As we all know, many cellular activities are controlled by post-translational modifications, the study of which is stuck by the lack of specific reagents due greatly to their nature of ubiquitousness and non-immunogenicity. With great efforts, Creative Biolabs has developed PTM-Ab™ technology, which offers services for post-translational modification specific antibody discovery.
Post-translational modifications are modifications that occur on a protein, catalysed by enzymes after its translation by ribosomes is complete. Post-translational modification generally refers to the addition of a functional group covalently to a protein as in phosphorylation and neddylation. Protein post-translational modifications play an important role in many cellular processes, such as cellular differentiation, protein degradation, signaling and regulatory processes, regulation of gene expression, and protein-protein interactions.....
Read MoreBMG LABTECH Donates 10,000 Euro to the Victims of Nepal EarthquakeJun 3, 2015
The major earthquake that struck west of Kathmandu, hits one of the poorest regions in the world.
The earthquake caused extensive damage to buildings and thousands of deaths and injuries. Vibrations were even felt in China, India and Bangladesh. Thousands of people need medical care and emergency shelters against rain and cold. The international department of Caritas Germany provides a 100 000 Euro emergency aid to help the victims as fast as possible. BMG LABTECH wants to help too and donated 10 000 Euro to the organization...
A new YouTube video published by Laboratory Information Management Systems (LIMS) specialist, Autoscribe, provides a practical demonstration of the ease of configuration of the Matrix Gemini LIMS.
Since each individual laboratory is a little different from its nearest equivalent and often vastly different from laboratories in different industries, Matrix Gemini’s unique OneTime™configuration tools provide the flexibility to ensure that customers are not forced into a particular system design. These versatile configuration tools offer a ‘drag and drop’ approach to build a personalised user interface with no impact on the underlying core...
Clear, bright broad spectrum illumination – without the mercury!
There’s now a better and safer alternative to a high-pressure mercury or metal-halide light source for fluorescence microscopy. Available from Alpha Laboratories, the pE-300white unit from CoolLED offers broad spectrum LED illumination for general use in fluorescence applications. With a comprehensive range of microscope adaptors, it can easily be fitted to most microscopes, old or new, providing a safe, convenient and economical illumination system...
LaVison BioTec, developers of advanced microscopy solutions for the life sciences, announces the dates and venue of the first international users' meeting on their UltraMicroscope light sheet microscopy products.
The first LaVision BioTec UltraMicroscope User Meeting will take place at the Max Planck Institute for Molecular Biomedicine in Münster, 21-22 September. Participants are cordially invited to join with all active and prospective UltraMicroscope users in a forum on the latest developments in light sheet microscopy. With this scientific gathering, LaVision BioTec is fostering the exchange of thoughts, experiences and views on this emerging and very active...
Chromatography specialists from Malvern Instruments will present a reliable optimized solution for lignin characterization at a series of upcoming conferences in 2015, the first of which is Nordic Polymer Days, Denmark, June 1 – 3.
Lignin is a vital industrial polymer but presents significant challenges when it comes to measurement of the properties that define its performance. Through experimental study Malvern has identified the best strategy to apply when using gel permeation/size exclusion chromatography (GPC/SEC) to secure reliable information. The results of this work will also be presented at the 13th Annual UNESCO/IUPAC Conference on...
Five years ago, few people had heard of 3D printing, but now computer-generated images are being used to create body parts.
Scientists at University College London are using 3D printing to create ears made out of polyurethane-type polymers, to be implanted onto children with severe disfigurements in the first clinical trial of its kind. The scientific team has been testing the process by implanting a 3D ear on a rat. The operation is a major medical breakthrough and could radically change organ transplants. Professor Seifalian’s Group at University College London...
LaVison BioTec, developers of advanced microscopy solutions for the life sciences, report on the research of Dr Matteo Iannacone of the San Raffaele Scientific Institute in Milan where intravital microscopy is being applied to the study of host-viruses and associated immune responses.
Matteo Iannacone, MD, PhD is the Group Leader in the Division of Immunology at the San Raffaele Scientific Institute, Milan, Italy. His research program seeks to dissect the complex dynamics of host-virus interactions with a particular focus on the development and function of adaptive immune responses. Since it is still beyond the reach of even the most sophisticated in vitro methodology to simulate the complex interplay of physical...
EKF Diagnostics, the global diagnostics company, announces that it has introduced the Stanbio Chemistry Procalcitonin (PCT) LiquiColor® Assay.
This new test enables the quantitative determination of PCT in serum samples, EDTA or lithium heparin plasma samples by latex enhanced immunoturbidimetric methodology. Procalcitonin is a marker for bacterial infection and sepsis and has been recognized as an important adjunct marker in the diagnosis of sepsis*. The new Stanbio Chemistry Procalcitonin (PCT) LiquiColor® Assay is fast, accurate and convenient. The test provides...
