Cresset Discovery, provider of CADD expertise for drug discovery, is collaborating with the Translation team at The Francis Crick Institute as expert computational chemist in residence. Computational chemistry is a powerful method in tool development and drug discovery. It enables chemists to predict the physical properties and biological activity of compounds prior to synthesis and analysis, saving significant time and money by removing unnecessary wet chemistry...
Fast UHPLC Analysis of Cell Penetrating Peptides Using a YMC-Triart C18 column. Cell penetrating peptides (CPPs) are an interesting class of compounds since they are capable of transporting themselves across a cell membrane and also carry so-called “cargo” molecules with them. Due to their advantages over other transport mechanisms they are a focus for current research...
A breakthrough in quantum imaging could lead to the development of advanced forms of microscopy for use in medical research and diagnostics. A team of physicists from the University of Glasgow and Heriot-Watt University have found a new way to create detailed microscopic images under conditions which would cause conventional optical microscopes to fail....
The Pistoia Alliance, a global, not-for-profit alliance that advocates for greater collaboration in life sciences R&D, launches its newest project: IDMP Common Core Ontology. The project will augment the existing Identification of Medicinal Products (IDMP) framework (ISO 11615:2021) defined by the International Standards Organization. The project team will devise a common core ontology under FAIR data principles to enable semantic interoperability and consistent representation of medicinal products...
The Institute of Cancer Research, London, strongly welcomes the news that 177Lu-PSMA-617, a potent radioactive medicine that searches for tumour cells to deliver a radioactive payload, has been approved by the US Food and Drug Administration (FDA) for treating some advanced prostate cancers. The approval means people with advanced prostate cancer previously treated with at least one targeted hormone treatment – such as enzalutamide or abiraterone – alongside taxane chemotherapy will be able to access the treatment in the US...
Accelerated Technology Laboratories, Inc. (ATL), a leader in Laboratory Information Management Systems (LIMS), continues the 2022 LIMS Webcast series on Wednesday, April 13th with The Importance of a Complete Solution: LIMS from A to Z. This webcast is ideal for those evaluating LIMS solutions and looking for guidance in defining their functional requirements. To assist with this process, we’ll walk through a virtual glossary of laboratory automation terms that will prove valuable as you are building the ideal LIMS for your organization....
BioChromato has published an interview with the Department of Biomedical Pharmaceutics at Gifu Pharmaceutical University in Japan that describes how its Smart Evaporator C1 fitted with 4-Kit has revolutionised its aqueous sample preparation. The Department of Biomedical Pharmaceutics, headed by Professor Kiyoyuki Kitaichi, is well known for its pioneering collaborative research on illegal drugs, pharmaceuticals, and new health food ingredients....
Software which helps speed up the process of creating new diagnostic tests could help combat future pandemics, its developers say. A team of bioengineers and chemists in Scotland and China have developed a system which suggests new reaction pathways to accelerate the design and development of new diagnostic assays. The system, which is now freely available for other researchers around the world to investigate, adapt and use, can also be used to identify the early stages of non-infectious diseases...
The difference that technology has had on compound management and the benefits it brought to the lab in terms of efficiencies and resource savings are immense. In a new educational paper - sample management guru - Neil Benn (CEO of Ziath) shares his views on the beneficial impact that new mobile digital technology and artificial intelligence innovations are likely to have on tracking and tracing samples in compound management facilities...
The surge in demand brought about by COVID-19 is pushing medical and non-medical laboratories to their limits, the head of a laboratory supplies company has said, with concerns that clinical laboratories have been favoured due to the pandemic. The Starlab Group, a European supplier of laboratory products with a UK division, conducted a survey of more than 200 laboratory employees from the UK, Germany, Austria, Italy and France...
Illumina, Inc. has announced the launch of TruSight™ Oncology (TSO) Comprehensive (EU), a single test that assesses multiple tumor genes and biomarkers to reveal the specific molecular profile of a patient's cancer. With its global launch first taking place in Europe, the in vitro diagnostic (IVD) kit will help inform precision medicine decisions for cancer patients across the continent...
