genOway guarantees freedom to operate (FTO) and offers important gains in conditional knockout development time for industry scientists
GenOway (Alternext-NYSE Euronext: ALGEN; ISIN: FR0004053510), the biotechnology company dedicated to the development of genetically modified animal models, the Wellcome Trust Sanger Institute (UK) and Helmholtz Zentrum München (Germany), members of the EUCOMM Program (European Conditional Mouse Mutagenesis Program) and its successor program EUCOMMTOOLS (EUCOMM: Tools for functional annotation of the mouse genome) announce today the signing of a license enabling genOway to provide industry scientists with conditional knockout (KO) models developed by...
The Welsh Government has launched the Life Sciences Hub Wales, a national and international focal point for the Life Sciences and Healthcare sectors in Wales.
Grant of over EUR 400,000 awarded by the Conseil Régional Provence-Alpes-Côte-D’azur to the consortium of TxCell, Gene and Cell therapy Unit, Nice (UTCG) and Biosafe
TxCell SA, a biotech developing innovative, personalized cell-based immunotherapies using antigen-specific regulatory T-cells (Ag-Tregs) for chronic inflammatory and autoimmune diseases, announces today the launch of, and funding awarded to, the POSITIVE project in collaboration with the Gene and Cell therapy Unit (UTCG) developing new antiviral cell-based immunotherapies and Biosafe, a Swiss private company, a developer of...
Resolve Optics Ltd. has supplied a number of non-browning zoom lens to the Satellite Servicing Capabilities Office (SSCO) at NASA’s Goddard Space Flight Center in Greenbelt, Md., USA.
A key aim of the Satellite Servicing Capabilities Office (SSCO) has been to investigate human and robotic satellite servicing while developing the technologies necessary to bring in-orbit spacecraft inspection, repair, refueling, component replacement and assembly capabilities to space. Following the mantra of “test, test and retest,” SSCO is conducting a number of tests and demonstrations in orbit, in the air and on the ground, to prove the readiness of this technology portfolio...
Thermo Fisher Scientific has demonstrated that a hydrophobic interaction chromatography (HIC) column, the Thermo Scientific™ ProPac™ HIC-10 column, is suitable for separating low-concentration species of an intentionally oxidized MAb from the native MAb.
The same method can be used to separate the papain fragments from the intentionally oxidized MAb, as well as the papain fragments of the native MAb. Application Note 1084: Separation of Papain Digests of Oxidized Monoclonal Antibodiesdetails how the ProPac HIC-10 column can be used to resolve antigen-binding fragments (Fab) and nonantigen-binding fragments (Fc) generated by papain digestion, as well as oxidized Fab/Fc from native Fab/Fc...
Dr Steven Bradshaw, a former Ophthalmologist and medical research expert, has signed up to be become a mentor at AuthorAID to support developing countries researchers in publishing their work to the global audience.
Dr Bradshaw has over 15 years of experience in pharmaceuticals and healthcare, with over 30 published articles in medical journals. He was once Editor at the Nature Publishing Group and is also a regular expert peer reviewer for journals such as British Journal of General Practice, American Journal of Ophthalmology, Indian Journal of Ophthalmology, and Aviation, Space and Environmental Medicine. AuthorAID is a charitable global research network that provides free support and...
A network of signals active in almost all types of cancer sends the protein factories in our cells into overdrive, and may help fuel a tumour’s uncontrolled growth, new research suggests.
Scientists at The Institute of Cancer Research, London, identified a molecular trigger responsible for ratcheting up activity of the endoplasmic reticulum (ER) – the cellular factory that makes the building blocks cancer cells need to keep growing. A protein in the TOR signalling pathway, called SREBP, controls the flow of messages to the endoplasmic reticulum telling it to expand – and could allow cancer cells to...
SP Scientific has announced its Summer 2014 program of LyoLearn webinars.
The LyoLearn program of free educational webinars, delivered by industry experts, are devoted to lyophilization, freeze-drying and related topics. Attendees to the live sessions are encouraged to ask questions of the presenter and get their answers in real time. On 25th June 2014 - Peter Stäertzel* of GILYOS GmbH will present 'Principles of Formulation Design' - an informative webinar that provides an introduction to freeze drying of...
