Independent committee recognizes significant contributions in plasma spectrochemistry
Thermo Fisher Scientific Inc., the world leader in serving science, today announced the winners of the 2016 Winter Conference Awards in Plasma Spectrochemistry. Selected by an independent awards committee, these industry leading scientists have made noteworthy contributions over time or through a single, significant breakthrough in the field of plasma spectrochemistry. Award winners will be honored during the Winter Plasma Conference in...
Optical Surfaces Ltd has produced a technical information brief that serves to provide an introduction to the company's broad range of capabilities in producing Off-Axis Paraboloids (OAPs).
In addition to supplying these standard specifications, Optical Surfaces technical team is at your disposal to discuss, propose and produce specialised custom OAP's to fulfil the most demanding applications. Off-axis paraboloids, sometimes referred to off-axis parabolic mirrors or off-axis parabola, provide optical designers with an unobstructed aperture allowing complete access to the focal region as well as reducing the size and minimising the weight of a design...
MediSieve founder Dr George Frodsham has secured £350,000 in seed funding to develop his company’s revolutionary magnetic malaria-filter.
George attracted the backing from angel investors with expertise in the medical device and healthcare industries, including leading patent attorneys, former CEOs and successful entrepreneurs in the field. Treatment with MediSieve’s device involves no drugs or chemicals and offers new hope for malaria patients whose cases are severe or resistant to existing medicines. Pre-clinical trials show that the 3D printed magnetic blood filter could extract up...
Chromatrap®, a business unit of Porvair Sciences, has produced an informative new guide entitled ‘Top 10 Tips for ChIP-seq Library Preparation'.
ChIP-sequencing, also known as ChIP-seq, is a method used primarily to determine how transcription factors and other chromatin-associated proteins influence phenotype-affecting mechanisms. Determining how proteins interact with DNA to regulate gene expression is essential for fully understanding many biological processes and disease states. ChIP-seq combines chromatin immunoprecipitation (ChIP) with massively parallel DNA sequencing to identify...
Women with the commonest type of ovarian cancer can safely take hormone replacement therapy (HRT), and it could have a beneficial effect on their survival, a long-term clinical trial reports.
The 24-year, phase III international trial provides the strongest evidence yet that women with epithelial ovarian cancer – which accounts for 80-90 per cent of cases – can safely take HRT during or after their treatment. Several major studies have found that HRT can increase the risk of developing some cancers, which is why there has been such interest in whether it is safe to take during cancer treatment. The new study, published in the Journal of Clinical...
Finding the correct antibody for the study can be costly and time consuming. In the fast paced world of scientific discovery such delays waste precious time and resources.
To help overcome such challenges One World Lab (OWL) – a unique company selling evaluation test size aliquots from multiple original antibody manufacturers – has announced its collaboration with BenchWise, a non-profit online review platform founded by students and researchers from Stanford University; one of the world’s most prestigious teaching institutions. The synergistic collaboration allows researchers to share their knowledge and experience of antibodies purchased through OWL, to ultimately help fellow scientists save time and money....
European Mass Spec/Chromatography Sales and Service Company KRSS Ltd have entered into a collaboration with the University of East Anglia/Norwich Medical School leading to the opening of a clinical application support laboratory in KRSS’s new 17,000sq ft. state-of-the art facility based in Runcorn, Cheshire.
The new facility will initially target clinical applications such as Total/Free Urinary and Plasma Metanephrines, Catecholamines, Vitamin D, Female Testosterone (Androgens), Steroids and Therapeutic Drugs. KRSS customers will have access to technical support from a Clinical applications team, headed up by John Dutton and Professor Bill Fraser of UEA, who have over 60 years’ experience in clinical laboratories. The agreement will benefit from the technical...
PETA US Expands Successful Million-Dollar Donation Programme That Saves Animals and Improves Medical Training
A PETA US donation of $1 million (£657k) in high-tech simulators will modernise physician-training programmes in seven countries and spare the lives of thousands of animals in Europe, the Middle East and Asia. Through a landmark partnership with Seattle-based medical simulation manufacturer Simulab – and with the support of PETA Germany, the McGrath Family Foundation and Cathay Pacific Airways – PETA US has donated 40 state-of-the-art...
