SP Scientific’s Genevac Series 3 HT Centrifugal Evaporator is widely proven to provide highly effective drying of samples previously stored in Dimethyl Sulphoxide (DMSO). Dimethyl sulfoxide (DMSO) is an important polar aprotic solvent that dissolves both polar and non-polar compounds and is miscible in a broad range of organic solvents as well as water. Because of these properties it is widely used as a universal sample storage solvent. However...
Driven by the requirement for completely dry samples, pharmaceutical compound handling groups are increasingly using SP Scientific’s Genevac LyoSpeed™,a hybrid process combining conventional centrifugal evaporation and lyophilization, as their preferred method for drying HPLC reverse-phase solvent fractions. Using LyoSpeed™ technology on Genevac EZ-2 Elite and Series 3 HT evaporators, HPLC fractions can be automatically concentrated to a few milliliters, then frozen and rapidly lyophilized....
SP Scientific announces the LyoConstellation S10, S20 and S30 as the first in a new series of advanced freeze dryers. All are configured-to-order for faster delivery freeze-drying cycle development and small-scale aseptic production, such as production of stability batches or early phase clinical trial batches. LyoConstellation is a Line of Sight™- enabled freeze-drying system with very powerful refrigeration, delivering an...
SP Scientific has launched a microsite dedicated to its new Line of Sight (TM) approach, a breakthrough suite of freeze-drying equipment with scalable lyophilization and process analytical tools (PAT). The goal of Line of Sight is to bring pharmaceutical products safely and quickly to market by enhancing product and process knowledge at every step and substantiate the process within...
SP Scientific announces the launch of LyoS™ 2.0 – a line-of-sight enabled lyophilizer control system able to control platforms from development to production units, making cycle transfer and scale-up that much simpler. Building upon over 50 years of freeze-drying experience, the LyoS 2.0 control system delivers unmatched process control for all stages of the cycle, from freezing to primary and secondary drying...
SP Scientific announces sponsorship of the popular 14th annual European freeze-drying seminar Lyoscopedia, being held in the Congress Centrum (Würzburg, Germany) on March 13, 2019. Designed for both freeze-drying experts and novices, the interactive seminar format of Lyoscopedia 2019 provides a platform for exciting discussions about freeze-drying topics relevant to both academic research and...
Join SP Scientific and Dr. Alexandra Braun, of GILYOS GmbH, for an insightful webinar on miniaturization in freeze drying. Miniaturization is an important topic – especially in the early development phase of new drug entities – due to the limited availability and costs of most Active Pharmaceutical Ingredients (API). This webinar, which takes place on January 24 2019, will focus on ways to jumpstart your development effort...
The AirJet XR Sample Cooler from SP Scientific is designed to provide precision sample temperature control (-90°C to +100°C) for NMR, EPR and X-Ray Diffraction instruments using a mechanically refrigerated, temperature-controlled air stream. Unlike some systems that use expensive, expendable cryogens such as liquid nitrogen or carbon dioxide to control temperature, the AirJet XR requires only house-compressed air to control temperature....
The AdVantage Pro freeze dryer with advanced controller from SP Scientific now offers users the benefit of ethernet communication to allow you to monitor your cycle from anywhere that you can receive email. Designed for pharmaceutical and biotech labs, the AdVantage Pro has comparable shelf temperature uniformity (+/- 1.0°C) and system vacuum control performance to larger production freeze dryers, but in a convenient benchtop package. At only 26 in (66 cm) wide, the Advantage Pro requires a minimal amount of your valuable bench space...
Wilmad-LabGlass, an SP Scienceware company, is a leading supplier of precision OEM glass and quartz parts for applications including flow cytometry, distillation, dissolution, rheology, clinical diagnostics and process flow measurement and their relevant equipment. Drawing upon over 76-years’ experience of innovative design and manufacturing to the highest tolerances with the strictest quality control – Wilmad-LabGlass has become the preferred glass products...
SP Scientific announces that its popular Benchtop Pro freeze dryers now include an Omnitronics™ controller as standard enabling application specific programming. The Omnitronics™ controller is driven by an industrial-grade programmable logic controller (PLC), which provides extreme versatility while remaining intuitively easy to use....
SP Scientific, a leading innovator in freeze drying and lyophilization equipment, has announced the dates, venues and agendas for its September 2018 international ‘Insights in Lyophilization Science’ tour. With informative seminar programs published for Basel (Switzerland), Dublin (Ireland), Boston (USA) and Warminster (USA), attending the tour is a must for anyone involved or interested in lyophilization science...
The Genesis Lyophilizer from SP Scientific has been designed with versatility in mind so that this freeze dryer can meet virtually any research, development or small-scale production lyophilization application. The Genesis is highly configurable and designed to deliver shelf temperatures as low as -70°C, condenser temperatures to -85°C, operate in bulk or stoppering configurations....
Genevac has published a technical article that describes how its Rocket™ Evaporator has been used by the Technical University of Munich (Germany) as a sample preparation tool for extraction of active phytochemicals from the leaves of Gymnema sylvestre. A Genevac Rocket Evaporator was chosen to dry the samples because of its high-volume sample capacity, unique technology that eliminates cross contamination due...
SP Industries Inc. has announced the appointment of Brian Larkin as its President and Chief Executive Officer effective February 19th replacing William (Bill) Downs who recently retired. Mr. Larkin brings to SP broad experience as a senior executive having spent the last 27 years in commercial and executive leadership roles in the medical device industry. Most recently he served as Vice President and General Manager for Becton Dickinson's...
