Porvair Sciences, in conjunction with researchers at Swansea University (UK) have written a new technical article entitled 'Chromatrap® 96: a new solid-state platform for high-throughput Chromatin Immunoprecipitation (ChIP)'
Epigenetics is a fast-growing research area with wide applications, including disease mechanism profiling and personalized medicine strategies. ChIP is crucial to epigenetic research. Published in the latest issue of Nature Methods (11, 2014) the article provides an introduction to Chromatrap® 96 - a high-throughput ChIP analysis platform and demonstrates how it is able to profile up to 96 transcription factors and epigenetic modifications...
New research published in the journal Advanced Functional Materials suggests that graphene-treated nanowires could soon replace current touchscreen technology, significantly reducing production costs and allowing for more affordable, flexible displays.
The majority of today’s touchscreen devices, such as tablets and smartphones are made using indium tin oxide (ITO) which is both expensive and inflexible. Researchers from the University of Surrey and AMBER, the materials science centre based at Trinity College Dublin have now demonstrated how graphene-treated nanowires can be used to produce flexible touchscreens at a fraction of the current cost. Using a simple, scalable and...
20-year study uncovers rising rates of antibiotic failure for common infections - research shows pneumonia and bronchitis are the most stubborn infections to treat.
Over a 22-year period more than one in 10 of all antibiotic treatments in a primary care setting have failed. This rate has increased and continues to rise, according to a new study which analysed almost 11 million antibiotic prescriptions in the UK. Much data has been gathered about antibiotic resistance in hospitals, but virtually nothing is known about the frequency and pattern of antibiotic failure in primary care....
Read MoreNew Methodology for CHN Determination of Liquid SamplesOct 23, 2014
Exeter Analytical has published an application note demonstrating the utility of its Model 440 CHN microanalysis system for precise determination of percentage Carbon, Hydrogen and Nitrogen content of often demanding liquid samples.
The analysis of liquid samples, including volatile liquids, can be done quite easily on the Exeter Analytical Model 440 system without sacrificing accuracy or precision and without the need for expensive liquid autosamplers. The new application note 233 describes how a special liquid sample preparation technique together with controlled introduction of the sealed capsules into the Model 440 eliminates the problems associated with...
Cepheid’s GeneXpert® Infinity System lies at the heart of an innovative, award-winning sexual health screening service in Soho, London. Dean Street Express – run by the Chelsea and Westminster Hospital NHS Foundation Trust – was recently declared the winner of the prestigious Health Service Journal ‘Value in Healthcare Award.
The recently launched CellSep Advanced kit, for use in combination with the Arrow™ Instrument for the automated isolation of up to three cell types directly from whole blood or buffy coat1, was among the new developments revealed to distributors at the Annual DiaSorin Molecular Distributor Meeting held in Bandol, South of France.
As demand for more automated methods for molecular diagnostics and research increases, DiaSorin aims to ensure that its distributors are equipped to meet the evolving needs of customers. The distributors received a range of support materials to help inform and train scientists interested in using CellSep Advanced, including animated films on the use of the Arrow™ Instrument, product literature, and an Application Note from the...
New technique that identifies rare stem cells from bone marrow will give clinicians a fillip in stem-cell treatment of joint, bone and muscle repair.
The research will be published in the journal Proceedings of the National Academy of Sciences this week. A team of scientists and engineers at the Singapore-MIT Alliance for Research and Technology (SMART) have invented a new technique to identify populations of rare stem cells from bone marrow based on their different combinations of biophysical characteristics such as cell size, cell stiffness and nucleus deformation...
greenovation Biotech GmbH and BIOMEVA GmbH announced today the successful production of the world's first GMP (Good Manufacturing Practice)-compliant batch of drug substance manufactured in moss for clinical use.
The drug substance, greenovation's pilot candidate Moss-aGal (recombinant human alpha-galactosidase), is planned to be used for clinical testing as a new generation of enzyme replacement therapy in patients with Fabry disease in the near term. Based on broad experience in the production of proteins for preclinical testing, this production technology has been raised to the next level of successful GMP-manufacturing. The manufacturing of...
Research to confirm clinical utility of PointMan™ and CTC-iChip technologies for non-invasive cancer diagnosis and monitoring.
EKF Diagnostics, the global diagnostics company, announces that it has entered into a two year research collaboration with Massachusetts General Hospital (MGH), a global leader in successfully bridging innovative science with state-of-the-art clinical medicine, to develop PointMan™ assays that can effectively detect treatable cancer mutations in blood samples. The collaboration agreement has been signed following a detailed evaluation of...
The fight against cancer could be aided by new technical advances in filtration and separation technology.
Porvair Filtration Group believes that the evolution of its range of sintered porous plastics can help molecular biologists and clinicians better understand the mechanisms underlying cancer and other diseases. Scientists at the Wrexham division have developed BioVyon™ porous plastic materials which can now be used in a wide variety of medical and pharmaceutical applications to offer better healthcare, improve medical knowledge and help with the diagnosis and treatment of diseases....
There are a number of key advantages of a continuous flow approach to photochemistry over a traditional batch method including consistent light penetration, controlled exposure times, precise temperature control and easy scalability as well as the removal of photochemical products from the irradiated area. Comparing the two methods when it comes to the Photochemical Transformation of Methyl Coumalate reveals the substantial efficiencies and economies that can be accrued from flow chemistry.
GENALICE and Knome, Inc. jointly announced that the Swiss Foundation for People with Rare Diseases has chosen to use their solutions in tandem to improve the Foundation’s processing and analysis of their Next-Generation Sequencing (NGS) data.
GENALICE MAP is an ultra-fast and highly accurate NGS data preprocessing solution and will be connected to Knome’s informatics and genomics interpretation system, the knoSYS® platform. “In the era of high volume NGS data production, a streamlined and affordable pipeline for data processing and analysis is key,” explains Gabor Matyas from the Foundation. “The combination of the solutions of GENALICE and Knome allows our work to...
TAP Biosystems will be co-presenting a new bioprocess webinar with major US contract manufacturing organisation (CMO) Gallus BioPharmaceuticals, on Thursday November 6th 2014 at 4pm GMT /5pm CEST / 8am PST / 11am EST.
The live event will detail how Gallus is using the ambr15™ automated microbioreactor system as a tool for implementing DoE (Design of Experiments) to accelerate biosimilar process development. Bioprocessing experts, Dr. Matt Zustiak, Principal Scientist at Gallus BioPharmaceuticals and Dr. Joanne Swihart, ambr15 Product Specialist at TAP Biosystems, will present data on how the ambr15 micro bioreactor system mimics large-scale cell culture to...
A new application note from AMSBIO, previously presented at both the 2014 Beatson International Cancer conference and the ELRIG Drug Discovery 2014 meeting in Manchester UK, introduces a more predictive and realistic model for early stage drug screening of cancer therapeutics.
The report shows that incorporating vascular and stromal cells with breast cancer tumor spheroids allows them to more closely mimic the extracellular environment, cellular architecture and behaviour of actual tumors; this triculture promotes growth, invasion and endothelial recruitment. Current 2D models for evaluating breast cancer progression do not provide a comprehensive, physiological approach to modeling the...
Use of Picsara will provide a more streamlined and secure approach to the patient journey.
HCA International, providers of world class private hospital care, are to collaborate with Swedish-based medical imaging specialists Mawell to transform the delivery of frontline care, enhance their service to patients and improve clinical safety and security. Launching across all HCA International’s clinical UK sites early next year Picsara, a unique multidisciplinary imaging software solution, will enable medical staff across various specialities to capture, store, distribute, analyse, annotate and measure all non-radiology medical images and videos efficiently and securely to help...
A developer of stem cell organ regenerative medicine which was built on the foundations of a ground breaking operation which saved a ten year old boy’s life has secured funding totalling £3.1m.
Youngster Ciaran Finn-Lynch was critically ill with a rare condition that meant he had a narrow windpipe (trachea) which resulted in difficulties breathing. He had multiple operations, including inserting a metal stent to open his airway but this started to erode and cause life threatening bleeding. Ciaran is alive and well today as he was the lucky recipient of pioneering transplant surgery in 2010 which combined a donor windpipe with...
Freeman Technology has published ‘Choosing a powder tester’, previewed at this year’s Powtech trade fair in Germany, the second in a series of educational guides on powder characterisation for industrial applications.
Following on from the well received ‘An Introduction to Powders’ the new guide provides straightforward guidance on the range of techniques available for powder characterisation. Both booklets are now available to download for free from the new Freeman Technology website. Understanding powder behaviour is essential to ensuring effective product and process performance. Powder testing techniques that allow users to understand and control both the product and manufacturing process therefore deliver substantial value...
Malvern Instruments will contribute a scientific poster at the 2014 Protein-Protein Interaction Conference, October 23-24, Boston, MA, USA.
The poster describes new work on rheological approaches to protein stability studies during biologics formulation and will be presented by Matt McGann, Malvern Instruments Life Science Sales and Application Specialist for the Americas. The study of rheology in protein formulation and biotherapeutic development is considered to be a developing and ultimately essential measurement. The Malvern presentation ‘Characterizing the stability of...
