Magritek, a leading worldwide provider of compact NMR and MRI instruments, have demonstrated the use of their Spinsolve benchtop NMR spectrometer to perform and monitor chemical reactions on-line.
As costs for energy and raw materials continue to rise, it becomes more critical for chemists to be able to mimic a reaction or to quantify the parameters required to produce a final product without the difficulty and expense of using production facilities. To be able to recreate a production process on a lab bench is therefore highly desirable for many chemists. The Magritek Spinsolve high-resolution benchtop NMR spectrometer is a...
Cancer Research UK is using Onyx Scientific to manage several of its drug development projects in a bid to maximise value for the UK’s leading cancer charity.
The UK-based contract research organisation is now supporting the charity across a portfolio of drug substance campaigns covering the development and manufacturing of API for use in clinical trials. Across the range of projects, Cancer Research UK’s Drug Development Office is utilising the contract manufacturing organisation’s (CMO) expertise in: process development, solid-state chemistry, analytical and GMP synthesis of API for use in Phase I clinical trials...
Over the past two decades, many discoveries have contributed to advances in the field of stem cell research. Researchers have had to maneuver through cuts in funding, legal and ethical barriers, and technological challenges—all in the pursuit of harnessing the power of stem cells.
GENALICE announced today it is partnering with deCODE Genetics to facilitate the large-scale testing of its unique DNA data processing software solution, GENALICE MAP.
After a first successful round of evaluating GENALICE MAP on speed and quality, both parties agreed to extend the evaluation to include up to 10,000 full human genomes. Population wide analysis is crucial if the potential of whole genome sequencing for medical application in patients with complex diseases is to be realized. Data processing at that level represents a major challenge, however, GENALICE’s unique ability to process a...
North West pharmaceutical company Proveca Limited has reached its fourth key agreement with the European Medicines Agency (EMA) that will enable the development of a fourth drug designed specifically for children and young people.
The EMA’s Paediatric Committee (PDCO) adopted a positive opinion on the paediatric investigation plan (PIP) for the development of captopril – a drug designed to treat heart failure in children. The adoption of the PIP provides Proveca with an agreed programme for the future development of the drug. It will deliver the required quality, safety and efficacy data needed for a future licence of captopril for children throughout Europe...
The University of York and a leading pharmaceutical manufacturer has partnered with PyroPure Ltd, the UK pioneer of micro-scale waste disposal, in order to trial its PyroPure® technology before the system is made available to the clinical waste disposal industry.
The collaboration follows Knowledge Transfer Partnership funding from the UK’s innovation agency, the Technology Strategy Board, which aims to help businesses improve their competitiveness and productivity by capitalising on the UK’s knowledge base. The trial aims to demonstrate PyroPure® technology’s capability of destroying the most thermally resistant Active Pharmaceutical Ingredients and is the last step the firm has to...
Imaging method improved by scrambling X-rays from a new source
X-ray phase-contrast imaging can provide high-quality images of objects with lower radiation dose. But until now these images have been hard to obtain and required special X-ray sources whose properties are typically only found at large particle accelerator facilities. Using a laboratory source with unprecedented brightness, scientists from the Technische Universität München (TUM), the Royal Institute of Technology in...
STFC’s Innovations Technology Access Centre (I-TAC) has strengthened its imaging capabilities by installing additional Hitachi benchtop SEMs at both its Harwell and Daresbury campuses.
These two instruments represent the 100th and 101st benchtop SEM’s installed by Hitachi in the UK, with over 600 now being used around Europe. STFC’s I-TAC initiative provides flexible access to lab space and equipment to over 60 companies working in bioscience, energy, space technologies, advanced materials and chemical engineering. This flexible access has enabled companies to achieve over £80 million in investment, to create over...
Investment Aims to Accelerate European Adoption of Clinical Analytics for Genetic Diseases
Sophia Genetics, the European leader in Data-Driven Medicine, has raised $13.75M in Series B financing in a round led by Dr Mike Lynch’s Invoke Capital, Swisscom and Endeavour Vision. Sophia Genetics is a pioneer in Data-Driven Medicine, a crossover field that requires deep expertise in Next Generation Sequencing (NGS), combined with highly accurate and scalable predictive algorithms to diagnose genetic diseases. With this investment, Sophia gains access to Invoke’s portfolio company Genalys, whose Cambridge-based mathematicians apply big data approaches to...