The new Spring 2018 program of LyoLearn™ educational webinars has been announced by SP Scientific. Devoted to lyophilization current research interest and related topics, and delivered by industry experts, attendees to each of the free live sessions are encouraged to ask questions of the presenter and get their answers in real time. On 21st February 2018, Dr Michael Pikal, recently retired...
The Freezemobile freeze dryer from SP Scientific is designed to provide a convenient and flexible solution for high quality preparation of peptides, proteins, plant materials and organic tissue. Unlike many traditional freeze dryers that employ coil condensers, Freezemobile freeze dryers use a smooth walled condenser which enables fast defrost & removal of ice for faster turn-around time and also...
The miVac DNA centrifugal sample concentrator from Genevac is purpose designed to efficiently remove water and organic solvents from biological samples containing nucleic acids. The compact benchtop system includes a built-in high-performance vacuum pump, concentration chamber with electromagnetic drive for quiet, maintenance-free operation, and a fixed aluminium rotor for microcentrifuge tubes. To use your miVac DNA – simply position the system on your lab bench, connect the power lead and exhaust tube and then start benefiting from fast, trouble-free nucleic acid concentration....
The miVac DNA centrifugal sample concentrator from Genevac is purpose designed to efficiently remove water and organic solvents from biological samples containing nucleic acids. The compact benchtop system includes a built-in high-performance vacuum pump, concentration chamber with electromagnetic drive for quiet, maintenance-free operation, and a fixed aluminium rotor for microcentrifuge tubes....
SP Scientific announces publication of an independent study evaluating their LyoCapsule™ Freeze Dryer for pharmaceutical product formulation and process development.
The development of biopharmaceuticals often requires lyophilized formulations to produce stable drug products, beginning with laboratory experiments followed by scale-up to larger lyophilizers. Limited supply and high cost of Active Pharmaceutical Ingredient (API) can present major challenges during formulation and process development....
SP Scientific reports upon the growing range of applications served by its premium Hotpack Stability Chambers.
Available in a variety of customizable models, these systems provide precision temperature control from 2°C to 70°C and 20% to 96%RH with exceptional uniformity throughout the chamber and therefore can serve a diverse array of applications across a multitude of industries....
SP Scientific reports upon the growing range of applications served by its premium Hotpack Stability Chambers.
Available in a variety of customizable models, these systems provide precision temperature control from 2°C to 70°C and 20% to 96%RH with exceptional uniformity throughout the chamber and therefore can serve a diverse array of applications across a multitude of industries....
Genevac reports that its Rocket Synergy centrifugal evaporator is being adopted by laboratories looking to replace multiple rotary evaporators, from benchtop to production capacity, saving them valuable bench space and improving productivity.
Rocket Synergy evaporator controls are very easy to use - simply load your samples, select the correct method, press start and walk away. The evaporator is equipped with high performance features that prevent foaming, bumping and cross contamination. A built-in cold trap provides very high levels of solvent recovery, even with volatile organic solvents....
SP Scientific announces the LyoCapsule™ Freeze Dryer.
An exciting new lyophilization instrument that delivers results comparable to larger R&D freeze dryers enabling a Quality by Design (QbD) approach to cycle development even when materials are highly expensive or limited in quantity. This addition aligns with SP’s mission to provide ‘line of sight’ scale-up equipment and technology from R&D through to commercial freeze drying....
SP Scientific announces the launch of a new dedicated website for its PennTech® brand of advanced aseptic processing equipment for the pharmaceutical and biotech industries.
As the only U.S.-based manufacturer to offer complete vial handling solutions covering washing, sterilization, filling, stoppering, capping and both tray and freeze dryer loading/unloading equipment – SP Scientific’s PennTech® brand has earned an international reputation for supplying reliable, high performance equipment....
SP Scientific announces the on-demand availability of a popular webinar by Jake Luoma of Genentech Inc. that discusses how controlled nucleation has emerged as a technology which promises improvements in lyophilization process throughput and consistency.
In this presentation, Mr. Luoma examines the benefits of the technology for high fill-volume configurations and presents new data regarding the mechanism of the ControLyo™ Technology. The presentation shows how gaining a more complete understanding of the mechanism of nucleation using ControLyo™ Technology ensures more robust freezing when scaling from the lab to commercial-scale freeze dryers....
Benefiting from a state-of-the-art -75°C condenser - the Series 3 HT Evaporator from Genevac sets a new benchmark for enhanced evaporation and lyophilisation results.
Drying HPLC purification fractions, such as water and acetonitrile, is a routine yet essential task in many pharmaceutical laboratories. Typically labs require HPLC fractions to be dried to a powder form, such that samples can be accurately weighed, easily sub-sampled and re-dissolved....
SP Scientific has published a white paper that discusses how the pharmaceutical industry and safety regulators are putting more emphasis on the importance of using external washers to remove particles from the outside of vials.
Many organizations today are electing to install external vial washers in association with filling applications involving powders, high potency liquids and freeze-dried materials to minimize the risk of operator or end-user exposure to harmful products. The white paper provides an informative introduction to...
Genevac reports on a customer paper that describes the development and advantages of a new evaporative methodology for Mass Spectroscopic (MS) analysis replacing the traditional Solid Phase Extraction (SPE) technique for preparing environmental samples.
