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Beckman Coulter’s Interleukin-6 test is now available for use in helping identify severe inflammatory response in COVID-19 patients

publication date: Mar 19, 2021
 | 
author/source: Beckman Coulter Europe/International

beckman-coulters-interleukin6-test-now-available-use

 

IL-6 assay aids in care management by determining patients at risk for intubation with mechanical ventilation

Beckman Coulter has announced that it has expanded claims for its CE-marked Access Interleukin-6 (IL-6) assay. The Access IL-6 assay is an in-vitro diagnostic test for the quantitative determination of IL-6 levels in human serum and plasma (heparin). The fully-automated assay helps physicians identify a severe inflammatory response in COVID-19 patients, often referred to as cytokine storm, and determine the risk of intubation with mechanical ventilation, in conjunction with clinical findings and the results of other laboratory testing.

At the beginning of the pandemic, information about the pathophysiology of SARS-CoV-2 led the Laboratory of Clinical Biochemistry (Laboratori Clínic Metropolitana Nord) together with the Emergency Department at Germans Trias i Pujol University Hospital in Badalona, Spain to search for biomarkers that could potentially predict severe responses to COVID-19, such as a cytokine storm.

Carme Garcia Martin, MD and Cristian Morales Indiano, MD of the Laboratory of Clinical Biochemistry (Laboratori Clínic Metropolitana Nord, at Campus Can Ruti in Badalona) said, “The results obtained showed that, when assessed alongside other laboratory results and a patient's medical history, IL-6 values higher than 35 pg/mL correlated with greater clinical severity and the need for invasive mechanical ventilation in patients with SARS-CoV-2. As a result of the studies carried out and the experience gained, we believe that a patient’s IL-6 level is a good indicator of COVID-19 severity, as the values reflect the exaggerated immune response in these types of patients.”

Several large studies1,2,3 have shown that IL-6, a multifunctional cytokine that promotes inflammation in certain clinical conditions, is a strong predictor of respiratory failure and death in COVID-19 patients. Identifying and treating hyperinflammation can help physicians plan resources and determine the best patient care pathway4.

“Our goal is to save lives and help avoid the need for intensive treatments, and we can do that by keeping patients off ventilators, which can ease the recovery for COVID-19 patients" said Shamiram R. Feinglass, MD, MPH, chief medical officer for Beckman Coulter. “This is a significant advance in the treatment of COVID-19. We expect it may obviate the need for and consequences of invasive mechanical ventilation for some patients, while also lowering costs for the health system and improving resource allocation, factors that have often not met the current high demand.”

 

 

Learn more about the Access IL-6 assay

 

About Beckman Coulter

Beckman Coulter is committed to advancing healthcare for every person by applying the power of science, technology and the passion and creativity of our teams to enhance the diagnostic laboratory’s role in improving healthcare outcomes. Our diagnostic systems are used in complex biomedical testing, and are found in hospitals, reference laboratories and physician office settings around the globe. Beckman Coulter offers a unique combination of people, processes and solutions designed to elevate the performance of clinical laboratories and healthcare networks. We do this by accelerating care with a menu that matters, bringing the benefit of automation to all, delivering greater insights through clinical informatics and unlocking hidden value through performance partnerships. An operating company of Danaher Corporation (NYSE: DHR) since 2011, Beckman Coulter is headquartered in Brea, California, and has more than 11,000 global associates working diligently to make the world a healthier place.

 

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