Channels

 

Special Offers & Promotions

 

 

Latest News

 

 

View Channel

New Products

 

 

View Channel

Video Presentations

 

 

View Channel

Separation Science

 

 

View Channel

Microscopy & Image Analysis

 

 

View Channel

Laboratory Automation & IT Solutions

 

 

View Channel

 

Marburg University Tests New Generation of Light Microscopes from Leica Microsystems

Cell biologist Prof. Dr. Ralf Jacob from Philipps University, Marburg.The University of Marburg is expanding its cooperation with Leica Microsystems: The Institute of Cytobiology is currently one of four institutes in the world to test a microscope with a resolution well below the diffraction limit (nanoscope). "With this new optical nanoscopy called GSDIM (ground state depletion microscopy followed by individual molecule return), resolutions down to 25 nanometers can be achieved. This makes it possible to image sub-cellular structures or protein complexes far beyond the resolving powers of a light microscope," says cell biologist Prof. Dr. Ralf Jacob. The new technology, for which Leica Microsystems has been granted an exclusive licence, is being tested until September in the Imaging Core Facility of the special Cell Biology Research Department 593 (SFB 593) in Marburg. 

True-to-detail imaging of the spatial arrangement of proteins and other biomolecules in cells and observing molecular processes - GSDIM makes this possible for researchers due to resolutions beyond the diffraction limit. The more insight science gains into these basic processes of life, the better it can find the causes of previously incurable diseases and develop suitable therapies.

One of the strengths of GSDIM is that it uses conventional fluorescence markers to image proteins or other biomolecules within the cells with sharpness down to a few nanometers. This includes fluorophores which are routinely used in biomedicine. 

With GSDIM, the fluorescent molecules in the specimen are almost completely switched off using laser light. However, individual molecules spontaneously return to the fluorescent state, while their neighbors remain non-illuminating. In this way, the signals of individual molecules can be acquired sequentially using a highly sensitive camera system and their spatial position in the specimen can be measured and stored. An extremely high-resolution image can then be created from the position of many thousands of molecules. This enables cell components that are situated very close to one another and cannot be resolved using conventional widefield fluorescence microscopy to be spatially separated and sharply reproduced in an image. 

With GSDIM technology, Leica Microsystems is extending its lead as an innovative provider of super-resolution light microscopes and nanoscopes. "With this new widefield microscope system we are extending our super-resolution portfolio and allow even more scientists to benefit from our innovative technology and advance their research," comments Anja Schué from Leica Microsystems. The current test phase of the microscope is important in this context, as optimal testing can only be done by active scientists like the members of the SFB 593, which is sponsored by the German Research Society. "Our research naturally derives great benefit from being able to work with a microscope like this one," adds Professor Jacob.

For further information please visit www.leica-microsystems.com


If you have not logged into the website then please enter your details below.



 

News Channels

 

 

Subscribe to any of our newsletters for the latest on new laboratory products, industry news, case studies and much more!

Newsletters from Lab Bulletin

 

Request your free copies HERE

 

 

 

Popular this Month

Top 10 most popular articles this month

 

 

Today's Picks

 

 

 

 

Looking for a Supplier?

Search by company or by product

 


Company Name:

Product:


 

 

 

 

Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd.


 

Media Partners

 

Exhibitions & Events