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Thermo Fisher Scientific Announces New Plasma-FIB for Volume Electron Microscopy, Cryo-Electron Tomography

publication date: Sep 20, 2023
author/source: Thermo Fisher Scientific


Biomedical research leverages volume electron microscopy techniques 

The new Thermo Scientific Hydra Bio Plasma-Focused Ion Beam (Plasma-FIB) is designed for cell biologists seeking simplified workflows while undertaking volume electron microscopy for cryo or resin-embedded samples.

Building on the cross-industry standard Thermo Scientific Helios Hydra DualBeam platform, the Hydra Bio Plasma-FIB is a versatile, multi-application instrument that supports volume electron microscopy and sample preparation for the cryo-electron tomography workflow. From tissues to proteins, this instrument is designed to be a bridge from cryo-EM to room temperature analysis or vice versa, and to help cell biologists spend more time focused on advancing their complex research projects.


Key Applications

Perform volume electron microscopy with frozen and room-temperature samples to study cellular architecture. Prepare samples to study the molecular architecture of cells and tissue.



  • Volume electron microscopy: the Hydra Bio Plasma-FIB supports various microscopy techniques, such as FIB-SEM serial sectioning (at room temperature and cryogenic conditions), array tomography, and cryo-electron tomography, allowing biomedical researchers to study the 3D complexities of cells, tissue and small organisms at nanometer resolution.
  • Multiple ion species: users can quickly switch between four ion species (Xe, Ar, O, and N) to optimize for the specific requirements of each sample.
  • Cryogenic operation: researchers can investigate cellular architecture, in native conditions, and with excellent contrast. They can uncover sub-cellular details on high-pressure-frozen and plunge-frozen samples with no staining required.
  • Room temperature operation: cell biologists can uncover large sample areas and visualize regions of interest with the Spin Mill Bio Method. This unique large area planar-milling technique generates areas of similar size as microtome slicing, but at slice thicknesses as small as 5 nm. Prepare clean, smooth surfaces used to localize regions of interest and subsequently image them in 2D or 3D.



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About Thermo Fisher Scientific

Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue over $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories, improving patient health through diagnostics or the development and manufacture of life-changing therapies, we are here to support them. Our global team delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon and PPD.


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