Channels

 

Special Offers & Promotions

 

 

Latest News

 

 

View Channel

New Products

 

 

View Channel

Video Presentations

 

 

View Channel

Separation Science

 

 

View Channel

Microscopy & Image Analysis

 

 

View Channel

Laboratory Automation & IT Solutions

 

 

View Channel

 

Dionex Demonstrates Fast Desalting of Oligonucleotide and Protein Samples

Dionex is proud to announce a new method to desalt oligonucleotide or protein samples for either on-line analysis by high-performance liquid chromatography (HPLC) or liquid chromatography-mass spectrometry (LC/MS). Application Update 174: On-Line High-Throughput Desalting to Prepare Samples for Mass Spectrometry demonstrates a simple, fast, and effective process that was completed within 2 min, including sample desalting and flushing, for an oligonucleotide sample and a bovine serum albumin (BSA) sample using a Dionex UltiMate® 3000 HPLC system and Chromeleon® Chromatography Data System (CDS) software.

MS has become a powerful tool for the analysis of complex biochemical samples. These samples often contain high concentrations of salts that interfere with the ionization process and may result in lower peak intensities, compromised peptide/protein detection, and frequent contamination of the ion source. Therefore, it is essential to remove salts from samples before subjecting them to MS detection. Although off-line solid-phase extraction (SPE) is the most common desalting method, it is time-consuming. This application update describes a simple, fast, and effective on-line method using an Acclaim® PolarAdvantage II Guard column for high-throughput sample desalting before MS detection.

For more details, visit www.dionex.com.

Dionex (NASDAQ:DNEX) is a global leader in the manufacturing and marketing of liquid chromatography and sample preparation systems, consumables, and software for chemical analysis. The company's systems are used worldwide in environmental analysis and by the life sciences, chemical, petrochemical, food and beverage, power generation, and electronics industries. Our expertise in applications and instrumentation helps analytical scientists to evaluate and develop pharmaceuticals, establish environmental regulations, and produce better industrial products.

Acclaim, Chromeleon, and UltiMate are registered trademarks of Dionex Corporation.



 

Subscribe to any of our newsletters for the latest on new laboratory products, industry news, case studies and much more!

Newsletters from Lab Bulletin

 

Request your free copies HERE

 

 

 

Popular this Month

Top 10 most popular articles this month

 

 

Today's Picks

 


 

Looking for a Supplier?

Search by company or by product

 


Company Name:

Product:


 

 

 

 

Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd.


 

Media Partners

 

Exhibitions & Events