Spectro Scientific has earned a Small Business Innovation Research (SBIR) Phase II award totaling $750,000 for its work in reevaluating the Joint Oil Analysis Program (JOAP) that consolidates and coordinates the oil analysis programs of the U.S. Army, Navy and Air Force.
The U.S. Small Business Administration makes the SBIR award to promote high-tech innovation in the fulfillment of specific research and development needs. The contract awarded to Spectro Scientific for Phase II efforts extends into calendar year 2016. Spectro Scientific undertook the reevaluation effort with the aim of improving the JOAP by modifying processes and/or equipment to create more effective oil analysis. The JOAP was formed following...
Magritek, a leading provider of compact NMR and MRI instruments, is pleased to announce the Spinsolve Phosphorus, the world’s first Phosphorus-31 capable benchtop NMR spectroscopy system.
Phosphorus is commonly found in many organic compounds, for example in biological membranes or DNA. The 31P nucleus has a 100% natural isotopic abundance and a large chemical shift range, making it one of the most commonly used nuclei in biological NMR. For the first time users can have the power of proton-phosphorus NMR in a benchtop instrument that can be safely used in the laboratory...
JPK Instruments, a world-leading manufacturer of nanoanalytic instrumentation for research in life sciences and soft matter, reports on the use of their AFM system, the NanoWizard® in the Physics Department at Swansea University.
Dr Peter Dunstan is an associate Professor in the Department of Physics at Swansea University and a member of the University’s Centre for Nanohealth. His research utilizes state of the art techniques and instrumentation to increase the fundamental understanding of the structural, chemical, optical and electronic properties of materials on the nanoscale, and by doing so advance the future application of those...
New Iam CMV provides speed and accuracy for the diagnosis and monitoring of CMV infection in immunocompromised patients DiaSorin strengthens its infectious disease diagnostic portfolio with the launch of the Iam CMV assay for the molecular detection and quantification of cytomegalovirus.
DiaSorin has further expanded its range of infectious disease assays for use on the DiaSorin Liaison® Iam analyser with the launch of a new molecular assay for the rapid and reliable detection and quantification of cytomegalovirus (CMV). CMV is the most prevalent infectious pathogen in solid organ and bone marrow transplant recipients, and can lead to allograft rejection and other serious complications1-5. The DiaSorin Iam CMV assay is used to...
Gaining more predictive results in anti-cancer drug discovery
In this webinar, our expert panel of speakers will introduce the new EnSight™ Multimode Plate Reader from PerkinElmer, which features well-imaging technology in combination with labeled and label-free detection technologies. Guest speaker Dr. Philip Gribbon (European ScreeningPort, Hamburg) will discuss the use of the EnSight system in anti-cancer drug discovery, for testing cell viability and proliferation in phenotypic readouts. Dr. Gribbon will present results obtained using EnSight, comparing the use of digital phase-contrast imaging and ATP detection for...
Thermo Fisher Scientific has developed a simple, rapid, reliable, and accurate high-performance liquid chromatography (HPLC) method for the simultaneous determination of amlodipine and besylate in an amlodipine besylate drug substance.
Application Note 1087: Simultaneous Determination of Amlodipine and Its Counterion Besylate by HPLC demonstrates that this method requires only 8 minutes per analysis using a column designed for pharmaceutical analysis and ultraviolet detection. In addition, combining the analysis of the active pharmaceutical ingredient (API) and counterion into a single method saves times, reduces mobile phase consumption, and minimizes waste. Amlodipine besylate is a...
AMSBIO announces MagSi-Direct - a revolutionary technology that brings the power, simplicity, and convenience of magnetic separation to researchers involved in cell biology, protein chemistry, flow cytometry, diagnostics development and many other fields
MagSi-Direct provides a convenient and efficient way to attach virtually any biomolecule to nanoscopic paramagnetic beads. It is particularly suited for exploiting interactions between a biomolecule and its binding partners. With MagSi-Direct, you can start with a molecule of interest, attach magnetic beads to it, and then use a magnet to isolate that molecule from any desired reaction mixture, together with any other molecules, complexes, or even intact cells to...
Advanced Cell Diagnostics Inc. (ACD), a leader in the field of molecular pathology and developer of cell and tissue-based analysis tools, has announced that its RNAscope® RNA in situ hybridization technology has reached two major milestones.
