A new whitepaper from Malvern Instruments provides detailed guidance on the analytical technologies that help to accelerate oral solid dosage (OSD) product formulation to a successful conclusion.
‘Analytical techniques with a place in the oral solid dosage formulation toolkit’ reviews the regulatory and QbD framework associated with OSD formulation and demonstrates how Malvern systems can be used to generate the data required. The goal of formulation is to incorporate an identified drug substance into a successful pharmaceutical product. The regulatory framework for OSD products highlights the need to comprehensively...
Optical Surfaces Ltd. has published a new guide to provide scientists and engineers with expert advice on maintaining the performance of their aluminum coated optics.
After a time, depending on the environment in which coated optics are used, they may become contaminated with dust or stained. Dust and stains can cause scattering, and impurities on the surface of the optics can react with incident light resulting in damage to the optical coating. Starting from the premise “If it’s not dirty don’t clean it” the new guide describes a simple to follow 5-step progressive process for cleaning coated optics in a clean, low dust environment...
INTEGRA Biosciences has launched PIPETGIRL - a new pink version of its popular PIPETBOY acu 2 pipette controller.
As part of their 'PIPETGIRL – Let’s fight breast cancer together!’ campaign - INTEGRA is committing to donating Euro 10 / US $15 for every PIPETGIRL purchased during 2015 to a selection of internationally renowned cancer research institutes. Liquid handling in the millilitre range is a daily task for many labs. Unlike rubber bulb fillers, the use of serological pipettors improves the efficiency and precision of your liquid handling...
Cresset, innovative provider of computational chemistry software and services, announces that its drug discovery arm Re-Pharm Ltd has used Forge to identify novel anti-inflammatory activity for an existing drug, which is widely prescribed for other non-inflammatory conditions.
Re-Pharm was searching for drugs to be re-purposed against a new enzyme target. Using known ligands and a crystal structure as a starting point, they used Cresset’s Forge to build computational templates to match any compounds likely to be active at the new target. The results were screened and RP0217 was identified as an effective new anti-inflammatory agent. Re-Pharm has filed patents on RP0217 for a variety of disease indications...
Flame brings flexible sensing power to research and teaching labs
Ocean Optics has launched a spectrometer line that combines decades of miniature spectrometer design expertise with industry-leading manufacturing techniques. The Flame spectrometer delivers high thermal stability and low unit to unit variation without compromising the flexibility and configurability that are the hallmark of modular, miniature spectrometers. Features such as interchangeable slits, indicator LEDs and simpler device...
Researchers at the Centre de research du Centre hospitalier universitaire de Sherbrooke (CRCHUS) unveiled today the results of a clinical study demonstrating equivalency between cyclotron-produced technetium (Tc-99m) and that produced in a nuclear reactor.
The result of many years of research, this major clinical breakthrough will significantly affect the quality and safety of care delivered to patients. Based on the study's findings, not only are the CRCHUS's medical-imaging research positioned as leaders in this area, they are demonstrating that tomorrow's supply of medical isotopes can be produced with a promising green technology. On hand for the announcement were the Minister of...
Healthy, safe and productive people create exceptional, sustainable science
KIMTECH personal protection equipment from KIMBERLY-CLARK PROFESSIONAL* is now available for sale in bundles appropriate to standard Laboratory Biosafety Levels (BSL-) 1-3 and for use in epidemic, field based, responses. This new product strategy is just one element of Kimberly-Clark’s efforts to help laboratory managers focus on creating healthier, safer and more efficient laboratories by ensuring the purchase of...
The latest generation of compact laboratory freeze-dryers –LyoQuest- will be presented by Telstar at Arablab 2015
The new generation of the most compact laboratory freeze-dryer incorporates significant improvements in efficiency, performance and maintenance. More robust vacuum pumps have been incorporated into the equipment, which helps ensure better performance and longevity, in addition to providing easier maintenance and operational advantages, such as reduced noise level. The new vacuum pumps integrated into the...
The latest addition to the Hygiena line of rapid micro-organism tests is InSite Salmonella, which is a rapid and convenient colorimetric Salmonella species test for environmental surfaces.
Its all-in-one test format contains both the pre-enrichment and selective enrichment procedures, maintains security and minimises the risk of cross contamination. It also retains the active culture for any subsequent verification and identification tests. InSite Salmonella is a self-contained, ready-to-use swab test which contains a specialised liquid medium which changes colour when Salmonella species are present in the sample...