Deben, leading providers of in-situ testing stages together with innovative accessories and components for electron microscopy, report on the work of Microscopy & Histology Core Facility at the University of Aberdeen.
The Microscopy and Histology Facility provide access to assorted technologies to researchers at the University of Aberdeen. One core technique is Transmission Electron Microscopy (TEM) which was recently upgraded with the installation of a new JEOL JEM-1400 plus TEM with AMT camera system from Deben. The current research done using this equipment is varied and includes samples such as bone cells, yeast cells and macrophages. Some...
In February 2015 Oxford Global’s 10th Annual Biomarkers Congress gave delegates the opportunity to present a poster and have the chance of winning an award of £3,000.
The award was decided by a panel of five judges made up from some of the esteemed congress speakers presenting across the two days. Mari Enoksson, of Novo Nordisk won the award by presenting: Biomarker discovery study for detection of a haemophilic joint bleed. Mari decided to donate the £3,000 award prize to a charity of our choice. Oxford Global continually supports the work of Cancer Research UK and therefore we made...
AMSBIO has launched a new and exclusive biotinylated protein collection specially designed to simplify your research.
Attaching biotin to proteins and other macromolecules is an established labelling method which allows specific detection of biotin-tagged molecules via anti-biotin antibody, avidin or streptavidin based reporter systems. Biotinylation reagents are available for targeting specific functional groups or residues, including primary amines, sulfhydryls, carboxyls and carbohydrates. Photoreactive biotin compounds that react nonspecifically...
UK-based MR Solutions demonstrate its latest commercially available cryogen-free multi-modality preclinical MRI imaging systems at the 23rd Annual Meeting of the International Society for Magnetic Resonance in Medicine (ISMRM).
The preclinical range, which is commercially available, includes the cryogen-free 3T, 4.7T and 7T MRI systems. MR Solutions has developed multi-modality preclinical imaging systems so the need for separate systems is no longer necessary. PET-MRI and SPECT-MRI imaging modules can either be inserted or clipped-on according to system configuration. PET-MRI and SPECT-MRI imaging can be carried out with independent acquisition of data, or sequential acquisition, or simultaneous acquisition.
A new technical poster from Haydale Ltd. describes a cost-effective and repeatable method for characterisation of functionalised carbon nanomaterials.
Two key, but independent, problems facing the graphene industry are the requirement for chemical functionalisation (essential for homogenous dispersion and application) and the pressing need for reliable, cost-effective, rapid, easy-to-use and accurate characterisation techniques to determine the type and extent of functionalisation present on graphene material. Current chemical characterisation techniques including X-ray photoelectron spectroscopy...
Biobank operators can now benefit from a cost-effective, rapidly deployable sample management software package
Titian Software has drawn from its extensive knowledge of biobanking requirements to develop a cost-effective, pre-configured software package optimised for managing small to medium-sized sample collections. Ideal for biobanks, the new Mosaic Freezer Management software package is being launched at the International Society for Biological and Environmental Repositories (ISBER) 2015 annual meeting and exhibition, on May 5th, 2015 in...
Scientists from the Hubrecht Institute and the University Medical Center Utrecht (UMC Utrecht) have developed a cell culture model of human colon cancer progression.
This model mimics the situation in patients more closely than any other colon cancer model so far. It enables researchers to study processes involved in colon cancer development and find new cancer drugs. The work by Clevers and colleagues is published online in Nature this week. Colon cancer is one of the most common and deadly forms of cancer. Like all cancers, it arises through an accumulation of DNA changes (mutations) in the...
The UK has the highest rate of Paget’s bone disease in the world, but now researchers from Liverpool John Moores University (LJMU), the Paget’s Association and Norton Priory Museum Trust are analysing ancient bones to better understand the progression of the disease, which may permit earlier diagnosis.
Paget’s disease disrupts the normal cycle of bone renewal and repair, causing bones to become weakened and deformed. It is known to affect up to 1 in 12 older men and 1 in 20 women over the age of 80. But symptoms often only show at the later stages. As Diana Wilkinson, Specialist’s Paget’s Nurse, of the Paget’s Association explains: “The North West of England is known to have the highest prevalence of Paget’s disease and evidence of the...
An international consortium of scientists led by a group from the University of Leicester has announced a new advance in understanding the mechanisms of cancer and how to target it more effectively with new treatments.
Two papers published in the same issue of the world-leading Journal of Cell Biology have arisen from research work led by Professor Andrew Fry at the University of Leicester. Both papers suggest that new understanding of the mechanics of cell division can reveal new targets for cancer therapy. Professor Fry, who is Director of Research in the College of Medicine, Biological Sciences and Psychology at Leicester, said: “Together...