The first clinical trials introducing electrospinning technology to address the loss of vision due to scarring of the cornea have been approved to take place in the LVPrasad eye clinic in India.
Membranes used in these initial trials will be produced by the UK’s Electrospinning Company that specialise in manufacturing materials for use in regenerative medicine. After 4 years of collaboration between organisations in India and the UK, led by the university of Sheffield, the Electrospinning Company can announce trials will begin in India in Autumn 2015, involving 10 patients whom have sustained an eye injury, primarily through either industrial...
Syngene, a world-leading manufacturer of image analysis solutions is delighted to announce that the G:BOX Chemi XRQ high resolution, multi-application image analysis system is being successfully used at the Lithuanian University of Health Sciences Academy of Medicine to study molecular mechanisms of cardiac stem cell function which could help in developing stem cell therapies for heart repair.
Researchers in the Laboratory of Cell Culture at the Lithuanian University of Health Sciences Academy of Medicine are utilising the easy-to-use G:BOX Chemi XRQ system to image and analyse proteins on chemiluminescent Western blots and DNA gels stained with SYBR® Safe dyes. The image analysis data is being used to investigate the effects that genetic modification have on how stem cells differentiate into cardiac myocytes and integrate into cardiac...
Scientists know that most cancer cells use glucose to fuel their uncontrolled growth and now an international team of researchers has identified a protein which if switched off could stop the disease in its tracks.
Explained lead academic Dr Concetta Bubici from Brunel University London: “The protein PARP 14 is over-produced in virtually every human cancer but not in normal cells. “What we have discovered is that its role in cancer is to allow cells to harness glucose in a different way from healthy ones which in turn powers their rapid, uncontrolled growth while also protecting them from the normal cycle of programmed cell death. “Almost all cells in the human body...
Boehringer Ingelheim and BioMed X announced today that they have successfully applied a crowdsourcing approach to establish a research team of outstanding scientists from around the world with bright ideas, who will endeavor to identify new approaches for the treatment of patients with chronic obstructive pulmonary disease (COPD).
COPD is a chronic, progressive, treatable but incurable lung disease affecting 210 million people worldwide. It is a growing world health priority and is predicted to become the 3rd leading cause of death by 2030. Boehringer Ingelheim has been a leader in the treatment of respiratory disease for over 90 years and continues to explore a pipeline of unique compounds to help patients with COPD, asthma, idiopathic pulmonary fibrosis (IPF), lung cancer...
Chromatrap®, a business unit of Porvair Sciences, has produced an informative new guide entitled ‘Top 10 Tips for ChIP-seq Library Preparation'.
ChIP-sequencing, also known as ChIP-seq, is a method used primarily to determine how transcription factors and other chromatin-associated proteins influence phenotype-affecting mechanisms. Determining how proteins interact with DNA to regulate gene expression is essential for fully understanding many biological processes and disease states. ChIP-seq combines chromatin immunoprecipitation (ChIP) with massively parallel DNA sequencing to identify...
AstraZeneca today announced updated data on AZD9291 in first-line patients with epidermal growth factor receptor mutation (EGFRm) positive advanced non-small cell lung cancer (NSCLC) and previously-treated patients with EGFRm T790M mutation-positive NSCLC.
The data being presented today at the World Conference on Lung Cancer (WCLC) 2015 were from the AURA Phase I trial first-line cohort and two AURA Phase II studies. Data demonstrated that in 60 patients who received AZD9291 once daily in the first-line setting, 72% (95% confidence interval (CI) 58% to 82%) were progression free (PFS) at 12 months. Confirmed overall response rate (ORR) was 75% (95% CI 62% to 85%). The longest duration of...
MIP Diagnostics recognised at Europe’s flagship Drug Discovery conference
A technology developed at the University of Leicester, and the prime focus of Leicester spin-out company MIP Diagnostics, has been recognised as ‘most commercially viable’ at Europe’s flagship Drug Discovery event. The annual ELRIG Drug Discovery conference, held at the Telford International Centre in September, is the largest Drug Discovery conference in Europe and featured a ‘Dragons’ Den’ competition. The coveted trophy is awarded to...