Thermo Fisher Scientific has developed a fast and robust ion chromatography (IC)-based method for the determination of chloride and sulfate in adenosine.
Application Note 1075: Ion Chromatography Assay for Chloride and Sulfate in Adenosine demonstrates that this method supports high sample throughput with a run time of just 3.5 min, requires no toxic chemicals, and can replace the U.S. Pharmacopeia monograph’s existing turbidity-based assays of these compounds. A high-pressure IC system (Thermo Scientific™ Dionex™ ICS-5000+ HPIC™ IC system) combined with a...
AMSBIO announces MagSi-NGSPREP- a magnetic bead based tool that offers an efficient solution for DNA clean-up and size selection in Next Generation Sequencing (NGS)applications.
MagSi-NGSPREP supports all standard DNA clean-up protocols encountered during Next-Gen library preparation, including the classical one-sided and two-sided "solid phase reversible immobilization" (SPRI) size selection protocols. The simple and flexible protocols employed using MagSi-NGSPREP can be adjusted to your specific application and NGS platform. MagSi-NGSPREP can be used manually but is also easy to automate fo...
A treasure trove of important human fossils has been discovered by a team of scientists from the Natural History Museum, including Liverpool John Moores University's Dr Isabelle De Groote.
Future Ancient DNA analyses of these bones, morphological studies and further dating of the material may shed light on the exodus of modern humans from Africa and on whether the Middle East is the place where Neanderthals and modern humans met and interbred. The collection consisted of boxes of bones discovered among the personal belongings of Sir Arthur Keith who had been the Master at Buckston Brown Farm, a research station of the Royal College of Surgeons next to Darwin’s home, Down House, Kent. After Sir Arthur Keith’s death in 1955 a number of fossils were transferred from the...
Delivery of macromolecules and nano-particles into cells at high speed and high volume
TTP, a leading UK technology and product development company, has recently developed an innovative new approach to the intracellular delivery of macromolecules and nano-particles into cells at high speed and high volume. This new technique could have major implications for a range of cellular applications including the transfection of cells with DNA material. TTP has already successfully demonstrated the transport of antibodies into cells and is now beginning to explore other biomolecules and the full capabilities of this exciting technology...
A question of tolerance: Liver transplants in patients with hepatitis C
Chronic hepatitis C virus infections are among the most common reasons for liver transplants. Because existing viruses also infect the new liver, the immune system is highly active there. Despite this, the new organ is not rejected, as scientists from the Helmholtz Zentrum München and the Technische Universität München (TUM) have now discovered. The long-term stimulation of the innate immune system by the virus actually increases the probability of tolerance...
The overwhelming majority of past and present imaging systems use a lens to focus the subject of interest, even today's super-resolution light microscopes that breach the diffraction limit through ingenious experimental methods.
Lensless imaging offers the prospect of a radical improvement in resolution by reconstructing a high-resolution image of an object from one or more diffraction patterns. One downside of lensless imaging is that samples typically need to fulfil very specific geometric constraints and illuminated with a narrow, stable and accurately defined spectrum. These technical limitations have been overcome recently by a team from LaserLaB Amsterdam at the VU University in Amsterdam. Writing in the new nature.com journal 'Light: Science and Applications', they describe a...
Warwick Analytical Service (WAS) has introduced the Quantitative ICP-Scan, a new service that determines the levels of 67 different elements at low part per million making it ideal for analysing unknown or suspect contamination samples.
The service is competitively priced and a great starting point in determining elemental sample composition. The 67 elements covered by this proprietary WAS ICP methodology range from Silver (Ag) through to Zirconium (Zr)**. The WAS Quantitative ICP Scan Service provides information on elements present at 10-100 ppm right up to greater than 1% w/w. Measured intensities are compared to intensities of traceable standards to obtain the...
Qinec, a company providing an operating model for better healthcare delivery, has today announced that Synexus has implemented QinecEnterprise across its 24 worldwide facilities, including dedicated research sites in South Africa, the UK, Germany, Poland, Ukraine, Hungary, Bulgaria and Romania.
The deployment is Qinec's first outside the UK and provides it with a foothold into several key emerging markets. Synexus is the largest company in the world to recruit and run clinical trials at its own facilities. Clinical trials are very time sensitive and Synexus needed an operating system that could help it to effectively manage people through the recruitment to care process as well as track the patient's ongoing progress. QinecEnteprise will...