In recent years HPLC/MS/MS and UPLC have become the sensitive and specific techniques of choice for the detection of algal toxins in water. While the majority of published studies employ SPE for preparing environmental samples for MS or UPLC analysis, using this methodology can be very time consuming. In this paper a direct solvent evaporation methodology...
SP Scientific has purchased ControLyo™ Nucleation Technology and all related patents from Praxair Inc. (Danbury, CT).
ControLyo™ nucleation technology controls the freezing stage of the freeze drying process for more consistent and repeatable outcomes that aid drug development, scale-up and production efforts. SP which manufactures a full range of research through production lyophilization equipment and technologies has had a licensing agreement with Praxair, Inc. to provide ControLyo™ technology as part of its portfolio since 2010...
SP Scientific, the market leader in freeze drying educational events, reports on the enthusiastic response from past attendees at its 'Hands-On' training courses and announces dates for its 2017 program.
Over the last 6 years, SP Scientific Hands-On freeze drying training courses have proven invaluable to attendees. Tangible benefits that attendees have immediately realised on returning to work include increased productivity through cutting hours from their freeze drying cycle recipes and troubleshooting real issues faced in their daily work environments....
SP Scientific is now able to offer a one-source solution for a complete range of pharmaceutical processing equipment.
From lyophilizers / freeze dryers, vial washers and sterilization tunnels right through to automated systems for filling, loading / unloading, capping and external washing of vials, PennTech, Hull and VirTis brands advantageously position SP Scientific with capability to manufacture complete aseptic vial processing lines....
SP Scientific announces the introduction of the LyoModelling Calculator (LMC) - a powerful new software utility that enables those developing freeze drying cycles to calculate the time required for primary drying and the maximum product temperature based on user data input.
This free software resource is available on the SP Scientific website**. Users obtain a starting point for primary drying duration and the maximum product temperature at the sublimation interface using pertinent information, such as shelf temperature and chamber pressure, from which an optimized freeze-drying cycle can be developed. The LMC is based on the steady-state heat and mass transfer model of primary drying developed by...
SP Scientific is now able to offer a one-source solution for a complete range of pharmaceutical processing equipment.
From lyophilizers / freeze dryers, vial washers and sterilization tunnels right through to automated systems for filling, loading / unloading, capping and external washing of vials, PennTech, Hull and VirTis brands uniquely position SP Scientific as the only company in the United States with capability to manufacture complete aseptic vial processing lines....
Genevac has posted a YouTube™ video of a demo at California Gold Extractions (San Diego, USA) which compares use of a rotary evaporator and the Genevac Rocket Synergy evaporator, for the batch concentration of 2 litres of winterised cannabis extract in ethanol.
Cannabis oil extract has been used medicinally for generations to help treat a variety of conditions, and its popularity has increased considerably in recent years. Of the various extraction methods used, ethanol extraction is increasingly becoming the method of choice because of its ability to economically and effectively produce an extract with a high terpene content that is safe for consumption...
SP Industries, Inc. (SP), a leading designer and manufacturer of state-of-the-art laboratory equipment ; research, pilot and production freeze dryers ; laboratory supplies and glassware has announced that it has acquired the assets of privately held PennTech Machinery Corporation.
Penntech is a global provider of complete vial handling solutions covering washing, sterilization, filling, stoppering, capping and both tray and freeze dryer loading/unloading equipment, located in Warminster (PA, USA). “PennTech has a well-earned reputation for producing high quality, often customized, equipment and is the only U.S. based manufacturer to offer complete aseptic processing lines,” stated...
Fast Lyophilisation on the Genevac Series 3 HT Evaporator was developed to provide a rapid, high-throughput alternative to freeze drying HPLC purification fractions.
Traditional evaporation methods of removing solvents, such as water and acetonitrile, often results in formation of a gum or oil due to solvent interactions with the dissolved sample. Employing a Series 3 HT Evaporator with LyoSpeed™ Fast Lyophilisation technology is enabling pharma labs to now routinely dry HPLC fraction samples to a powder form, such that the samples can then be accurately weighed, easily sub-sampled and redissolved. While standard evaporation works...
Fast Lyophilisation on the Genevac Series 3 HT Evaporator was developed to provide a rapid, high-throughput alternative to freeze drying HPLC purification fractions.
Traditional evaporation methods of removing solvents, such as water and acetonitrile, often results in formation of a gum or oil due to solvent interactions with the dissolved sample. Employing a Series 3 HT Evaporator with LyoSpeed™ Fast Lyophilisation technology is enabling pharma labs to now routinely dry HPLC fraction samples to a powder form, such that the samples can then be accurately weighed, easily sub-sampled and redissolved. While standard evaporation works...
Genevac Series 3 HT evaporators provide an ideal solution for evaporation bottlenecks in high throughput medicinal chemistry, natural product and production laboratories that generate large numbers of samples for processing.
Compact in design and offering a very high capacity for a wide range of sample formats including microplates, vials, and fraction collection tubes, Series 3 HT evaporators offer the versatility and productivity to assist chemists tasked with drying large numbers of samples. The high-throughput design of a Series 3 HT evaporator allows up to 48 shallow-well microplates to be dried down at the same time, while capacity for standard 16 x 100mm fraction collector tubes is...
SP Scientific has announced their next series of educational events to be held during 2016 for scientists involved with lyophilization.