Merck Millipore, the Life Science division of Merck, announced publication of a study showing that its Strat-M® synthetic membrane predicts skin permeation of chemical compounds during in vitro transdermal diffusion studies as effectively as human or animal skin.
The study was conducted by researchers at Josai University in Japan and published in the January 25, 2015 issue of European Journal of Pharmaceutical Sciences.
Results showed similar permeability coefficients for human skin, rat skin and Strat-M ® membrane
Demonstrated Strat-M® membrane is an effective alternative to use of animal or human skin for permeation studies
Ideal for transdermal diffusion testing for a wide range of pharmaceutical and cosmetic compounds
In addition to a number of laboratory autoclaves on show by Priorclave on stand D37 - Hall 4.2 at the forthcoming Achema exhibition the company is expected to announce the launch of a new step-by-step guide to choosing the next autoclave purchase.
At Achema this British autoclave design and manufacturing company is showing examples from its mid-size front-loading autoclave which has a cylindrical 150 litre capacity chamber, a compact 60 litre top loading vacuum model and another larger top-loading laboratory autoclave. They typify the consistent build quality that is maintained across the entire Priorclave laboratory autoclave range of benchtop, top and front loading and pass-through models available...
DELMIC develops and manufactures products which are focused on high performance, user friendly, integrated microscopy solutions.
Users of Delmic's SPARC technology from Stanford University and the FOM Institute AMOLF in the Netherlands are using cathodoluminescence measurements for nanoscale optical tomography. Engineers at Stanford University and the FOM Institute AMOLF, in the Netherlands, have developed a way to visualise the optical properties of objects that are thousands of times smaller than a grain of sand, in 3-D and with nanometer-scale...
Market leaders in temperature controlled microscopy, Linkam Scientific Instruments, have upgraded the control systems for their family of temperature stages with the launch of the new LinkPad 2 touch screen system.
The LinkPad 2 has been developed from Linkam's successful stand-alone series of controllers. The key motivation behind its release is to provide users with the ability to control complete experiments from an intuitive touch screen without the need for a PC. LinkPad 2 is now the flagship controller for the complete range of Linkam's temperature stages. These stages have been individually designed to meet specific applications needs, each calling...
The earthquake caused extensive damage to buildings and thousands of deaths and injuries. Vibrations were even felt in China, India and Bangladesh. Thousands of people need medical care and emergency shelters against rain and cold. The international department of Caritas Germany provides a 100 000 Euro emergency aid to help the victims as fast as possible. BMG LABTECH wants to help too and donated 10 000 Euro to the organization...
Since each individual laboratory is a little different from its nearest equivalent and often vastly different from laboratories in different industries, Matrix Gemini’s unique OneTime™configuration tools provide the flexibility to ensure that customers are not forced into a particular system design. These versatile configuration tools offer a ‘drag and drop’ approach to build a personalised user interface with no impact on the underlying core...
There’s now a better and safer alternative to a high-pressure mercury or metal-halide light source for fluorescence microscopy. Available from Alpha Laboratories, the 
The first LaVision BioTec UltraMicroscope User Meeting will take place at the Max Planck Institute for Molecular Biomedicine in Münster, 21-22 September. Participants are cordially invited to join with all active and prospective UltraMicroscope users in a forum on the latest developments in light sheet microscopy. With this scientific gathering, LaVision BioTec is fostering the exchange of thoughts, experiences and views on this emerging and very active...
Lignin is a vital industrial polymer but presents significant challenges when it comes to measurement of the properties that define its performance. Through experimental study Malvern has identified the best strategy to apply when using gel permeation/size exclusion chromatography (GPC/SEC) to secure reliable information. The results of this work will also be presented at the 13th Annual UNESCO/IUPAC Conference on...
Scientists at University College London are using 3D printing to create ears made out of polyurethane-type polymers, to be implanted onto children with severe disfigurements in the first clinical trial of its kind. The scientific team has been testing the process by implanting a 3D ear on a rat. The operation is a major medical breakthrough and could radically change organ transplants. Professor Seifalian’s Group at University College London...
Matteo Iannacone, MD, PhD is the Group Leader in the Division of Immunology at the San Raffaele Scientific Institute, Milan, Italy. His research program seeks to dissect the complex dynamics of host-virus interactions with a particular focus on the development and function of adaptive immune responses. Since it is still beyond the reach of even the most sophisticated in vitro methodology to simulate the complex interplay of physical...