The Clinical and Laboratory Standards Institute (CLSI) has published an updated standard—Evaluation of Precision of Quantitative Measurement Procedures; Approved Guideline—Third Edition (EP05-A3).
This document provides guidance for studies intended to establish the within-site precision performance characteristics of quantitative measurement procedures used in clinical laboratories, and also for studies addressing site-to-site variability. In CLSI document EP05-A3, multiple experimental protocols are described, along with considerations on how to select and optimize the protocol(s) best suited for a specific measurement...
The Pirbright Institute hosted its Centenary Conference at The University of Surrey to mark its 100th anniversary of the prevention and control of livestock infectious diseases and discuss current research into virus diseases of livestock and viruses that spread from animals to humans.
The event showcased the importance, challenges and progress in the control of livestock diseases and zoonoses and gave delegates the opportunity to interact and debate recent advances in the control, epidemiology, virology, immunology and vaccinology of viral diseases of livestock, including poultry, and viral zoonoses. Delegates were also provided with a unique opportunity to tour the Institute’s new state-of the-art high biocontainment laboratory facility, the...
IBA (Ion Beam Applications SA), the world's leading provider of proton therapy solutions for the treatment of cancer, announces that University of Iowa and IBA have signed a research collaboration agreement and a technology license agreement to develop ultra-high precision IMPT(*).
This agreement includes an exclusive license on the Dynamic Collimation System (DCS) recently developed and presented by the University of Iowa at the American Association of Physicists in Medicine (AAPM) meeting in Austin, Texas. The Dynamic Collimation System is an innovative device developed by University of Iowa Carver College of Medicine faculty members(**) to improve dose conformity in IMPT...
Syngene, a world-leading manufacturer of image analysis solutions, today announced its G:BOX Chemi XT4 is being used by scientists at the University of Edinburgh to accurately quantify DNA and proteins from bacteria engineered to produce metal nanoparticles.
This work is contributing to speeding up throughput of research on novel methods of processing toxic metals from contaminated soil. Researchers in the Horsfall Laboratory at the University of Edinburgh in Scotland are using a G:BOX Chemi XT4 multi-application imager to analyse agarose gels of bacterial DNA stained with the green fluorescent dye SafeView™. They are also utilising the G:BOX Chemi XT4 to image SDS-PAGE gels and...
Epigenetics is a fast-growing research area with wide applications, including disease mechanism profiling and personalized medicine strategies. ChIP is crucial to epigenetic research. Published in the latest issue of Nature Methods (11, 2014) the article provides an introduction to Chromatrap® 96 - a high-throughput ChIP analysis platform and demonstrates how it is able to profile up to 96 transcription factors and epigenetic modifications...
The majority of today’s touchscreen devices, such as tablets and smartphones are made using indium tin oxide (ITO) which is both expensive and inflexible. Researchers from the University of Surrey and AMBER, the materials science centre based at Trinity College Dublin have now demonstrated how graphene-treated nanowires can be used to produce flexible touchscreens at a fraction of the current cost. Using a simple, scalable and...
Over a 22-year period more than one in 10 of all antibiotic treatments in a primary care setting have failed. This rate has increased and continues to rise, according to a new study which analysed almost 11 million antibiotic prescriptions in the UK. Much data has been gathered about antibiotic resistance in hospitals, but virtually nothing is known about the frequency and pattern of antibiotic failure in primary care....
The analysis of liquid samples, including volatile liquids, can be done quite easily on the Exeter Analytical Model 440 system without sacrificing accuracy or precision and without the need for expensive liquid autosamplers. The new application note 233 describes how a special liquid sample preparation technique together with controlled introduction of the sealed capsules into the Model 440 eliminates the problems associated with...
'Value and Improvement in the use of Diagnostics’ in recognition of its user-friendly, walk-in sexual health check-up service for symptom-free patients. This fast, effective and modern facility takes advantage of the rapid, sensitive near-patient testing capabilities of Cepheid’s GeneXpert Infinity System to provide results within two to six hours....
As demand for more automated methods for molecular diagnostics and research increases, DiaSorin aims to ensure that its distributors are equipped to meet the evolving needs of customers. The distributors received a range of support materials to help inform and train scientists interested in using CellSep Advanced, including animated films on the use of the Arrow™ Instrument, product literature, and an Application Note from the...
The research will be published in the journal Proceedings of the National Academy of Sciences this week. A team of scientists and engineers at the Singapore-MIT Alliance for Research and Technology (SMART) have invented a new technique to identify populations of rare stem cells from bone marrow based on their different combinations of biophysical characteristics such as cell size, cell stiffness and nucleus deformation...
