After a major investment in multiple systems with semi-permanently mounted vessels, each occupying a dedicated fume hood with a dedicated circulator, Dart Neuroscience switched to Reactor-Ready and Reactor-Ready Pilot systems with a selection of vacuum jacketed process vessels.
The systems included software control, as valuable process data was not being recorded via manual methods. Radley systems have mostly replaced the previous brand in the lab and the user experience is much improved due to well-designed hardware:
Breakthrough in non-invasive gut health testing opens path for new therapeutics
The small, pill-shaped IntelliCap wireless medical device is opening up research opportunities into the impact of the small intestine microbiota on health and disease. For the first time, scientists have been able to obtain and analyse samples of the small intestine’s microbiome in a non-invasive way. This is likely to lead to a greater understanding of the significant role the gut microbiome plays in health and disease; and with it, opportunities for...
£20,000 prize from Royal Society of Chemistry’s Emerging Technology Competition
A University of Leicester spin-out company has won a prestigious £20,000 award for a new technology it is developing to control bleeding in surgery and trauma. The Nottingham-based company, Haemostatix Ltd, claimed top spot in the healthcare sector at the Royal Society of Chemistry’s Emerging Technology Competition with its new peptide dendrimer technology. This new generation compound is based on a purely synthetic peptide construct...
Scientists studying the regional climate have discovered the reason why British summers are getting wetter.
The study, published in the International Journal of Climatology, and led by Liverpool John Moores University’s (LJMU’s) Dr Tom Matthews has provided context for the region’s recent wash-out summers. The experts have assessed 142-year record of storms for the British-Irish Isles. Compared to earlier decades (around the 1960s-1980s), the researchers found that summers in the UK and Ireland have become much wetter as a result of more...
The hotly anticipated Royal Society of Chemistry (RSC) conference, returns to Lab Innovations, taking place at Birmingham’s NEC on 4 & 5 November 2015.
The two day free-to-attend programme will focus on an array of critical industry themes, including 3D Printing, Science in Space, Laboratory Safety, Best Practices and Tax Relief. Dr Geraint Morgan, Project Officer within the Faculty of Science at The Open University, will be taking to the stage on day one of the show to present ‘Down to Earth’ - a look at the first ever landing of a space craft on a comet. He will explore how the European Space...
Renishaw, a world leader in metrology and spectroscopy technologies, reports on the use of its SEM-SCA interface at the Vibrational Spectroscopy Core Facility of the University of Sydney.
Dr Elizabeth Carter is Manager of the Vibrational Spectroscopy Core Facility, VSCF, at the University of Sydney. This professional services unit houses one of the largest concentrations of state-of-the-art Raman and FT-IR spectrometers in Australia. The research interests of facility users are diverse and applications include: nanotechnology; materials science; art and archaeology; polymer science; pharmaceutics; environmental; forensics; mineralogy and...
First study of its kind reveals role of homozygosity and Britain’s biggest killer disease
A study to examine recessively inherited genome-wide DNA sequences has for the first time discovered a potential link with Britain’s biggest killer – Coronary Artery Disease (CAD). The research led by a team from the University of Leicester was the first time that recessively inherited DNA sequences in the whole genome called Runs of homozygosity (ROHs) were examined for a connection to the disease. The study appears in The American Journal of Human Genetics...
Quotient Clinical, the Translational Pharmaceutics® Company, has announced the initiation of a new RapidFACT program for Druggability Technologies (DRGT) for evaluating enhanced formulations of abiratone acetate, a marketed drug prescribed in combination with prednisone to patients suffering from metastatic prostate cancer.
The program will assess new formulations using DRGT’s proprietary Super-API technology, and aims to reduce dose and address food effects associated with the drug. Quotient’s RapidFACT service provides formulation development, real-time GMP manufacturing and clinical testing, all in one location, creating a streamlined approach to optimizing drug formulations for clinical development. It has been proven to accelerate program timelines...
Wyatt Technology Corporation, the world leader in instrumentation for absolute macromolecular and nanoparticle characterization, has published a new whitepaper outlining how to evaluate the solution quality of biotherapeutic candidates prior to screening via Surface Plasmon Resonance (SPR) or Bio Layer Interferometry (BLI).
The DynaPro® Plate Reader II. Analyte quality is critical to obtaining accurate and meaningful measurements in order to select the most promising therapeutic candidates, so ensuring the quality of samples is a vital step in the screening process. The DynaPro high- throughput dynamic light scattering (HT-DLS) system provides an effective method of assessing sample materials using a non-invasive, non-pertubative optical technique...
