European laboratories testing feed and food for dioxins and dioxin-like substances now have lower-cost, smaller-footprint alternatives to high-resolution mass spectrometers (HRMS) for confirming levels of the toxic contaminants, thanks to a new European Union regulation.
Thermo Fisher Scientific worked closely with national reference labs (NRLs) in the European Union to support the development of the new regulation, known as Commission Regulation (EU) No. 709/2014, which permits use of gas chromatograph-triple stage quadrupole mass spectrometers (GC-MS/MS) for confirmation. EU regulations previously permitted the use of GC-MS/MS only to screen samples for dioxins, a group of persistent organic chemicals that can cause...
Thermo Fisher Scientific has developed a high-resolution hydrophobic interaction chromatography (HIC) method that can separate a fusion protein from a truncated version and a structural isomer.
Application Brief 171: High-Resolution Separation of a Fusion Protein demonstrates that two different HIC columns—the Thermo Scientific™ ProPac™ HIC-10 column and the new MAbPac™ HIC-10 column—can each perform this challenging separation. While the ProPac HIC-10 column is an established column for the analysis of monoclonal antibody post-translational modifications, the MAbPac™ HIC-10 column exhibits the best performance....
For rapid and precise determination of liquids and gases, particularly in the trace range, the use of vertical systems has become standard.
With the increase in complexity and viscosity of samples, however, it is necessary to use the horizontal mode. The multi EA® 5000 combines both modes in one and the same device. The double furnace can be quickly set up vertically or horizontally. The use of only one multi-purpose combustion tube for all standard applications makes conversion child's play. Therefore the multi EA® 5000 perfectly meets the requirements of...
Search and buying tool offers instant, simple access to millions of clone, antibody and protein products
Source BioScience, the international laboratory services and products business, today announced the launch of an updated version of its GenomeCUBE® search engine, an intelligent and powerful clone, antibody and protein products search and buying tool, which gives researchers easy access to millions of products, as well as Source BioScience’s scientific and technical support services. Users can enter free text in GenomeCUBE, which...
The desire to gain a better understanding of how inhaled products perform in patients has highlighted the importance and value of achieving better correlations between in-vitro test data and in-vivo performance - better IVIVCs.
This deepened interest has been echoed by the US FDA, for example, through research grants supporting the identification of realistic in-vitro clinically relevant representations of the human throat, as well as a dissolution method for inhaled product testing. To help meet this pressing need for better IVIVCs, Copley Scientific has refined the design of a number of pieces of in-vitro testing equipment to enable a streamlined, easy-to-use, and...
Benefits of integrated formulation preparation and analytics for the development of biotherapeutics to be demonstrated in webinar sponsored by Freeslate
Wyatt Technology Corporation, the world leader in instrumentation for characterization of macromolecules and nanoparticles, is pleased to announce co-presentation of a webinar in partnership with Freeslate. Covering the “Application of Automation for Biologics Formulation Preparation and Stability Studies” and sponsored by Freeslate, the leading provider of high throughput research solutions for biopharmaceutical development, the webinar will take place on...
Max Planck researchers assemble metamaterial crystal formations that obey laws of quantum physics and allow exploration of the exotic nature of the microworld.
A team of physicists at the Max Planck Institute of Quantum Optics is gaining unique insights into the nature of solid materials by monitoring the behaviour of quasi-crystalline 'super atoms' created inside a giant, room-sized Quantum Simulator, capturing the interactions with an Andor iXon 897 EMCCD camera.
A meeting of World Health Organisation (WHO) experts has declared the Ebola outbreak in West Africa as an ‘extraordinary event’ and a public health risk globally.
The group report that the possible consequences of international spread are particularly serious, and that a coordinated international response is necessary. The outbreak has now become the largest ever reported, with more than 1700 cases and 900 deaths. The discussions highlighted inadequate healthcare infrastructure in the most affected countries, and a high proportion of cases in healthcare workers due to inadequate use of...
New research published today in the journal ACS Nano identifies a new type of sensor that can monitor body movements and could help revolutionise healthcare.
Although body motion sensors already exist in different forms, they have not been widely used due to their complexity and cost of production. Now researchers from the University of Surrey and Trinity College Dublin have for the first time treated common elastic bands with graphene, to create a flexible sensor that is sensitive enough for medical use and can be made cheaply. Once treated, the rubber bands remain highly pliable. By fusing this material with graphene - which imparts an electromechanical response on movement – the team discovered that...
A series of solutions for NHS hospitals designed to face the growing threat of Ebola have been developed by specialist infection control experts in the UK.
With flexible single patient infection control enclosures that can be erected without the need to close a unit, and powerful bug killing robotic technology, global bio-decontamination leader Bioquell is all set to help heathcare professionals minimise any infectious spread. Western hospitals are facing a challenge when confronted to the risk of Ebola contamination. The UK Department of Health has issued infection prevention...
