AMSBIO has announced a new range of Directed in vivo Angiogenesis Assay (DIVAA^TM) kits that address the short-comings of the traditional plug assay by controlling the site for angiogenesis, increasing reproducibility, conserving test compounds, and supplying more statistical data for quantitative analysis. This range of kits is designed to test for activation, inhibition and tube formation.

The Directed In Vivo Angiogenesis Assay (DIVAA^TM) is the first in vivo system for the study of angiogenesis that provides quantitative and reproducible results. The DIVAA kits provide implant grade silicone cylinders closed at one end, called angioreactors. The angioreactors are filled with 20 microlitres of AMSBIO's Basement Membrane Extract (BME) premixed with or without angiogenesis modulating factors. These angioreactors are then implanted subcutaneously in the dorsal flanks of nude mice. With the onset of angiogenesis, cellular vascularization proceeds to invade the angioreactor, and as early as nine days post-implantation, there are enough cells to determine an effective dose response to angiogenic modulating factors. The sleek design of the patented angioreactor optimizes sensitivity and allows for up to four units per mouse, giving a more controlled experiment and decreasing the number of mice required for a study.

Tumour cells can be implanted into the angioreactor, to study their angiogenic effects in an in vivo system. AMSBIO's DIVAA Kit is provided with FITC-Lectin for fluorescent quantitative analysis. Optional protocols are available for analysis with Calcein-AM and Dextran-FITC.

For further information please visit www.amsbio.com/in-vivo-Angiogenesis-Assay-kits-DIVAA.aspx or contact AMSBIO on +44-1235-828200 / +1-949-768-8365 or email info@amsbio.com.

Founded in 1987, AMS Biotechnology (AMSBIO) is recognized as a leading international provider of unique & innovative products & custom services for life sciences research. The AMSBIO range includes over 23,000 polyclonal & monoclonal antibodies, peptides, recombinant proteins, extracellular matrix, molecular detection reagents, & tissue DNA, RNA, protein & microarray products. Key research areas include: apoptosis, cell invasion & migration, cell signaling, DNA damage, electrophoresis, glycobiology, posttranslational modification & stem cell biology.