A classic boxing move, the ‘one-two punch’, could also be effective against cancer: a left jab knocks cancer cells senseless, quickly followed by a right hook that knocks them out altogether. Researchers at the Netherlands Cancer Institute have shown that cancer cells are vulnerable to this kind of approach. “This is a beautiful, universal principle, that could be used for all forms of cancer.” On October 2nd the researchers publish their results in Nature....
Research published in Nature by the Korea Advanced Institute of Science (KAIST) found that lymphatic vessels in the scull involved in the clearance of cerebrospinal fluid often become compromised with age. This finding was only possible through advances in imaging technology. Using MR Solutions’ 3T/17 preclinical liquid-helium free MRI system the KAIST researchers observed how the meningeal lymphatic vessels (mLVs), mainly in the basal part of the skull...
UK-based scientists have engineered plants to produce an oil that mimics the chemical structure of human milk fat, a major component of breast milk. Previous studies suggest the human form of this molecule, triacylglycerol, aids absorption of key nutrients by the infant gut, but few infant formulas contain anything like it. Now a team from Rothamsted Research have found a way to modify the biochemical pathways of plants so they can produce the human form of this key nutrient....
The HD-X - the very latest fully automated technology platform from Quanterix for developing and performing digital immunoassays – has been unveiled at LGC’s GLP/GCP-accredited lab in Fordham, near Cambridge, UK. The HD-X builds on the success of the HD-1 analyser in conveying unprecedented levels of sensitivity, robustness, and throughput to Pharmacokinetic-Pharmacodynamic (PK-PD) bioanalytical studies....
From its beginnings at the University of Oxford in 2016, Arctoris has established the world’s first fully automated, robotic laboratory dedicated to drug discovery, providing global drug discovery teams with on-demand access to a broad range of cellular, molecular and biochemical assays. The company’s automated system delivers high-quality data through standardised, pre-optimised and fully validated processes, while its innovative online portal makes it easy for researchers to plan, order and track their experiments from anywhere in the world....
Illumina, Inc. and the Broad Institute of MIT and Harvard have announced they have entered into a collaboration for the co-development of secondary genomic analysis algorithms and software. Top data scientists from both institutions will collaborate to bring together the industry-leading open-source GATK algorithms with the speed and enhanced accuracy of Illumina’s DRAGEN™ (Dynamic Read Analysis for GENomics) Bio-IT Platform for commonly used methods....
Provepharm Life Solutions, a laboratory specializing in molecule revitalization, built this 500m2 pilot plant within a 3,000m2 production site in order to produce the group’s active pharmaceutical ingredients (APIs) in an environment that meets the most demanding international requirements. When the first quantities are synthesized, it will allow the company to fill applications...
St George Street Capital (SGSC), a UK registered charity, has signed a license agreement with AstraZeneca to develop two compounds in the clinic: one for idiopathic male infertility, and the other for renal transplant rejection. The agreement enables additional compounds to be added in the future...
Agilent Technologies Inc. has announced that Professor Hualiang Jiang has received an Agilent Thought Leader Award. Professor Jiang directs the Shanghai Institute of Materia Medica at the Chinese Academy of Sciences and is a leading researcher in the area of medicinal chemistry and computational drug design. Professor Jiang has a strong track record identifying new targets for cancer therapy and designing inhibitors that block protein-protein interactions.....
This will be celebrated with an event welcoming back high-calibre Award Alumni to talk about their science and careers: The Young European Investigators Conference held at the EMBL Advanced Training Centre in Heidelberg, on June 25, 2020. This free one-day conference is open to all scientists in biomedical research. The scientific program is organized by former winners Simon Boulton (The Francis Crick Institute, United Kingdom) and Óscar Fernández-Capetillo (CNIO, Spain & Karolinska Institute, Sweden)....
Digital Science has launched a report focusing on falsifiability and reproducibility in scientific research. The report addresses three areas including appropriate documentation and sharing of research data, clear analysis and processes, and the sharing of code. Making Science Better: Reproducibility, Falsifiability and the Scientific Method looks at the current state of reproducibility in 2019...
This application note shows a high-resolution UHPLC separation using a robust YMC-Triart C18 column including the previous sample preparation. The simultaneous analysis of etizolam, triazolam, and their metabolites 8-ethylhydroxyetizolam, alpha-hydroxyetizolam, 4-hydroxytriazolam and alpha-hydroxytriazolam in biological samples is performed by MS/MS detection....
Source Bioscience, an international provider of integrated laboratory services and products, has announced it has invested €585,000 in microbiology and sterility testing labs at its stability storage facility in Tramore, Co Waterford, Ireland. The investment expands the Company’s current service offering at the site, adding a comprehensive suite of microbiology and sterility testing services with the aim of reducing turnaround times to allow more rapid feedback to customers and to minimise risk when storing samples....
As the world wakes up to our environmental crisis it is important to note that every person living on our planet bears a responsibility for the world we have to live in. Global contamination of our seas and oceans is only the tip of the iceberg. Today's research scientists bear an enormous responsibility as they endeavour to reduce and repair the impact we are having on our planet....