Irish genetics company IndentiGEN today announced details of a new DNA testing technology which will offer it major advantages in the global marketplace.
IdentiGEN has patented a new chemistry based technology which can cut the labour cost of DNA testing by 60%. IdentiGEN is based in Dublin and offers DNA traceability services to major meat producers across the globe with offices and laboratories in Dublin, Wales, the US and Canada. The company today said that the novel chemistry based approach to genotyping that it has tested and validated brings major advantages over the market leading alternatives. IdentiGEN Founder and Managing Director Ciaran Meghen said: “The new testing approach, for which...
Dr Alan Rawle, Applications Manager for Malvern Instruments, will give a plenary lecture at Particulate Systems Analysis (PSA) 2014, organized by the Royal Society of Chemistry’s Particle Characterization Group.
The event takes place from 15-17 September 2014 at the Manchester Conference Centre, Manchester UK, and this year incorporates the UK Particle Technology Forum and Fine Bubble Symposium. The title of Dr Rawle’s lecture is ‘TLAs and the 4Qs in relation to elucidation of particle sizing issues’ where, of course, TLA stands for ‘Three-Letter Acronyms’. “The prime objective is entertainment with an educational experience as a sideline,” said Alan Rawle. “I’ve used TLAs over the years as an...
IPROVE (Innovation Partnership for Roadmap on Vaccines in Europe) has announced the preparation of a comprehensive roadmap on the future of vaccine research and development (R&D) in the European Union (EU).
Financed under the EU 7th Framework Programme (FP7), IPROVE aims to set out a clear vision on priority innovations and technologies in immunisation needed to ensure the development of treatments for infectious and non-infectious threats to public health across Europe and beyond. Recently 16 SMEs (small to medium sized enterprises) took, part in a dedicated consultation workshop alongside representations from the...
Companies combine expertise to produce cytomegalovirus vaccine candidates.
Redbiotec, a biopharmaceutical company specializing in vaccine development, has successfully applied its unique expertise and innovative technology platform to complete a collaborative program with global multinational, GE Healthcare Life Sciences. Using GE Healthcare's single-use WAVE Bioreactor and ReadyToProcess crossflow filtration system, the team developed a novel process for the production, clarification, and concentration of...
Citing concern about suspected threats to the health of humans and wildlife, the European Union’s Marie Curie European Industrial Doctorate program has awarded a €1.2 million research grant to four early-stage researchers from Asia, Australia and Europe to study the environmental effects of one of the most common types of flame retardants.
The four-year grant, entitled “Elucidating Sources and Pathways of Environmental Contamination with Brominated Persistent Organic Chemicals Using Advanced Instrumental Tools (ELUTE),” will allow researchers to pursue individual projects in the laboratory of Stuart Harrad, MSc, Ph.D.at the University of Birmingham, UK, and the Thermo Fisher Scientific Persistent Organic Pollutants (POPs) Center of Excellence in Bremen, Germany...
Scientists from the University of Leeds have discovered a gene that plays a vital role in blood vessel formation, research which adds to our knowledge of how early life develops.
The discovery could also lead to greater understanding of how to treat cardiovascular diseases and cancer. Professor David Beech, of the School of Medicine at the University of Leeds, who led the research, said: “Blood vessel networks are not already pre-constructed but emerge rather like a river system. Vessels do not develop until the blood is already flowing and they are created in response to the amount of flow. This gene, Piezo1, provides the instructions for sensors that tell the body that blood is flowing correctly and gives the signal to form new vessel structures...
JPK Instruments reports on how researchers at the University of Freiburg is combining the use of AFM and advanced fluorescence microscopy to characterize the local mechanical properties of cells.
The research team of Junior Professor Dr Winfried Römer is located at the Centre for Biological Signalling Studies (BIOSS) at the University of Freiburg. Under the title of Synthetic Biology of Signalling Processes, the Römer team studies the interactions of human pathogens (bacteria, viruses) and pathogenic products (toxins) with various human cells by using a highly interdisciplinary research approach at the interface of...
The Clinical and Laboratory Standards Institute (CLSI) released a new microbiology standard, Principles and Procedures for Detection of Anaerobes in Clinical Specimens; Approved Guideline (M56-A).
This document presents standardized, cost-effective, and efficient best practice processes for anaerobe bacteriology to assist clinical laboratories in selecting those methods that lead to improved patient care. “M56-A is an up-to-date manual for anaerobic bacteriology written to guide the novice microbiologist as well as those experienced with anaerobes,” notes Document Development Committee Chairholder, Maria D. Appleman, PhD, Professor of Clinical Pathology at the...
