Channels

 

Special Offers & Promotions

 

 

Latest News

 

 

View Channel

New Products

 

 

View Channel

Video Presentations

 

 

View Channel

Separation Science

 

 

View Channel

Microscopy & Image Analysis

 

 

View Channel

Laboratory Automation & IT Solutions

 

 

View Channel

 

JPK reports on the research activities of Dr Jochen Guck and his teams at Dresden & Cambridge Universities

Kathrin Holtzmann.JPK Instruments, a world-leading manufacturer of nanoanalytic instrumentation for research in life sciences and soft matter, reports on the multi-faceted research projects of Dr Jochen Guck who runs simultaneous research at the Universities of Dresden and Cambridge.

The biophysicist Dr. Jochen Guck has recently started his Humboldt Professorship of Cellular Machines at the Biotechnology Center of the TU Dresden (BIOTEC) while continuing to lead a team at the Cavendish Laboratory at Cambridge University (UK). His work at BIOTEC focuses on the development of new biophysical approaches for stem cell research, blood cell diagnostics and neuroregeneration. One of his main tools for characterization of biomaterials are the NanoWizard® systems from JPK Instruments. Unlike many other users, he does not apply them for basic scanning measurements but uses them to study cellular behaviour and to quantify their interactive forces.

Talking about his research, Professor Guck said "Most of our work uses AFM for mapping the mechanical properties of tissues. It is starting to be recognized that cells respond to the mechanical properties of the environment they are in contact with. They can differentiate into different lineages when in contact with stiff or compliant surfaces. Or they migrate towards stiffer areas or softer areas - a phenomenon called durotaxis. We are one of the few groups that have started to consider this mechanosensitivity of cells in the CNS; in the context of neural development and pathological disorders. One important prerequisite for these studies is to know quantitatively, how stiff or how soft CNS tissues actually are so that we can mimic this environment in vitro, and whether there are heterogeneities that cells could respond to. If everything is the same, there is no queue for migration for example. This is where we have pioneered the use of AFMs for the mapping of mechanical properties of CNS tissues with high spatial resolution."

Continuing about his experiences in working with JPK, he said "NanoWizard is perfect for measuring mechanical properties of biological cells and tissues, while keeping the cells and tissues in their physiological environment at the right temperature and their preferred medium (BioCellTM). And, we can correlate mechanical mapping with optical microscopy such as bright-field or fluorescence microscopy. This helps us to know what we are actually measuring: which cell type, which state (quiescent or activated) or which area in a tissue."

For more details about JPK's specialist products and applications for the bio and nano sciences, please contact JPK on +49 30533112070, visit the web site: www.jpk.com


If you have not logged into the website then please enter your details below.



 

News Channels

 

 

Subscribe to any of our newsletters for the latest on new laboratory products, industry news, case studies and much more!

Newsletters from Lab Bulletin

 

Request your free copies HERE

 

 

 

Popular this Month

Top 10 most popular articles this month

 

 

Today's Picks

 

 

 

 

Looking for a Supplier?

Search by company or by product

 


Company Name:

Product:


 

 

 

 

Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd.


 

Media Partners

 

Exhibitions & Events