Researchers at University Medical Center (UMC) Utrecht are developing an innovative cancer treatment with the help of a grant from Alpe d’HuZes/Dutch Cancer Society (KWF) of nearly 300,000 euros.
The treatment involves the injection of radioactive beads into tumors, thereby enabling a very precise localized radiotherapy. Direct injection of radioactive beads may be an effective treatment of tumors that are difficult or impossible to remove surgically. This is the basic principle of medical biologist Dr. Frank Nijsen, dental surgeon Dr. Robert van Es and nuclear physician Dr. Marnix Lam of UMC Utrecht. They are working...
Taking pictures with your camera you may find that images often look okay on a first glimpse, but when zooming in fine details are barely noticeable.
In contrast, the high information density of high resolution images will reveal even the smallest details. Since the introduction of ICP optical emission spectrometry, the spectral resolution has been a main concern with respect to accuracy and sensitivity. The wealth of emission lines from the plasma frequently leads to overlapping between lines of the analyte and that of accompanying elements. In many sample matrices such spectral interferences...
Micronic has launched the new Univo Manual Capper CM480 - a versatile product designed to seal an entire rack of tubes with push caps in a single action.
Compact and robust in design the Univo Manual Capper is able to repeatedly and reliably securely cap tubes (up to 1.40 ml) in all ANSI /SLAS format racks up to a maximum height of 48mm. To ensure optimum results an adapter matched to your specific rack type and tube height is supplied. Built to meet the varying needs of different users, the Univo Manual Capper can seal full or partially full racks with the complete range of Micronic TPE or EVA plug style...
A new series of environmental test chambers now available from Tovatech in 4 storage capacities from 24 to 80 cubic feet feature ultrasonic humidifiers producing far smaller water particles than centrifugal humidifiers.
The ultrasonic humidifiers are placed above rather than inside storage cabinets thereby freeing space for additional test specimens. Dehumidification is handled by a separate latent coil. Both systems are operated by a programmable logic microprocessor controller. The ultrasonic humidifiers require water with low mineral content delivered at 10 to 60 psi. As a means of conserving this water an optional purification system for tap water is...
Company extends support and reach in the US for its Mosaic sample management software
Titian Software has further expanded its US operation following years of robust growth. Over the past decade, innovation and continued development of its pre-eminent sample management software, Mosaic, has secured it as the preferred choice for most of the world’s top 20 bio-pharma companies. Mosaic 6.0, released in late 2014, is optimised for the storage, processing, tracking and ordering of compounds, biologicals and reagents...
To ensure full compatibility with robotic systems, DNase / RNase- and pyrogen-free PCR plates from Porvair Sciences feature high rigidity to minimise distortion before and after thermal cycling.
Produced in Class 10,000 clean room conditions – Porvair range of PCR plates are certified free of pyrogens as well as DNAse and RNAse enzyme activity enabling routine achievement of excellent PCR results. Porvair PCR plates are based upon a well design where the liquid meniscus comes below the plate surface eliminating sample carryover problems when using a plate lid. Summarised in an easy-to-use selection guide...
Pioneering prostate cancer drug abiraterone significantly extends the lives of men with advanced prostate cancer if given before chemotherapy, the results of a major phase III clinical trial have shown.
The results, published in Lancet Oncology, showed that men with advanced, aggressive prostate cancer lived more than four months longer on average if they received abiraterone before chemotherapy than if they did not. The trial, led in the UK by Professor Johann de Bono of The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust, could fill an important gap in previous evidence for abiraterone’s...
If you use antibodies for research or diagnostics you could be better served by switching to aptamers. Base Pair Biotechnologies, based in Pearland, Texas, USA, offers a total solution for developing aptamer-based technologies.
Their continually expanding range of products and services is now available in Europe through Cambio. Aptamers, like antibodies, are molecules that bind to pre-selected targets including small molecules, proteins and peptides with high affinity and specificity. They are not proteins, but formed of single stranded DNA or RNA. The specificity and characteristics of aptamers are not determined by their primary sequence, but by their...
Now available from Alpha Laboratories, the Picus® NxT electronic pipette from the Sartorius Biohit Family, features a sophisticated design, exceptional accuracy and precision, plus new features that provide distinct advantages for highly regulated laboratories. It brings all the benefits of the original Picus models that help ease your workload and deliver superb pipetting results. Weighing in at only a 100g, the comfortable handle and light electronic tip ejection will...
