Integration of PAA’s S-LAB with Sphere Fluidics’ Cyto-Mine Single Cell Analysis System increases throughput in antibody discovery and cell line development

Sphere Fluidics, a company commercializing single cell analysis systems underpinned by its patented picodroplet technology, and Peak Analysis and Automation (PAA), a leading supplier of intelligent laboratory automation solutions, have announced the optimization of the Cyto-Mine® Single Cell Analysis System through integration with PAA’s automated plate handler, S-LAB™. The addition of S-LAB to the Cyto-Mine provides researchers with a further streamlined solution for single cell analysis in biopharmaceutical workflows.

Combining automated micro-plate handling with the Cyto-Mine offers a simple solution to minimize hands-on involvement and reduce timelines in antibody discovery and cell line development. By replacing manual barcode scanning of multi-well microtiter plates and plate loading in the final picodroplet dispensing phase of the Cyto-Mine, the integration of S-LAB increases user flexibility, overall throughput and efficiency. The integrated system combines single cell screening, sorting, imaging, isolation and clone verification, and can process up to 40 million heterogenous mammalian cells in a few hours. It has a small footprint to enable use in a cell culture hood, which, coupled with the de-lidding capability of S-LAB, ensures that the processed cells remain sterile.

The launch follows the announcement of Sphere Fluidics and PAA’s collaboration in January 2019, and consolidates 10 months of research optimizing the communication between both devices. PAA has utilized the flexible application programming interface (API) of the Cyto-Mine Studio Software Suite to communicate easily with S-LAB across a range of analytical cellular procedures, offering a simple add-on for Cyto-Mine users.

Dr Rob Marchmont, VP of Sales and Marketing, Sphere Fluidics, commented: “Peak Analysis and Automation has a strong reputation as a trusted supplier of lab automation solutions, hence our decision to partner with the team to support our customers’ requirements for a complete, automated workflow. The integration of our Cyto-Mine with PAA’s S-LAB gives customers the freedom and flexibility to incorporate both instruments into multiple workflows, to further reduce their biopharmaceutical timelines. We will continue to work with PAA to further the opportunities in the synergy of our technologies.”

Dr Malcolm Crook, Technical Director, Peak Analysis and Automation, said: “This collaboration illustrates S-LAB’s cost-effectiveness and ease of use, in addition to its adaptability to different scientific applications. We look forward to our continued partnership with Sphere Fluidics to bring automated solutions to customers across a broad range of processes.”

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About Sphere Fluidics

Sphere Fluidics develops and manufactures single cell analysis and monoclonality assurance systems for biologics discovery and cell line development.

Sphere Fluidics’ Cyto-Mine® System integrates selective screening of tens of millions of single cells, sorting, dispensing, imaging and clone verification into a single automated platform to streamline workflows, reduce costs, improve throughput and enable high-value clones to be captured in a single run. Cyto-Mine® is underpinned by the Company’s patented, microfluidic picodroplet technology.

Sphere Fluidics is located in Granta Park, Cambridgeshire (UK) and Monmouth Junction, New Jersey (USA). The Company has also internationalized its business via a global network of distributors.

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About Peak Analysis and Automation

Peak Analysis & Automation (PAA) is a leading supplier of intelligent laboratory automation solutions, trusted by scientists across the globe within the pharmaceutical and biotechnology industries. The company designs and builds an extensive range of laboratory workcells and robots, storage products and automation accessories as well as providing its own unique software solutions.

PAA is located in Farnborough, Hampshire (UK) and Colorado Springs, Colorado (USA)

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