New instrument provides greater sensitivity to enable additional applications for discovery and characterization of novel therapeutics with unrivalled throughput and efficiency

Carterra Inc., the world leader in innovative technologies enabling high-throughput biology, launched its latest HT-SPR instrument, the LSA^XT, at the Society for Laboratory Automation and Screening (SLAS) Conference and Exhibition in San Diego, CA. The LSA^XT brings augmented sensitivity to Carterra’s highly successful LSA platform enabling additional applications throughout drug discovery and development at throughput levels unseen in any other instrument. Carterra are showcasing the new LSA^XT platform for high-throughput SPR at the SLAS event (booth 2127) with a launch program that includes a user presentation by Dragonfly Therapeutics.

The LSA^XT instrument boasts additional hardware and software features that build upon the capabilities of Carterra’s original and highly successful LSA instrument while maintaining its impressive throughput and sample efficiency. The LSA delivers 100 times the data in 10% of the time-to-answer and uses 1% of the sample required by other label-free platforms. The LSA^XT enables an expanded range of applications that include some of the most exciting and growing areas in drug discovery such as proteolysis-targeting chimeras (PROTAC®s), membrane proteins, DNA-Encoded Library (DEL) compounds, and rapid kinetic systems such as cytokines, protein-protein inhibitors, and Fc gamma receptors. Additionally, the increased performance in the LSA^XT allows measurement of lower molecular weight analytes including kinase inhibitors.  

Since its launch in 2018, Carterra’s LSA antibody discovery and characterization platform has penetrated 19 of the largest 20 pharmaceutical companies, CROs, and biotechs on four continents. Characterizing binding kinetics and epitope coverage of large numbers of antibodies early in the drug discovery process has been transformative. The speed at which antibodies can now be identified and characterized as candidate therapeutics has vastly improved compared to traditional methods. The LSA platform has been profiled in multiple Science, Nature, and Cell peer-reviewed papers, one of which profiled the development of a novel monoclonal antibody therapeutic, bamlanivimab, which was the world’s first COVID-19 therapeutic and the fastest biologic ever to reach clinical trials thanks to Eli Lilly and AbCellera.

At SLAS, scientists from Dragonfly Therapeutics will discuss the benefits of running the Fc gamma receptor (FcγR) binding application which is a critical component of ADCC, ADCP, and CDC and an important feature to measure in Fc-containing molecules. Data will be presented showcasing the ability to characterize a full panel of biotinylated FcγRs now possible with the Carterra LSA^XT’s throughput and greater flexibility, resulting in significantly faster time to results and sample efficiency than currently available 8-channel biosensor instruments in the market.

Speaking about the launch of the LSA^{XT a}t SLAS 2023, Christopher Silva, Vice President of Marketing and Product at Carterra added, “This is a great day for biologics discovery scientists and for Carterra. You always run the risk of missed expectations when you launch a follow-on product after a game changer like the LSA. But we’ve proved that with the LSA^XT the story only gets better for us and our customers.”

About Carterra, Inc.

Carterra® is privately held and is the leading provider of high-throughput technologies designed to accelerate and improve the discovery of novel therapeutic candidates. Carterra’s LSA® instrument, software, and consumables for biotherapeutic discovery and characterization deliver up to 100 times the throughput of existing platforms in 10% of the time while using only 1% of the sample required by other systems. The LSA combines patented microfluidics technology with real-time high-throughput Surface Plasmon Resonance (HT-SPR) and industry-leading data analysis and visualization software to revolutionize mAb screening. The new LSA^XT provides enhanced optics to enable additional applications in biotherapeutic discovery and characterization. Carterra, Inc. is based in Salt Lake City, Utah, and has Customer Experience Centers in San Francisco, Salt Lake City, Boston, Manchester, England, and Munich, Germany. Carterra products are available in Asia-Pacific and Oceania through our exclusive distributor, PerkinElmer.