A worldwide study of the DNA of 100,000 women has discovered two new genetic variants associated with an increased risk of breast cancer.
The genetic variants are specifically linked to the most common form of breast cancer, oestrogen receptor positive, and provide important insights into how the disease develops. Scientists believe screening women for all the genetic variants so far identified could eventually pick out those at highest risk of breast cancer and improve strategies for preventing the disease. The study was led by scientists at The Institute of Cancer Research...
FLIR Systems has announced the release of their new GF343; an optical gas imaging camera that lets you detect and visualize Carbon Dioxide (CO2) leaks quickly, easily, and from a safe distance.
Whether the CO2 emission is a byproduct of a production process, a trace gas used to detect leaks from power generators or as part of an Enhanced Oil Recovery program, fast and accurate detection of CO2 leaks is key to keeping your operation running safely, efficiently, and profitably. Reliable, non-contact CO2 detection using the FLIR Systems GF343 lets plants prevent unplanned outages by allowing them to inspect equipment while...
What studies into male birds tell us about reproduction in later life
Studies into male birds that produce offspring well into their old age could deepen concerns over the trend for delaying parenthood until later in life, for both men and women. An international team of scientists, led by Dr Brian Preston from Liverpool John Moores University (LJMU), have studied the large, flamboyant houbara bustard, for insights into how aging has evolved. In their most recent work, published in...
Spectronics Corporation’s Select™ XLE-Series is a high quality, inexpensive ultraviolet crosslinker.
This unit makes it possible to identify and analyze trace amounts of DNA/RNA with far greater sensitivity, accuracy and speed than with conventional analysis. The Select™ XLE-Series UV crosslinker covalently binds nucleic acids to membranes in under 30 seconds — 240 times faster than vacuum-oven baking! It has a unique true-UV-monitoring circuitry that safeguards valuable test results from washouts, even when the tubes age. Researchers also rely on...
‘Analytical techniques with a place in the oral solid dosage formulation toolkit’ reviews the regulatory and QbD framework associated with OSD formulation and demonstrates how Malvern systems can be used to generate the data required. The goal of formulation is to incorporate an identified drug substance into a successful pharmaceutical product. The regulatory framework for OSD products highlights the need to comprehensively...
After a time, depending on the environment in which coated optics are used, they may become contaminated with dust or stained. Dust and stains can cause scattering, and impurities on the surface of the optics can react with incident light resulting in damage to the optical coating.
Re-Pharm was searching for drugs to be re-purposed against a new enzyme target. Using known ligands and a crystal structure as a starting point, they used Cresset’s Forge to build computational templates to match any compounds likely to be active at the new target. The results were screened and RP0217 was identified as an effective new anti-inflammatory agent. Re-Pharm has filed patents on RP0217 for a variety of disease indications...
Ocean Optics has launched a spectrometer line that combines decades of miniature spectrometer design expertise with industry-leading manufacturing techniques. The Flame spectrometer delivers high thermal stability and low unit to unit variation without compromising the flexibility and configurability that are the hallmark of modular, miniature spectrometers. Features such as interchangeable slits, indicator LEDs and simpler device...
The result of many years of research, this major clinical breakthrough will significantly affect the quality and safety of care delivered to patients. Based on the study's findings, not only are the CRCHUS's medical-imaging research positioned as leaders in this area, they are demonstrating that tomorrow's supply of medical isotopes can be produced with a promising green technology. On hand for the announcement were the Minister of...
KIMTECH personal protection equipment from KIMBERLY-CLARK PROFESSIONAL* is now available for sale in bundles appropriate to standard Laboratory Biosafety Levels (BSL-) 1-3 and for use in epidemic, field based, responses. This new product strategy is just one element of Kimberly-Clark’s efforts to help laboratory managers focus on creating healthier, safer and more efficient laboratories by ensuring the purchase of...
The new generation of the most compact laboratory freeze-dryer incorporates significant improvements in efficiency, performance and maintenance. More robust vacuum pumps have been incorporated into the equipment, which helps ensure better performance and longevity, in addition to providing easier maintenance and operational advantages, such as reduced noise level. The new vacuum pumps integrated into the...
Its all-in-one test format contains both the pre-enrichment and selective enrichment procedures, maintains security and minimises the risk of cross contamination. It also retains the active culture for any subsequent verification and identification tests. InSite Salmonella is a self-contained, ready-to-use swab test which contains a specialised liquid medium which changes colour when Salmonella species are present in the sample...