This new test enables the quantitative determination of PCT in serum samples, EDTA or lithium heparin plasma samples by latex enhanced immunoturbidimetric methodology. Procalcitonin is a marker for bacterial infection and sepsis and has been recognized as an important adjunct marker in the diagnosis of sepsis*. The new Stanbio Chemistry Procalcitonin (PCT) LiquiColor® Assay is fast, accurate and convenient. The test provides...
The Microscopy and Histology Facility provide access to assorted technologies to researchers at the University of Aberdeen. One core technique is Transmission Electron Microscopy (TEM) which was recently upgraded with the installation of a new JEOL JEM-1400 plus TEM with AMT camera system from Deben. The current research done using this equipment is varied and includes samples such as bone cells, yeast cells and macrophages. Some...
The award was decided by a panel of five judges made up from some of the esteemed congress speakers presenting across the two days. Mari Enoksson, of Novo Nordisk won the award by presenting: Biomarker discovery study for detection of a haemophilic joint bleed. Mari decided to donate the £3,000 award prize to a charity of our choice. Oxford Global continually supports the work of Cancer Research UK and therefore we made...
Attaching biotin to proteins and other macromolecules is an established labelling method which allows specific detection of biotin-tagged molecules via anti-biotin antibody, avidin or streptavidin based reporter systems. Biotinylation reagents are available for targeting specific functional groups or residues, including primary amines, sulfhydryls, carboxyls and carbohydrates. Photoreactive biotin compounds that react nonspecifically...
The preclinical range, which is commercially available, includes the cryogen-free 3T, 4.7T and 7T MRI systems. MR Solutions has developed multi-modality preclinical imaging systems so the need for separate systems is no longer necessary. PET-MRI and SPECT-MRI imaging modules can either be inserted or clipped-on according to system configuration. PET-MRI and SPECT-MRI imaging can be carried out with independent acquisition of data, or sequential acquisition, or simultaneous acquisition.
Two key, but independent, problems facing the graphene industry are the requirement for chemical functionalisation (essential for homogenous dispersion and application) and the pressing need for reliable, cost-effective, rapid, easy-to-use and accurate characterisation techniques to determine the type and extent of functionalisation present on graphene material. Current chemical characterisation techniques including X-ray photoelectron spectroscopy...
Titian Software has drawn from its extensive knowledge of biobanking requirements to develop a cost-effective, pre-configured software package optimised for managing small to medium-sized sample collections. Ideal for biobanks, the new Mosaic Freezer Management software package is being launched at the International Society for Biological and Environmental Repositories (ISBER) 2015 annual meeting and exhibition, on May 5th, 2015 in...
This model mimics the situation in patients more closely than any other colon cancer model so far. It enables researchers to study processes involved in colon cancer development and find new cancer drugs. The work by Clevers and colleagues is published online in Nature this week. Colon cancer is one of the most common and deadly forms of cancer. Like all cancers, it arises through an accumulation of DNA changes (mutations) in the...
Paget’s disease disrupts the normal cycle of bone renewal and repair, causing bones to become weakened and deformed. It is known to affect up to 1 in 12 older men and 1 in 20 women over the age of 80. But symptoms often only show at the later stages. As Diana Wilkinson, Specialist’s Paget’s Nurse, of the Paget’s Association explains: “The North West of England is known to have the highest prevalence of Paget’s disease and evidence of the...
Two papers published in the same issue of the world-leading Journal of Cell Biology have arisen from research work led by Professor Andrew Fry at the University of Leicester. Both papers suggest that new understanding of the mechanics of cell division can reveal new targets for cancer therapy. Professor Fry, who is Director of Research in the College of Medicine, Biological Sciences and Psychology at Leicester, said: “Together...
At Achema this British autoclave design and manufacturing company is showing examples from its mid-size front-loading autoclave which has a cylindrical 150 litre capacity chamber, a compact 60 litre top loading vacuum model and another larger top-loading laboratory autoclave. They typify the consistent build quality that is maintained across the entire Priorclave laboratory autoclave range of benchtop, top and front loading and pass-through models available...
Users of Delmic's SPARC technology from Stanford University and the FOM Institute AMOLF in the Netherlands are using cathodoluminescence measurements for nanoscale optical tomography. Engineers at Stanford University and the FOM Institute AMOLF, in the Netherlands, have developed a way to visualise the optical properties of objects that are thousands of times smaller than a grain of sand, in 3-D and with nanometer-scale...
The LinkPad 2 has been developed from Linkam's successful stand-alone series of controllers. The key motivation behind its release is to provide users with the ability to control complete experiments from an intuitive touch screen without the need for a PC. LinkPad 2 is now the flagship controller for the complete range of Linkam's temperature stages. These stages have been individually designed to meet specific applications needs, each calling...