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Charles River Launches Endosafe Nexus 200, Emphasizes Critical Importance of Smart Automation for Endotoxin Detection

publication date: Dec 20, 2022
author/source: Charles River Laboratories International, Inc


Charles River Laboratories International, Inc. launches the Endosafe® Nexus 200™, expanding its robust endotoxin testing portfolio.

The Nexus 200 is the next evolution of Charles River’s data integrity compliant, fully robotic instrument, capable of processing both undiluted or complex, serial dilutions for water, in-process, and final product testing via Endosafe Limulus Amebocyte Lysate (LAL) cartridge technology in a fully enclosed system. Powered by Endosafe EndoScan-V version 6.1, the system allows for data to be exported into a Laboratory Information Management System (LIMS) integration and provides improved traceability, security, and data management on an integrated touch screen.

Automation through robotics represents an evolution of bacterial endotoxin testing and streamlines quality control (QC) processes. Smart automation can improve overall process efficiency, including:

  • Minimizing variation, time, and resources of performing laboratory investigations.
  • Improving workflow of quality control operations, which can reduce product lead times by 60-70 percent, enabling real-time product releases.
  • Avoiding the cost and time needed to train individuals to perform repetitive tasks to allocate to more high-priority tasks, such as interpreting data, analyzing trends, and proactively addressing risks.
  • Reducing the risk for human error in testing processes by implementing automation, leading to greater confidence in product quality and setting a standard of excellence in line with the new revisions to Annex 1.


Unlocking the Benefits of Endosafe LAL Cartridge Technology

Nexus 200 combines technology, innovation, and control to optimize and streamline testing by combining the Endosafe LAL cartridge technology, the Endosafe® nexgen-MCS™ multi-cartridge system, and the Hamilton Microlab® Nimbus platforms for a low-maintenance, high-precision walkaway platform. Charles River’s FDA-licensed LAL cartridge is designed to optimize the standard LAL test. All necessary components are included in the self-contained disposable cartridge, including precise amounts of LAL reagent, chromogenic substrate, and control standard endotoxin (CSE). Cartridges are manufactured in accordance with rigid QC procedures and have been approved by the FDA for in-process and final product release testing.


View Product Information



About Charles River

Charles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them.



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