The drug substance, greenovation's pilot candidate Moss-aGal (recombinant human alpha-galactosidase), is planned to be used for clinical testing as a new generation of enzyme replacement therapy in patients with Fabry disease in the near term. Based on broad experience in the production of proteins for preclinical testing, this production technology has been raised to the next level of successful GMP-manufacturing. The manufacturing of...
EKF Diagnostics, the global diagnostics company, announces that it has entered into a two year research collaboration with Massachusetts General Hospital (MGH), a global leader in successfully bridging innovative science with state-of-the-art clinical medicine, to develop PointMan™ assays that can effectively detect treatable cancer mutations in blood samples. The collaboration agreement has been signed following a detailed evaluation of...
Porvair Filtration Group believes that the evolution of its range of sintered porous plastics can help molecular biologists and clinicians better understand the mechanisms underlying cancer and other diseases. Scientists at the Wrexham division have developed BioVyon™ porous plastic materials which can now be used in a wide variety of medical and pharmaceutical applications to offer better healthcare, improve medical knowledge and help with the diagnosis and treatment of diseases....
There are a number of key advantages of a continuous flow approach to photochemistry over a traditional batch method including consistent light penetration, controlled exposure times, precise temperature control and easy scalability as well as the removal of photochemical products from the irradiated area. Comparing the two methods when it comes to the Photochemical Transformation of Methyl Coumalate reveals the substantial efficiencies and economies that can be accrued from flow chemistry.
GENALICE MAP is an ultra-fast and highly accurate NGS data preprocessing solution and will be connected to Knome’s informatics and genomics interpretation system, the knoSYS® platform. “In the era of high volume NGS data production, a streamlined and affordable pipeline for data processing and analysis is key,” explains Gabor Matyas from the Foundation. “The combination of the solutions of GENALICE and Knome allows our work to...
The live event will detail how Gallus is using the ambr15™ automated microbioreactor system as a tool for implementing DoE (Design of Experiments) to accelerate biosimilar process development. Bioprocessing experts, Dr. Matt Zustiak, Principal Scientist at Gallus BioPharmaceuticals and Dr. Joanne Swihart, ambr15 Product Specialist at TAP Biosystems, will present data on how the ambr15 micro bioreactor system mimics large-scale cell culture to...
Youngster Ciaran Finn-Lynch was critically ill with a rare condition that meant he had a narrow windpipe (trachea) which resulted in difficulties breathing. He had multiple operations, including inserting a metal stent to open his airway but this started to erode and cause life threatening bleeding. Ciaran is alive and well today as he was the lucky recipient of pioneering transplant surgery in 2010 which combined a donor windpipe with...
Following on from the well received ‘An Introduction to Powders’ the new guide provides straightforward guidance on the range of techniques available for powder characterisation. Both booklets are now available to download for free from the new Freeman Technology website. Understanding powder behaviour is essential to ensuring effective product and process performance. Powder testing techniques that allow users to understand and control both the product and manufacturing process therefore deliver substantial value...
The poster describes new work on rheological approaches to protein stability studies during biologics formulation and will be presented by Matt McGann, Malvern Instruments Life Science Sales and Application Specialist for the Americas. The study of rheology in protein formulation and biotherapeutic development is considered to be a developing and ultimately essential measurement. The Malvern presentation ‘Characterizing the stability of...
This document provides guidance for studies intended to establish the within-site precision performance characteristics of quantitative measurement procedures used in clinical laboratories, and also for studies addressing site-to-site variability. In CLSI document EP05-A3, multiple experimental protocols are described, along with considerations on how to select and optimize the protocol(s) best suited for a specific measurement...
The event showcased the importance, challenges and progress in the control of livestock diseases and zoonoses and gave delegates the opportunity to interact and debate recent advances in the control, epidemiology, virology, immunology and vaccinology of viral diseases of livestock, including poultry, and viral zoonoses. Delegates were also provided with a unique opportunity to tour the Institute’s new state-of the-art high biocontainment laboratory facility, the...
This agreement includes an exclusive license on the Dynamic Collimation System (DCS) recently developed and presented by the University of Iowa at the American Association of Physicists in Medicine (AAPM) meeting in Austin, Texas. The Dynamic Collimation System is an innovative device developed by University of Iowa Carver College of Medicine faculty members(**) to improve dose conformity in IMPT...
This work is contributing to speeding up throughput of research on novel methods of processing toxic metals from contaminated soil. Researchers in the Horsfall Laboratory at the University of Edinburgh in Scotland are using a G:BOX Chemi XT4 multi-application imager to analyse agarose gels of bacterial DNA stained with the green fluorescent dye SafeView™. They are also utilising the G:BOX Chemi XT4 to image SDS-PAGE gels and...