A new whitepaper from Malvern Instruments on Oral Solid Dose (OSD) deformulation demonstrates how the analytical technique of Morphologically Directed Raman Spectroscopy (MDRS) can be used to accelerate the development of generic products to a successful conclusion.
Deformulation, the unpicking and investigation of a reference labeled drug (RLD), enables generic developers to understand the features of a product that define its clinical performance. “Accelerating the deformulation workflow for oral solid dosage forms” reviews the current regulatory landscape associated with generic development and considers the workflow for preparing OSD product Abbreviated New Drug Applications (ANDAs)...
BioTek Instruments will be recognized for their efforts in worksite wellness by the Governor's Council on Physical Fitness & Sports and Vermont Department of Health on March 25, 2015 at the Sheraton Hotel & Conference Center in Burlington from 7:30 a.m. to 4 p.m.
BioTek is one of 92 businesses that will receive an award for 2014. This is the fourth year the company has been honored. “Worksites that promote healthy eating, physical activity, tobacco use cessation, and breastfeeding, contribute to the overall health and wellness of all Vermonters, and they are one of the key reasons we are routinely rated the nation’s healthiest state,” said Health Commissioner Harry Chen, MD...
LINK, the innovative developer and manufacturer of nucleic acid reagents, has announced the incorporation of a Scientific Advisory Board (SAB), and the first two appointments of Drs Brian Sproat and Thomas Rupp.
LINK’s SAB will identify and prioritise the development of new nucleic acid reagents designed to help researchers synthesise novel oligonucleotide therapeutics and diagnostics. The SAB will also support the management team in identifying other markets where LINK’s chemistry expertise can be beneficial. Brian Sproat (currently Managing Director, Chemconsilium GCV) has worked in the oligonucleotide market since its inception over 30 years ago. A graduate of the...
In line with MHRA recommendations that all temperature controlled storage equipment should be temperature mapped annually, medical refrigeration specialist, Lec Medical, is urging pharmacies, practices, hospitals and laboratories, to invest in a temperature mapping service which will show if your medical refrigerator is working to optimum temperature, ensuring the safety of the drugs and vaccines stored.
Lec Medical’s temperature mapping service is suitable for all units and is designed to ensure that the unit is functioning correctly to avoid patient safety being compromised. The procedure does not intrude on the functioning of the busy environment, and involves a minimum three-point temperature map as standard. Additional points can be offered to suit the size of your refrigerator. As part of the package, a fully trained technician will complete a temperature performance...
Researchers at the University of Lethbridge, Alberta, Canada, are using Viscotek multi-detector Gel Permeation/Size Exclusion Chromatography (GPC/SEC) (Malvern Instruments, UK) to analyze performance defining polymer features in the development of novel polymer coatings for metal nanoparticles.
“Multi-detection GPC/SEC helps us to monitor and control reaction conditions to engineer advanced polymer coatings which stabilize nanoparticle suspensions to ease their handling and preserve their industrial value,” said Dr. Farhad Faghihi, Research Associate at the University of Lethbridge. “GPC/SEC is the only technique that we have to determine molecular weight and molecular weight distribution with the speed and accuracy...
Automatic application of Matsy method for matched series analysis within StarDrop™ will guide compound optimisation in drug discovery
Optibrium™ and NextMove Software, developers of software and chemoinformatics solutions for drug discovery, today announced an agreement to collaborate on the integration of NextMove Software’s Matsy technology with Optibrium’s StarDrop software suite. The combination of these technologies will help guide scientists to quickly identify novel compounds based on matched molecular series analysis with a high chance of success...
Irvine Scientific, a world leader in the innovation and manufacture of cell culture media, announced today the introduction of PRIME-XV® T Cell Expansion XSFM, a xeno-free and serum-free medium.
PRIME-XV T Cell Expansion XSFM is a medium optimized for the expansion of human T cells that reliably maintains potency and is the newest medium in the PRIME-XV cell therapy product line that supports immunotherapy. Immunotherapy has emerged as a viable approach for treating some forms of cancer. Using a process called adoptive cell transfer (ACT), T cells have been engineered to produce chimeric antigen receptors (CARs), a surface...
Researchers at the Hubrecht Institute and the University Medical Center (UMC) Utrecht successfully developed a culturing system for human liver stem cells as well as stem cells from pancreatic cancer.
They describe the development of these culturing systems in two articles in this week’s edition of Cell magazine. Until recently it appeared impossible to keep healthy or diseased tissue from patients alive under laboratory conditions, let alone multiply it. However, in 2009, the research group headed by Hans Clevers, professor of molecular genetics at the Hubrecht Institute/UMC Utrecht and president of the Royal Dutch Academy of Arts and...