The treatment involves the injection of radioactive beads into tumors, thereby enabling a very precise localized radiotherapy. Direct injection of radioactive beads may be an effective treatment of tumors that are difficult or impossible to remove surgically. This is the basic principle of medical biologist Dr. Frank Nijsen, dental surgeon Dr. Robert van Es and nuclear physician Dr. Marnix Lam of UMC Utrecht. They are working...
In contrast, the high information density of high resolution images will reveal even the smallest details. Since the introduction of ICP optical emission spectrometry, the spectral resolution has been a main concern with respect to accuracy and sensitivity. The wealth of emission lines from the plasma frequently leads to overlapping between lines of the analyte and that of accompanying elements. In many sample matrices such spectral interferences...
Compact and robust in design the Univo Manual Capper is able to repeatedly and reliably securely cap tubes (up to 1.40 ml) in all ANSI /SLAS format racks up to a maximum height of 48mm. To ensure optimum results an adapter matched to your specific rack type and tube height is supplied. Built to meet the varying needs of different users, the Univo Manual Capper can seal full or partially full racks with the complete range of Micronic TPE or EVA plug style...
The ultrasonic humidifiers are placed above rather than inside storage cabinets thereby freeing space for additional test specimens. Dehumidification is handled by a separate latent coil. Both systems are operated by a programmable logic microprocessor controller. The ultrasonic humidifiers require water with low mineral content delivered at 10 to 60 psi. As a means of conserving this water an optional purification system for tap water is...
Titian Software has further expanded its US operation following years of robust growth. Over the past decade, innovation and continued development of its pre-eminent sample management software, Mosaic, has secured it as the preferred choice for most of the world’s top 20 bio-pharma companies. Mosaic 6.0, released in late 2014, is optimised for the storage, processing, tracking and ordering of compounds, biologicals and reagents...
Produced in Class 10,000 clean room conditions – Porvair range of PCR plates are certified free of pyrogens as well as DNAse and RNAse enzyme activity enabling routine achievement of excellent PCR results. Porvair PCR plates are based upon a well design where the liquid meniscus comes below the plate surface eliminating sample carryover problems when using a plate lid. 
The results, published in Lancet Oncology, showed that men with advanced, aggressive prostate cancer lived more than four months longer on average if they received abiraterone before chemotherapy than if they did not. The trial, led in the UK by Professor Johann de Bono of The Institute of Cancer Research, London, and The Royal Marsden NHS Foundation Trust, could fill an important gap in previous evidence for abiraterone’s...
Their continually expanding range of products and services is now available in Europe through Cambio. Aptamers, like antibodies, are molecules that bind to pre-selected targets including small molecules, proteins and peptides with high affinity and specificity. They are not proteins, but formed of single stranded DNA or RNA. The specificity and characteristics of aptamers are not determined by their primary sequence, but by their...
Now available from Alpha Laboratories, the Picus® NxT electronic pipette from the Sartorius Biohit Family, features a sophisticated design, exceptional accuracy and precision, plus new features that provide distinct advantages for highly regulated laboratories. It brings all the benefits of the original Picus models that help ease your workload and deliver superb pipetting results. Weighing in at only a 100g, the comfortable handle and light electronic tip ejection will...
Whether the CO2 emission is a byproduct of a production process, a trace gas used to detect leaks from power generators or as part of an Enhanced Oil Recovery program, fast and accurate detection of CO2 leaks is key to keeping your operation running safely, efficiently, and profitably. Reliable, non-contact CO2 detection using the FLIR Systems GF343 lets plants prevent unplanned outages by allowing them to inspect equipment while...
Studies into male birds that produce offspring well into their old age could deepen concerns over the trend for delaying parenthood until later in life, for both men and women. An international team of scientists, led by Dr Brian Preston from Liverpool John Moores University (LJMU), have studied the large, flamboyant houbara bustard, for insights into how aging has evolved. In their most recent work, published in...
This unit makes it possible to identify and analyze trace amounts of DNA/RNA with far greater sensitivity, accuracy and speed than with conventional analysis. The Select™ XLE-Series UV crosslinker covalently binds nucleic acids to membranes in under 30 seconds — 240 times faster than vacuum-oven baking! It has a unique true-UV-monitoring circuitry that safeguards valuable test results from washouts, even when the tubes age. Researchers also rely on...