Sygnature Discovery (Nottingham, UK) has been using an Asynt DrySyn SnowStorm system to perform low temperature reactions which have traditionally been difficult  to undertake reproducibly on a small to medium scale.

The Asynt DrySyn SnowStorm offers an attractive solution to laboratories undertaking low temperature reaction chemistries. Available in a choice of configurations, the DrySyn SnowStorm system provides controlled cooling and heating for sub-ambient parallel chemistry without the need for jacketed reaction vessels, or ice baths. Operating with a suitable chiller / circulator, a DrySyn SnowStorm system provides accurate, stable temperature control down to -50 °C and up to +150 °C.

Dr Geraint Jones, Associate Director of Chemistry at Sygnature Discovery commented, "Being able to maintain a sub-ambient temperature sometimes for significant periods is really important for reaction reproducibility. The DrySyn SnowStorm connects to an external chiller unit and holds temperatures at a set-point for as long as is required. Setting temperature ramping profiles is also possible which is important in optimisation studies and is a real added benefit to us"

His colleague Mark Mills, Senior Research Chemist at Sygnature Discovery added, "We purchased the DrySyn SnowStorm to achieve tight temperature control (at -20°C) for a reaction involving a stereoselective cyclisation. If we had not been able to maintain this temperature for a sustained period, racemisation could have occurred. We selected this Asynt equipment because it integrated well into our way of working and allowed the use of round-bottomed flasks in a variety of sizes, thereby providing the flexibility to conduct small to medium scale reactions". 

Sygnature Discovery, founded in 2004 in Nottingham, UK, is a leading provider of integrated drug discovery services to pharmaceutical / biotech companies and academic institutions located in Europe and the USA.  The company employs over 90 laboratory-based, industry-experienced PhD medicinal chemists, computational chemists and in vitro biologists.  Through its unique ‘federated’ CRO model, Sygnature undertakes complete drug discovery programmes and hit finding, hit-to-lead and lead optimisation projects for clients.  For more information, visit: www.sygnaturediscovery.com and www.integrateddrugdiscovery.com .

Asynt (www.asynt.com) is a leading supplier of affordable products, consumables and services for chemists in industry and academia. With staff of trained chemists - Asynt is able to draw upon this in-depth applications knowledge to provide a high level of customer support for its DrySyn Heating Blocks, Controlled Laboratory Reactors, Synthesis Tools, Evaporators, Circulators, temperature Control Systems, Vacuum Pumps and Laboratory Safety Equipment.

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