In just three years, over 100 peer-reviewed papers featuring the technology have been published, and with the significant increase in use of RNAscope, ACD has now built a library of over 4000 target probes for numerous species. Probes are designed to order in under two weeks, and in just six months the library has grown by over 1500, reflecting the wide interest in ACD’s breakthrough technology. RNAscope uniquely has the sensitivity to enable...
The Clinical and Laboratory Standards Institute (CLSI) has produced a new version of the video Making a Difference Through Newborn Screening: Blood Collection on Filter Paper (NBS01-A6 DVD).
This video is an updated version of the LA04-A5 DVD and is based off of CLSI document Blood Collection on Filter Paper for Newborn Screening Programs; Approved Standard—Sixth Edition (NBS01-A6). For hundreds of years, newborns who appeared healthy at birth later had severe intellectual or physical disability, or died because their genetic and heritable disorders went undetected and untreated. Thanks to advancing science and...
Thermo Fisher Scientific has developed a high-performance anion-exchange chromatography with pulsed amperometric detection method, based on AOAC Official Method 2011.18, to determine free and bound myo-inositol in infant formula and adult nutritionals.
Application Note (AN) 1083: Determination of Myo-Inositol (Free and Bound as Phosphatidylinositol) in Infant Formula and Adult Nutritionalsdemonstrates a column-switching technique used to remove strongly retained carbohydrates in the sample, thereby reducing run time. Pulsed amperometric detection with a gold on polytetrafluoroethylene disposable electrode offers high sensitivity while eliminating the need for sample derivatization and electrode polishing...
It was recently announced that the Longitude Prize 2014 will focus on the ability to “create a cost-effective, accurate, rapid and easy-to-use test for bacterial infections” to help combat the scourge of antibiotic resistant microbial infection, putting this critical and growing problem under the spotlight again.
The AdvanDx QuickFISH test, exclusively available in the UK from Alpha Laboratories Ltd. could provide a solution. QuickFISH enables a targeted, species specific, antimicrobial therapeutic strategy to be employed much sooner, by enabling species ID to be reported at the same time as the gram stain result. This is especially helpful when dealing with microorganisms that share an identical morphology when viewed under gram stain...
An informative video interview with Professor Steve Conlan of the College of Medicine at Swansea University (UK) highlights the latest research developments in women’s reproductive health using unique molecular biology tools.
d3 Medicine LLC and Viroclinics Biosciences BV announced today that they have signed a non-exclusive Memorandum of Understanding to provide biopharmaceutical customers with an integrated solution to accelerate the preclinical and clinical development of drugs, biologicals, vaccines and diagnostics targeting viral infectious diseases.
The alliance leverages the strengths of the two companies and will offer services that enable biopharmaceutical customers to accelerate virological investigational agents through preclinical and clinical development to market launch. Viroclinics Biosciences will provide a range of preclinical and clinical diagnostic services, including high throughput serology, virology and molecular assays, phenotyping and genotyping in both translational studies and...
As costs for energy and raw materials continue to rise, it becomes more critical for chemists to be able to mimic a reaction or to quantify the parameters required to produce a final product without the difficulty and expense of using production facilities. To be able to recreate a production process on a lab bench is therefore highly desirable for many chemists. The Magritek Spinsolve high-resolution benchtop NMR spectrometer is a...
The UK-based contract research organisation is now supporting the charity across a portfolio of drug substance campaigns covering the development and manufacturing of API for use in clinical trials. Across the range of projects, Cancer Research UK’s Drug Development Office is utilising the contract manufacturing organisation’s (CMO) expertise in: process development, solid-state chemistry, analytical and GMP synthesis of API for use in Phase I clinical trials...
After a first successful round of evaluating GENALICE MAP on speed and quality, both parties agreed to extend the evaluation to include up to 10,000 full human genomes. Population wide analysis is crucial if the potential of whole genome sequencing for medical application in patients with complex diseases is to be realized. Data processing at that level represents a major challenge, however, GENALICE’s unique ability to process a...
The EMA’s Paediatric Committee (PDCO) adopted a positive opinion on the paediatric investigation plan (PIP) for the development of captopril – a drug designed to treat heart failure in children. The adoption of the PIP provides Proveca with an agreed programme for the future development of the drug. It will deliver the required quality, safety and efficacy data needed for a future licence of captopril for children throughout Europe...
