Bruker has released an application note on the evaluation of matrix effects on the analysis of carbendazim in orange juice and wine using the EVOQ Elite liquid chromatography mass spectrometer (LC-MS/MS).

Carbendazim is a fungicide and a known endocrine with potentially harmful effects on human health. The US Food and Drug Administration (FDA) has limited the concentration of carbendazim in imports to 10 ppb. Using the EVOQ, Bruker has developed a quantitative Multiple Reaction Monitoring (MRM) method for carbendazim analysis in orange juice and wine matrices. The EVOQ’s sensitivity was demonstrated as detections of 0.005 ppb were made, far below the FDA limit. The application note is available to download...

Genevac has developed a protocol using its SuperCool 75 condenser

Genevac has developed a protocol using its SuperCool 75 condenser that, in conjunction with the Genevac HT-12 High Throughput Evaporator, has been proven to set a new benchmark for enhanced evaporation and lyophilisation results. The SuperCool 75 chills to -75C and operates at higher power than any other commercially available condenser, opening the door to greatly improved results with the Genevac LyoSpeed fast lyophilisation process for preparing powdered samples from HPLC fractions...

Thermo Fisher Scientific has developed a reliable method for determining levels of dithiocarbamate fungicides (DTCs) with high precision using gas chromatography-mass spectrometry (GC-MS).

The complex extraction and identification of DTCs is performed on various food samples after a thorough method validation. Application Note 10333, Analysis of Dithocarbamate Pesticides by GC-MS, compares DTC levels in various food samples to matrix-matched calibration standards. SIM mode analysis provides high selectivity with easy-to-integrate chromatograms. The analysis uses a Thermo Scientific™ TRACE GC Ultra™ gas chromatograph equipped with a Thermo Scientific™ TriPlus™ RSH liquid autosampler coupled to a Thermo Scientific™ ITQ™ 900 ion trap mass spectrometer...

The launch of Malvern Instruments’ Viscotek SEC-MALS 20 chromatography detector has triggered record downloads of one of the supporting white papers ‘Static light scattering technologies for GPC/SEC explained’, underlining the enthusiasm amongst users for straightforward information on GPC/SEC analysis.

The recent addition of Viscotek SEC-MALS 20 to Malvern’s range of detectors puts the company in the unique position of being the sole provider of every commercially available light scattering technology for GPC/SEC. Customers can therefore be assured of a truly unbiased choice of detector solutions. The popular white paper is just one of a suite of educational information and application notes provided by Malvern’s specialist team to help users select the right detector for their application...

Thermo Fisher Scientific has developed a simple and economical size-exclusion chromatography (SEC) analysis method that enables nuclear power plants (NPPs) with pressurized water reactors to determine low concentrations of polyacrylic acid (PAA) in secondary feed water containing ethanolamine (ETA) and hydrazine.

Application Note 1058: Determination of Polyacrylic Acid in Nuclear Power Plant Pressurized Water Reactor Secondary Feed Water demonstrates that a SEC column separation with detection at 200 nm can determine PAA with a method detection limit of 2.6 μg/L. This method uses water as the eluent to maximize sensitivity and eliminate the need for eluent preparation...

Thermo Fisher Scientific has developed an on-line solid phase extraction (SPE)high-performance liquid chromatography (HPLC) with ultraviolet absorbance detection method to determine the 14 explosives and related compounds specified in U.S.

Environmental Protection Agency Method 8330A in environmental water samples. Application Note 1066: Sensitive Determination of Explosive Compounds in Waterdemonstrates that this approach eliminates the labor associated with off-line extraction and provides a convenient method that achieves reduced method detection limits (less than 0.35 μg/mL) when determining these compounds in water...

Thermo Fisher Scientific has developed a reliable method for determining phthalates in alcoholic beverages by single-quadrupole gas chromatography-mass spectrometry. The method met the special testing requirements set by the China method GB/T 21911-2008 for determining phthalates in food.