Automation will accelerate analysis of blood samples for expanded colorectal cancer screening trial
VolitionRx Limited (OTCQB: VNRX), a life sciences company focused on developing blood-based diagnostic tests for different types of cancer, today announced it has installed a Tecan EVO200 automated liquid handling system in its Namur, Belgium laboratory. The Tecan EVO200 is a robot that will significantly accelerate VolitionRx’s large scale clinical studies by increasing the throughput and rate of blood sample analysis by up to five times that of...
Protagen AG, a company dedicated to the development of powerful diagnostic tools to address some of the most severe autoimmune diseases, has today launched its first ELISA research use test kit for Systemic Sclerosis (SSc), the ADx®SSc Multilisa®.
Protagen developed the new assay to synergistically combine two proprietary, novel disease markers with two standard diagnostic markers to support medical research in autoimmune diseases. Stefan Müllner, CEO of Protagen AG, said: “Based on our long track record in the discovery and validation of autoantigen biomarkers using the proprietary SeroTag® technology, our development pipeline is built on a strong patent portfolio and designed to support clinical research, targeted therapy, and the...
In search of process improvement, a coating manufacturer recently approached Galbraith Laboratories to evaluate the carbon black content in lots of material received from different suppliers.
Galbraith Laboratories, one of the largest independent analytical testing laboratories in the world, tested the lots using thermogravimetric analysis coupled with differential thermal analysis. TGA/DTA determines carbon black in a single analysis using a small sample size. The analysis revealed that the carbon black content differed between the sample lots by 4%. With this insight, the manufacturer could reliably determine the...
Scientists have developed a computational model to help better understand how the sexually-transmitted infection chlamydia spreads within a patient.
It is hoped that the work led by Nottingham Trent University could in future help to shed light on potential new therapies and treatments for the condition. Chlamydia is the world’s most prevalent STI, with more than 100 million new cases globally every year. The new software has been developed to bring mathematical modelling directly into laboratories – allowing clinicians and biologists across the globe to run...
Thermo Fisher Scientific worked closely with national reference labs (NRLs) in the European Union to support the development of the new regulation, known as Commission Regulation (EU) No. 709/2014, which permits use of gas chromatograph-triple stage quadrupole mass spectrometers (GC-MS/MS) for confirmation. EU regulations previously permitted the use of GC-MS/MS only to screen samples for dioxins, a group of persistent organic chemicals that can cause...
Application Brief 171: High-Resolution Separation of a Fusion Protein demonstrates that two different HIC columns—the Thermo Scientific™ ProPac™ HIC-10 column and the new MAbPac™ HIC-10 column—can each perform this challenging separation. While the ProPac HIC-10 column is an established column for the analysis of monoclonal antibody post-translational modifications, the MAbPac™ HIC-10 column exhibits the best performance....
With the increase in complexity and viscosity of samples, however, it is necessary to use the horizontal mode. The multi EA® 5000 combines both modes in one and the same device. The double furnace can be quickly set up vertically or horizontally. The use of only one multi-purpose combustion tube for all standard applications makes conversion child's play. Therefore the multi EA® 5000 perfectly meets the requirements of...
Source BioScience, the international laboratory services and products business, today announced the launch of an updated version of its GenomeCUBE® search engine, an intelligent and powerful clone, antibody and protein products search and buying tool, which gives researchers easy access to millions of products, as well as Source BioScience’s scientific and technical support services. Users can enter free text in GenomeCUBE, which...
This deepened interest has been echoed by the US FDA, for example, through research grants supporting the identification of realistic in-vitro clinically relevant representations of the human throat, as well as a dissolution method for inhaled product testing. To help meet this pressing need for better IVIVCs, Copley Scientific has refined the design of a number of pieces of in-vitro testing equipment to enable a streamlined, easy-to-use, and...
Wyatt Technology Corporation, the world leader in instrumentation for characterization of macromolecules and nanoparticles, is pleased to announce co-presentation of a webinar in partnership with Freeslate. Covering the “Application of Automation for Biologics Formulation Preparation and Stability Studies” and sponsored by Freeslate, the leading provider of high throughput research solutions for biopharmaceutical development, the webinar will take place on...
A team of physicists at the Max Planck Institute of Quantum Optics is gaining unique insights into the nature of solid materials by monitoring the behaviour of quasi-crystalline 'super atoms' created inside a giant, room-sized Quantum Simulator, capturing the interactions with an Andor iXon 897 EMCCD camera.
The group report that the possible consequences of international spread are particularly serious, and that a coordinated international response is necessary. The outbreak has now become the largest ever reported, with more than 1700 cases and 900 deaths. The discussions highlighted inadequate healthcare infrastructure in the most affected countries, and a high proportion of cases in healthcare workers due to inadequate use of...
