Vapourtec has developed the Peptide-Builder, a fully automated, high throughput, benchtop peptide synthesiser, which was launched at the recent TIDES Europe event in Hamburg.

Incorporating Vapourtec’s disruptive Variable Bed Flow Reactor (VBFR) technology, it dramatically improves cycle efficiency and reduces solvent consumption.

Based on customer feedback, the Peptide-Builder is designed to be the smallest high throughput synthesiser available, delivering more peptides per square meter of lab space, whilst keeping reagent consumption low.

The flexible scale of the synthesiser ranges from 0.05 mmol to 1 mmol and is compatible with any type of resin.

Operating in a sequential way, one GLP-1 analogue can be synthesized in under four hours and 16 analogues over a weekend.

Vapourtec’s Dr Manuel Nuño explained: “This new synthesizer features intuitive software developed in collaboration with major pharma companies. Just type the sequence and amount of resin, press ‘run’ and walk away.”

The technology ensures minimal consumption of reagents (< 3 equivalents of AA) and solvents (< 80 ml / mmol / cycle) and provides rapid and efficient solvent exchange enabling automated addition of side chains.

Unique insights into synthesis, including detailed analysis of aggregation events and quantification of Fmoc group removal, are provided in a report at the conclusion of synthesis.

“The disruptive VBFR technology makes this synthesiser a game-changer for peptide synthesis by improving efficiency, optimising workflows and reducing space requirements,” concluded Manuel.

About Vapourtec

Vapourtec is the world’s leading manufacturer of laboratory scale flow chemistry instruments. Founded in 2003, the company has been at the forefront of the flow chemistry industry ever since.

Headquartered near Cambridge, UK, Vapourtec design and manufacture the R-Series and E-Series flow chemistry systems together with an exciting range of innovative fast-flow peptide synthesisers. Vapourtec instruments have empowered chemists throughout the world to further scientific discovery.

Trusted by scientists, chemists and fine chemical manufacturers around the world, the modular R-Series system has revolutionized the way many deliver the research, chemicals and products we all rely on. With an installation base of more than 750 instruments, resulting in being cited in over 1000 peer reviewed scientific publications, Vapourtec continues to support customers across the globe with world-class products and services.

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