Application Note 10339, Determination of Phthalates in Liquor Beverages by Single Quadrupole GC-MS, describes a sensitive and accurate single-quadrupole GC-MS method for determining levels of phthalate plasticizers in alcoholic beverages. The method is sensitive, rapid, and accurate, and covers a wide linear range to meet the need for trace level detection of phthalate esters in different types of beverages. The analysis uses a Thermo Scientific™ ISQ™ Series single-quadrupole GC-MS coupled to a Thermo Scientific™ TRACE™ 1310 GC.

Thermo Fisher Scientific has developed efficient high-performance liquid chromatography (HPLC) methods combined with ultraviolet detection to determine carbonyl compounds found in vehicle passenger cabin air samples.

Application Note 1056: Determination of Carbonyl Compounds in Vehicle Cabin Compartments demonstrates that all 13 carbonyl compounds specified in California Air Resources Board Method No. 1004, International Organization for Standardization 16000-3:2011, U.S. Environmental Protection Agency (EPA) Compendium Method TO-11A, and the Chinese HJ/T 400-2007 are derivatized with 2,4-dinitrophenylhydrazine and well separated on a reversed-phase column in less than 10 minutes...

Thermo Fisher Scientific has developed an accurate and reproducible method that uses an innovative ion chromatography system for the determination of methylamine (or monomethylamine, MMA) in drug products.

Application Note (AN) 1057: Determination of Methylamine in Drug Productsdemonstrates simple off-line sample preparation followed by an on-line step to complete the sample preparation before analysis. This approach requires only 32 min per analysis. The method uses a cation-exchange column and the eluent is produced by aneluent generator to preclude the labor and potential error associated with eluent preparation...

Thermo Fisher Scientific has developed a method for the fast determination of PCDD/Fs in sediments, soils, bottom and fly ash (as incineration by-products) using gas chromatography-tandem mass spectrometry (GC-MS/MS).

Application Note 10336, Determination of PCDD/Fs in Environmental Samples using Accelerated Solvent Extraction and GC-MS/MS,describes a sensitive and accurate GC-MS/MS method for determining levels of dioxins and furans in various environmental samples using GC-MS/MS. Instrumental LOQs using GC-MS/MS were calculated in the low fgL concentration ranges...

Thermo Fisher Scientific has developed an ion chromatography(IC)-based method for the accurate determination of ammonia in tobacco smoke.

Ammonia is on the U.S. Food and Drug Administration’s (FDA) list of toxic compounds in tobacco smoke. Application Note 1054: Determination of Ammonia in Tobacco Smoke describes an approach that achieves better resolution of ammonium from other analytes present in tobacco smoke when compared to other IC methods and therefore is not subject to interference from small amines. The method has high precisions, a low detection limit (0.01 mg/L), and good recoveries (86–115%)...

A new article detailing a round table discussion on quality by design (QbD) authored by leading industry experts including Spinnovation  Biologics CEO Frederic Girard is now available online.

Entitled ‘QbD and PAT in Upstream and Downstream Processing’, the article details the fundamental principles of QbD, how it is used to improve process control, and the impact technological advances have made on QbD biopharmaceutical upstream process optimization. Originally published in the July addition of Biopharm International the full article is now available to read...

Thermo Fisher Scientific is pleased to announce a new technical note on fast separations in a carbonated beverage using increased flow rates on our high-pressure capillary Ion Chromatography (IC) system, the Thermo Scientific Dionex ICS-5000+ Reagent Free HPIC system.

Technical Note 118: Fast Separations of Anions and Organic Acids in a Carbonated Beverage Using High-Pressure Capillary IC describes the determinations of organic acids in these carbonated beverages. The beverage industry uses these acidulants and flavoring agents to maintain beverage freshness, to minimize microbiological growth and to add a characteristic flavor...

Thermo Fisher Scientific has developed a high-performance liquid chromatography (HPLC) method for a fast and sensitive determination of paraquat and diquat in tap and environmental water samples.

This approach uses on-line solid phase extraction (SPE) and achieves method detection limits that meet the requirements of both U.S. Environmental Protection Agency Method 549.2 and European Union 98/83/EC. Application Note (AN) 1051: Sensitive and Rapid Determination of Paraquat and Diquat in Tap and Environmental Water demonstrates use of a mixed-mode column to provide sufficient retention, excellent resolution, and good peak shape for these herbicides...