New Clarit-E® Choice Stretch Horizontal Electrophoresis Tank
If you need to separate samples with very similar molecular weights, the new Clarit-E® Choice Stretch Electrophoresis Gel Tanks from Alpha Laboratories Ltd. provide the perfect solution. Plus, when you need high throughput, these tanks allow up to 350 samples to be resolved per gel. The extended run lengths of the Choice Stretch Horizontal Tanks allow restriction fragments or other close molecular weight sample bands...
Abcam plc (AIM: ABC), a global leader in the supply of life science research tools, today announces that it has entered into a definitive agreement to acquire the entire issued share capital of Firefly BioWorks Inc ("Firefly") ("the Acquisition") on a cash-free/debt-free basis for £18.5m ($28.0m).
The consideration, which is payable in cash on completion, will be funded from Abcam's existing resources [1]. Firefly has developed a novel multiplex assay platform for the detection of biomarkers, based on a microfabrication technology developed by the founders at Massachusetts Institute of Technology and has developed its first product for detection of microRNAs (miRNAs). Firefly has 15 employees and is based in Cambridge...
Treeway B.V., founded by entrepreneurs Bernard Muller and Robbert Jan Stuit, both diagnosed with ALS, have announced a collaboration with uniQure N.V., a leading gene therapy company, (NASDAQ:QURE), to develop a gene therapy treatment for ALS.
Under the terms of the licensing and collaboration agreement, uniQure has granted Treeway an exclusive license in this field to uniQure’s relevant AAV5 viral vector and GDNF (Glial cell- derived neurotrophic factor) intellectual property. Treeway is responsible for the preclinical and clinical development of the ALS gene therapy treatment. uniQure will provide Treeway with its manufacturing capabilities and will further collaborate with Treeway on...
After a Nigerian UN peacekeeper contracted Ebola and was transported to the Netherlands for treatment, advanced decontamination technology was deployed to minimise the risk of cross-infection.
The University Medical Centre (UMC) in Utrecht called the local representative of a UK decontamination specialist to intervene on an isolation suite where the patient had been hospitalised. Using hydrogen peroxide vapour (HPV) technology, capable of eliminating 99.9999% of pathogens, Bioquell technology was used to neutralise the risks of any cross-contamination. The Netherlands as well as other European countries have agreed...
Waters Corporation has announced that its ionKey/MS System™ was ranked among thetop analytical instrument innovations of 2014 by TheAnalytical Scientist magazine.
Introduced at Pittcon 2014, ionKey/MS represents a new approach for achieving exceptional sensitivity, robustness and ease-of-use out of mass spectrometry for applications as far-ranging as bioanalyses, pharmacokinetic studies, and biomarker validation to food safety and environmental analyses. Intended for use with the Waters ACQUITY® UPLC® M-Class System and Waters mass spectrometers including the Xevo® TQ-S Mass Spectrometer and SYNAPT® G2-Si Mass Spectrometer, the Waters® ionKey/MS System physically integrates a UPLC separation into the mass spectrometer....
TSQ Endura LC-MS delivers high sensitivity, extreme uptime
Laboratories performing clinical research and other high throughput LC-MS workflows have access to a new triple quadrupole platform designed for higher uptime than any competitive instrument. The Thermo Scientific Endura triple stage quadrupole mass spectrometer shares much of the advanced technology of the Thermo Scientific TSQ Quantiva MS system developed at the same time to transform the triple quadrupole LC-MS category.....
The Pittcon Organizing Committee is pleased to announce the third annual Food Labs Conference, the only food conference focused on the food laboratory, will be held in conjunction with Pittcon 2015, in New Orleans, Louisiana.
The co-location of the two conferences provides that the registration fee to attend the two-day Food Lab Conference, March. 9-10, will also include unlimited week long admission to the Pittcon exposition floor and technical program. The Food Labs Conference is unique in that it is not just focused on one discipline such as microbiology or chemistry, but takes a more holistic approach to best practices in managing food testing and analyses needs...
GENALICE and Knome, Inc. USA jointly announced a strategic partnership to offer their products together as a turn-key solution for those using next-generation sequencing (NGS) data to interpret patients’ genomes.
GENALICE MAP is an ultra-fast and highly accurate preprocessing solution for aligning and calling NGS data and seamlessly connects to Knome’s informatics and genomics interpretation system, the knoSYS® platform. Stated CEO and President of Knome, Wolfgang Daum, “The GENALICE and Knome partnership came about in response to the reality that the amount of NGS data and its increasing usage requires processing and...
The publication of a scientific paper by a group of American and European researchers announcing the identification of a new antibiotic with the potential to treat MRSA is fantastic news says Professor Colin Garner, Chief Executive of Antibiotic Research UK (ANTRUK).
We are desperately short of new antibiotics and the novel strategy used by the researchers could lead to the identification of many more novel antibiotics. The new antibiotic has been named teixobactin and was discovered in the soil of back garden at the home of one of the American researchers, Dr Ling using a new device called the iChip. Teixobactin was particularly active against against Gram-positive bacteria such as Staph...