Pharmaceutical development and clinical manufacturing expert, Velesco Pharma, is set to triple its clinical manufacturing capacity with the purchase and fit-out of a new, state-of-the-art facility in Wixom, Michigan. This facility will be supported by Velesco Pharma’s existing QC release and stability testing laboratory also located in Wixom...
Batavia Biosciences has signed a license agreement to utilize Horizon Discovery’s GS knockout CHO K1 cell line expression system for the development of high yield antibody-expressing cell lines. Initially, Batavia will deploy the system for production of a potent Zika virus neutralizing antibody, working in collaboration with Vanderbilt University Medical Center and IDBiologics...
Cell and gene therapy manufacturing consultancy eXmoor pharma has announced a strategic collaboration with Karoo CGT to accelerate the huge potential of UK gene therapies coming out of academia. The funding gap between academic research and an investable proposition after Phase I/II trials is well reported. Karoo is building the expertise and infrastructure necessary to provide a fully integrated service...
This new report provides market data and insights for 11 categories of portable analytical instrumentation. Its contents will provide detailed qualitative and quantitative data to those with a vested interest in the market for portable or handheld analytical instruments. The portable instrumentation market was $1.4 billion in 2018 and is expected to grow by 4.4% over the next five years....
Deben, a leading provider of in-situ testing stages together with innovative accessories and components for microscopy, reports on how Bristol Composites Institute of University of Bristol use the Deben 200N in-situ tensile stage to study Advanced Composite Materials for Aerospace applications. The Bristol Composites Institute (ACCIS) is a department of the University of Bristol looking at materials...
HORIBA UK Ltd, Medical announces the publication of scientific studies which demonstrate the excellent performance of its new HELO high throughput fully automated haematology platform on body fluid and pathological samples. HORIBA’s Yumizen® H2500 and H1500 automated haematology analysers within the HELO platform deliver enhanced precision for complete blood counts and white blood cell....
A parasite, largely thought to be asexual, has been shown to reproduce sexually after scientists uncover clues hidden in its genomic code. Trypanosoma cruzi is the parasite responsible for Chagas Disease, found in Latin America. Around eight million people are currently infected by the disease, which can cause irreversible damage to the heart and digestive tract...
Agilent Technologies Inc., has announced that its instruments and expertise contributed to a groundbreaking study commissioned by the World Anti-Doping Agency, or WADA. Researchers at Freie Universität Berlin used gas and liquid chromatography instruments, along with high-resolution mass spectrometry systems—all from Agilent—to study to the strength-building characteristics of ecdysterone, the main component of spinach extracts....
A classic boxing move, the ‘one-two punch’, could also be effective against cancer: a left jab knocks cancer cells senseless, quickly followed by a right hook that knocks them out altogether. Researchers at the Netherlands Cancer Institute have shown that cancer cells are vulnerable to this kind of approach. “This is a beautiful, universal principle, that could be used for all forms of cancer.” On October 2nd the researchers publish their results in Nature....
Research published in Nature by the Korea Advanced Institute of Science (KAIST) found that lymphatic vessels in the scull involved in the clearance of cerebrospinal fluid often become compromised with age. This finding was only possible through advances in imaging technology. Using MR Solutions’ 3T/17 preclinical liquid-helium free MRI system the KAIST researchers observed how the meningeal lymphatic vessels (mLVs), mainly in the basal part of the skull...
UK-based scientists have engineered plants to produce an oil that mimics the chemical structure of human milk fat, a major component of breast milk. Previous studies suggest the human form of this molecule, triacylglycerol, aids absorption of key nutrients by the infant gut, but few infant formulas contain anything like it. Now a team from Rothamsted Research have found a way to modify the biochemical pathways of plants so they can produce the human form of this key nutrient....
The HD-X - the very latest fully automated technology platform from Quanterix for developing and performing digital immunoassays – has been unveiled at LGC’s GLP/GCP-accredited lab in Fordham, near Cambridge, UK. The HD-X builds on the success of the HD-1 analyser in conveying unprecedented levels of sensitivity, robustness, and throughput to Pharmacokinetic-Pharmacodynamic (PK-PD) bioanalytical studies....
From its beginnings at the University of Oxford in 2016, Arctoris has established the world’s first fully automated, robotic laboratory dedicated to drug discovery, providing global drug discovery teams with on-demand access to a broad range of cellular, molecular and biochemical assays. The company’s automated system delivers high-quality data through standardised, pre-optimised and fully validated processes, while its innovative online portal makes it easy for researchers to plan, order and track their experiments from anywhere in the world....
Illumina, Inc. and the Broad Institute of MIT and Harvard have announced they have entered into a collaboration for the co-development of secondary genomic analysis algorithms and software. Top data scientists from both institutions will collaborate to bring together the industry-leading open-source GATK algorithms with the speed and enhanced accuracy of Illumina’s DRAGEN™ (Dynamic Read Analysis for GENomics) Bio-IT Platform for commonly used methods....
Provepharm Life Solutions, a laboratory specializing in molecule revitalization, built this 500m2 pilot plant within a 3,000m2 production site in order to produce the group’s active pharmaceutical ingredients (APIs) in an environment that meets the most demanding international requirements. When the first quantities are synthesized, it will allow the company to fill applications...