A prototype of new technology to help specially trained dogs ‘sniff out’ the tell-tale signs of cancer in biological samples has been unveiled by The Open University (OU) at the 2014 Royal Society Summer Exhibition.
The High-Throughput DynaPro Plate Reader Utilizes Dynamic Light Scattering to Identify Most Promising mAb Buffer Conditions Prior to Extended Stability Testing
Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation, is pleased to highlight a study recently authored by Martin Skov Neergaard from the Faculty of Health and Medical Sciences at the University of Copenhagen, “Protein-Protein Interactions Investigated by DLS: Determination at High and Low Protein Concentration.” This article outlines the benefits of quantifying protein-protein interactions (PPI) using...
New technology supports HIV-1 drug resistance surveillance in resource-limited countries
ATCC, the premier global biological materials resource and standards organization, has licensed technology from the Centers for Disease Control and Prevention (CDC) and partnered with Thermo Fisher Scientific, to bring a rapid and cost- effective PCR-based method of monitoring HIV drug resistance to resource-limited countries. The ATCC® HIV-1 Drug Resistance Genotyping Kit was optimized for off-the-shelf detection, sequencing, and genotyping of...
ADME/Tox is an acronym for the investigation of basic small molecule compound behavior in Absorption, Distribution, Metabolism and Excretion, combined with toxicity assessments.
In its simplest form, ADME studies are principally concerned with the effects of an organism, tissue or cell on the compound. Toxicology however looks at the effects of the compound on an organism, tissue or cell. There are myriad microplate-based assays using a wide range of detection technologies for the analysis of ADME/Tox properties. These assays can use purified enzymes, engineered cell lines, primary cells and...
This comprehensive new medical compendium commemorates ten years of Sebia’s excellence in the field of hemoglobin separation using capillary electrophoresis
Sebia, a market leader in protein electrophoresis and tests for the diagnosis of hemoglobin disorders, announces today the debut of its Hemoglobins Atlas. This tool, which has been developed for the first time, is dedicated to helping Sebia’s capillary electrophoresis users orientate their diagnosis of hemoglobinopathies. Hemoglobin electrophoresis is an established technique routinely used in clinical laboratories for screening samples for...
Suppression plays a key role in ion-exchange chromatography and conductivity detection. It is widely used, e.g., for the analysis of anions and organic acids.
Metrohm is pleased to present a new brochure putting the theoretical aspects and practical benefits of suppression in ion chromatography in a nutshell.
Suppression as a practical solution for ion chromatography
decreases the background conductivity of the eluent
TxCell SA, a biotech developing innovative, personalized cell-based immunotherapies using antigen-specific regulatory T-cells (Ag-Tregs) for chronic inflammatory and autoimmune diseases, announces today the launch of, and funding awarded to, the POSITIVE project in collaboration with the Gene and Cell therapy Unit (UTCG) developing new antiviral cell-based immunotherapies and Biosafe, a Swiss private company, a developer of...
A key aim of the Satellite Servicing Capabilities Office (SSCO) has been to investigate human and robotic satellite servicing while developing the technologies necessary to bring in-orbit spacecraft inspection, repair, refueling, component replacement and assembly capabilities to space. Following the mantra of “test, test and retest,” SSCO is conducting a number of tests and demonstrations in orbit, in the air and on the ground, to prove the readiness of this technology portfolio...
The same method can be used to separate the papain fragments from the intentionally oxidized MAb, as well as the papain fragments of the native MAb. Application Note 1084: Separation of Papain Digests of Oxidized Monoclonal Antibodiesdetails how the ProPac HIC-10 column can be used to resolve antigen-binding fragments (Fab) and nonantigen-binding fragments (Fc) generated by papain digestion, as well as oxidized Fab/Fc from native Fab/Fc...
Dr Bradshaw has over 15 years of experience in pharmaceuticals and healthcare, with over 30 published articles in medical journals. He was once Editor at the Nature Publishing Group and is also a regular expert peer reviewer for journals such as British Journal of General Practice, American Journal of Ophthalmology, Indian Journal of Ophthalmology, and Aviation, Space and Environmental Medicine. AuthorAID is a charitable global research network that provides free support and...
