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New media prep station from Copley Scientific increases productivity in tablet dissolution testing

The new Dissomate media preparation unit from Copley Scientific is an automated, compact system for preparing and gravimetrically dispensing the pre-warmed, de-aerated, dosed dissolution media required for accurate tablet dissolution testing.

Dissomate media preparation unitOperating on the “filtering, warming, and stirring under vacuum principle” recommended by the pharmacopoeias and FDA, it can prepare 8 litres of fresh dissolution media in under 15 minutes. These fast preparation times in combination with rapid dispensing reduce the down time between dissolution experiments, with proven savings compared with manual preparation.

Dissolution testing is vital in tablet manufacture. Accurate analysis requires well-prepared dissolution media as air bubbles and other dissolved gases are widely recognised as sources of problems. Efficiently producing warmed, degassed dissolution media ensures productive operation of a dissolution testing lab, and the integrity of the resulting data.

The Copley Scientific Dissomate combines preparation and dispensing in a single unit. It warms and degasses the medium in accordance with the procedures defined in the pharmacopoeias, and then dispenses on the basis of weight. Gravimetric dispensing avoids the issues known to be associated with volumetric filling when the standard filling temperature (25oC) differs from the temperature on dispensing (37oC ), and is recommended by the US pharmacopoeia for its superior accuracy.

Automatic addition of the required volume of acid, buffer or surfactant prior to mixing and dispensing eliminates any requirement for pre-preparation while the unit’s remote dispensing gun allows in situ filling, avoiding any need to transport the dissolution vessels. The standard 8 L Dissomate supports several dissolution testers but a larger 15 L version is available on request. This can fill two complete dissolution testers from a single preparation process.


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