A team of international scientists including academics from LJMU’s Astrophysics Research Institute (ARI) and the Max-Planck Institute for Extraterrestrial Physics, have discovered that there is a link between ultra-long Gamma Ray Bursts (extremely energetic explosions that have been observed in distant galaxies) and superluminous supernovae, a class of very luminous stellar explosions. They found that these are both the result of the birth of...
CLSI Excellence Awards are bestowed upon volunteers who are dedicated and committed to CLSI’s mission, and are recognized for significantly contributing their services to the development, implementation, and promotion of consensus standards.
The winners were nominated by their peers and then selected by the CLSI Awards Committee. CLSI volunteers are essential to the organization’s mission to develop best practices in clinical and laboratory testing, and promote their use worldwide. CLSI congratulates all of the 2015 Excellence Awards winners...
Ingenza Ltd, a world leader in the application of industrial biotechnology and synthetic biology, is pleased to announce that it is collaborating with global healthcare company GlaxoSmithKline (GSK) on an innovative research project.
A vital part of any collaboration is the selection of a trusted partner. Andrew Collis, Synthetic Biochemistry Lead in GSK Global Manufacturing and Supply, explained why the company chose to work with Ingenza: “In any external collaboration, it is essential to partner with a company that can quickly and efficiently deliver GSK’s proof of concept. It is important to choose a partner that will interact well with our own scientists, with an established track record in the field....
Read MoreSyrris Atlas Calorimeter Benefits Process Scale-UpJul 28, 2015
A Syrris Atlas Calorimeter is proving advantageous to the Kyushu works manufacturing technology department of Nippon Steel & Sumikin Chemical Co., Ltd. in Japan, aiding scale-up of new product processes.
Mr. Kenji Umeda from the Production & Technical Department explained: “Our department performs mass production studies for new product development, supporting the company’s business of manufacturing coal tar, basic and fine chemicals. During product development, we undertake a series of processes from small-scale laboratory studies through to large-scale production. To ensure safe practices, we need to acquire calorimetric data during process scale-up and, after looking at various products...
Analytical scientists at the University of Lincoln’s School of Pharmacy are accelerating their drug development research thanks to Bibby Scientific’s Integrity 10 Reaction Station, which enables different reactions to be performed simultaneously with varied process conditions.
Bibby’s Reaction Stations are designed for screening and optimising ten different reactions in parallel across individually controlled units for applications including solubility and protein crystallisation. The Integrity 10 Reaction Station offers precise control of temperature and stirring speed for each individual reaction, for sample volumes ranging from 1 - 25 mL and temperatures ranging from -30°C to 150°C. It is easily operated with...
A series of highly interactive 2-day seminars delivered by Malvern Instruments, which encompassed expert presentations and ‘up close’ practical workshops showcasing the latest in nanoparticle characterization technology, have been widely praised by attendees.
Feedback from delegates to the ‘Latest Methods in Nanoparticle Characterization’ events, which took place in various locations across the USA, Canada, Mexico and Brazil from April through to June, confirmed especially an appreciation of the detailed presentations about different characterization technologies and their applications, and the value of being able to participate in live instrument demonstrations. The seminars were presented as part...
Need for genetic and molecular testing data management solutions will generate strong demand for these products, says Frost & Sullivan
Investments in cloud-based laboratory information management systems (LIMS) are part of Europe’s eHealth strategy. Even as LIMS providers in Western Europe focus on offering hosted software-as-a-service with free automatic upgrades and built-in customisations, their success will depend on the ability of the products to meet the needs of diagnostic, speciality and hospital laboratories, which demand low turnaround times for patient samples...
Analytik, leading suppliers of innovative analytical instrumentation, report on the work of researchers at the John Innes Centre in Norwich.
The Videometer VL3 multispectral imaging system provides high throughput screening of wheat samples. The John Innes Centre (JIC) is located on the Norwich Research Park in the heart of East Anglia, supported by the Biotechnology and Biological Sciences Research Council (BBSRC). Its mission is to generate knowledge of plants and microbes through innovative research and to apply knowledge of nature’s diversity to benefit agriculture...
DELMIC develops and manufactures products which are focused on high performance, user friendly, integrated microscopy solutions.