Scientists at The Institute of Cancer Research, London, identified a molecular trigger responsible for ratcheting up activity of the endoplasmic reticulum (ER) – the cellular factory that makes the building blocks cancer cells need to keep growing. A protein in the TOR signalling pathway, called SREBP, controls the flow of messages to the endoplasmic reticulum telling it to expand – and could allow cancer cells to...
The LyoLearn program of free educational webinars, delivered by industry experts, are devoted to lyophilization, freeze-drying and related topics. Attendees to the live sessions are encouraged to ask questions of the presenter and get their answers in real time. On 25th June 2014 - Peter Stäertzel* of GILYOS GmbH will present 'Principles of Formulation Design' - an informative webinar that provides an introduction to freeze drying of...
MagSi-NGSPREP supports all standard DNA clean-up protocols encountered during Next-Gen library preparation, including the classical one-sided and two-sided "solid phase reversible immobilization" (SPRI) size selection protocols. The simple and flexible protocols employed using MagSi-NGSPREP can be adjusted to your specific application and NGS platform. MagSi-NGSPREP can be used manually but is also easy to automate fo...
TTP, a leading UK technology and product development company, has recently developed an innovative new approach to the intracellular delivery of macromolecules and nano-particles into cells at high speed and high volume. This new technique could have major implications for a range of cellular applications including the transfection of cells with DNA material. TTP has already successfully demonstrated the transport of antibodies into cells and is now beginning to explore other biomolecules and the full capabilities of this exciting technology...
Chronic hepatitis C virus infections are among the most common reasons for liver transplants. Because existing viruses also infect the new liver, the immune system is highly active there. Despite this, the new organ is not rejected, as scientists from the Helmholtz Zentrum München and the Technische Universität München (TUM) have now discovered. The long-term stimulation of the innate immune system by the virus actually increases the probability of tolerance...
The service is competitively priced and a great starting point in determining elemental sample composition. The 67 elements covered by this proprietary WAS ICP methodology range from Silver (Ag) through to Zirconium (Zr)**. The WAS Quantitative ICP Scan Service provides information on elements present at 10-100 ppm right up to greater than 1% w/w. Measured intensities are compared to intensities of traceable standards to obtain the...
The deployment is Qinec's first outside the UK and provides it with a foothold into several key emerging markets. Synexus is the largest company in the world to recruit and run clinical trials at its own facilities. Clinical trials are very time sensitive and Synexus needed an operating system that could help it to effectively manage people through the recruitment to care process as well as track the patient's ongoing progress. QinecEnteprise will...
Wyatt Technology Corporation, the world leader in absolute macromolecular characterization instrumentation, is pleased to highlight a study recently authored by Martin Skov Neergaard from the Faculty of Health and Medical Sciences at the University of Copenhagen, “Protein-Protein Interactions Investigated by DLS: Determination at High and Low Protein Concentration.” This article outlines the benefits of quantifying protein-protein interactions (PPI) using...
ATCC, the premier global biological materials resource and standards organization, has licensed technology from the Centers for Disease Control and Prevention (CDC) and partnered with Thermo Fisher Scientific, to bring a rapid and cost- effective PCR-based method of monitoring HIV drug resistance to resource-limited countries. The ATCC® HIV-1 Drug Resistance Genotyping Kit was optimized for off-the-shelf detection, sequencing, and genotyping of...
In its simplest form, ADME studies are principally concerned with the effects of an organism, tissue or cell on the compound. Toxicology however looks at the effects of the compound on an organism, tissue or cell. There are myriad microplate-based assays using a wide range of detection technologies for the analysis of ADME/Tox properties. These assays can use purified enzymes, engineered cell lines, primary cells and...
Sebia, a market leader in protein electrophoresis and tests for the diagnosis of hemoglobin disorders, announces today the debut of its Hemoglobins Atlas. This tool, which has been developed for the first time, is dedicated to helping Sebia’s capillary electrophoresis users orientate their diagnosis of hemoglobinopathies. Hemoglobin electrophoresis is an established technique routinely used in clinical laboratories for screening samples for...
Suppression as a practical solution for ion chromatography