Information and registration details for these upcoming events which include LyoLearn webinars, seminars and hands-on training courses is available through the SP LyoTech Center**. In addition to upcoming events, the LyoTech Center offers a comprehensive repository of previously recorded webinars; informative articles and technical papers; and a variety of free tools and programs to assist freeze dryer users. LyoLearn webinars...
SP Scientific has announced their next series of educational events to be held during 2016 for scientists involved with lyophilization.
Information and registration details for these upcoming events which include LyoLearn webinars, seminars and hands-on training courses is available through the SP LyoTech Center**. In addition to upcoming events, the LyoTech Center offers a comprehensive repository of previously recorded webinars; informative articles and technical papers; and a variety of free tools and programs to assist freeze dryer users. LyoLearn webinars...
SP Scientific has introduced a new range of Hotpack Undercounter and Doublestack Glassware Washers that are engineered for productive, reliable and energy efficient operation.
Technological developments allow the new washers to deliver enhanced drying performance from an upgraded dual fan system incorporated in the washer chambers. Wash cycles with temperatures up to 70°C (158°F) enable fast, efficient cleaning of different types of glassware in wide ranging load scenarios. New soft touch features with multiple cycle selections and microprocessor control systems ensure that each load is processed with minimum energy consumption. A delayed start...
SP Scientific has introduced a new range of Hotpack Undercounter and Doublestack Glassware Washers that are engineered for productive, reliable and energy efficient operation.
Technological developments allow the new washers to deliver enhanced drying performance from an upgraded dual fan system incorporated in the washer chambers. Wash cycles with temperatures up to 70°C (158°F) enable fast, efficient cleaning of different types of glassware in wide ranging load scenarios. New soft touch features with multiple cycle selections and microprocessor control systems ensure that each load is processed with minimum energy consumption. A delayed start...
SP Scientific has announced the Horizontal Drum Manifold - a new accessory to maximize the performance of its BenchTop Pro freeze dryer while adding bulk and flask drying capabilities for aqueous application.
Designed for use with 3-, 8- and 9-Liter BenchTop Pro units the new manifold provides a highly economic solution to further increase the versatility of the popular tray dryer either purchased with a new system or easily assembled on an existing unit in the field with no additional hardware required. The Horizontal Drum Manifold comes standard with two adjustable unheated trays that provide ample room for bulk samples such as plants, leaf...
SP Scientific has partnered with Bioquell (Andover, UK) to produce an off-the-shelf surface sterilization/decontamination system for SP freeze dryers.
The freeze drying production of many pharmaceuticals and biological materials requires sterile conditions. Traditionally freeze dryers have used steam for sterilization. Unfortunately, working with steam means that the freeze dryers are exposed to many different stresses and strains. SP Scientific, in conjunction with Bioquell, have developed an equally effective and less expensive solution to perform surface sterilization / decontamination of freeze dryers using hydrogen peroxide vapor (HPV)...
SP Scientific has partnered with Bioquell (Andover, UK) to produce an off-the-shelf surface sterilization/decontamination system for SP freeze dryers.
The freeze drying production of many pharmaceuticals and biological materials requires sterile conditions. Traditionally freeze dryers have used steam for sterilization. Unfortunately working with steam means that the freeze dryers are exposed to many different stresses and strains. SP Scientific, in conjunction with Bioquell, have developed an equally effective and less expensive solution to perform surface sterilization / decontamination of freeze dryers using hydrogen peroxide vapor...
Genevac has launched a web page that brings together the latest technological innovations and application advances, with links to reference papers, detailing how new fast, safe evaporative sample preparation techniques are benefiting metabolism and toxicology studies.
Visitors to the new web page can gain an insight into how Genevac evaporators are providing fast, safe sample preparation, free from artefact, contamination or loss, from simple concentration or drying of solvent extracts from tissue samples right through to quantitative screening of workers or athletes for the presence of a drug...
SP Scientific has announced a new LyoLearn webinar, due to run on 27th June 2013, entitled 'Sub-visible Particles: Impacts on Aggregation Pathways, Adverse Immunogenicity and Regulatory Expectations for Therapeutic Proteins'.
During the session, Dr. John Carpenter Professor of Pharmaceutical Sciences and Co-Director of the Center for Pharmaceutical Biotechnology, University of Colorado (USA), discusses key areas and presents the latest results from his research. In addition, he will highlight the particle counting instruments that have been vital to the progress made to date. Over the past several years there has been greatly increasing attention on sub-visible particles in therapeutic protein products...
The new VirTis BenchTop Pro freeze dryer range from SP Scientific have been designed to be highly affordable, yet meet the needs of the most demanding research laboratories. Each system can be configured to meet your present and future needs.
Condenser refrigeration packages of -55°C, -75°C, -85°C and -105°C allow you to meet the demands of both aqueous or aqueous solvent based formulations. You can configure your system for smaller sample numbers or to process a relatively heavy workload with condenser size choices of 3 liter, 8 liter or 9 liter. This built-in flexibility allows you to maximize the use of the freeze dryer in your lab while not paying needlessly for unnecessary capacity or refrigeration....
Using a SP Scientific LyoStar Freeze Drying System, leading pharmaceutical process development experts - GILYOS GmbH (Wuerzburg, Germany) will participate in a research program called "FORMOsA" which was recently funded with about two million euros by the German Bavarian Research Foundation. The project focuses on age-related muscle atrophy (sarcopenia)
In this project, GILYOS will be actively involved in the formulation development and freeze drying process design and optimization of follistatin for subcutaneous application. Follistatin is a messenger substance which is present in almost all types of tissue. The protein effectively inhibits myostatin which, in turn, plays a key role in skeletal muscle atrophy. Follistatin might therefore be a promising substance for treating sarcopenia...