St George Street Capital (SGSC), a UK registered charity, has signed a license agreement with AstraZeneca to develop two compounds in the clinic: one for idiopathic male infertility, and the other for renal transplant rejection. The agreement enables additional compounds to be added in the future...
Agilent Technologies Inc. has announced that Professor Hualiang Jiang has received an Agilent Thought Leader Award. Professor Jiang directs the Shanghai Institute of Materia Medica at the Chinese Academy of Sciences and is a leading researcher in the area of medicinal chemistry and computational drug design. Professor Jiang has a strong track record identifying new targets for cancer therapy and designing inhibitors that block protein-protein interactions.....
This will be celebrated with an event welcoming back high-calibre Award Alumni to talk about their science and careers: The Young European Investigators Conference held at the EMBL Advanced Training Centre in Heidelberg, on June 25, 2020. This free one-day conference is open to all scientists in biomedical research. The scientific program is organized by former winners Simon Boulton (The Francis Crick Institute, United Kingdom) and Óscar Fernández-Capetillo (CNIO, Spain & Karolinska Institute, Sweden)....
Digital Science has launched a report focusing on falsifiability and reproducibility in scientific research. The report addresses three areas including appropriate documentation and sharing of research data, clear analysis and processes, and the sharing of code. Making Science Better: Reproducibility, Falsifiability and the Scientific Method looks at the current state of reproducibility in 2019...
This application note shows a high-resolution UHPLC separation using a robust YMC-Triart C18 column including the previous sample preparation. The simultaneous analysis of etizolam, triazolam, and their metabolites 8-ethylhydroxyetizolam, alpha-hydroxyetizolam, 4-hydroxytriazolam and alpha-hydroxytriazolam in biological samples is performed by MS/MS detection....
Source Bioscience, an international provider of integrated laboratory services and products, has announced it has invested €585,000 in microbiology and sterility testing labs at its stability storage facility in Tramore, Co Waterford, Ireland. The investment expands the Company’s current service offering at the site, adding a comprehensive suite of microbiology and sterility testing services with the aim of reducing turnaround times to allow more rapid feedback to customers and to minimise risk when storing samples....
As the world wakes up to our environmental crisis it is important to note that every person living on our planet bears a responsibility for the world we have to live in. Global contamination of our seas and oceans is only the tip of the iceberg. Today's research scientists bear an enormous responsibility as they endeavour to reduce and repair the impact we are having on our planet....
Pharmaceutical development and clinical manufacturing expert, Velesco Pharma, is set to triple its clinical manufacturing capacity with the purchase and fit-out of a new, state-of-the-art facility in Wixom, Michigan. This facility will be supported by Velesco Pharma’s existing QC release and stability testing laboratory also located in Wixom...
Batavia Biosciences has signed a license agreement to utilize Horizon Discovery’s GS knockout CHO K1 cell line expression system for the development of high yield antibody-expressing cell lines. Initially, Batavia will deploy the system for production of a potent Zika virus neutralizing antibody, working in collaboration with Vanderbilt University Medical Center and IDBiologics...
Cell and gene therapy manufacturing consultancy eXmoor pharma has announced a strategic collaboration with Karoo CGT to accelerate the huge potential of UK gene therapies coming out of academia. The funding gap between academic research and an investable proposition after Phase I/II trials is well reported. Karoo is building the expertise and infrastructure necessary to provide a fully integrated service...
This new report provides market data and insights for 11 categories of portable analytical instrumentation. Its contents will provide detailed qualitative and quantitative data to those with a vested interest in the market for portable or handheld analytical instruments. The portable instrumentation market was $1.4 billion in 2018 and is expected to grow by 4.4% over the next five years....
Deben, a leading provider of in-situ testing stages together with innovative accessories and components for microscopy, reports on how Bristol Composites Institute of University of Bristol use the Deben 200N in-situ tensile stage to study Advanced Composite Materials for Aerospace applications. The Bristol Composites Institute (ACCIS) is a department of the University of Bristol looking at materials...
HORIBA UK Ltd, Medical announces the publication of scientific studies which demonstrate the excellent performance of its new HELO high throughput fully automated haematology platform on body fluid and pathological samples. HORIBA’s Yumizen® H2500 and H1500 automated haematology analysers within the HELO platform deliver enhanced precision for complete blood counts and white blood cell....
A parasite, largely thought to be asexual, has been shown to reproduce sexually after scientists uncover clues hidden in its genomic code. Trypanosoma cruzi is the parasite responsible for Chagas Disease, found in Latin America. Around eight million people are currently infected by the disease, which can cause irreversible damage to the heart and digestive tract...
Agilent Technologies Inc., has announced that its instruments and expertise contributed to a groundbreaking study commissioned by the World Anti-Doping Agency, or WADA. Researchers at Freie Universität Berlin used gas and liquid chromatography instruments, along with high-resolution mass spectrometry systems—all from Agilent—to study to the strength-building characteristics of ecdysterone, the main component of spinach extracts....