INTEGRA Biosciences’ ASSIST PLUS pipetting robot is helping the Arbovirus Testing Lab at the New Hampshire Public Health Laboratories in Concord, USA, to streamline sample pooling for West Nile and Eastern equine encephalitis virus testing. Laboratory supervisor Denise Bolton explained: “We adopted pooled testing in summer 2020, initially constructing the sample pools manually....
Gibco cell culture at 60. As part of our anniversary celebrations, we’re revisiting pivotal moments from the past 60 years of cell culture. From the first time a budding scientist looked down the microscope, to one young professional’s career-defining conversation, our round-up of industry leaders, product designers and cell culturists have spoken and shared their stories and poignant snapshots....
Scientists at Rejuveron Vascular Therapeutics AG, a company specializing in the development of therapies to tackle neurodegeneration, are using INTEGRA’s VIAFLO 384 handheld electronic pipette to accelerate their research. Combining this convenient benchtop system with endothelial cells cultured in Corning® HTS Transwell® 96 well plates allows the team to investigate the ability of drugs to penetrate the blood brain barrier...
Scientists at Aston University have found a way to significantly increase the antimicrobial properties of a material used in many medical devices and clinical surfaces: bioactive glass. The Aston University team had already developed bacteria-killing bioactive glass laced with a single metal oxide of either zinc, cobalt or copper. Their latest research combined pairs of metal oxides in the material - and found that some combinations were more than 100 times better at killing bacteria than using single oxides alone.
Agilent Technologies has announced that the recipient of the 2022 Darlene Solomon Award is Federica Fiorini, Ph.D., a research associate studying metabolomics at the Institute of Biology and Pathology at the Grenoble Alpes University Hospital (CHU Grenoble Alpes) in France. The award was presented at the iSLS10–10th International Singapore Lipid Symposium held March 8–10 at the National University of Singapore....
The first Pharma User Club meeting organized by Granutools was successfully held on January 26th, 2022. More than 200 attendees joined this virtual meeting, which was the perfect occasion to hear renowned speakers, join a large and diverse community, and network. The talks covered a wide range of subjects and aspects of the pharmaceutical industry and academy: from lactose excipients to APIs, from flowability to electrostatics, from feedstock to production lines, from process simulation to model calibration...
INTEGRA Biosciences’ VOYAGER adjustable tip spacing pipettes save time and improve lab productivity, and the company has created a testimonial video showcasing the pipette’s many useful features. The video shows how the VOYAGER increases productivity using a real-life situation, portraying how researchers at the National Centre for Scientific Research (CNRS) in Montpellier, France, are using it to study the dynamics of the latent HIV reservoir and investigate drug-resistant mutations...
Simplified calculation model for tissue properties developed at Karl Landsteiner University for Health Sciences Krems (Austria). Viscous mechanical properties of biological tissues can now be described more easily than before. This is shown by a recently published paper of a team of the Karl Landsteiner University of Health Sciences Krems. The team demonstrates that an established mathematical model for soft biological tissues can be greatly simplified, allowing extensive time and cost savings...
EVONETIX LTD the synthetic biology company bringing semiconductor technology to DNA synthesis, has announced it has achieved enzymatic DNA synthesis capability with its proprietary, thermally controlled synthesis chemistry. The culmination of a three-year development program, supported by Innovate UK and in collaboration with Durham University, the results demonstrate that Evonetix’s unique, semiconductor array-based platform is compatible with both chemical and enzymatic DNA synthesis...
BioChromato has published a technical note that compares using Evolved Gas Analysis (EGA) and Thermal Desorption (DART) sample preparation methods for Mass Spectrometry analysis of Nylon 6,6. Synthesized by polycondensation of hexamethylenediamine and adipic acid – Nylon 6,6 is a polyamide or nylon that is commonly used in the textile and plastic industries. Nylon 6,6 is a polymer of choice when high mechanical strength, rigidity, good stability under heat and/or chemical resistance are required....