SP Scientific has announced its fall 2012 program of free educational webinars delivered by industry experts on topics in Lyophilisation and Freeze Drying
Presented by Yves Mayeresse, Director of Manufacturing at GlaxoSmithKline Biologicals - the 23rd August webinar examines and discusses 'Challenges and Opportunities When Scaling Up Your Lyophilized Pharmaceutical Products'. The presentation provides an overview of factors influencing the success of scale-up. The equipment difference, the robustness of the formulation and the required adaptation of the freeze-dried sample will be reviewed in the presentation...
The researchers demonstrate how SMARTTM Freeze Dryer technology is able to simplify and accelerate the determination of product resistance during controlled nucleation freeze drying experiments. SMART Freeze Dryer technology is a unique control software tool proven to enable development scientists to accelerate and streamline the arduous task of developing and optimizing freeze drying cycles...
SP Scientific and Praxair Expand Technology Agreement
Jun 13, 2012SP Scientific, and Praxair Inc., headquartered in Danbury, CT, are pleased to announce the expansion of their collaborative relationship to commercialize Praxair's ControLyoTM Nucleation on Demand Technology.
The original agreement, signed in October 2010, gave SP Scientific the exclusive, global rights to commercialize the technology on Development Lyophilizers <1.0 m. The Praxair ControLyoTM Technology was implemented on SP Scientific's Lyostar 3 Freeze Dryer in December 2010. The expansion of the agreement allows SP Scientific to also equip its clinical, pilot and production dryers (Benchmark series and Hull Production Dryers) with the ControLyoTM Technology...
Freeze Drying of Pharmaceuticals & Biologicals
Nov 7, 2011SP Scientific has announced new dates for its popular educational seminars and hands-on laboratory training courses in freeze drying techniques. A new seminar 'Freeze Drying of Pharmaceuticals & Biologicals' has been developed in conjunction with Dr. Henning Gieseler and the University of Erlangen Freeze Drying Focus Group - one of the premier academic groups in the world focused on lyophilization...
Lyophilization Cycle Development & Optimization
Aug 10, 2011SP Scientific has announced, in response to widespread enthusiastic participant response to its previous hands-on laboratory training courses in freeze drying techniques, new dates for a Fall 2011 programme...
Improving Accelerated Solvent Extraction (ASE) Workflow
Jun 29, 2011Genevac has launched the Flip-FlopTM system to improve post Accelerated Solvent Extraction (ASE®) concentration and preparation of samples. Using the special double-ended Flip-FlopTM tube - samples can be collected directly from a Dionex ASE® system. A SampleGenieTM adaptor with GC vial is then fitted. The tube is flipped over and placed into the Puck sample holder in a Genevac Rocket Evaporator and the cap removed. The samples are then concentrated directly into a GC autosampler vial...
Fast and Efficient Benchtop Freeze Drying
Jun 29, 2011The BenchtopTM K Series of Manifold Freeze Dryers from SP Scientific are designed for laboratories looking for compactness and ease of use without compromising performance. The Benchtop K Series brings fast and efficient freeze drying within the budget of almost any laboratory. Ease of use is ensured by one button start-up that activates all operating parameters in the correct sequence. All Benchtop K Series Freeze Dryers employ environmentally friendly CFC-free refrigeration systems...
SP Scientific’s Genevac Series 3 HT Centrifugal Evaporator is widely proven to provide highly effective drying of samples previously stored in Dimethyl Sulphoxide (DMSO). Dimethyl sulfoxide (DMSO) is an important polar aprotic solvent that dissolves both polar and non-polar compounds and is miscible in a broad range of organic solvents as well as water. Because of these properties it is widely used as a universal sample storage solvent. However...
Driven by the requirement for completely dry samples, pharmaceutical compound handling groups are increasingly using SP Scientific’s Genevac LyoSpeed™,a hybrid process combining conventional centrifugal evaporation and lyophilization, as their preferred method for drying HPLC reverse-phase solvent fractions. Using LyoSpeed™ technology on Genevac EZ-2 Elite and Series 3 HT evaporators, HPLC fractions can be automatically concentrated to a few milliliters, then frozen and rapidly lyophilized....
SP Scientific announces the LyoConstellation S10, S20 and S30 as the first in a new series of advanced freeze dryers. All are configured-to-order for faster delivery freeze-drying cycle development and small-scale aseptic production, such as production of stability batches or early phase clinical trial batches. LyoConstellation is a Line of Sight™- enabled freeze-drying system with very powerful refrigeration, delivering an...
SP Scientific has launched a microsite dedicated to its new Line of Sight (TM) approach, a breakthrough suite of freeze-drying equipment with scalable lyophilization and process analytical tools (PAT). The goal of Line of Sight is to bring pharmaceutical products safely and quickly to market by enhancing product and process knowledge at every step and substantiate the process within...
SP Scientific announces the launch of LyoS™ 2.0 – a line-of-sight enabled lyophilizer control system able to control platforms from development to production units, making cycle transfer and scale-up that much simpler. Building upon over 50 years of freeze-drying experience, the LyoS 2.0 control system delivers unmatched process control for all stages of the cycle, from freezing to primary and secondary drying...