Although body motion sensors already exist in different forms, they have not been widely used due to their complexity and cost of production. Now researchers from the University of Surrey and Trinity College Dublin have for the first time treated common elastic bands with graphene, to create a flexible sensor that is sensitive enough for medical use and can be made cheaply. Once treated, the rubber bands remain highly pliable. By fusing this material with graphene - which imparts an electromechanical response on movement – the team discovered that...
IdentiGEN has patented a new chemistry based technology which can cut the labour cost of DNA testing by 60%. IdentiGEN is based in Dublin and offers DNA traceability services to major meat producers across the globe with offices and laboratories in Dublin, Wales, the US and Canada. The company today said that the novel chemistry based approach to genotyping that it has tested and validated brings major advantages over the market leading alternatives. IdentiGEN Founder and Managing Director Ciaran Meghen said: “The new testing approach, for which...
The event takes place from 15-17 September 2014 at the Manchester Conference Centre, Manchester UK, and this year incorporates the UK Particle Technology Forum and Fine Bubble Symposium. The title of Dr Rawle’s lecture is ‘TLAs and the 4Qs in relation to elucidation of particle sizing issues’ where, of course, TLA stands for ‘Three-Letter Acronyms’. “The prime objective is entertainment with an educational experience as a sideline,” said Alan Rawle. “I’ve used TLAs over the years as an...
Financed under the EU 7th Framework Programme (FP7), IPROVE aims to set out a clear vision on priority innovations and technologies in immunisation needed to ensure the development of treatments for infectious and non-infectious threats to public health across Europe and beyond. Recently 16 SMEs (small to medium sized enterprises) took, part in a dedicated consultation workshop alongside representations from the...
The four-year grant, entitled “Elucidating Sources and Pathways of Environmental Contamination with Brominated Persistent Organic Chemicals Using Advanced Instrumental Tools (ELUTE),” will allow researchers to pursue individual projects in the laboratory of Stuart Harrad, MSc, Ph.D.at the University of Birmingham, UK, and the Thermo Fisher Scientific Persistent Organic Pollutants (POPs) Center of Excellence in Bremen, Germany...
The discovery could also lead to greater understanding of how to treat cardiovascular diseases and cancer. Professor David Beech, of the School of Medicine at the University of Leeds, who led the research, said: “Blood vessel networks are not already pre-constructed but emerge rather like a river system. Vessels do not develop until the blood is already flowing and they are created in response to the amount of flow. This gene, Piezo1, provides the instructions for sensors that tell the body that blood is flowing correctly and gives the signal to form new vessel structures...
The research team of Junior Professor Dr Winfried Römer is located at the Centre for Biological Signalling Studies (BIOSS) at the University of Freiburg. Under the title of Synthetic Biology of Signalling Processes, the Römer team studies the interactions of human pathogens (bacteria, viruses) and pathogenic products (toxins) with various human cells by using a highly interdisciplinary research approach at the interface of...
This document presents standardized, cost-effective, and efficient best practice processes for anaerobe bacteriology to assist clinical laboratories in selecting those methods that lead to improved patient care. “M56-A is an up-to-date manual for anaerobic bacteriology written to guide the novice microbiologist as well as those experienced with anaerobes,” notes Document Development Committee Chairholder, Maria D. Appleman, PhD, Professor of Clinical Pathology at the...
VolitionRx Limited (OTCQB: VNRX), a life sciences company focused on developing blood-based diagnostic tests for different types of cancer, today announced it has installed a Tecan EVO200 automated liquid handling system in its Namur, Belgium laboratory. The Tecan EVO200 is a robot that will significantly accelerate VolitionRx’s large scale clinical studies by increasing the throughput and rate of blood sample analysis by up to five times that of...
Protagen developed the new assay to synergistically combine two proprietary, novel disease markers with two standard diagnostic markers to support medical research in autoimmune diseases. Stefan Müllner, CEO of Protagen AG, said: “Based on our long track record in the discovery and validation of autoantigen biomarkers using the proprietary SeroTag® technology, our development pipeline is built on a strong patent portfolio and designed to support clinical research, targeted therapy, and the...
Galbraith Laboratories, one of the largest independent analytical testing laboratories in the world, tested the lots using thermogravimetric analysis coupled with differential thermal analysis. TGA/DTA determines carbon black in a single analysis using a small sample size. The analysis revealed that the carbon black content differed between the sample lots by 4%. With this insight, the manufacturer could reliably determine the...
It is hoped that the work led by Nottingham Trent University could in future help to shed light on potential new therapies and treatments for the condition. Chlamydia is the world’s most prevalent STI, with more than 100 million new cases globally every year. The new software has been developed to bring mathematical modelling directly into laboratories – allowing clinicians and biologists across the globe to run...