Thermo Fisher Scientific is pleased to announce a new technical note discussing rapid separation of inorganic cations in municipal wastewater using our high pressure capillary Ion Chromatography system, the Thermo Scientific Dionex 5000+ ICS HPIC system.

Technical Note 121: Fast Determinations of Inorganic Cations in Municipal Wastewater Using High-Pressure Capillary IC demonstrates how the separation of inorganic cations are important to municipal drinking water and wastewater treatment plants for compliance monitoring. Cationic determinations are necessary as part of the water monitoring program’s secondary water specification of acceptable taste....

Thermo Fisher Scientific is pleased to announce a new technical note on the fast separations of inorganic ions in saline solution samples.

TN 130: Fast Determinations in Salton Sea Samples Using a High-Pressure IC System demonstrates fast separations of inorganic anions and cations in a Salton Sea surface water sample and a neighboring municipal drinking water sample using ion-exchange chromatography. Monitoring salinity levels in estuarine ecosystems is critical to preventing salinity-specific diseases... 

Thermo Fisher Scientific has developed an accurate and reproducible high-performance liquid chromatography (HPLC) method for the single-injection determination of tolterodine and tartrate—the active pharmaceutical ingredient (API) and its counterion—in an encapsulated drug product containing tolterodine tartrate.

Application Note 1047: Simultaneous Determination of Tartaric Acid and Tolterodine in Tolterodine Tartrate demonstrates that this method requires only 13 minutes per analysis. This new approach uses a trimode silica-based column and a detector that is ideal for the determination of counterions, many of which lack a chromophore. Pharmaceutical companies must ensure that a drug product contains the appropriate amount of its API. This is typically validated with an HPLC-based assay...

Malvern Instruments has published ‘Static Light Scattering Technologies For GPC/SEC Explained’, a valuable guide for anyone assessing the value of a light scattering detector for gel permeation/size exclusion chromatography (GPC/SEC).

Kinesis has published a new Application Note: Extraction of Metaldehyde, Geosmin and 2-Methylisoborneol from Water

The latest TELOS^® SPE Application Note from Kinesis highlights the extraction of Metaldehyde, Geosmin and 2-Methylisoborneol from Water. Metaldehyde is a molluscicide whose use has markedly increased in recent years as a result of changing agricultural practices. Geosmin and 2-methylisoborneol (MIB) are naturally occurring alicyclic alcohols which possess potent earthy/musty taste and odour tainting properties. They can occur in raw and potable waters as metabolites derived from various micro-organisms...

Thermo Fisher Scientific has developed an ion chromatography method for nuclear power plants (NPPs) that determines trace concentrations (less than 1 µg/L) of fluoride, chloride, and sulfate in simulated secondary feed water that contains ethanolamine, hydrazine, and polyacrylic acid in just 20 minutes.

Application Brief (AB) 151: Determination of Trace Anions in Nuclear Power Plant Secondary Feed Water Containing Polyacrylic Acid demonstrates excellent retention time and peak area reproducibilities from 69 consecutive injections of a spiked simulated sample...

Thermo Fisher Scientific has developed an efficient high-performance liquid chromatography (HPLC) method using ultraviolet detection for the simultaneous determination in drinking water of all 19 phthalate compounds listed in key environmental regulatory documents.

Application Note 1045: Determination of Phthalates in Drinking Water by UHPLC with UV Detection demonstrates that the phthalates listed in European Union Directive 2005/84/EC, U.S. Environmental Protection Agency Methods 606 and 8061A, the Chinese HJ/T 72-2001, and the Standardization Administration of China GB/T 20388-2006 and GB/T 21911-2008 are well separated on a reversed-phase HPLC column in less than 25 minutes...

In a new paper published in Polymers & Polymer Composites (Vol 21, No 1, 2013), researchers at Kingston University in the UK report the results of continuing work to examine the effects of gamma irradiation on intraocular lenses (IOLs) used in cataract surgery. Triple detection gel permeation chromatography (GPC) using the Viscotek TDAmax system from Malvern Instruments was a key analytical tool in this work.