Haydale, a leader in the development of enhanced graphene and nanoparticulate materials, has announced that its composites division, Haydale Composite Solutions Ltd (HCS), has signed a letter of intent to start a joint development and commercialisation agreement with Huntsman Advanced Materials (Switzerland) GmbH (Huntsman), a leading global manufacturer of epoxy, acrylic and polyurethane based polymer products.
As part of agreement Haydale will functionalise Graphene Nano Platelets (GNPs) using its proprietary HDPlas® process and add them to Huntsman's ARALDITE® resins to create a highly loaded masterbatch. Under the proposed agreement, it is anticipated that Huntsman and HCS will develop and validate the use of GNPs in ARALDITE® epoxy resins, using HCS's proprietary HDPlas® process. The ultimate objective of the collaboration will be to commercialise graphene enhanced ARALDITE® resins for...
New whitepaper demonstrates how customisable, medically focused array designs complement NGS for clinical genetics research
Oxford Gene Technology (OGT), The Molecular Genetics Company, has been speaking to genetic scientists, Dr Tracey Lewis (Associated Regional and University Pathologists [ARUP] Laboratories) and Dr Emily Farrow (Children’s Mercy Hospital), in a new whitepaper entitled “Examining the Medical Exome”. This whitepaper describes their experiences with OGT’s CytoSure™ Medical Research Exome Array and explores how this customisable array targets a variety of genetic disorders to...
Specialised Imaging has updated and expanded its resources web page for scientists and engineers interested in or involved with ultra high-speed imaging.
The company's comprehensive range of high resolution framing cameras, trajectory trackers, still cameras, image intensifiers and accessories open the door to exciting discoveries, ground breaking research and new measurement solutions in a wide range of applications areas. Visitors to the website are given open access to an informative bibliography of research articles, application notes, video clips and still images...
Research by a Northumbria academic could have a significant impact on the teaching of chemistry after he developed a radical new interpretation of a 99-year-old rule featured in all standard textbooks.
Dr Marcus Durrant, a Reader in Northumbria?s Department of Applied Sciences, realised that the treatment of hypervalency in the Lewis theory of chemical bonding was flawed while he was teaching the theory to students. The Lewis model, which was first published in 1916, features in every elementary chemistry textbook and has been taught to generations of chemists. It states that a nitrogen atom cannot have five covalent bonds, as this would...
Courses offered at beginner and intermediate levels
Pittcon is pleased to announce the 2016 Short Courses . (March 5-10). Courses, offered at beginner and intermediate levels, range from one-half day up to two-days. With more than 100 from which to choose, there are a wide variety of classes covering relevant analytical topics in food science, water/wastewater, environmental, life science, pharmaceutical to name a few. Courses for broad-based application and general lab functions include lab management...
BRD4 inhibitors are among the most promising new agents in cancer therapy that are currently evaluated in clinical trials.
In a study published in NATURE today, a team of researchers at the Research Institute of Molecular Pathology (IMP) and Boehringer Ingelheim in Vienna reveals how leukemia cells can evade the deadly effects of BRD4 inhibition. Understanding this adaptation process could aid the development of sequential therapies to outsmart resistant leukemias. Over the past years, scientists have drawn an almost complete map of mutations in cancer. However, translating complex genetic knowledge into effective...
Greenovation Biotech GmbH announced today that it has received approval to begin a phase I clinical trial in Europe for its first drug candidate moss-aGal (agalsidase) from Germany's regulatory authority, the Federal Institute for Drugs and Medical Devices (BfArM).
Moss-aGal, a recombinant form of human alpha galactosidase, has been developed by Greenovation as an enzyme replacement therapy (ERT) for patients with the genetic lysosomal storage disorder Fabry disease. Greenovation has used its proprietary BryoTechnology, an innovative moss gene expression system, to express the moss-aGal protein in Physcomitrella patens. The technology attaches mannose molecules to the surface of the moss aGal protein...
