Channels

 

Special Offers & Promotions

 

 

Latest News

 

 

View Channel

New Products

 

 

View Channel

Video Presentations

 

 

View Channel

Separation Science

 

 

View Channel

Microscopy & Image Analysis

 

 

View Channel

Laboratory Automation & IT Solutions

 

 

View Channel

 

Critical Outcome Technologies Inc. Discovers Novel Scaffolds For Inhibiting HIV Integrase

publication date: May 21, 2010
 | 
author/source: b3c newswire

Critical Outcome Technologies Inc. (COTI) (TSX Venture: COT) today announced positive results from the first phase of its HIV integrase inhibitor discovery program.  These results provide novel intellectual property to the Company and further validation of the CHEMSAS® drug discovery technology.

The significance of these results is that the majority of currently marketed and developmental stage HIV Integrase inhibitors have a very similar way of interacting with and inhibiting the enzyme through a diketo acid type moiety.  COTI has used its proprietary technology, CHEMSAS®, to discover several novel small molecule scaffolds that have an entirely new binding mode and interaction with the active site of the viral enzyme.  

COTI has completed the synthesis and initial confirmatory in vitro testing of the first three novel scaffolds from this program.  All three scaffolds demonstrated good inhibitory activity in a biochemical HIV integrase assay at nanomolar concentrations.  On the basis of these results, COTI has filed composition of matter patents and intends to proceed with the next phase of this project that consists of optimizing a small series of potential lead candidates based on these scaffolds.

"These encouraging results provide further validation of our CHEMSAS® technology and its ability to rapidly identify innovative small molecules for difficult drug targets. The discovery of new HIV integrase inhibiting scaffolds having an entirely novel mode of interacting with the enzyme has been challenging for HIV researchers, which makes these early results quite gratifying," said Dr Wayne Danter, COTI's President and CSO. 

As previously announced, these novel scaffolds are part of a co-development program with a major pharmaceutical partner.  The co-development partner is now conducting and funding agreed upon in vitro experiments in their evaluation of the compounds.  Once these experiments have been completed and the results have been received by COTI, the co-development partner will have an exclusive time period to negotiate a licensing agreement with COTI for the compounds.



 

News Channels

 

 

Subscribe to any of our newsletters for the latest on new laboratory products, industry news, case studies and much more!

Newsletters from Lab Bulletin

 

Request your free copies HERE

 

 

 

Popular this Month

Top 10 most popular articles this month

 

 

Today's Picks

 

 

 

 

Looking for a Supplier?

Search by company or by product

 


Company Name:

Product:


 

 

 

 

Please note Lab Bulletin does not sell, supply any of the products featured on this website. If you have an enquiry, please use the contact form below the article or company profile and we will send your request to the supplier so that they can contact you directly.

Lab Bulletin is published by newleaf marketing communications ltd.


 

Media Partners

 

Exhibitions & Events