The globalization of the food chain has meant that the focus on food safety is greater than ever before and as a result, food manufacturers are facing increasingly stringent regulatory requirements.
One area that is receiving a growing amount of attention is mycotoxin intake from contaminated food and feed which causes mycotoxin intoxication. Mycotoxins are secondary fungal metabolites that are typically produced by fungi growing on grains and fruit during shipment or storage. When ingested, mycotoxins may cause acute or chronic disease and it has been shown that repeated exposure to low level mycotoxin ingestion can affect...
Orla Protein Technologies has developed an expanded range of cell culture surfaces that mimic natural interactions and provide reliable and consistent growth media for assay development, biomedical and cell biology applications.
The technology uses specially engineered animal and xeno-free proteins, carefully engineered to mimic specific extracellular matrix components (laminins, vitronectin, collagen, and many more), growth factors (such as FGF, EGF and others) and numerous other proteins that control cell behaviour. Developed using the patented OrlaSURF technology, traditional limitations in the manufacture and immobilisation of proteins on surfaces...
Partnership to develop high-quality immunoassays for life science research
Abcam plc, a global leader in the supply of life science research tools, announced today it has signed a partnership agreement with the Institute of Molecular and Cell Biology (IMCB), a research institute under the Agency for Science, Technology and Research (A*STAR), Singapore. Under the terms of the agreement, Abcam will develop a range of RabMAb® antibody pairs against targets jointly selected by IMCB and Abcam, to be...
University of Leicester Professor contributes to major International Review of peptide Urotensin II
A major international review of a peptide originally found in fish that could be used in the battle against cardiovascular disease has been published. Professor David Lambert from the University of Leicester’s Department of Cardiovascular Sciences contributed to the review, which has been largely written by the International Union of Basic and Clinical Pharmacology (IUPHAR) subcommittee, to pull together the vast literature on...
Tecan will soon be launching a new Fluent™ Laboratory Automation Solution designed to offer greater throughput and flexibility for compound management workflows*.
Building on the success of the Fluent™ cell-based assay workstation launched in summer 2014, this second application-oriented system introduces a number of new hardware and software options that simplify and improve the productivity of compound management and assay plate generation activities. The is ideally suited to drug discovery laboratories and centralized compound library facilities, offering a host of features intended to streamline day-to-day activities such as daughter plate generation, plate reformatting and hit picking....
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Deformulation, the unpicking and investigation of a reference labeled drug (RLD), enables generic developers to understand the features of a product that define its clinical performance. “Accelerating the deformulation workflow for oral solid dosage forms” reviews the current regulatory landscape associated with generic development and considers the workflow for preparing OSD product Abbreviated New Drug Applications (ANDAs)...
BioTek is one of 92 businesses that will receive an award for 2014. This is the fourth year the company has been honored. 
LINK’s SAB will identify and prioritise the development of new nucleic acid reagents designed to help researchers synthesise novel oligonucleotide therapeutics and diagnostics. The SAB will also support the management team in identifying other markets where LINK’s chemistry expertise can be beneficial. Brian Sproat (currently Managing Director, Chemconsilium GCV) has worked in the oligonucleotide market since its inception over 30 years ago. A graduate of the...
Lec Medical’s temperature mapping service is suitable for all units and is designed to ensure that the unit is functioning correctly to avoid patient safety being compromised. The procedure does not intrude on the functioning of the busy environment, and involves a minimum three-point temperature map as standard. Additional points can be offered to suit the size of your refrigerator. As part of the package, a fully trained technician will complete a temperature performance...
“Multi-detection GPC/SEC helps us to monitor and control reaction conditions to engineer advanced polymer coatings which stabilize nanoparticle suspensions to ease their handling and preserve their industrial value,” said Dr. Farhad Faghihi, Research Associate at the University of Lethbridge. “GPC/SEC is the only technique that we have to determine molecular weight and molecular weight distribution with the speed and accuracy...
Optibrium™ and NextMove Software, developers of software and chemoinformatics solutions for drug discovery, today announced an agreement to collaborate on the integration of NextMove Software’s Matsy technology with Optibrium’s StarDrop software suite. The combination of these technologies will help guide scientists to quickly identify novel compounds based on matched molecular series analysis with a high chance of success...
PRIME-XV T Cell Expansion XSFM is a medium optimized for the expansion of human T cells that reliably maintains potency and is the newest medium in the PRIME-XV cell therapy product line that supports immunotherapy. Immunotherapy has emerged as a viable approach for treating some forms of cancer. Using a process called adoptive cell transfer (ACT), T cells have been engineered to produce chimeric antigen receptors (CARs), a surface...