Thermo Fisher Scientific Inc., the world leader in serving science, today announced the winners of the 2016 Winter Conference Awards in Plasma Spectrochemistry. Selected by an independent awards committee, these industry leading scientists have made noteworthy contributions over time or through a single, significant breakthrough in the field of plasma spectrochemistry. Award winners will be honored during the Winter Plasma Conference in...
In addition to supplying these standard specifications, Optical Surfaces technical team is at your disposal to discuss, propose and produce specialised custom OAP's to fulfil the most demanding applications. Off-axis paraboloids, sometimes referred to off-axis parabolic mirrors or off-axis parabola, provide optical designers with an unobstructed aperture allowing complete access to the focal region as well as reducing the size and minimising the weight of a design...
George attracted the backing from angel investors with expertise in the medical device and healthcare industries, including leading patent attorneys, former CEOs and successful entrepreneurs in the field. Treatment with MediSieve’s device involves no drugs or chemicals and offers new hope for malaria patients whose cases are severe or resistant to existing medicines. Pre-clinical trials show that the 3D printed magnetic blood filter could extract up...
ChIP-sequencing, also known as ChIP-seq, is a method used primarily to determine how transcription factors and other chromatin-associated proteins influence phenotype-affecting mechanisms. Determining how proteins interact with DNA to regulate gene expression is essential for fully understanding many biological processes and disease states. ChIP-seq combines chromatin immunoprecipitation (ChIP) with massively parallel DNA sequencing to identify...
The 24-year, phase III international trial provides the strongest evidence yet that women with epithelial ovarian cancer – which accounts for 80-90 per cent of cases – can safely take HRT during or after their treatment. Several major studies have found that HRT can increase the risk of developing some cancers, which is why there has been such interest in whether it is safe to take during cancer treatment. The new study, published in the Journal of Clinical...
The new facility will initially target clinical applications such as Total/Free Urinary and Plasma Metanephrines, Catecholamines, Vitamin D, Female Testosterone (Androgens), Steroids and Therapeutic Drugs. KRSS customers will have access to technical support from a Clinical applications team, headed up by John Dutton and Professor Bill Fraser of UEA, who have over 60 years’ experience in clinical laboratories. The agreement will benefit from the technical...
A PETA US donation of $1 million (£657k) in high-tech simulators will modernise physician-training programmes in seven countries and spare the lives of thousands of animals in Europe, the Middle East and Asia. Through a landmark partnership with Seattle-based medical simulation manufacturer Simulab – and with the support of PETA Germany, the McGrath Family Foundation and Cathay Pacific Airways – PETA US has donated 40 state-of-the-art...
Membranes used in these initial trials will be produced by the UK’s Electrospinning Company that specialise in manufacturing materials for use in regenerative medicine. After 4 years of collaboration between organisations in India and the UK, led by the university of Sheffield, the Electrospinning Company can announce trials will begin in India in Autumn 2015, involving 10 patients whom have sustained an eye injury, primarily through either industrial...
Researchers in the Laboratory of Cell Culture at the Lithuanian University of Health Sciences Academy of Medicine are utilising the easy-to-use G:BOX Chemi XRQ system to image and analyse proteins on chemiluminescent Western blots and DNA gels stained with SYBR® Safe dyes. The image analysis data is being used to investigate the effects that genetic modification have on how stem cells differentiate into cardiac myocytes and integrate into cardiac...
Explained lead academic Dr Concetta Bubici from Brunel University London: “The protein PARP 14 is over-produced in virtually every human cancer but not in normal cells. “What we have discovered is that its role in cancer is to allow cells to harness glucose in a different way from healthy ones which in turn powers their rapid, uncontrolled growth while also protecting them from the normal cycle of programmed cell death. “Almost all cells in the human body...
COPD is a chronic, progressive, treatable but incurable lung disease affecting 210 million people worldwide. It is a growing world health priority and is predicted to become the 3rd leading cause of death by 2030. Boehringer Ingelheim has been a leader in the treatment of respiratory disease for over 90 years and continues to explore a pipeline of unique compounds to help patients with COPD, asthma, idiopathic pulmonary fibrosis (IPF), lung cancer...
