Channels

 

Special Offers & Promotions

 

 

Latest News

 

 

View Channel

New Products

 

 

View Channel

Video Presentations

 

 

View Channel

Separation Science

 

 

View Channel

Microscopy & Image Analysis

 

 

View Channel

Laboratory Automation & IT Solutions

 

 

View Channel

 

Lonza Announces New Offering of Silensomes HLM for Drug Metabolism Studies

publication date: Dec 1, 2017
 | 
author/source: Lonza

Lonza Walkersville announced its new offering of Silensomes™ Human Liver Microsomes (HLM) products – pooled human liver microsomes for in vitro cytochrome P450 (CYP) phenotyping.

lonza

CYP phenotyping is a regulatory requirement for new drug candidates to understand their metabolism and to predict drug-drug interactions. Lonza Walkersville's new Silensomes™ HLM products provide researchers a fully characterized pre-made solution for CYP phenotyping, resulting in more consistent and reliable results.

Lonza's Silensomes™ HLM products include seven cryopreserved human liver microsomes pools that are each pre-treated with a mechanistic-based inhibitor targeting a single CYP enzyme. This chemical inactivation is mechanism-based and irreversible, giving researchers confidence that their results are accurate and reliable. Each of the seven CYP Silensomes™ HLM are packaged as Silensomes™ CYP Phenotyping Kits to include a production-matched control microsome that was treated the same way without the inhibitor. A panel consisting of all seven Silensomes™ HLM with a single matched control is also available.

This new product offering from Lonza is a result of the company's recent agreement with Biopredic International and strengthens Lonza's position as a leading supplier of ADME-Tox products for scientists working in drug development. The addition of Silensomes™ HLM products expands Lonza's extensive ADME-Tox portfolio, which includes fresh and cryopreserved human and animal primary hepatocytes, specialized media and cell culture systems.

"With regulatory authorities specifying CYP phenotyping as part of the drug development process, we wanted to support scientists working in this area by offering more-reliable and easier-to-use models," said Maureen Bunger, Product Manager for ADME-Tox Solutions at Lonza. "Our Silensomes™ HLM products are supplied in a ready-to-use format and provide a single in vitro solution for CYP phenotyping, helping to simplify drug metabolism studies for researchers."

Silensomes™ HLM products are produced by and are a trademark of Biopredic International.


more about lonza


 



 

News Channels

 

 

Subscribe to any of our newsletters for the latest on new laboratory products, industry news, case studies and much more!

Newsletters from Lab Bulletin

 

Request your free copies HERE

 

 

 

Popular this Month

Top 10 most popular articles this month

 

 

Today's Picks

 

 

 

 

Looking for a Supplier?

Search by company or by product

 


Company Name:

Product:


 

 

 

 

Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd.


 

Media Partners

 

Exhibitions & Events