SP Scientific announces sponsorship of the popular 14th annual European freeze-drying seminar Lyoscopedia, being held in the Congress Centrum (Würzburg, Germany) on March 13, 2019. Designed for both freeze-drying experts and novices, the interactive seminar format of Lyoscopedia 2019 provides a platform for exciting discussions about freeze-drying topics relevant to both academic research and...
Join SP Scientific and Dr. Alexandra Braun, of GILYOS GmbH, for an insightful webinar on miniaturization in freeze drying. Miniaturization is an important topic – especially in the early development phase of new drug entities – due to the limited availability and costs of most Active Pharmaceutical Ingredients (API). This webinar, which takes place on January 24 2019, will focus on ways to jumpstart your development effort...
The AirJet XR Sample Cooler from SP Scientific is designed to provide precision sample temperature control (-90°C to +100°C) for NMR, EPR and X-Ray Diffraction instruments using a mechanically refrigerated, temperature-controlled air stream. Unlike some systems that use expensive, expendable cryogens such as liquid nitrogen or carbon dioxide to control temperature, the AirJet XR requires only house-compressed air to control temperature....
The AdVantage Pro freeze dryer with advanced controller from SP Scientific now offers users the benefit of ethernet communication to allow you to monitor your cycle from anywhere that you can receive email. Designed for pharmaceutical and biotech labs, the AdVantage Pro has comparable shelf temperature uniformity (+/- 1.0°C) and system vacuum control performance to larger production freeze dryers, but in a convenient benchtop package. At only 26 in (66 cm) wide, the Advantage Pro requires a minimal amount of your valuable bench space...
Wilmad-LabGlass, an SP Scienceware company, is a leading supplier of precision OEM glass and quartz parts for applications including flow cytometry, distillation, dissolution, rheology, clinical diagnostics and process flow measurement and their relevant equipment. Drawing upon over 76-years’ experience of innovative design and manufacturing to the highest tolerances with the strictest quality control – Wilmad-LabGlass has become the preferred glass products...
SP Scientific announces that its popular Benchtop Pro freeze dryers now include an Omnitronics™ controller as standard enabling application specific programming. The Omnitronics™ controller is driven by an industrial-grade programmable logic controller (PLC), which provides extreme versatility while remaining intuitively easy to use....
SP Scientific, a leading innovator in freeze drying and lyophilization equipment, has announced the dates, venues and agendas for its September 2018 international ‘Insights in Lyophilization Science’ tour. 
The Genesis Lyophilizer from SP Scientific has been designed with versatility in mind so that this freeze dryer can meet virtually any research, development or small-scale production lyophilization application. The Genesis is highly configurable and designed to deliver shelf temperatures as low as -70°C, condenser temperatures to -85°C, operate in bulk or stoppering configurations....
Genevac has published a technical article that describes how its Rocket™ Evaporator has been used by the Technical University of Munich (Germany) as a sample preparation tool for extraction of active phytochemicals from the leaves of Gymnema sylvestre. A Genevac Rocket Evaporator was chosen to dry the samples because of its high-volume sample capacity, unique technology that eliminates cross contamination due...
SP Industries Inc. has announced the appointment of Brian Larkin as its President and Chief Executive Officer effective February 19th replacing William (Bill) Downs who recently retired. Mr. Larkin brings to SP broad experience as a senior executive having spent the last 27 years in commercial and executive leadership roles in the medical device industry. Most recently he served as Vice President and General Manager for Becton Dickinson's...
The new Spring 2018 program of LyoLearn™ educational webinars has been announced by SP Scientific. Devoted to lyophilization current research interest and related topics, and delivered by industry experts, attendees to each of the free live sessions are encouraged to ask questions of the presenter and get their answers in real time. On 21st February 2018, Dr Michael Pikal, recently retired...
The Freezemobile freeze dryer from SP Scientific is designed to provide a convenient and flexible solution for high quality preparation of peptides, proteins, plant materials and organic tissue. Unlike many traditional freeze dryers that employ coil condensers, Freezemobile freeze dryers use a smooth walled condenser which enables fast defrost & removal of ice for faster turn-around time and also...
The miVac DNA centrifugal sample concentrator from Genevac is purpose designed to efficiently remove water and organic solvents from biological samples containing nucleic acids. The compact benchtop system includes a built-in high-performance vacuum pump, concentration chamber with electromagnetic drive for quiet, maintenance-free operation, and a fixed aluminium rotor for microcentrifuge tubes. To use your miVac DNA – simply position the system on your lab bench, connect the power lead and exhaust tube and then start benefiting from fast, trouble-free nucleic acid concentration....
The development of biopharmaceuticals often requires lyophilized formulations to produce stable drug products, beginning with laboratory experiments followed by scale-up to larger lyophilizers. Limited supply and high cost of Active Pharmaceutical Ingredient (API) can present major challenges during formulation and process development....
Available in a variety of customizable models, these systems provide precision temperature control from 2°C to 70°C and 20% to 96%RH with exceptional uniformity throughout the chamber and therefore can serve a diverse array of applications across a multitude of industries....
Rocket Synergy evaporator controls are very easy to use - simply load your samples, select the correct method, press start and walk away. The evaporator is equipped with high performance features that prevent foaming, bumping and cross contamination. A built-in cold trap provides very high levels of solvent recovery, even with volatile organic solvents....
