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R&D 100 Award for Super-Resolution Microscope from Leica Microsystems

Leica SR GSD

Leica SR GSD Convinces Jury with Unprecedented Performance in Fluorescence Microscopy

The Leica SR GSD is a winner of the R&D100 Award, granted by R&D Magazine for outstanding technical developments. It is the 50th anniversary of this prestigeous award. Leica Microsystems was honored together with the Max Planck Institute for Biophysical Chemistry in Göttingen for the development of this ground-breaking widefield super-resolution microscope.

Superlative resolution and reliability

Launched in August 2011, this microscope system achieves resolutions far below the limit of diffraction never attained before in a commercial widefield fluorescence microscope. The Leica SR GSD is capable of resolving details as small as 20 nanometers. This provides the resolution to image single proteins and biomolecules in cells to observe molecular processes. The Leica SR GSD is based on GSDIM technology (Ground State Depletion followed by Individual Molecule return) developed by Professor Stefan Hell at the Max Planck Institute). One of the key advantages of the GSDIM method over other localization techniques is that it can be used with standard fluorescence labels routinely applied in biomedical research.

The Leica SR GSD is not only remarkable for offering higher resolution than previously possible, but also for its efficiency. One example is the novel SuMo Stage (Supressed Motion Stage) that ensures minimal (sub resolution) drift. Besides gaining unprecedented accuracy in localization of molecules, the user of a Leica SR GSD also sees the super-resolution image during acquisition - with no post-processing or need of fiducial markers.

More information on the super-resolution systems of Leica Microsystems can be found at

"This is a great honor for the entire team and rewards the outstanding quality and unique performance of our super-resolution systems, which help in uncovering and answering new scientific questions," comments Sebastian Tille, Head of ‘Widefield Imaging' at Leica Microsystems' Life Science Division. "The fact that this is already the third time this year that the Leica SR GSD was selected for an award nominated by an international panel of experts is further evidence of its truly innovative character."

Based on many years of experience and success with the confocal super-resolution technologies of STED and STED CW, Leica Microsystems has again set new standards in nanoscopy with the Leica SR GSD. The company has continued its series of innovations with the new Leica gated STED - a patented technology for enhanced confocal super-resolution based on the temporal properties of STED fluorescence emission.

R&D 100 Awards - Benchmark of Excellence

Since 1963, the R&D 100 Awards have annually identified revolutionary technologies newly introduced to the market. The hundred award winners are selected by an independent panel of judges and the editors of the US-American R&D Magazine. Many of the winning products and technologies have helped to shape everyday lives, such as the automated teller machine (1973), the fax machine (1975), and HDTV (1998). The R&D 100 Awards have long been a benchmark of excellence for industry sectors as diverse as biotechnology, telecommunications, software and manufacturing. The winners represent a cross-section of industry, academia, private research firms, and government labs. The R&D Magazine has published a full list of this year's winners on its website

About Leica Microsystems

Leica Microsystems is a world leader in microscopes and scientific instruments. Founded as a family business in the nineteenth century, the company's history was marked by unparalleled innovation on its way to becoming a global enterprise.

Its historically close cooperation with the scientific community is the key to Leica Microsystems' tradition of innovation, which draws on users' ideas and creates solutions tailored to their requirements. At the global level, Leica Microsystems is organized in three divisions, all of which are among the leaders in their respective fields: the Life Science Division, Industry Division and Medical Division.

The company is represented in over 100 countries with 6 manufacturing facilities in 5 countries, sales and service organizations in 20 countries and an international network of dealers. The company is headquartered in Wetzlar, Germany.

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