Evolving
operational conditions are the order of the day in today's biotech labs. That's why Sartorius Stedim Biotech developed
SARTOFLOW® Alpha plus - the flexible modular benchtop crossflow filtration
system. SARTOFLOW® Alpha plus provides
semi-automatic micro, ultra und diafiltration and is especially suited for
process development, clinical testing and for smaller production
processes. Thanks to its standardized
options, the system can be adapted quickly and easily to the changing
production demands of downstream processing.
Intelligent Modules
The
unique SIP (steaming-in-place) module for thermal sterilization gives users the
option to run all crossflow processes aseptically. For such applications, heat-resistant Sartocon®
filter cassettes are available along with custom-built valves and sterile
connectors. This makes in situ
sterilization of the entire system possible.
The SARTOFLOW® Alpha plus system is cGMP-compliant and self-draining.
The
system operates with both disposable bag technology or permanently installed
tank. So equipped, the new SARTOFLOW® Alpha plus features the ultimate in
flexibility. Thanks to consistent
modularity and wide-ranging accessories like conductivity sensors, pH
electrodes, peristaltic pumps and 21 CFR part 11 compliant software, the
SARTOFLOW® Alpha plus is adaptable to every process.
The
crossflow system is equipped with a well-established DCU4 control module, which
allows communication with the SCADA MFCS/WIN data logging and control software
from Sartorius Stedim Biotech and makes integration with existing networks
effortless. Thanks to pre-programmed
sequences, the MFCS software is easy to operate and enables semi-automatic
workflows. Start-up is thus faster than
ever.
The Ultimate in Flexibility
The
filter holder takes up to five Sartocon® Slice cassettes, each of which has a
filter surface of 0.1m
2. The
hydrodynamic properties of the filtration cassettes can be transferred to
larger cassettes in the Sartocon® family.
All available SARTOFLOW® Alpha plus modules are designed for a minimum
recirculation volume of 300 ml (with a 0.1m
2 Sartocon® Slice
cassette).
Thanks
to its IP54 rating for pump and the control module, the complete system can be
used in refrigerated rooms and rough production climates. The system is easy to install; it only needs
an electrical connection and cooling water access, and optionally a steam
generator. Other components, such as
compressed air, are not required for operation.
For further information
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A profile of Sartorius Stedim Biotech
Sartorius Stedim
Biotech is a leading provider of cutting-edge equipment and services for the
development, quality assurance and production processes of the
biopharmaceutical industry. Its integrated solutions covering fermentation, filtration,
purification, fluid management and lab technologies are supporting the
biopharmaceutical industry around the world to develop and produce drugs
safely, timely and economically. Sartorius Stedim Biotech focuses on single-use
technologies and value-added services to meet the rapidly changing technology
requirements of the industry it serves. Strongly rooted in the scientific
community and closely allied with customers and technology partners, the
company is dedicated to its philosophy of "turning science into solutions".
Headquartered in Aubagne, France, Sartorius Stedim
Biotech is listed on the Eurolist of Euronext Paris. With its own manufacturing
and R&D sites in Europe, North America and Asia and a global network of
sales companies, Sartorius Stedim Biotech enjoys a worldwide presence. Its key
manufacturing and R&D site is in Germany. The company employs approximately
2,400 people, and earned in 2009 sales
revenue of 401,2 million euros according to preliminary figures.