ASIR Purification system from Dynamic Extractions Standard Impurity isolation
Sep 22, 2011In medicinal chemistry a challenging aspect to preparing compounds for testing, as lead molecules, can be their isolation from the crude reaction mixture that may contain catalysts, salts, metals, and other components which interfere with traditional purification methods. One such problematic compound is triphenylphosphine oxide (TPPO). TPPO is notoriously difficult and time consuming to remove using standard solid phase chromatography methods. In this example a standard HPCCC method has been developed that targets TPPO, regardless of the compound of interest's polarity...
In medicinal chemistry a challenging aspect to preparing compounds for testing, as lead molecules, can be their isolation from the crude reaction mixture that may contain catalysts, salts, metals, and other components which interfere with traditional purification methods. One such problematic compound is triphenylphosphine oxide (TPPO). TPPO is notoriously difficult and time consuming to remove using standard solid phase chromatography methods. In this example a standard HPCCC method has been developed that targets TPPO, regardless of the compound of interest's polarity...