the most efficient living factories, as well as to study difficult diseases. Enzymes are proteins found in all living cells. Their job is to act as catalysts that increase the rate of specific chemical reactions that take place in the cells....
Agilent Technologies has announced that it is collaborating with METTLER TOLEDO to address one of the biggest concerns in any laboratory—error-prone sample preparation. This integrated solution allows the automatic and seamless transfer of weighing results and the associated metadata from METTLER TOLEDO LabX™ Balance software to Agilent OpenLab software...
Accelerated Technology Laboratories, Inc. (ATL), a leader in Laboratory Information Management Systems (LIMS), continues the 2022 LIMS Webcast series on Wednesday, September 14 with LIMS: What You Should Know About SaaS vs. On-Premises Deployment. The move to cloud (also known as Software as a Service or SaaS) deployment has seen explosive growth the past few years and all signs point to continuing this upward trend....
Asynt report how award-winning formulation and development lab – Here2Grow Cosmetics & Homecare Labs (Selby, UK) used the ReactoMate DATUM laboratory reaction vessel system in the development of a next generation clinical haircare product. To tackle common scalp issues encountered by patients, a tricology clinic had been developing scalp therapy products in collaboration with formulation laboratories and manufacturers....
The life science group Sartorius, through its French listed subgroup Sartorius Stedim Biotech, has agreed to acquire 100 percent of Albumedix Ltd. from private investors. The Nottingham, UK-based company provides best-in-class recombinant albumin-based solutions. Recombinant human albumin is an important component for the biopharmaceutical industry required for various applications...
Olympus Corporation (“Olympus”) and EVIDENT Co., Ltd. ("Evident"), a wholly-owned subsidiary of Olympus announce that Olympus concluded a definitive agreement with Bain Capital Private Equity, LP (“Bain Capital”), regarding the transfer of Evident. Based on this agreement, all shares of Evident will be transferred to Bain Capital on January 4, 2023, subject to regulatory approvals and closing conditions....
Validair Diamond Scientific (VDS) has invested in a new cleanroom at its Chester-le-Street headquarters. The in-house facility was specified and designed to meet exacting requirements for research and fault-finding as well as for use by the company’s field service team as a hands-on training resource. VDS worked closely with Total Clean Air to design and configure the cleanroom to be exceptionally flexible in its performance and functionality, allowing the VDS team to push the boundaries...
Molnupiravir (Lagevrio®) is an antiviral medication to treat mild to medium COVID-19 infection. Molnupiravir is actually a prodrug of the active substrate N4-hydroxycytidine (NHC), a synthetic ribonucleoside analogue. The treatment leads to the introduction of copying errors during viral RNA replication and by this inhibits the viral reproduction. This new Application Note demonstrates how molnupiravir and its active agent β-d-N4-hydroxycytidine can be separated by using a YMC-Triart C18 UHPLC column...
At the start of July 2022, The NHS became the first health system to embed net zero into legislation. However, its goal of achieving net zero by 2040 is challenging when every stage of the pharmaceutical supply chain has a carbon footprint, from packaging pills to active pharmaceutical ingredient (API) development. Here Aleiya Lonsdale, Head of Event, at the UK’s largest laboratory trade show Lab Innovations, explains how pharmaceutical companies in the UK can do their part to help reach this goal....
PhoreMost to deploy its SITESEEKER platform to identify novel targets for Roche’s discovery programmes. PhoreMost Ltd., the UK-based biopharmaceutical company dedicated to 'Drugging the Undruggable®' disease targets, has announced it has entered into a multi-project target discovery collaboration with Roche, one of the world's leading biotechnology companies. Under the terms of the agreement, PhoreMost will receive an upfront payment and is eligible for preclinical success-based milestones...
Beckman Coulter Life Sciences, a global leader in laboratory automation and innovation, announces it has acquired ValitaCell Ltd. (“ValitaCell”), a biotechnology company that creates pioneering analytical products and technologies for the biopharmaceutical industry. Headquartered in Dublin, Ireland, ValitaCell creates analytical technologies and products for the biopharmaceutical industry with the goal of reducing new therapeutics' cost and time to market...
Waters Corporation announced it is providing both technology and expertise to help advance plant-based protein science in collaboration with researchers of the Plant Protein Innovation Center (PPIC) at the University of Minnesota. Waters scientists will work with PPIC researchers to develop a workflow for measuring the amino acid content of plant-based proteins using a Waters ACQUITY™ Premier UPLC System....
Cherwell Laboratories, specialist supplier of environmental monitoring (EM) and process validation solutions for the pharmaceutical and related industries, has launched a new online video training library sharing educational content for individuals in the pharmaceutical and healthcare industries. Cherwell’s Delivering Knowledge platform offers best practice information delivered by experts in monitoring of controlled environments, aseptic processes and sterility...
Researchers at the University of Huddersfield have combined differential scanning calorimetry (DSC) with thermomicroscopy to reveal detailed energy changes in specific materials. In this first ever study that uses DSC-thermomicroscopy to harness the benefits of analysing rubidium nitrate and polyethylene oxidation using both methods simultaneously, researchers at the University of Huddersfield’s Thermal Methods Research Unit (TMRU) used the Optical DSC450 System from Linkam Scientific Instruments...