“Automation and industrialization of COVID-19 PCR-testing will facilitate an immense scale-up of the global PCR-testing capacity. It will allow for a new approach to keep society open: preventive, regular testing (twice per week), which will create green bubbles and get us ahead of the curve” - Niels Kruize, CCO, MolGen. To get ahead of the curve, we will need to change our methodology of COVID-19 testing...
Cresset Discovery, provider of CADD expertise for drug discovery, is collaborating with the Translation team at The Francis Crick Institute as expert computational chemist in residence. Computational chemistry is a powerful method in tool development and drug discovery. It enables chemists to predict the physical properties and biological activity of compounds prior to synthesis and analysis, saving significant time and money by removing unnecessary wet chemistry...
ast UHPLC Analysis of Cell Penetrating Peptides Using a YMC-Triart C18 column. Cell penetrating peptides (CPPs) are an interesting class of compounds since they are capable of transporting themselves across a cell membrane and also carry so-called “cargo” molecules with them. Due to their advantages over other transport mechanisms they are a focus for current research...
A breakthrough in quantum imaging could lead to the development of advanced forms of microscopy for use in medical research and diagnostics. A team of physicists from the University of Glasgow and Heriot-Watt University have found a new way to create detailed microscopic images under conditions which would cause conventional optical microscopes to fail....
The Pistoia Alliance, a global, not-for-profit alliance that advocates for greater collaboration in life sciences R&D, launches its newest project: IDMP Common Core Ontology. The project will augment the existing Identification of Medicinal Products (IDMP) framework (ISO 11615:2021) defined by the International Standards Organization. The project team will devise a common core ontology under FAIR data principles to enable semantic interoperability and consistent representation of medicinal products...
The Institute of Cancer Research, London, strongly welcomes the news that 177Lu-PSMA-617, a potent radioactive medicine that searches for tumour cells to deliver a radioactive payload, has been approved by the US Food and Drug Administration (FDA) for treating some advanced prostate cancers. The approval means people with advanced prostate cancer previously treated with at least one targeted hormone treatment – such as enzalutamide or abiraterone – alongside taxane chemotherapy will be able to access the treatment in the US...
Accelerated Technology Laboratories, Inc. (ATL), a leader in Laboratory Information Management Systems (LIMS), continues the 2022 LIMS Webcast series on Wednesday, April 13th with The Importance of a Complete Solution: LIMS from A to Z. This webcast is ideal for those evaluating LIMS solutions and looking for guidance in defining their functional requirements. To assist with this process, we’ll walk through a virtual glossary of laboratory automation terms that will prove valuable as you are building the ideal LIMS for your organization....
BioChromato has published an interview with the Department of Biomedical Pharmaceutics at Gifu Pharmaceutical University in Japan that describes how its Smart Evaporator C1 fitted with 4-Kit has revolutionised its aqueous sample preparation. The Department of Biomedical Pharmaceutics, headed by Professor Kiyoyuki Kitaichi, is well known for its pioneering collaborative research on illegal drugs, pharmaceuticals, and new health food ingredients....
The difference that technology has had on compound management and the benefits it brought to the lab in terms of efficiencies and resource savings are immense. In a new educational paper - sample management guru - Neil Benn (CEO of Ziath) shares his views on the beneficial impact that new mobile digital technology and artificial intelligence innovations are likely to have on tracking and tracing samples in compound management facilities.
The surge in demand brought about by COVID-19 is pushing medical and non-medical laboratories to their limits, the head of a laboratory supplies company has said, with concerns that clinical laboratories have been favoured due to the pandemic. The Starlab Group, a European supplier of laboratory products with a UK division, conducted a survey of more than 200 laboratory employees from the UK, Germany, Austria, Italy and France...
Illumina, Inc. has announced the launch of TruSight™ Oncology (TSO) Comprehensive (EU), a single test that assesses multiple tumor genes and biomarkers to reveal the specific molecular profile of a patient's cancer. With its global launch first taking place in Europe, the in vitro diagnostic (IVD) kit will help inform precision medicine decisions for cancer patients across the continent...
