With the new Leica
SR GSD from Leica Microsystems, scientists can now achieve resolutions far
below the limit of diffraction that have never been attained before in
widefield fluorescence microscopy. The system is capable of resolving details
as small as 20 nanometers. This enables research of structures of single
proteins and other biomolecules in cells and observation of molecular processes
to gain new insights into fundamental processes of life.
The Leica SR GSD is based on GSDIM technology (Ground State Depletion
followed by Individual Molecule return; exclusively licensed from MPI
Goettingen, based on the work of Professor Stefan Hell). It has already
delivered amazing results in scientific experiments during its test phase. One
of the key advantages of the GSDIM method is that it can be used with
conventional fluorescence labels routinely applied in fluorescence imaging
applications. GSDIM provides the highest resolution possible with a light
microscope today, almost equaling that of an electron microscope.
Extended super-resolution portfolio
Based on many years of experience in
super-resolution microscopy with its confocal laser scanning microscopy systems
Leica
TCS STED (2007) and
Leica
TCS STED CW (2009), Leica Microsystems is now extending its innovative
portfolio of super-resolution light microscopy and nanoscopy products. "We are
thrilled that the outstanding performance of the new Leica SR GSD has been
confirmed by many experts. We have already received orders from the research
community, and are eagerly awaiting first publications," comments Sebastian
Tille, head of the Business Segment ‘Widefield Imaging' at Leica Microsystems.
Highly Integrated Multi-Modal System
The Leica SR GSD is based on a fully
automated TIRF system (Total Internal Reflection Fluorescence). Combining the
benefits of super-resolution with TIRF microscopy is one of many options. The
system can also be used for a wide range of applications in all areas of live
cell microscopy and high-end fluorescence microscopy. As a flexible,
multi-functional system, the Leica SR GSD gives researchers the freedom to
tailor the system exactly to their needs.
Novel Drift Optimization
The prevention of drift during image
acquisition is a key issue in super-resolution microscopy for exact
localization of molecules. The Leica SR GSD is equipped with the novel SuMo
Stage technology (SUpressed MOtion) that guarantees minimum drift, eliminating
the need for time-consuming drift compensation post acquisition. With the Leica
SR GSD the user can immediately see the super-resolution image of the selected
sample location during acquisition. The reduction of drift also simplifies
specimen preparation, as there is no need to use gold particles or other
standards for reference.
The Leica
SR GSD is a reliable research tool for a wide range of biomedical applications,
providing neuroscientists, cell biologists, virologists, structural biologists,
microbiologists, and physiologists with new opportunities for studying the
function and interaction of single molecules and visualization of sub-cellular
structures.
For further information
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