To ensure all medicines are produced to the highest quality, pharmaceutical manufacturers around the world are subjected to strict regulations. The problem is, monitoring the conditions in a manufacturing facility 24/7 requires high-end, often costly networking technology. Here Ian Loudon, international sales and marketing manager at remote monitoring instrumentation manufacturer Omniflex, discusses how temperature monitoring systems can be cost effective, reliable and compliant with regulatory standards...
Learn about CRISPR technology’s impact on cell and gene therapies and drug discovery and discover tips and tricks for optimized CRISPR editing and screening. On September 20, 2022, Lonza will host a free virtual workshop on using genome editing technologies for cell and gene therapies and drug discovery. The 3-hour workshop brings together renowned genome editing experts from across industry and academia and comprises four interactive speaker sessions....
Benchling, the R&D Cloud powering the biotechnology industry, today launched the industry’s first full set of capabilities for designing, modelling, and studying both natural and chemically modified RNA in a single solution. As the biopharmaceutical industry increases its focus on developing RNA therapeutics, Benchling’s new RNA solution is the first purpose-built offering on the market to help R&D organizations accelerate the delivery of drug candidates...
Medical research charity LifeArc and Great Ormond Street Hospital Children’s Charity (GOSH Charity) have jointly awarded more than£1.3 million of funding to help four GOSH researchers drive their discoveries towards new tests and treatments to tackle rare diseases affecting children. Four researchers based at the UCL Great Ormond Street Institute of Child Health and Great Ormond Street Hospital for Children NHS Foundation Trust have received project grants that aim to translate research discoveries...
Beckman Coulter Life Sciences, a global leader in laboratory automation and biotechnology innovation, announces a partnership with Flownamics to create an automated, on-line solution for bioprocess culture monitoring and control. This delivers a critical and practical update to the significant unmet need for automated, real-time cell analysis in the current bioprocessing environment....
Cansford Laboratories has made a significant investment in equipment at its in-house drug and alcohol testing laboratory in Cardiff, as part of its continuing development programme. The investment has been made in a new Robotic Automatic Liquid Pipetting Handler (RALPH) machine which will help the lab work more efficiently by allowing operators to perform separate processes, simultaneously....
Miniaturisation has existed for a while, but usually at a high cost to medical device manufacturers. When Manchester-based UK Robotics, a specialist in building integrated lab automation solutions for the life sciences, needed to create a new cost-effective two valve nanolitre microplate reagent dispenser, it turned to precision DC motor manufacturer maxon UK and Ireland for help...
EVONETIX LTD, the synthetic biology company bringing semiconductor technology to DNA synthesis, has announced the opening of its early access program for semiconductor synthesised DNA. Evonetix’s DNA synthesis capability brings together patented semiconductor chip design and proprietary, thermally controlled synthesis chemistry, which will be integral to the Company’s future gene synthesis platforms...
Drug molecules and biofuels can be made to order by living cell factories, where biological enzymes do the job. Now researchers at Chalmers University of Technology have developed a computer model that can predict how fast enzymes work, making it possible to find the most efficient living factories, as well as to study difficult diseases. Enzymes are proteins found in all living cells. Their job is to act as catalysts that increase the rate of specific chemical reactions that take place in the cells....
Agilent Technologies has announced that it is collaborating with METTLER TOLEDO to address one of the biggest concerns in any laboratory—error-prone sample preparation. This integrated solution allows the automatic and seamless transfer of weighing results and the associated metadata from METTLER TOLEDO LabX™ Balance software to Agilent OpenLab software...
Accelerated Technology Laboratories, Inc. (ATL), a leader in Laboratory Information Management Systems (LIMS), continues the 2022 LIMS Webcast series on Wednesday, September 14 with LIMS: What You Should Know About SaaS vs. On-Premises Deployment. The move to cloud (also known as Software as a Service or SaaS) deployment has seen explosive growth the past few years and all signs point to continuing this upward trend....
Asynt report how award-winning formulation and development lab – Here2Grow Cosmetics & Homecare Labs (Selby, UK) used the ReactoMate DATUM laboratory reaction vessel system in the development of a next generation clinical haircare product. To tackle common scalp issues encountered by patients, a tricology clinic had been developing scalp therapy products in collaboration with formulation laboratories and manufacturers....
The life science group Sartorius, through its French listed subgroup Sartorius Stedim Biotech, has agreed to acquire 100 percent of Albumedix Ltd. from private investors. The Nottingham, UK-based company provides best-in-class recombinant albumin-based solutions. Recombinant human albumin is an important component for the biopharmaceutical industry required for various applications...
Olympus Corporation (“Olympus”) and EVIDENT Co., Ltd. ("Evident"), a wholly-owned subsidiary of Olympus announce that Olympus concluded a definitive agreement with Bain Capital Private Equity, LP (“Bain Capital”), regarding the transfer of Evident. Based on this agreement, all shares of Evident will be transferred to Bain Capital on January 4, 2023, subject to regulatory approvals and closing conditions....
Validair Diamond Scientific (VDS) has invested in a new cleanroom at its Chester-le-Street headquarters. The in-house facility was specified and designed to meet exacting requirements for research and fault-finding as well as for use by the company’s field service team as a hands-on training resource. VDS worked closely with Total Clean Air to design and configure the cleanroom to be exceptionally flexible in its performance and functionality, allowing the VDS team to push the boundaries...