They describe the development of these culturing systems in two articles in this week’s edition of Cell magazine. Until recently it appeared impossible to keep healthy or diseased tissue from patients alive under laboratory conditions, let alone multiply it. However, in 2009, the research group headed by Hans Clevers, professor of molecular genetics at the Hubrecht Institute/UMC Utrecht and president of the Royal Dutch Academy of Arts and...
If you need to separate samples with very similar molecular weights, the new Clarit-E® Choice Stretch Electrophoresis Gel Tanks from Alpha Laboratories Ltd. provide the perfect solution. Plus, when you need high throughput, these tanks allow up to 350 samples to be resolved per gel. The extended run lengths of the Choice Stretch Horizontal Tanks allow restriction fragments or other close molecular weight sample bands...
The consideration, which is payable in cash on completion, will be funded from Abcam's existing resources [1]. Firefly has developed a novel multiplex assay platform for the detection of biomarkers, based on a microfabrication technology developed by the founders at Massachusetts Institute of Technology and has developed its first product for detection of microRNAs (miRNAs). Firefly has 15 employees and is based in Cambridge...
Under the terms of the licensing and collaboration agreement, uniQure has granted Treeway an exclusive license in this field to uniQure’s relevant AAV5 viral vector and GDNF (Glial cell- derived neurotrophic factor) intellectual property. Treeway is responsible for the preclinical and clinical development of the ALS gene therapy treatment. uniQure will provide Treeway with its manufacturing capabilities and will further collaborate with Treeway on...
The University Medical Centre (UMC) in Utrecht called the local representative of a UK decontamination specialist to intervene on an isolation suite where the patient had been hospitalised. Using hydrogen peroxide vapour (HPV) technology, capable of eliminating 99.9999% of pathogens, Bioquell technology was used to neutralise the risks of any cross-contamination. The Netherlands as well as other European countries have agreed...
Introduced at Pittcon 2014, ionKey/MS represents a new approach for achieving exceptional sensitivity, robustness and ease-of-use out of mass spectrometry for applications as far-ranging as bioanalyses, pharmacokinetic studies, and biomarker validation to food safety and environmental analyses. Intended for use with the Waters ACQUITY® UPLC® M-Class System and Waters mass spectrometers including the Xevo® TQ-S Mass Spectrometer and SYNAPT® G2-Si Mass Spectrometer, the Waters® ionKey/MS System physically integrates a UPLC separation into the mass spectrometer....
Laboratories performing clinical research and other high throughput LC-MS workflows have access to a new triple quadrupole platform designed for higher uptime than any competitive instrument. The Thermo Scientific Endura triple stage quadrupole mass spectrometer shares much of the advanced technology of the Thermo Scientific TSQ Quantiva MS system developed at the same time to transform the triple quadrupole LC-MS category.....
The co-location of the two conferences provides that the registration fee to attend the two-day Food Lab Conference, March. 9-10, will also include unlimited week long admission to the Pittcon exposition floor and technical program. The Food Labs Conference is unique in that it is not just focused on one discipline such as microbiology or chemistry, but takes a more holistic approach to best practices in managing food testing and analyses needs...
GENALICE MAP is an ultra-fast and highly accurate preprocessing solution for aligning and calling NGS data and seamlessly connects to Knome’s informatics and genomics interpretation system, the knoSYS® platform. Stated CEO and President of Knome, Wolfgang Daum, “The GENALICE and Knome partnership came about in response to the reality that the amount of NGS data and its increasing usage requires processing and...
We are desperately short of new antibiotics and the novel strategy used by the researchers could lead to the identification of many more novel antibiotics. The new antibiotic has been named teixobactin and was discovered in the soil of back garden at the home of one of the American researchers, Dr Ling using a new device called the iChip. Teixobactin was particularly active against against Gram-positive bacteria such as Staph...
One area that is receiving a growing amount of attention is mycotoxin intake from contaminated food and feed which causes mycotoxin intoxication. Mycotoxins are secondary fungal metabolites that are typically produced by fungi growing on grains and fruit during shipment or storage. When ingested, mycotoxins may cause acute or chronic disease and it has been shown that repeated exposure to low level mycotoxin ingestion can affect...
The technology uses specially engineered animal and xeno-free proteins, carefully engineered to mimic specific extracellular matrix components (laminins, vitronectin, collagen, and many more), growth factors (such as FGF, EGF and others) and numerous other proteins that control cell behaviour. Developed using the patented OrlaSURF technology, traditional limitations in the manufacture and immobilisation of proteins on surfaces...
A major international review of a peptide originally found in fish that could be used in the battle against cardiovascular disease has been published. Professor David Lambert from the University of Leicester’s Department of Cardiovascular Sciences contributed to the review, which has been largely written by the International Union of Basic and Clinical Pharmacology (IUPHAR) subcommittee, to pull together the vast literature on...