INTEGRA Biosciences’ ASSIST PLUS pipetting robot is helping the Arbovirus Testing Lab at the New Hampshire Public Health Laboratories in Concord, USA, to streamline sample pooling for West Nile and Eastern equine encephalitis virus testing. Laboratory supervisor Denise Bolton explained: “We adopted pooled testing in summer 2020, initially constructing the sample pools manually....
Gibco cell culture at 60. As part of our anniversary celebrations, we’re revisiting pivotal moments from the past 60 years of cell culture. From the first time a budding scientist looked down the microscope, to one young professional’s career-defining conversation, our round-up of industry leaders, product designers and cell culturists have spoken and shared their stories and poignant snapshots....
Scientists at Rejuveron Vascular Therapeutics AG, a company specializing in the development of therapies to tackle neurodegeneration, are using INTEGRA’s VIAFLO 384 handheld electronic pipette to accelerate their research. Combining this convenient benchtop system with endothelial cells cultured in Corning® HTS Transwell® 96 well plates allows the team to investigate the ability of drugs to penetrate the blood brain barrier...
Scientists at Aston University have found a way to significantly increase the antimicrobial properties of a material used in many medical devices and clinical surfaces: bioactive glass. The Aston University team had already developed bacteria-killing bioactive glass laced with a single metal oxide of either zinc, cobalt or copper. Their latest research combined pairs of metal oxides in the material - and found that some combinations were more than 100 times better at killing bacteria than using single oxides alone.
Agilent Technologies 
The first Pharma User Club meeting organized by Granutools was successfully held on January 26th, 2022. More than 200 attendees joined this virtual meeting, which was the perfect occasion to hear renowned speakers, join a large and diverse community, and network. The talks covered a wide range of subjects and aspects of the pharmaceutical industry and academy: from lactose excipients to APIs, from flowability to electrostatics, from feedstock to production lines, from process simulation to model calibration...
INTEGRA Biosciences’ VOYAGER adjustable tip spacing pipettes save time and improve lab productivity, and the company has created a testimonial video showcasing the pipette’s many useful features. The video shows how the VOYAGER increases productivity using a real-life situation, portraying how researchers at the National Centre for Scientific Research (CNRS) in Montpellier, France, are using it to study the dynamics of the latent HIV reservoir and investigate drug-resistant mutations...
Simplified calculation model for tissue properties developed at Karl Landsteiner University for Health Sciences Krems (Austria). Viscous mechanical properties of biological tissues can now be described more easily than before. This is shown by a recently published paper of a team of the Karl Landsteiner University of Health Sciences Krems. The team demonstrates that an established mathematical model for soft biological tissues can be greatly simplified, allowing extensive time and cost savings...
EVONETIX LTD the synthetic biology company bringing semiconductor technology to DNA synthesis, has announced it has achieved enzymatic DNA synthesis capability with its proprietary, thermally controlled synthesis chemistry. The culmination of a three-year development program, supported by Innovate UK and in collaboration with Durham University, the results demonstrate that Evonetix’s unique, semiconductor array-based platform is compatible with both chemical and enzymatic DNA synthesis...
BioChromato has published a technical note that compares using Evolved Gas Analysis (EGA) and Thermal Desorption (DART) sample preparation methods for Mass Spectrometry analysis of Nylon 6,6. Synthesized by polycondensation of hexamethylenediamine and adipic acid – Nylon 6,6 is a polyamide or nylon that is commonly used in the textile and plastic industries. Nylon 6,6 is a polymer of choice when high mechanical strength, rigidity, good stability under heat and/or chemical resistance are required....
“Automation and industrialization of COVID-19 PCR-testing will facilitate an immense scale-up of the global PCR-testing capacity. It will allow for a new approach to keep society open: preventive, regular testing (twice per week), which will create green bubbles and get us ahead of the curve” - Niels Kruize, CCO, MolGen. To get ahead of the curve, we will need to change our methodology of COVID-19 testing...