Study published in Nature outlines use of Wyatt’s Calypso II system to confirm the stoichiometry of αSNAP-SNARE complex
Wyatt Technology Corporation, the world leader in instrumentation for absolute macromolecular and nanoparticle characterization, is pleased to highlight a new study that describes the use of composition-gradient multi-angle light scattering (CG-MALS) for the characterization of complex protein-protein interactions. The study, entitled ‘Mechanistic insights into the recycling machine of the SNARE complex’, was published in the...
A report published by the Cabinet Office for the first time estimates that 80,000 people could die each year in the UK from antibiotic resistant infections.
The National Risk Register of Civil Emergencies states that this number may die each year if no new antibiotics are introduced. This is an alarming figure, particularly as it is likely to be the very young or very old who would be most at risk. Antibiotic Research UK, the world’s first charity devoted to finding new antibiotics, is trying to do something about the problem before it becomes a medical catastrophe.
Read MoreNational Institute for Occupational Safety and Health Partners with Protea BiosciencesApr 21, 2015
NIOSH utilizes mass spectrometry imaging tools for workplace toxin inhalation studies
Protea Biosciences Group, Inc. announced that the National Institute for Occupational Safety and Health (NIOSH) has established a scientific collaboration with Protea’s Imaging and Bioanalytical Laboratory to study the occupational hazards of the inhalation of aerosols released during welding and electronic manufacturing processes. NIOSH is the federal agency that conducts research and makes recommendations for preventing...
New results in the rapidly advancing study of microbial ecology
In the last decade, the study of microbes in soil and water has advanced through new DNA technology. Through this, studies of marine waters have found many types of astonishingly rare bacteria in the oceans - the so called ?rare biosphere.? Now, researchers from Liverpool John Moores University (LJMU) and the Chinese Academy of Sciences Institute of Urban Environment have turned their attention to the rare biosphere of freshwater...
In 2014 the State of California was in the midst of an unprecedented drought with a big drive from the State of California University Office of the President to save water.
Professor Seth Cohen of the Department of Chemistry and Biochemistry at the University of California San Diego (UCSD) says "Safety culture improvement is a high priority at UCSD. When I was introduced to Findenser, I immediately saw the opportunity to eliminate costly floods that result from condenser hose leaks. UCSD has also undertaken a campus-wide initiative to reduce energy and water consumption and Findenser is the perfect product for...
Veolia Water Technologies new PURELAB Chorus solves a process water problem
Veolia has supplied a new PURELAB® Chorus 3 water purification system to spectacle lens manufacturers the Norville Group. Gloucester based Norville provides a comprehensive high-tech lens coating service, specialising in multi anti-reflection thin coats, as well as hydrophobic (anti-fog) and mirror coatings, using the very latest equipment available. The coating process use about 50 litres per day of water for chemical etching and ultrasonic cleaning which during some stages requires heated...
JPK Instruments, a world-leading manufacturer of nanoanalytic instrumentation for research in life sciences and soft matter, reports on the use of their NanoTracker™ optical tweezers system to study collagen fibrils at Illinois Institute of Technology in Chicago.
The Schieber Research Group is led by Jay Schieber, Professor of Chemical Engineering at the Illinois Institute of Technology where he is also Director of the Center for Molecular Study of Condensed Soft Matter. Current research focuses on the kinetic theory of macromolecules to model the rheological, thermodynamic and thermal behaviour of polymeric fluids. These models are then used to predict the properties of advanced materials...
IDT supports bioengineering educational initiative that will provide color-changing flowers
To help the general public understand how bioengineering is changing the world for the better, Integrated DNA Technologies (IDT) is supporting a unique public outreach program led by expert plant synthetic biologists at Revolution Bioengineering. Detailed in a recent DECODED article, “Color-Changing Flowers—Biotechnology for Everyone”, Revolution Biotechnology is creating bioengineered Petunia flowers that change color on...
An image of a diamond-coated forest of carbon nanotubes that can act as miniature electron emitters, has won the overall prize in a national science photography competition organised by the Engineering and Physical Sciences Research Council (EPSRC).
‘March of the Triffids’, by Paul May, from the University of Bristol, shows carbon nanotubes, around 50,000 times smaller than the width of a human hair, that are joined to form structures that act as emitters for electrical current. This false-colour electron microscope image stole the show ahead of many other stunning pictures, featuring research in action, in the EPSRC competition – now in its second year. Paul May explained: “Carbon-nanotubes...
Due to their specificity related to action and substance, enzymes enable a multitude of simultaneous metabolic processes in the human body.