Users of Delmic's SECOM solution for Correlated Light & Electron Microscopy (CLEM) have recently published a review in Nature Methods that illustrates the power of CLEM in the world of biology. The boom in the use of super-resolution microscopies in recent years reached a peak with the award of the 2014 Nobel Prize in Chemistry to Betzig, Hell and Moerner for their contributions in the development of super-resolved fluorescence microscopy...
From targeted drug delivery to the self-assembly of nano robots, new research by Northumbria University, Newcastle, is using super-sized atoms to reveal the behaviour of liquids in microscopic channels.
The study, which has been led by Dr Rodrigo Ledesma-Aguilar; a senior lecturer in the Department of Physics and Electrical Engineering in Northumbria University, is a collaborative effort between Oxford University, the University of Barcelona and UT Malaysia. Using the already established ?lab on a chip? device which can perform complex laboratory functions in a tiny space, the team has unveiled how fluids behave under extreme confinement by...
Chromatrap®, a business unit of Porvair Sciences, has published a new application note that describes how Chromatrap® ChIP-seq assays now enable unbiased, genome-wide understanding of protein-DNA regulatory networks.
Genome-wide mapping of protein-DNA interactions is essential for a complete understanding of gene regulation. A detailed map of epigenetic marks and transcription factor binding is necessary for deducing the regulatory networks that underpin gene expression in a variety of biological systems. The most widely used tool for examining these interactions is ChIP followed by massively parallel sequencing (ChIP-seq). The new application note reports on how the Chromatrap...
Jennifer Aniston, Clint Eastwood and Halle Berry images used in ‘mind game’ to establish for the first time how new memories are formed
Observations based on human brain studies
Study reveals that the same brain neuron that fires for one image (Jennifer Aniston) would also fire instantly for another image (Eiffel Tower) if the volunteer had been shown an image of Jennifer Aniston at the Eiffel Tower
This remarkable result shows that the neurons changed their firing properties at...
Breakthrough proves efficacy of new sample preparation method that could accelerate cancer research and development of treatments and diagnostic tests as reported in peer-reviewed PLOS One.
Scientists at NuGEN Technologies, Inc. have simultaneously surveyed RNA of more than 400 targeted genes in a single assay, using next generation sequencing (NGS) to detect fusions known to be key drivers of tumor growth in several cancer types. The scientists, who employed an innovative method of targeted sequence library preparation, also discovered low-frequency fusions that had not previously been reported. The new method, which allows...
The systems included software control, as valuable process data was not being recorded via manual methods. Radley systems have mostly replaced the previous brand in the lab and the user experience is much improved due to well-designed hardware:
The small, pill-shaped IntelliCap wireless medical device is opening up research opportunities into the impact of the small intestine microbiota on health and disease. For the first time, scientists have been able to obtain and analyse samples of the small intestine’s microbiome in a non-invasive way. This is likely to lead to a greater understanding of the significant role the gut microbiome plays in health and disease; and with it, opportunities for...
A University of Leicester spin-out company has won a prestigious £20,000 award for a new technology it is developing to control bleeding in surgery and trauma. The Nottingham-based company, Haemostatix Ltd, claimed top spot in the healthcare sector at the Royal Society of Chemistry’s Emerging Technology Competition with its new peptide dendrimer technology. This new generation compound is based on a purely synthetic peptide construct...
The study, published in the International Journal of Climatology, and led by Liverpool John Moores University’s (LJMU’s) Dr Tom Matthews has provided context for the region’s recent wash-out summers. The experts have assessed 142-year record of storms for the British-Irish Isles. Compared to earlier decades (around the 1960s-1980s), the researchers found that summers in the UK and Ireland have become much wetter as a result of more...
The two day free-to-attend programme will focus on an array of critical industry themes, including 3D Printing, Science in Space, Laboratory Safety, Best Practices and Tax Relief. Dr Geraint Morgan, Project Officer within the Faculty of Science at The Open University, will be taking to the stage on day one of the show to present ‘Down to Earth’ - a look at the first ever landing of a space craft on a comet. He will explore how the European Space...
Dr Elizabeth Carter is Manager of the Vibrational Spectroscopy Core Facility, VSCF, at the University of Sydney. This professional services unit houses one of the largest concentrations of state-of-the-art Raman and FT-IR spectrometers in Australia. The research interests of facility users are diverse and applications include: nanotechnology; materials science; art and archaeology; polymer science; pharmaceutics; environmental; forensics; mineralogy and...
