publication date: May 17, 2012
|
author/source: Alto Marketing Limited

Plexpress, developer of the
innovative TRAC platform for high-throughput gene expression analysis, has announced
a new collaboration with the contract research organisation (CRO),
Admescope, which will now
include TRAC as part of its services for investigating
in vitro drug
interactions and pre-clinical ADME-Tox responses. Admescope customers can now
take advantage of the benefits offered by Plexpress' novel
TRAC (Transcript Analysis with the aid
of Affinity Capture) technology. These include higher sample
throughput, increased assay speed and reduced technical variation when compared
to similar gene expression analyses undertaken using qPCR or microarrays. In
the first instance, Admescope will offer
Plexpress'
well-validated multiplex assays targeting the Cytochrome P450 (CYP) family,
which can be used as an insightful indicator of potential drug toxicity and
efficacy. The new service is particularly well suited to meeting recent
draft
recommendations from the FDA, which suggest that CYP mRNA analysis
might be more informative for drug metabolism studies than measuring CYP
activity (1).
For more information about
how TRAC could boost the efficiency of your drug discovery pipeline, please
visit
www.plexpress.com. For more
information about the new Admescope services utilising TRAC, please email
info@admescope.com or
view the
detailed TRAC announcement on the Admescope website.
Reference:
1.
FDA Guidance for Industry Report (Feb 2012):
Drug
Interaction Studies Study Design, Data Analysis, Implications for Dosing, and
Labeling Recommendations
About Plexpress
Plexpress was established as a spinoff from the Finnish
Technology Research Center VTT in 2007. Including R&D at VTT, the company's
TRAC technology has been developed continuously for nearly 10 years and it has
been documented in over 15 publications. The technology was originally
developed for demanding bioprocess applications, which required a very robust
solution for gene expression analysis. Since starting operations in 2008, the
company has carried out over 50 projects using the TRAC technology in the fields
of pharmaceutical development and academic research.
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