Therefore, enzymatic methods are of great importance in routine clinical chemistry analysis. The analysis with the aid of enzymes can be completed quickly and without extensive sample preparation. It is run under physiological conditions and the reagents are harmless and easy to handle. With the SPECORD ® PLUS, enzymatic analysis is quick, easy and precise. The use of the Peltier-tempered accessories further allows the performance...
Today, biomedical big data solutions company GENALICE and Personalized medicine & biotechnology company Macrogen Inc (CEO Hyonyong Chong) jointly announced that Macrogen has chosen GENALICE MAP to reinforce its big data processing and analysis capacity for large-scale genome analysis and clinical sequencing services.
GENALICE MAP is a breakthrough Next-Generation Sequencing (NGS) data processing solution, which processes genomics data up to 100 times faster than conventional tools. GENALICE MAP produces improved quality outcome data, while radically reducing storage requirements. It is the only product on the market today that makes large-scale genomics data processing effective and affordable. Macrogen provides various genome...
Protea Biosciences Group, Inc. presented a NEW Chip-Based Technology at the Pittsburgh Conference (Pittcon), in New Orleans, LA.
This nanopost array technology, called REDIchip™ (Resonance-Enhanced Desorption Ionization), was invented in the laboratory of Akos Vertes, PhD., Department of Chemistry, The George Washington University. The chip is designed to be used for mass spectrometric analysis on MALDI platforms without the need for matrix. Protea’s REDIchip technology features were presented at Pittcon and the commercial product is expected to be...
Greenovation Biotech GmbH has successfully completed GLP toxicology studies in non-human primates, and has demonstrated that the moss-aGal (Agalsidase) is safe and very well-tolerated in repeated high dose administrations.
The plant-based cGMP manufacturing process resulted in a high yield batch of moss-aGal to be used in upcoming clinical trials. The GLP toxicology studies in non-human primates demonstrate the moss-aGal to be safe and well tolerated at a dose of 5 to 10 fold higher than the expected human therapeutic dose. In summary, the study investigated intravenous administration of moss-aGal via two 40-minute infusions at doses of either...
Horizon’s Diagnostics division to provide genetically defined, human genomic reference standards
Horizon Discovery Group plc (LSE:HZD) (Horizon), a leading provider of research tools to support translational genomics and the development of personalized medicines, today announced that it will be providing genomic Reference Materials to support Phase Two of Cancer Research UK’s Stratified Medicine Programme (SMP). Financial details of the agreement were not disclosed. The work will focus on supporting the validation...
New research from the University of Padova in Italy shows how the Zetasizer Nano S, a nanomaterial and molecular characterization system from Malvern Instruments, is supporting the development of soluble carbon nanotubes (CNTs).
CNTs exhibit unique electronic, optical, mechanical and structural properties and are emerging as potentially important for a number of industrial applications including organic photovoltaic cells. One of the benefits of using soluble CNTs is that they are amenable to solution-based, low-cost, commercial manufacturing methods. The Zetasizer Nano is proving to be an easy-to-use tool for tracking and optimizing the functionalization reactions...
Lonza will host the 1st Global Endotoxin Testing Summit, which will take place from June 1-3rd 2015 in Annapolis, MD and Pickering Beach, DE.
The summit, hosted by one of the world’s leading suppliers of endotoxin detection products, will cover topics such as low endotoxin recovery, the use of alternative test methods that do not rely on horseshoe crab blood, and new options for process optimization. The Summit will feature a broad panel of internationally renowned speakers spanning industry, vendors and regulatory bodies. They will discuss and explore the latest...
Kaldi Pharma granted its first license to CleveXel Pharma, who will develop a preclinical candidate for Parkinson’s disease
Domain Therapeutics, a biopharmaceutical company specializing in the research and early development of new drug candidates targeting G protein-coupled receptors (GPCRs), today announces the creation of a Specific Purpose Vehicle (SPV), Kaldi Pharma, for the exclusive development of its A2a/A1 and A2a antagonist programs. The mission of Kaldi Pharma is to exploit the patented series of A2a/A1 and A2a antagonists discovered...
Advanced Cell Diagnostics, Inc. (ACD) announced today that Merrimack Pharmaceuticals, Inc. is using ACD's RNAscope technology to select patients for its Phase 2 clinical trial of its product candidate MM-121.
Merrimack will utilize RNAscope to identify patients with heregulin positive, locally advanced or metastatic non-small cell lung cancer, making this Merrimack's first MM-121 trial to include only patients with a high heregulin biomarker profile. In previous MM-121 Phase 2 clinical trials, heregulin-positive patients, determined by RNAscope, have demonstrated significant therapeutic benefits when treated with a combination of MM-121 and...