The collaboration follows Knowledge Transfer Partnership funding from the UK’s innovation agency, the Technology Strategy Board, which aims to help businesses improve their competitiveness and productivity by capitalising on the UK’s knowledge base. The trial aims to demonstrate PyroPure® technology’s capability of destroying the most thermally resistant Active Pharmaceutical Ingredients and is the last step the firm has to...
These two instruments represent the 100th and 101st benchtop SEM’s installed by Hitachi in the UK, with over 600 now being used around Europe. STFC’s I-TAC initiative provides flexible access to lab space and equipment to over 60 companies working in bioscience, energy, space technologies, advanced materials and chemical engineering. This flexible access has enabled companies to achieve over £80 million in investment, to create over...
Sophia Genetics, the European leader in Data-Driven Medicine, has raised $13.75M in Series B financing in a round led by Dr Mike Lynch’s Invoke Capital, Swisscom and Endeavour Vision. Sophia Genetics is a pioneer in Data-Driven Medicine, a crossover field that requires deep expertise in Next Generation Sequencing (NGS), combined with highly accurate and scalable predictive algorithms to diagnose genetic diseases. With this investment, Sophia gains access to Invoke’s portfolio company Genalys, whose Cambridge-based mathematicians apply big data approaches to...
The U.S. Small Business Administration makes the SBIR award to promote high-tech innovation in the fulfillment of specific research and development needs. The contract awarded to Spectro Scientific for Phase II efforts extends into calendar year 2016. Spectro Scientific undertook the reevaluation effort with the aim of improving the JOAP by modifying processes and/or equipment to create more effective oil analysis. The JOAP was formed following...
Phosphorus is commonly found in many organic compounds, for example in biological membranes or DNA. The 31P nucleus has a 100% natural isotopic abundance and a large chemical shift range, making it one of the most commonly used nuclei in biological NMR. For the first time users can have the power of proton-phosphorus NMR in a benchtop instrument that can be safely used in the laboratory... 
Dr Peter Dunstan is an associate Professor in the Department of Physics at Swansea University and a member of the University’s Centre for Nanohealth. His research utilizes state of the art techniques and instrumentation to increase the fundamental understanding of the structural, chemical, optical and electronic properties of materials on the nanoscale, and by doing so advance the future application of those...
DiaSorin has further expanded its range of infectious disease assays for use on the DiaSorin Liaison® Iam analyser with the launch of a new molecular assay for the rapid and reliable detection and quantification of cytomegalovirus (CMV). CMV is the most prevalent infectious pathogen in solid organ and bone marrow transplant recipients, and can lead to allograft rejection and other serious complications1-5. The DiaSorin Iam CMV assay is used to...
MagSi-Direct provides a convenient and efficient way to attach virtually any biomolecule to nanoscopic paramagnetic beads. It is particularly suited for exploiting interactions between a biomolecule and its binding partners. With MagSi-Direct, you can start with a molecule of interest, attach magnetic beads to it, and then use a magnet to isolate that molecule from any desired reaction mixture, together with any other molecules, complexes, or even intact cells to...
In just three years, over 100 peer-reviewed papers featuring the technology have been published, and with the significant increase in use of RNAscope, ACD has now built a library of over 4000 target probes for numerous species. Probes are designed to order in under two weeks, and in just six months the library has grown by over 1500, reflecting the wide interest in ACD’s breakthrough technology. RNAscope uniquely has the sensitivity to enable...
This video is an updated version of the LA04-A5 DVD and is based off of CLSI document Blood Collection on Filter Paper for Newborn Screening Programs; Approved Standard—Sixth Edition (NBS01-A6). For hundreds of years, newborns who appeared healthy at birth later had severe intellectual or physical disability, or died because their genetic and heritable disorders went undetected and untreated. Thanks to advancing science and...
The AdvanDx 
The alliance leverages the strengths of the two companies and will offer services that enable biopharmaceutical customers to accelerate virological investigational agents through preclinical and clinical development to market launch. Viroclinics Biosciences will provide a range of preclinical and clinical diagnostic services, including high throughput serology, virology and molecular assays, phenotyping and genotyping in both translational studies and...