New mass photometer enables rapid, autonomous, and label-free mass characterisation of biomolecules at the single-molecule level

Refeyn, the mass photometry pioneer, has announced the launch of its new TwoMP Auto mass photometer, a unique instrument for the automatic loading and analysis of biomolecular samples for protein characterisation at the single-molecule level. Launched at SLAS in Boston, the instrument provides researchers with automated direct mass measurements of up to 14 samples in one hour using the unmatched sensitivity and simplicity of mass photometry - Refeyn’s novel molecular mass measurement technology.

The introduction of the TwoMP Auto closely follows the launch of Refeyn’s SamuxMP benchtop mass photometer for AAV analysis, continuing the company’s momentum in product innovations based on mass photometry. The TwoMP Auto represents a significant shift in protein characterisation workflows, enabling scientists to save time and effort through autonomous label-free analysis of biomolecules in solution with minimal sample consumption. Applications of the technology range from purity assessments to interaction analyses. The automation simplifies workflows such as titrations and screening assays, which can be run accurately and reproducibly without operator input, freeing up valuable research time and minimising the chance of human error.

The TwoMP Auto, which integrates a liquid-handling robot, is operated with Refeyn's AcquireMP software. Refeyn’s complete software solution enables the user to define the experimental setup, collect data, and analyse and visualise the results. The robotics unit can also be retrofitted to Refeyn’s existing OneMP and TwoMP mass photometers, and is ideal for any task that requires precise, repeated molecular mass characterisation and comparison of different conditions or sample compositions.

“We are pleased to continue our new product introductions with the launch of our TwoMP Auto mass photometer for the rapid and autonomous direct measurement of molecular mass in a variety of applications”, said Matthias Langhorst, CPO, Refeyn. “We developed the TwoMP Auto to free up valuable time for scientists and enable labs to work more efficiently.”

Mass photometry is a highly novel tool that is unmatched in its versatility and capability in delivering rapid, simple single-molecule measurement. In addition to offering distinct information on individual particles, mass photometry enables more efficient and effective use of existing specialised technologies, for example, in verifying sample quality prior to cryoEM analysis. The technology also provides significant practical benefits over other methods, such as mass spectrometry, size exclusion chromatography, and surface plasmon resonance by removing the need for labels and providing accurate characterisation of biomolecules in solution at the single-molecule level.

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About Refeyn

Refeyn Ltd. specialises in the development, production, and distribution of mass photometry technology for industry and academia. Mass photometry is a unique bioanalytical technology pioneered by Refeyn that enables the measurement of molecular mass at the single-particle level by quantifying light scattering from biomolecules in solution. Spun out of Oxford University in 2018, the company aims to make mass photometry accessible to all in the scientific community, enabling users to achieve new and better outcomes. Refeyn has been recognised for its unique approach to biomolecular analysis through multiple awards, including the Royal Society of Chemistry Emerging Technologies Competition. Applications of mass photometry include: sample characterisation and analysis of protein oligomerisation, biomolecular interactions, and macromolecular assemblies. Utilising the novel technology of mass photometry, Refeyn’s products are capable of accurate mass measurement of single molecules in solution, in their native state, and without the need for labels, opening up new possibilities for bioanalytic and research into biomolecular function.