Oxford Gene Technology (OGT), The Molecular Genetics Company, has teamed up with clinical research experts in a new article available online, discussing the role of next generation sequencing (NGS) in cancer medicine.
The article, entitled “The role of NGS in stratified cancer medicine”, presents a valuable resource to better understand the present and the future of NGS in stratified cancer medicine, detailing the most relevant aspects of this revolutionary technology. A key focus of current cancer research is developing the use of stratified medicine. The approach is highly advantageous in guiding effective therapy as it profiles the genetic makeup of individual tumour samples...
The Clinical and Laboratory Standards Institute (CLSI) has published Molecular Diagnostic Methods for Infectious Diseases (MM03-Ed3).
This report addresses topics relating to clinical applications, amplified and nonamplified nucleic acid methods, selection and qualification of nucleic acid sequences, establishment and evaluation of test performance characteristics, inhibitors, and interfering substances, controlling false-positive reactions, reporting and interpretation of results, quality assurance, regulatory issues, and recommendations for manufacturers and clinical laboratories...
The European Infrastructure for Translational Medicine has announced its second conference ‘Building Bridges in TranslationalMedicine’, to be held May 27-28, 2015 in Zuiderkerk, Amsterdam.
For two days pioneers in the field – spanning from researchers, governments, patient organisations, and funders – will discuss the challenges involved in navigating the complex pathways for drug and diagnostics development. Registration is free, but places are limited. EATRIS is the permanent, academic translational research infrastructure supporting researchers and funders in mitigating risk and adding value to high potential products...
Wyatt Technology Corporation, the world leader in instrumentation for absolute macromolecular and nanoparticle characterization, is pleased to highlight a new study that describes the use of composition-gradient multi-angle light scattering (CG-MALS) for the characterization of complex protein-protein interactions. The study, entitled ‘Mechanistic insights into the recycling machine of the SNARE complex’, was published in the...
The National Risk Register of Civil Emergencies states that this number may die each year if no new antibiotics are introduced. This is an alarming figure, particularly as it is likely to be the very young or very old who would be most at risk. Antibiotic Research UK, the world’s first charity devoted to finding new antibiotics, is trying to do something about the problem before it becomes a medical catastrophe.
Protea Biosciences Group, Inc. announced that the National Institute for Occupational Safety and Health (NIOSH) has established a scientific collaboration with Protea’s Imaging and Bioanalytical Laboratory to study the occupational hazards of the inhalation of aerosols released during welding and electronic manufacturing processes. NIOSH is the federal agency that conducts research and makes recommendations for preventing...
In the last decade, the study of microbes in soil and water has advanced through new DNA technology. Through this, studies of marine waters have found many types of astonishingly rare bacteria in the oceans - the so called ?rare biosphere.? Now, researchers from Liverpool John Moores University (LJMU) and the Chinese Academy of Sciences Institute of Urban Environment have turned their attention to the rare biosphere of freshwater...
Professor Seth Cohen of the Department of Chemistry and Biochemistry at the University of California San Diego (UCSD) says "Safety culture improvement is a high priority at UCSD. When I was introduced to Findenser, I immediately saw the opportunity to eliminate costly floods that result from condenser hose leaks. UCSD has also undertaken a campus-wide initiative to reduce energy and water consumption and Findenser is the perfect product for...
Veolia has supplied a new PURELAB® Chorus 3 water purification system to spectacle lens manufacturers the Norville Group. Gloucester based Norville provides a comprehensive high-tech lens coating service, specialising in multi anti-reflection thin coats, as well as hydrophobic (anti-fog) and mirror coatings, using the very latest equipment available. The coating process use about 50 litres per day of water for chemical etching and ultrasonic cleaning which during some stages requires heated...
The Schieber Research Group is led by Jay Schieber, Professor of Chemical Engineering at the Illinois Institute of Technology where he is also Director of the Center for Molecular Study of Condensed Soft Matter. Current research focuses on the kinetic theory of macromolecules to model the rheological, thermodynamic and thermal behaviour of polymeric fluids. These models are then used to predict the properties of advanced materials...
To help the general public understand how bioengineering is changing the world for the better, Integrated DNA Technologies (IDT) is supporting a unique public outreach program led by expert plant synthetic biologists at Revolution Bioengineering. Detailed in a recent DECODED article, “Color-Changing Flowers—Biotechnology for Everyone”, Revolution Biotechnology is creating bioengineered Petunia flowers that change color on...