An exciting new lyophilization instrument that delivers results comparable to larger R&D freeze dryers enabling a Quality by Design (QbD) approach to cycle development even when materials are highly expensive or limited in quantity. This addition aligns with SP’s mission to provide ‘line of sight’ scale-up equipment and technology from R&D through to commercial freeze drying....
As the only U.S.-based manufacturer to offer complete vial handling solutions covering washing, sterilization, filling, stoppering, capping and both tray and freeze dryer loading/unloading equipment – SP Scientific’s PennTech® brand has earned an international reputation for supplying reliable, high performance equipment....
In this presentation, Mr. Luoma examines the benefits of the technology for high fill-volume configurations and presents new data regarding the mechanism of the ControLyo™ Technology. The presentation shows how gaining a more complete understanding of the mechanism of nucleation using ControLyo™ Technology ensures more robust freezing when scaling from the lab to commercial-scale freeze dryers....
Drying HPLC purification fractions, such as water and acetonitrile, is a routine yet essential task in many pharmaceutical laboratories. Typically labs require HPLC fractions to be dried to a powder form, such that samples can be accurately weighed, easily sub-sampled and re-dissolved....
Many organizations today are electing to install external vial washers in association with filling applications involving powders, high potency liquids and freeze-dried materials to minimize the risk of operator or end-user exposure to harmful products. The white paper provides an informative introduction to...
In recent years HPLC/MS/MS and UPLC have become the sensitive and specific techniques of choice for the detection of algal toxins in water. While the majority of published studies employ SPE for preparing environmental samples for MS or UPLC analysis, using this methodology can be very time consuming. In this paper a direct solvent evaporation methodology...
ControLyo™ nucleation technology controls the freezing stage of the freeze drying process for more consistent and repeatable outcomes that aid drug development, scale-up and production efforts. SP which manufactures a full range of research through production lyophilization equipment and technologies has had a licensing agreement with Praxair, Inc. to provide ControLyo™ technology as part of its portfolio since 2010...
Over the last 6 years, SP Scientific Hands-On freeze drying training courses have proven invaluable to attendees. Tangible benefits that attendees have immediately realised on returning to work include increased productivity through cutting hours from their freeze drying cycle recipes and troubleshooting real issues faced in their daily work environments....
From lyophilizers / freeze dryers, vial washers and sterilization tunnels right through to automated systems for filling, loading / unloading, capping and external washing of vials, PennTech, Hull and VirTis brands advantageously position SP Scientific with capability to manufacture complete aseptic vial processing lines....
This free software resource is available on the SP Scientific website**. Users obtain a starting point for primary drying duration and the maximum product temperature at the sublimation interface using pertinent information, such as shelf temperature and chamber pressure, from which an optimized freeze-drying cycle can be developed. The LMC is based on the steady-state heat and mass transfer model of primary drying developed by...
From lyophilizers / freeze dryers, vial washers and sterilization tunnels right through to automated systems for filling, loading / unloading, capping and external washing of vials, PennTech, Hull and VirTis brands uniquely position SP Scientific as the only company in the United States with capability to manufacture complete aseptic vial processing lines....
Cannabis oil extract has been used medicinally for generations to help treat a variety of conditions, and its popularity has increased considerably in recent years. Of the various extraction methods used, ethanol extraction is increasingly becoming the method of choice because of its ability to economically and effectively produce an extract with a high terpene content that is safe for consumption...
Penntech is a global provider of complete vial handling solutions covering washing, sterilization, filling, stoppering, capping and both tray and freeze dryer loading/unloading equipment, located in Warminster (PA, USA). “PennTech has a well-earned reputation for producing high quality, often customized, equipment and is the only U.S. based manufacturer to offer complete aseptic processing lines,” stated...
Traditional evaporation methods of removing solvents, such as water and acetonitrile, often results in formation of a gum or oil due to solvent interactions with the dissolved sample. Employing a Series 3 HT Evaporator with LyoSpeed™ Fast Lyophilisation technology is enabling pharma labs to now routinely dry HPLC fraction samples to a powder form, such that the samples can then be accurately weighed, easily sub-sampled and redissolved. While standard evaporation works...
Traditional evaporation methods of removing solvents, such as water and acetonitrile, often results in formation of a gum or oil due to solvent interactions with the dissolved sample. Employing a Series 3 HT Evaporator with LyoSpeed™ Fast Lyophilisation technology is enabling pharma labs to now routinely dry HPLC fraction samples to a powder form, such that the samples can then be accurately weighed, easily sub-sampled and redissolved. 
Compact in design and offering a very high capacity for a wide range of sample formats including microplates, vials, and fraction collection tubes, Series 3 HT evaporators offer the versatility and productivity to assist chemists tasked with drying large numbers of samples. The high-throughput design of a Series 3 HT evaporator allows up to 48 shallow-well microplates to be dried down at the same time, while capacity for standard 16 x 100mm fraction collector tubes is...
Information and registration details for these upcoming events which include LyoLearn webinars, seminars and hands-on training courses is available through the 
Information and registration details for these upcoming events which include LyoLearn webinars, seminars and hands-on training courses is available through the 
Technological developments allow the new washers to deliver enhanced drying performance from an upgraded dual fan system incorporated in the washer chambers. Wash cycles with temperatures up to 70°C (158°F) enable fast, efficient cleaning of different types of glassware in wide ranging load scenarios. New soft touch features with multiple cycle selections and microprocessor control systems ensure that each load is processed with minimum energy consumption. A delayed start...
