New Advancement Builds on 25-Year Commitment to T-Cell Research

Beckman Coulter Life Sciences, a global leader in laboratory automation and innovation, continues to lead the way with first-to-market concepts to help laboratories achieve goals faster and with greater accuracy. The company announces it has developed the first commercially available anti-TRBC2 conjugated antibody for flow cytometry, providing greater clarity to clinical researchers in the identification of T-cell neoplasms in areas including cancer research.

Traditional approaches to identify clonal T-cell expansion have been complex and challenging, relying on the assessment of abnormal antigen expression, which is often difficult to clearly identify and can overlap with reactive T-cell subsets. B-cells can offer a richer and more simplistic solution, with the detection of clonal B-cell expansion enabled by the staining of both surface kappa and lambda immunoglobulin light chains utilizing flow cytometry.

The TCR constant β chains 1 and 2, or TRBC1 and TRBC2, are randomly selected during T-cell development in the thymus and are mutually exclusive. Normal T-cell populations include a mix of the two, while clonal populations include only one. TRBC1 and TRBC2 staining using flow cytometry offers a low-cost, rapid, and specific T-cell clonality test. Both can be conjugated to any dye in the Beckman Coulter Life Sciences portfolio through Custom Design Services either as a standalone conjugated antibody, or part of liquid or dry custom panels.

“Beckman Coulter Life Sciences has been committed to T-cell research for more than 25 years as we launched our Beta Mark TCR Vβ Repertoire Kit, and we’ve aggressively continued to innovate and raise the bar with solutions for this pioneering method to help labs ensure greater accuracy with fewer touchpoints,” said Pietro Lopriore, Vice President and General Manager of the Flow Cytometry Business Unit. “This advancement creates a revolutionary step forward in reducing complexities while providing clearer results in the important area of T-cell cancer research.”

Currently for Research Use Only (RUO), the company is pursuing development of a diagnostic version for commercial availability. Laboratory staff may request a free sample with demonstration
 

 
About Beckman Coulter Life Sciences

Life sciences. Research. Precision manufacturing. If your life’s calling is in any of these or related fields, you need to know Beckman Coulter Life Sciences. Our mission is to empower those seeking answers to life’s important scientific and healthcare questions. Since 1935, the Beckman name has been synonymous with technologies that simplify and automate complex biomedical testing. Decades later, our global organization also came to embody the scientific legacy of the Coulter name. Today, Beckman Coulter Life Sciences is a trusted, worldwide resource for tools to help optimize research and manufacturing efficiency. Centrifuges. Particle counters/analyzers. Automated liquid handlers. Flow cytometers. Genomic reagents. All these products—and many more—continue to make a difference in people’s lives by improving the productivity of dedicated scientists, quality control experts and others. Wherever people need answers, from prestigious universities and major pharmaceutical companies, to small biotech startups, food/beverage and electronics manufacturing facilities, you can find Beckman Coulter Life Sciences.

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