ChIP-sequencing, also known as ChIP-seq, is a method used primarily to determine how transcription factors and other chromatin-associated proteins influence phenotype-affecting mechanisms. Determining how proteins interact with DNA to regulate gene expression is essential for fully understanding many biological processes and disease states. ChIP-seq combines chromatin immunoprecipitation (ChIP) with massively parallel DNA sequencing to identify...
The data being presented today at the World Conference on Lung Cancer (WCLC) 2015 were from the AURA Phase I trial first-line cohort and two AURA Phase II studies. Data demonstrated that in 60 patients who received AZD9291 once daily in the first-line setting, 72% (95% confidence interval (CI) 58% to 82%) were progression free (PFS) at 12 months. Confirmed overall response rate (ORR) was 75% (95% CI 62% to 85%). The longest duration of...
A technology developed at the University of Leicester, and the prime focus of Leicester spin-out company MIP Diagnostics, has been recognised as ‘most commercially viable’ at Europe’s flagship Drug Discovery event. The annual ELRIG Drug Discovery conference, held at the Telford International Centre in September, is the largest Drug Discovery conference in Europe and featured a ‘Dragons’ Den’ competition. The coveted trophy is awarded to...
As part of agreement Haydale will functionalise Graphene Nano Platelets (GNPs) using its proprietary HDPlas® process and add them to Huntsman's ARALDITE® resins to create a highly loaded masterbatch. Under the proposed agreement, it is anticipated that Huntsman and HCS will develop and validate the use of GNPs in ARALDITE® epoxy resins, using HCS's proprietary HDPlas® process. The ultimate objective of the collaboration will be to commercialise graphene enhanced ARALDITE® resins for...
Oxford Gene Technology (OGT), The Molecular Genetics Company, has been speaking to genetic scientists, Dr Tracey Lewis (Associated Regional and University Pathologists [ARUP] Laboratories) and Dr Emily Farrow (Children’s Mercy Hospital), in a new whitepaper entitled “Examining the Medical Exome”. This whitepaper describes their experiences with OGT’s CytoSure™ Medical Research Exome Array and explores how this customisable array targets a variety of genetic disorders to...
The company's comprehensive range of high resolution framing cameras, trajectory trackers, still cameras, image intensifiers and accessories open the door to exciting discoveries, ground breaking research and new measurement solutions in a wide range of applications areas. Visitors to the website are given open access to an informative bibliography of research articles, application notes, video clips and still images...
Dr Marcus Durrant, a Reader in Northumbria?s Department of Applied Sciences, realised that the treatment of hypervalency in the Lewis theory of chemical bonding was flawed while he was teaching the theory to students. The Lewis model, which was first published in 1916, features in every elementary chemistry textbook and has been taught to generations of chemists. It states that a nitrogen atom cannot have five covalent bonds, as this would...
Pittcon is pleased to announce the 2016 Short Courses . (March 5-10). Courses, offered at beginner and intermediate levels, range from one-half day up to two-days. With more than 100 from which to choose, there are a wide variety of classes covering relevant analytical topics in food science, water/wastewater, environmental, life science, pharmaceutical to name a few. Courses for broad-based application and general lab functions include lab management...
In a study published in NATURE today, a team of researchers at the Research Institute of Molecular Pathology (IMP) and Boehringer Ingelheim in Vienna reveals how leukemia cells can evade the deadly effects of BRD4 inhibition. Understanding this adaptation process could aid the development of sequential therapies to outsmart resistant leukemias. Over the past years, scientists have drawn an almost complete map of mutations in cancer. However, translating complex genetic knowledge into effective...
Moss-aGal, a recombinant form of human alpha galactosidase, has been developed by Greenovation as an enzyme replacement therapy (ERT) for patients with the genetic lysosomal storage disorder Fabry disease. Greenovation has used its proprietary BryoTechnology, an innovative moss gene expression system, to express the moss-aGal protein in Physcomitrella patens. The technology attaches mannose molecules to the surface of the moss aGal protein...