Technological developments allow the new washers to deliver enhanced drying performance from an upgraded dual fan system incorporated in the washer chambers. Wash cycles with temperatures up to 70°C (158°F) enable fast, efficient cleaning of different types of glassware in wide ranging load scenarios. New soft touch features with multiple cycle selections and microprocessor control systems ensure that each load is processed with minimum energy consumption. A delayed start...
Designed for use with 3-, 8- and 9-Liter BenchTop Pro units the new manifold provides a highly economic solution to further increase the versatility of the popular tray dryer either purchased with a new system or easily assembled on an existing unit in the field with no additional hardware required. The Horizontal Drum Manifold comes standard with two adjustable unheated trays that provide ample room for bulk samples such as plants, leaf...
The freeze drying production of many pharmaceuticals and biological materials requires sterile conditions. Traditionally freeze dryers have used steam for sterilization. Unfortunately, working with steam means that the freeze dryers are exposed to many different stresses and strains. SP Scientific, in conjunction with Bioquell, have developed an equally effective and less expensive solution to perform surface sterilization / decontamination of freeze dryers using hydrogen peroxide vapor (HPV)...
The freeze drying production of many pharmaceuticals and biological materials requires sterile conditions. Traditionally freeze dryers have used steam for sterilization. Unfortunately working with steam means that the freeze dryers are exposed to many different stresses and strains. SP Scientific, in conjunction with Bioquell, have developed an equally effective and less expensive solution to perform surface sterilization / decontamination of freeze dryers using hydrogen peroxide vapor...
Visitors to the new web page can gain an insight into how Genevac evaporators are providing fast, safe sample preparation, free from artefact, contamination or loss, from simple concentration or drying of solvent extracts from tissue samples right through to quantitative screening of workers or athletes for the presence of a drug...
During the session, Dr. John Carpenter Professor of Pharmaceutical Sciences and Co-Director of the Center for Pharmaceutical Biotechnology, University of Colorado (USA), discusses key areas and presents the latest results from his research. In addition, he will highlight the particle counting instruments that have been vital to the progress made to date. 
Condenser refrigeration packages of -55°C, -75°C, -85°C and -105°C allow you to meet the demands of both aqueous or aqueous solvent based formulations. You can configure your system for smaller sample numbers or to process a relatively heavy workload with condenser size choices of 3 liter, 8 liter or 9 liter. This built-in flexibility allows you to maximize the use of the freeze dryer in your lab while not paying needlessly for unnecessary capacity or refrigeration....
In this project, GILYOS will be actively involved in the formulation development and freeze drying process design and optimization of follistatin for subcutaneous application. Follistatin is a messenger substance which is present in almost all types of tissue. The protein effectively inhibits myostatin which, in turn, plays a key role in skeletal muscle atrophy. Follistatin might therefore be a promising substance for treating sarcopenia...
Presented by Yves Mayeresse, Director of Manufacturing at GlaxoSmithKline Biologicals - the 23rd August webinar examines and discusses 'Challenges and Opportunities When Scaling Up Your Lyophilized Pharmaceutical Products'. The presentation provides an overview of factors influencing the success of scale-up. The equipment difference, the robustness of the formulation and the required adaptation of the freeze-dried sample will be reviewed in the presentation...
The researchers demonstrate how SMARTTM Freeze Dryer technology is able to simplify and accelerate the determination of product resistance during controlled nucleation freeze drying experiments. SMART Freeze Dryer technology is a unique control software tool proven to enable development scientists to accelerate and streamline the arduous task of developing and optimizing freeze drying cycles...
The original agreement, signed in October 2010, gave SP Scientific the exclusive, global rights to commercialize the technology on Development Lyophilizers <1.0 m. The Praxair ControLyoTM Technology was implemented on SP Scientific's Lyostar 3 Freeze Dryer in December 2010. The expansion of the agreement allows SP Scientific to also equip its clinical, pilot and production dryers (Benchmark series and Hull Production Dryers) with the ControLyoTM Technology...
SP Scientific has announced new dates for its popular educational seminars and hands-on laboratory training courses in freeze drying techniques. A new seminar 'Freeze Drying of Pharmaceuticals & Biologicals' has been developed in conjunction with Dr. Henning Gieseler and the University of Erlangen Freeze Drying Focus Group - one of the premier academic groups in the world focused on lyophilization...
SP Scientific has announced, in response to widespread enthusiastic participant response to its previous hands-on laboratory training courses in freeze drying techniques, new dates for a Fall 2011 programme...
Genevac has launched the Flip-FlopTM system to improve post Accelerated Solvent Extraction (ASE®) concentration and preparation of samples. Using the special double-ended Flip-FlopTM tube - samples can be collected directly from a Dionex ASE® system. A SampleGenieTM adaptor with GC vial is then fitted. The tube is flipped over and placed into the Puck sample holder in a Genevac Rocket Evaporator and the cap removed. The samples are then concentrated directly into a GC autosampler vial...
The BenchtopTM K Series of Manifold Freeze Dryers from SP Scientific are designed for laboratories looking for compactness and ease of use without compromising performance. The Benchtop K Series brings fast and efficient freeze drying within the budget of almost any laboratory. Ease of use is ensured by one button start-up that activates all operating parameters in the correct sequence. All Benchtop K Series Freeze Dryers employ environmentally friendly CFC-free refrigeration systems...