‘March of the Triffids’, by Paul May, from the University of Bristol, shows carbon nanotubes, around 50,000 times smaller than the width of a human hair, that are joined to form structures that act as emitters for electrical current. This false-colour electron microscope image stole the show ahead of many other stunning pictures, featuring research in action, in the EPSRC competition – now in its second year. Paul May explained: “Carbon-nanotubes...
Therefore, enzymatic methods are of great importance in routine clinical chemistry analysis. The analysis with the aid of enzymes can be completed quickly and without extensive sample preparation. It is run under physiological conditions and the reagents are harmless and easy to handle. With the SPECORD ® PLUS, enzymatic analysis is quick, easy and precise. The use of the Peltier-tempered accessories further allows the performance...
GENALICE MAP is a breakthrough Next-Generation Sequencing (NGS) data processing solution, which processes genomics data up to 100 times faster than conventional tools. GENALICE MAP produces improved quality outcome data, while radically reducing storage requirements. It is the only product on the market today that makes large-scale genomics data processing effective and affordable. Macrogen provides various genome...
This nanopost array technology, called REDIchip™ (Resonance-Enhanced Desorption Ionization), was invented in the laboratory of Akos Vertes, PhD., Department of Chemistry, The George Washington University. The chip is designed to be used for mass spectrometric analysis on MALDI platforms without the need for matrix. Protea’s REDIchip technology features were presented at Pittcon and the commercial product is expected to be...
The plant-based cGMP manufacturing process resulted in a high yield batch of moss-aGal to be used in upcoming clinical trials. The GLP toxicology studies in non-human primates demonstrate the moss-aGal to be safe and well tolerated at a dose of 5 to 10 fold higher than the expected human therapeutic dose. In summary, the study investigated intravenous administration of moss-aGal via two 40-minute infusions at doses of either...
Horizon Discovery Group plc (LSE:HZD) (Horizon), a leading provider of research tools to support translational genomics and the development of personalized medicines, today announced that it will be providing genomic Reference Materials to support Phase Two of Cancer Research UK’s Stratified Medicine Programme (SMP). Financial details of the agreement were not disclosed. The work will focus on supporting the validation...
CNTs exhibit unique electronic, optical, mechanical and structural properties and are emerging as potentially important for a number of industrial applications including organic photovoltaic cells. One of the benefits of using soluble CNTs is that they are amenable to solution-based, low-cost, commercial manufacturing methods. The Zetasizer Nano is proving to be an easy-to-use tool for tracking and optimizing the functionalization reactions...
The summit, hosted by one of the world’s leading suppliers of endotoxin detection products, will cover topics such as low endotoxin recovery, the use of alternative test methods that do not rely on horseshoe crab blood, and new options for process optimization. The Summit will feature a broad panel of internationally renowned speakers spanning industry, vendors and regulatory bodies. They will discuss and explore the latest...
Domain Therapeutics, a biopharmaceutical company specializing in the research and early development of new drug candidates targeting G protein-coupled receptors (GPCRs), today announces the creation of a Specific Purpose Vehicle (SPV), Kaldi Pharma, for the exclusive development of its A2a/A1 and A2a antagonist programs. The mission of Kaldi Pharma is to exploit the patented series of A2a/A1 and A2a antagonists discovered...
Merrimack will utilize RNAscope to identify patients with heregulin positive, locally advanced or metastatic non-small cell lung cancer, making this Merrimack's first MM-121 trial to include only patients with a high heregulin biomarker profile. In previous MM-121 Phase 2 clinical trials, heregulin-positive patients, determined by RNAscope, have demonstrated significant therapeutic benefits when treated with a combination of MM-121 and...
Study suggests that millions of modern Asian men are descended from 11 ancient leaders, including Genghis Khan
The article, entitled “The role of NGS in stratified cancer medicine”, presents a valuable resource to better understand the present and the future of NGS in stratified cancer medicine, detailing the most relevant aspects of this revolutionary technology. A key focus of current cancer research is developing the use of stratified medicine. The approach is highly advantageous in guiding effective therapy as it profiles the genetic makeup of individual tumour samples...
This report addresses topics relating to clinical applications, amplified and nonamplified nucleic acid methods, selection and qualification of nucleic acid sequences, establishment and evaluation of test performance characteristics, inhibitors, and interfering substances, controlling false-positive reactions, reporting and interpretation of results, quality assurance, regulatory issues, and recommendations for manufacturers and clinical laboratories...
For two days pioneers in the field – spanning from researchers, governments, patient organisations, and funders – will discuss the challenges involved in navigating the complex pathways for drug and diagnostics development. Registration is free, but places are limited. EATRIS is the permanent, academic translational research infrastructure supporting researchers and funders in mitigating risk and adding value to high potential products...