The program will assess new formulations using DRGT’s proprietary Super-API technology, and aims to reduce dose and address food effects associated with the drug. Quotient’s RapidFACT service provides formulation development, real-time GMP manufacturing and clinical testing, all in one location, creating a streamlined approach to optimizing drug formulations for clinical development. It has been proven to accelerate program timelines...
The DynaPro® Plate Reader II. Analyte quality is critical to obtaining accurate and meaningful measurements in order to select the most promising therapeutic candidates, so ensuring the quality of samples is a vital step in the screening process. The DynaPro high- throughput dynamic light scattering (HT-DLS) system provides an effective method of assessing sample materials using a non-invasive, non-pertubative optical technique...
The winners were nominated by their peers and then selected by the CLSI Awards Committee. CLSI volunteers are essential to the organization’s mission to develop best practices in clinical and laboratory testing, and promote their use worldwide. CLSI congratulates all of the 2015 Excellence Awards winners...
A vital part of any collaboration is the selection of a trusted partner. Andrew Collis, Synthetic Biochemistry Lead in GSK Global Manufacturing and Supply, explained why the company chose to work with Ingenza: “In any external collaboration, it is essential to partner with a company that can quickly and efficiently deliver GSK’s proof of concept. It is important to choose a partner that will interact well with our own scientists, with an established track record in the field....
Mr. Kenji Umeda from the Production & Technical Department explained: “Our department performs mass production studies for new product development, supporting the company’s business of manufacturing coal tar, basic and fine chemicals. During product development, we undertake a series of processes from small-scale laboratory studies through to large-scale production. To ensure safe practices, we need to acquire calorimetric data during process scale-up and, after looking at various products...
Bibby’s Reaction Stations are designed for screening and optimising ten different reactions in parallel across individually controlled units for applications including solubility and protein crystallisation. The Integrity 10 Reaction Station offers precise control of temperature and stirring speed for each individual reaction, for sample volumes ranging from 1 - 25 mL and temperatures ranging from -30°C to 150°C. It is easily operated with...
Feedback from delegates to the ‘Latest Methods in Nanoparticle Characterization’ events, which took place in various locations across the USA, Canada, Mexico and Brazil from April through to June, confirmed especially an appreciation of the detailed presentations about different characterization technologies and their applications, and the value of being able to participate in live instrument demonstrations. The seminars were presented as part...
Investments in cloud-based laboratory information management systems (LIMS) are part of Europe’s eHealth strategy. Even as LIMS providers in Western Europe focus on offering hosted software-as-a-service with free automatic upgrades and built-in customisations, their success will depend on the ability of the products to meet the needs of diagnostic, speciality and hospital laboratories, which demand low turnaround times for patient samples...
The Videometer VL3 multispectral imaging system provides high throughput screening of wheat samples. The John Innes Centre (JIC) is located on the Norwich Research Park in the heart of East Anglia, supported by the Biotechnology and Biological Sciences Research Council (BBSRC). Its mission is to generate knowledge of plants and microbes through innovative research and to apply knowledge of nature’s diversity to benefit agriculture...
Users of Delmic's SECOM solution for Correlated Light & Electron Microscopy (CLEM) have recently published a review in Nature Methods that illustrates the power of CLEM in the world of biology. The boom in the use of super-resolution microscopies in recent years reached a peak with the award of the 2014 Nobel Prize in Chemistry to Betzig, Hell and Moerner for their contributions in the development of super-resolved fluorescence microscopy...
The study, which has been led by Dr Rodrigo Ledesma-Aguilar; a senior lecturer in the Department of Physics and Electrical Engineering in Northumbria University, is a collaborative effort between Oxford University, the University of Barcelona and UT Malaysia. Using the already established ?lab on a chip? device which can perform complex laboratory functions in a tiny space, the team has unveiled how fluids behave under extreme confinement by...
Genome-wide mapping of protein-DNA interactions is essential for a complete understanding of gene regulation. A detailed map of epigenetic marks and transcription factor binding is necessary for deducing the regulatory networks that underpin gene expression in a variety of biological systems. The most widely used tool for examining these interactions is ChIP followed by massively parallel sequencing (ChIP-seq). The new application note reports on how the Chromatrap...
Scientists at NuGEN Technologies, Inc. have simultaneously surveyed RNA of more than 400 targeted genes in a single assay, using next generation sequencing (NGS) to detect fusions known to be key drivers of tumor growth in several cancer types. The scientists, who employed an innovative method of targeted sequence library preparation, also discovered low-frequency fusions that had not previously been reported. The new method, which allows...