Search News Archives
Follow us on
Conferences | Events

Media Partners

 

Horizon Discovery Extends CRISPR Screening Service to Primary Human T Cells

publication date: Feb 5, 2019
 | 
author/source: Horizon Discovery Group

horizon discoveryExtended screening service offers novel capabilities for immuno-oncology research in ex vivo T lymphocytes

Horizon Discovery Group plc a global leader in gene editing and gene modulation technologies, has announced the extension of its CRISPR Screening Service to include ex vivo T lymphocytes.

The service extension meets the requirements of immunology-based research in drug discovery, enabling new gene targets to be identified in biologically and potentially therapeutically relevant settings.

CRISPR screens in primary T lymphocytes have proved challenging, owing to complex issues around the introduction of the screening components and Cas9 in particular. Horizon has adapted its established CRISPRko (knockout) platform to address these issues and to deliver a robust screening platform in human T lymphocytes, which will enable complex biological processes, novel targets and more effective drug therapies to be investigated in a therapeutically relevant cell type.

Horizon has added CRISPRko screens in ex vivo T lymphocytes to its established CRISPR screening formats – CRISPRko, CRISPRi (interference) and CRISPRa (activation) – in cancer cell lines. The Company’s extension of its CRISPRko Screening Service strengthens its existing immuno-oncology platform and reinforces its commitment to supporting researchers working in this rapidly growing field of research.

Terry Pizzie, Chief Executive Officer, Horizon Discovery Group, commented: “The successful demonstration of primary human T cells in Horizon’s CRISPR screening platforms is a breakthrough format for our clients working in the immuno-oncology space; enabling them to find gene targets and potential therapeutic avenues in an immediately biologically relevant setting rather than having to work through surrogate cell lines. We expect that this approach will allow our customers to save considerable time and resources in downstream validation, helping them to get therapeutics to the clinic faster.”


 



 

Popular this month

 

Thermo Fisher Scientific’s Analytical Instruments Receive Industry Recognition with Prestigious Awards


Bruker Introduces new SKYSCAN 1273 Benchtop 3D X-ray Microscope


How To Increase Productivity & Efficiency In Laboratories


Opportunities and challenges in the booming North American cannabis market


ZEISS Develops First Multifunctional Smart Glass


Eppendorf & Science Prize for Neurobiology 2019: Call for Entries!


Industry forecast for analytical instruments market in 2019


MGI Introduces Automated Sample Preparation Workstations, Streamlining Genomic Sequencing Workflow


WIN a VIAFLO 96/384 to supercharge your microplate pipetting!


Know the Unknown – with Cora Raman Spectrometers from Anton Paar

 


 

 

Can't find what you are looking for?


Search by company or by product


Company Name:

Product:





Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd