Proteomics research is increasingly involved in the development of modern clinical medicine from the identification of drug targets, the validation of biomarkers, and optimization of resulting drug leads and assays.

Pharmaceutical and diagnostic companies spend tens of billions of dollars on translational research, which has increased the focus on instruments capable of powerfully assaying and identifying proteins implicated in disease pathways.

The Proteomic Research Market Opportunity, Defined 

Report analyst Emil Salazar examines proteomics research processes in detail and in terms of their instrument and technological requirements relating to mass spectrometry, liquid chromatography and electrophoresis. The instruments and technologies of this report are profiled in terms of their application in proteomics research workflows; analytical strengths and weaknesses; diverse features; major suppliers and their market shares; and market trends. As part of its coverage, the report includes market size estimates (2014) and market projections (2019) for the following instrument groups: 

- Mass Spectrometry 

- Liquid Chromatography 

- Electrophoresis 

Proteomics research factors into life sciences research as a demanding, advanced area of research antecedent to clinical research and clinical trials that are performed more widely across the world. Proteomics is only one strand of systems biology or one of several "omics" fields comprehensively tasked with elucidating various biological molecules in terms of their structure and interaction within cells and organisms. Among the "omics," proteomics trails only the fields of genomics and transcriptomics in terms of maturity and heft in research investment. Systems biology is a significant resource for translational research and achieving a greater depth of understanding regarding disease pathways. This report also explores proteomics research market by the current and forecast size of disease group market segments that include: 

- Oncology 

- Neurology 

- Cardiovascular 

- Other 

How Proteomics Research is Conducted Today 

No market assessment of proteomics research is complete without a thorough discussion of its instrument-based core processes, current practices and future trends, and where pitfalls occur and opportunities for companies might lie. The backbone of proteomics research is formed by electrophoresis and liquid chromatography for sample fractionation and analytical separation and mass spectrometry for protein identification, characterization and quantitative analysis. The report discusses each instrument, how it is used, and what might be future positions of different instrument technologies. Proteomics ideally functions within a translational research pipeline for the development of therapeutics and assays for research and clinical use. The proteomics research workflow for translational product development is in large part facilitated by mass spectrometry, liquid chromatography and electrophoresis technologies - the market focus of this report. 

Mass spectrometry-based proteomics is a particular focus of this report, as MS-based research methods represent a leading option for pharmaceutical and life science companies to mitigate research expenditures by multiplexing detection in a relatively 'antibody-less' workflow. This report compares the following types of MS in terms of resolution, mass accuracy, sensitivity, dynamic range, speed, cost, and proteomics research workflow applications: 

- Triple Quadrupole (QqQ) 

- Time-of-flight (TOF) 

- Quadrupole-TOF (Q-TOF) 

- Ion Traps (IT,QIT,LIT) 

- Orbitraps- FT-ICR 

The process of validating useful proteins for new drugs and clinical tests begins with translational research that transforms laboratory or preclinical study discoveries into useful pre-clinical studies and clinical trials. Following protein biomarker and drug target validation, translational research proceeds alternatively with the optimization of drug leads active for the identified target or the development of assays used in preclinical studies, as a less-regulated lab developed test (LDT), research use only (RUO) assay, or clinically. 

The following is among the topics addressed in this report: 

- Current Practices in Drug Discovery 

- The Translational Research Workflow 

- Proteomics in Biomarker Research 

- Biomarker Discovery 

- Biomarker Verification 

- Biomarker Validation 

- Company Market Shares by Research Instrument 

- Company Revenues and Detailed Product Offerings 

- Analyst Conclusions Regarding the Present and Future Market 

Who Competes in This Market and Where Do They Stand? 

As part of its superior analysis of proteomics research instrument markets, the report identifies company market share for specific instrument areas including liquid chromatography and mass spectrometry as well as the market leaders in electrophoresis. 

The report notes the background, products and revenue of the major market players. Companies profiled include: 

- AB Sciex (Danaher) 

- Agilent Technologies 

- Bruker Corporation 

- Thermo Fisher Scientific 

- Waters Corporation 

- Bio-Rad Laboratories 

- GE Healthcare Life Sciences 

- JEOL Ltd. 

- Shimadzu Corporation 

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